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World Journal of Gastroenterology 1998年第1期4卷 66-68页

作者： ZhanG Shu-Lin han xiao-bing YUE Ya-Fei 不详

IM To determine the incidence of hepatitis B virus (HBV) intrauterine infection and to explore the relationship between HBV viremia level of pregnant women and HBV intrauterine infection.METHODS Sixtynine pregnant women were divided into three groups. Group A, 41 HBsAg positive patients, 14 of them were HBeAg positive (group A1), and 27 HBeAg negative (group A2); Group B, 12 HBsAg negative patients, but positive for antiHBs and/or antiHBe and/or antiHBc; and Group C, 16 patients negative for all HBV markers. Blood samples of mothers were taken at delivery, samples of their infants were collected within 24 hours after birth (before injection of HBIG and HBV vaccine). All the serum samples were stored at -20℃. HBV serum markers were tested by radioimmunoassay and HBV NDA were detected by nested polymerase chain reaction.RESULTS In group C, all of 16 newborns were negative for HBsAg and HBV DNA. In group A, 7 infants were HBsAg positive (171%), and 17 (415%) were HBV DNA positive (Phan that in group A2 (HBsAg 429% vs 37%, HBV DNA 929% vs 148%, P<005). The incidence of HBV intrauterine infection was significantly different between high and low HBV viremia of mothers (933% vs 429%, P<005).CONCLUSION The incidence of HBV intrauterine infection is high when HBV DNA in newborns detected with nested PCR is used as a marker of HBV infection. It is related to HBV viremia level of mothers.

关键词： hepatitis B DNA,viral/analysis radioimmunoassay polymerase chain reaction intrauterine infection

碳纳米颗粒形貌对聚乙烯复合材料性能影响的正电子湮没研究

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精细与专用化学品 2024年第2期32卷 13-19页

作者：高洁周振豪梅佳明韩小兵湖北科技学院辐射化学与功能材料湖北省重点实验室核技术与化学生物学院湖北咸宁437100

在高性能聚合物纳米复合材料的构筑中,为了实现碳纳米颗粒的精准选择,揭示碳纳米颗粒形貌对聚合物复合材料微观结构及宏观性能的影响十分必要。采用热压法制备了富勒烯、碳纳米管、石墨烯和炭黑等不同形貌碳纳米颗粒填充改性的聚乙烯复... 详细信息

在高性能聚合物纳米复合材料的构筑中,为了实现碳纳米颗粒的精准选择,揭示碳纳米颗粒形貌对聚合物复合材料微观结构及宏观性能的影响十分必要。采用热压法制备了富勒烯、碳纳米管、石墨烯和炭黑等不同形貌碳纳米颗粒填充改性的聚乙烯复合材料,并利用正电子湮没寿命谱探讨了碳纳米颗粒形貌对复合材料自由体积特性的影响。此外,系统地研究了碳纳米颗粒形貌对聚乙烯复合材料流变、力学、电学和热学性能的影响,并将形貌对宏观性能的影响与复合材料自由体积分数的变化进行了关联。

关键词：碳纳米颗粒形貌正电子湮没微观结构性能

2022-2023年广东某大学感染性腹泻细菌病原谱及流行特征分析

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罕少疾病杂志 2024年第7期31卷 112-114页

作者：余烈中刘锦洪韩小兵广东财经大学门诊部检验室广东广州510320 佛山市三水区疾控预防控制中心检验室广东佛山528100 广州金域医学检验中心微生物检验室广东广州510330

目的为临床制订有效的科学的治疗和预防措施,熟悉和了解广东某大学2022-2023年的感染性腹泻细菌病原谱和流行特征。方法收集2022年1月到2023年1月广东某大学门诊部收治的586份感染性腹泻病例患者的粪便样本,对304份样本进行伤沙门氏菌... 详细信息

目的为临床制订有效的科学的治疗和预防措施,熟悉和了解广东某大学2022-2023年的感染性腹泻细菌病原谱和流行特征。方法收集2022年1月到2023年1月广东某大学门诊部收治的586份感染性腹泻病例患者的粪便样本,对304份样本进行伤沙门氏菌、志贺菌、肠致泻性大肠埃希菌、金黄色葡萄球菌、变形杆菌、副溶血性弧菌检测,对282份样本进行轮状病毒、诺如病毒检测,观察2022-2023年广东某大学感染性腹泻病原检测情况和病原谱构成及不同月份和年龄的检测情况。结果在采集的586例腹泻标本中检出病原体68例(11.60%),304例在进行肠道致病菌后检出18例(5.92%)肠道致病菌,282例在进行肠道病毒检测后检出50例(17.73%)肠道病毒,二者比较差异有统计学意义(P<0.05);感染性腹泻在6-8月经肠道致病菌为主,在10月-次年5月经肠道病毒为主且17-22岁年龄阶段容易高发感染性腹泻。结论2022-2023年广东某大学感染性腹泻主要是以诺如病毒为主,其次是副溶血性弧菌导致的细菌性腹泻,不同病原在不同季节和不同年龄阶段的分布存在差异,需针对性的采取预防措施。

关键词：感染性腹泻细菌性病原谱流行特征

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电子束固化丙烯酸酯压敏胶的制备及性能研究

精细与专用化学品 2024年第8期32卷 31-34,40页

作者：高洁宋亚军胡正杭韩小兵湖北科技学院辐射化学与功能材料湖北省重点实验室核技术与化学生物学院湖北咸宁437100

电子束(electron beam,EB)辐射固化是实现丙烯酸酯压敏胶环保和高效生产最有前景的技术。以聚氨酯丙烯酸酯为光敏树脂、丙烯酸酯树脂为增粘剂、三丙二醇二丙烯酸酯为交联剂、常规丙烯酸酯单体为活性稀释剂,通过EB辐射固化技术制得新型... 详细信息

电子束(electron beam,EB)辐射固化是实现丙烯酸酯压敏胶环保和高效生产最有前景的技术。以聚氨酯丙烯酸酯为光敏树脂、丙烯酸酯树脂为增粘剂、三丙二醇二丙烯酸酯为交联剂、常规丙烯酸酯单体为活性稀释剂,通过EB辐射固化技术制得新型压敏胶。研究了光敏树脂、增粘剂、交联剂等的用量对所制得压敏胶初粘力和初粘力的影响,在优化配方的基础上进一步研究了辐照剂量的影响。

关键词：电子束固化聚丙烯酸酯压敏胶性能

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辐射固化压敏胶研究进展

精细与专用化学品 2024年第6期32卷 1-5页

作者：宋亚军梅佳明沈树人高洁韩小兵湖北科技学院核技术与化学生物学院湖北咸宁437100 赤壁凯利隆科技有限公司湖北咸宁437100

辐射固化技术,特别是紫外光(ultraviolet, UV)/电子束(electron beam, EB)固化技术,由于具有节能、环保、经济、高效和适用性广等优点,被广泛应用于各种胶黏剂的制备。在介绍辐射固化胶黏剂组成及应用的基础上,具体阐述了UV/EB固化的原... 详细信息

辐射固化技术,特别是紫外光(ultraviolet, UV)/电子束(electron beam, EB)固化技术,由于具有节能、环保、经济、高效和适用性广等优点,被广泛应用于各种胶黏剂的制备。在介绍辐射固化胶黏剂组成及应用的基础上,具体阐述了UV/EB固化的原理和设备,并总结了UV/EB固化压敏胶的最新研究进展,对其发展方向和前景进行了展望。

关键词：压敏胶辐射固化紫外光电子束

Identifying and localizing of seismogenic electromagnetic anomalies from data observed by permanent MT stations

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Science China Earth Sciences 2024年第5期67卷 1698-1713页

作者： bing han Wenbao HU Guoze ZHAO Ji TANG State Key Laboratory of Earthquake Dynamics Institute of GeologyBeijing 100029China Key Laboratory of Exploration Technologies for Oil and Gas Resources of Ministry of Education Yangtze UniversityWuhan 430100China

In this research, an arbitrarily oriented electric dipole at subsurface is used to simulate Seismogenic Electromagnetic(SEM) radiation emanating from a seismic zone during its gestation phase. Analytical synthesis of responses at the Lijiang magnetotelluric(MT) station has revealed that SEM radiation could induce identifiable anomalies in the electromagnetic(EM)spectrum, apparent resistivity and phase within specific frequency bands. Background variations were extracted from long-term observation data of Dali and Lijiang MT stations, enabling the identification of SEM anomalies related to the Yunlong and Yangbi earthquakes. Multiple parameters of dipole sources at subsurface were obtained by applying the Differential Ant Colony Optimization(DACO) algorithm to anomalous data of two stations with multi-frequencies and various response functions. The spatial distribution of these predicted dipoles is predominantly clustered in or around the seismogenic area, with their azimuthal orientation aligning towards the seismogenic fault in general. This study has demonstrated the potential of using subsurface electric dipole simulations for SEM radiation analysis, offering a feasible approach for the prediction and understanding of seismogenic zones.

关键词： MT responses Identifying SEM anomaly Vector electric dipole responses Localizing SEM sources by inversion

A mixed-valence polyoxometalate-based 3D inorganic framework cathode material for high-efficiency rechargeable AZIBs

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Rare Metals 2024年第8期43卷 3677-3691页

作者： Qing han Hao-Ran xiao Tao Zhou bing-Chuan Li Liu Yang Ling-Ling Xie Xue-Jing Qiu Xian-Yong Wu Li-Min Zhu xiao-Yu Cao School of Chemistry and Chemical Engineering Henan University of TechnologyZhengzhou 450001China Key Laboratory of High Specific Energy Materials for Electrochemical Power Sources of Zhengzhou City Zhengzhou 450001China College of Materials Engineering Henan University of EngineeringZhengzhou450007China School of Environmental Engineering Henan University of TechnologyZhengzhou 450001China Department of Chemistry University of Puerto Rico-Rio Piedras CampusSan JuanPR 00925USA

The global trend towards new energy storage systems has stimulated the development of electrochemical energy storage *** these technologies,rechargeable aqueous zinc-ion batteries(AZIBs)have attracted considerable interest as a potential alternative to lithium-ion batteries(LIBs)due to their affordable cost,environmental compatibility and high safety *** this study,a high-quality electrode for AZIBs has been successfully developed using a dehydrated mixed-valence polyoxometalate-based three-dimensional(3D)inorganic framework material known as[H_6Mn_(3)V^Ⅳ_(15)V-^Ⅴ_(4O)_(46)(H_2O)_(12)](3D-MnVO).This innovative 3D-MnVO material is built from the alternate connections of{V_(19)O_(46)}"sphere-shaped"clusters andμ_(2)-{Mn(H_(2)O)_(4)}bridges,where each{V_(19)O_(46)}cluster is surrounded by three pairs of vertically distributed{Mn(H_(2)O)_(4)}units,thus resulting in the 3D interpenetrating grid-like network from the infinite[-{V_(19)O_(46)}-μ_(2)-Mn(H_(2)O)_(4)-{V_(19)O_(46)}]_∞chains in three mutually perpendicular *** 3D framework structure of 3D-MnVO possesses abundant oxygen vacancies,spacious and multi-level interconnected channels for ion transport,which facilitates the efficient intercalation/deintercalation of hydrated Zn^(2+)into the pores of the primary structure via the intercalation capacitance *** a result,the 3D-MnVO electrode exhibits excellent diffusion rates and minimal interfacial *** a current density of 0.1 A·g^(-1),the 3D-MnVO cathode delivers a commendable discharge capacity of170.5 mAh·g^(-1)with 81.6%capacity retention after100 charge/discharge ***,even at a high current density of 1.0 A·g^(-1),the 3D-MnVO electrode delivers a remarkable reversible capacity of198.9 mAh·g^(-1).Our research results provide valuable insights into the development of advanced polyoxometalate-based 3D inorganic framework electrode materials for high-performance rechargeable AZIBs.

关键词： Cathode Polyoxometalate 3D inorganic framework Zinc-ion batteries Energy storage mechanism

Progress in the treatment of advanced hepatocellular carcinoma with immune combination therapy

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 273-286页

作者： Di Pan Hao-Nan Liu Peng-Fei Qu xiao Ma Lu-Yao Ma xiao-xiao Chen Yu-Qin Wang xiao-bing Qin Zheng-Xiang han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

Advanced hepatocellular carcinoma(HCC)is a severe malignancy that poses a serious threat to human *** to challenges in early diagnosis,most patients lose the opportunity for radical treatment when ***,recent advancements in cancer immunotherapy provide new directions for the treatment of *** instance,monoclonal antibodies against immune check-point inhibitors(ICIs)such as programmed cell death protein 1/death ligand-1 inhibitors and cytotoxic t-lymphocyte associated antigen-4 significantly improved the prognosis of patients with ***,tumor cells can evade the immune system through various *** the rapid development of genetic engineering and molecular biology,various new immunotherapies have been used to treat HCC,including ICIs,chimeric antigen receptor T cells,engineered cytokines,and certain cancer *** review summarizes the current status,research progress,and future directions of different immunotherapy strategies in the treatment of HCC.

关键词： Hepatocellular carcinoma Immunotherapies Immune checkpoint inhibitor Clinical efficacy Adverse reactions

Impact of baseline hepatitis B virus viral load on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2504-2519页

作者： Di Pan Hao-Nan Liu Zhi-Yuan Yao xiao-xiao Chen Yu-Qi Li Jing-Jing Zhu Zheng-Xiang han xiao-bing Qin Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Although the combination of lenvatinib and PD-1 inhibitors has become the standard regimen for the treatment of advanced hepatocellular carcinoma(HCC),real data on the impact of baseline hepatitis B virus(HBV)-DNA levels on the clinical efficacy of this regimen is still *** To evaluate the effectiveness of camrelizumab combined with lenvatinib in patients with HCC at varying levels of *** One hundred and twenty patients with HCC who received camrelizumab and lenvatinib treatment were categorized into two cohorts:HBV-DNA≤2000(n=66)and HBV-DNA>2000(n=54).The main outcomes measured were overall survival(OS)and progression-free survival(PFS),while additional outcomes included the rate of objective response rate(ORR),disease control rate(DCR),and any negative *** proportional hazards regression analysis revealed independent predictors of OS,leading to the creation of a nomogram incorporating these *** The median PFS was 8.32 months for the HBV-DNA≤2000 group,which was similar to the 7.80 months observed for the HBV DNA>2000 group(P=0.88).Likewise,there was no notable variation in the median OS between the two groups,with durations of 13.30 and 14.20 months respectively(P=0.14).The ORR and DCR were compared between the two groups,showing ORR of 19.70%vs 33.33%(P=0.09)and DCR of 72.73%vs 74.07%(P=0.87).The nomogram emphasized the importance of antiviral treatment as the main predictor of patient results,with portal vein tumor thrombus and Barcelona Clinic Liver Cancer staging following closely *** The clinical outcomes of patients with HBV-associated HCC treated with camrelizumab in combination with lenvatinib are not significantly affected by HBV viral load.

关键词： Hepatitis B virus Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy

Non-volatile dynamically switchable color display via chalcogenide stepwise cavity resonators

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Opto-Electronic Advances 2024年第1期7卷 16-27页

作者： Kuan Liu Zhenyuan Lin bing han Minghui Hong Tun Cao School of Optoelectronic Engineering and Instrumentation Science Dalian University of TechnologyDalian 116024China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361102China Institute of Laser Engineering Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China

High-resolution multi-color printing relies upon pixelated optical nanostructures,which is crucial to promote color display by producing nonbleaching colors,yet requires simplicity in fabrication and dynamic *** trisulfide(Sb_(2)S_(3))is a newly rising chalcogenide material that possesses prompt and significant transition of its optical characteristics in the visible region between amorphous and crystalline phases,which holds the key to color-varying ***,we proposed a dynamically switchable color printing method using Sb_(2)S_(3)-based stepwise pixelated Fabry-Pérot(FP)cavities with various cavity *** device was fabricated by employing a direct laser patterning that is a less timeconsuming,more approachable,and low-cost *** switching the state of Sb_(2)S_(3) between amorphous and crystalline,the multi-color of stepwise pixelated FP cavities can be actively *** color variation is due to the profound change in the refractive index of Sb_(2)S_(3) over the visible spectrum during its phase ***,we directly fabricated sub-50 nm nano-grating on ultrathin Sb_(2)S_(3) laminate via microsphere 800-nm femtosecond laser irradiation in far *** minimum feature size can be further decreased down to~45 nm(λ/17)by varying the thickness of Sb_(2)S_(3) *** switchable Sb_(2)S_(3) photonic devices can take one step toward the next generation of inkless erasable papers or displays and enable information encryption,camouflaging surfaces,anticounterfeiting,***,our work explores the prospects of rapid and rewritable fabrication of periodic structures with nano-scale resolution and can serve as a guideline for further development of chalcogenide-based photonics components.

关键词： tunable color displays Fabry-Pérot cavity resonators color printing chalcogenide materials