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Changes in Rat Brain MicroRNA Expression Profiles Following Sevoflurane and Propofol Anesthesia

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Chinese Medical Journal 2015年第11期128卷 1510-1515页

作者： Yu Lu Min-Yu Jian Yi-Bing Ouyang ru-Quan han Department of Anesthesia Beijing Tian Tan Hospital Capital Medical University Beijing 100050 China Graduate School of Capital Medical University Beiiina 100069 China Department of Anesthesia Stanford University School of Medicine Stanford CA 94305 USA

Background： Sevoflurane and propofol are widely nsed anesthetics focused on changes in protein expression properties and membrane for surgery. Studies on the mechanisms of general anesthesia have lipid. MicroRNAs （miRNAs） regulate neural function by altering protein expression. We hypothesize that sevoflurane and propofol affect miRNA expression profiles in the brain, expect to understand the mechanism of anesthetic agents. Methods： Rats were randomly assigned to a 2% sevoflurane group, 600 μg-kg -1min propofol group, and a control group without anesthesia （n = 4, respectively）. Treatment group was under anesthesia for 6 h, and all rats breathed spontaneously with continuous monitoring of respiration and blood gases. Changes in rat cortex miRNA expression profiles were analyzed by miRNA microarrays and validated by quantitative real-time polymerase chain reaction （qRT-PCR）. Differential expression of miRNA using qRT-PCR among the control, sevoflurane, and propotbl groups were compared using one-way analysis of variance （ANOVA）. Results： Of 677 preloaded rat miRNAs, the microarray detected the expression of 277 miRNAs in rat cortex （40.9%）, of which 9 were regulated by propofol and （or） sevoflurane. Expression levels of three miRNAs （rno-miR-339-3p, rno-miR-448, rno-miR-466b- 1 ＊） were significantly increased following sevoflurane and six （rno-miR-339-3p, rno-miR-347, rno-miR-378＊, rno-miR-412＊, rno-miR-702-3p, and rno-miR-7a-2＊） following propofol. Three miRNAs （rno-miR-466b-I ＊, rno-miR-3584-Sp and rno-miR-702-3p） were differentially expressed by the two anesthetic treatment groups. Conclusions： Sevoflurane and propofol anesthesia induced distinct changes in brain miRNA expression patterns, suggesting differential regulation of protein expression. Determining the targets of these differentially expressed miRNAs may help reveal both the common and agent-specific actions of anesthetics on neurological and physiological function.

关键词： Brain: MicroRNA Prooofol Sevoflurane

Propofol Ameliorates Calpain-induced Collapsin Response Mediator Protein-2 Proteolysis in Traumatic Brain Injury in Rats

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Chinese Medical Journal 2015年第7期128卷 919-927页

作者： Yun Yu Min-Yu Jian Yun-Zhen Wang ru-Quan han Department of Anesthesiology Beijing Tian Tan Hospital Capital Medical University Beijing 100050 China

Background： Collapsin response mediator protein-2 （CRMP2）, a multifunctional cytosolic protein highly expressed in the brain, is degraded by calpain following traumatic brain injury （TBI）, possibly inhibiting posttraumatic neurite regeneration. Lipid peroxidation （LP） is involved in triggering postinjury CRMP2 proteolysis. We examined the hypothesis that propo（bl could attenuate LP, calpain-induced CRMP2 degradation, and brain injury after TBI. Methods： A unilateral moderate controlled cortical impact injury was induced in adult male Sprague-Dawley rats. The animals were randomly divided into seven groups： Sham control group, TBI group, TB1 ＋ propofol groups （including propofol I h, 2 h, and 4 h groups）, TBI ＋ U83836E group and TBI ＋ fat emulsion group. The LP inhibitor U83836E was used as a control to identify that antioxidation partially accounts for the potential neuroprotective effects of propofol. The solvent of propofol, （＇at emulsion, was used as the vehicle control, lpsilateral cortex tissues were harvested at 24 h post-TBI. Immunofluorescent staining, Western blot analysis, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling were used to evaluate LP, calpain activity, CRMP2 proteolysis and programmed cell death. The data were statistically analyzed using one-way analysis of variance and a paired t-test. Results： Propofol and U83836E significantly ameliorated the CRMP2 proteolysis, In addition, both propofol and U83836E significantly decreased the ratio of 145-kDa cdl-spectrin breakdown products to intact 270-kDa spectrin, the 4-hydroxynonenal expression and programmed cell death in the pericontusional cortex at 24 h after TBI. There was no difference between the TB1 group and the （＇at emulsion group. Conclusions： These results demonstrate that propofol postconditioning alleviates calpain-mediated CRMP2 proteolysis and provides neuroprotective effects following moderate TBI potentially by counteracting LP and reducing calpain activation

关键词： Collapsin Response Mediator Protein-2 Lipid Peroxidation Neuroprotection Propofol Traumatic Brain Injury

Symbolic Reasoning About Quantum Circuits in Coq

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Journal of Computer Science & Technology 2021年第6期36卷 1291-1306页

作者： Wen-Jun Shi Qin-Xiang Cao Yu-Xin Deng han-ru Jiang Yuan Feng Shanghai Key Laboratory of Trustworthy Computing East China Normal UniversityShanghai 200062China John Hopcroft Center of Computer Science Shanghai Jiao Tong UniversityShanghai 200240China Yanqi Lake Beijing Institute of Mathematical Sciences and Applications Beijing 101408China Centre for Quantum Software and Information University of Technology SydneySydney NSW 2007Australia

A quantum circuit is a computational unit that transforms an input quantum state to an output state.A natural way to reason about its behavior is to compute explicitly the unitary matrix implemented by ***,when the number of qubits increases,the matrix dimension grows exponentially and the computation becomes *** this paper,we propose a symbolic approach to reasoning about quantum *** is based on a small set of laws involving some basic manipulations on vectors and *** symbolic reasoning scales better than the explicit one and is well suited to be automated in Coq,as demonstrated with some typical examples.

关键词： quantum circuit symbolic reasoning Dirac notation Coq

Optimization of ambipolar current and analog/RF performance for T-shaped tunnel field-effect transistor with gate dielectric spacer

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Chinese Physics B 2019年第1期28卷 656-662页

作者： ru han Hai-Chao Zhang Dang-Hui Wang Cui Li School of Computer Science and Engineering Northwestern Polytechnical University

A new T-shaped tunnel field-effect transistor(TTFET) with gate dielectric spacer(GDS) structure is proposed in this paper. To further studied the effects of GDS structure on the TTFET, detailed device characteristics such as current-voltage relationships, energy band diagrams, band-to-band tunneling(BTBT) rate and the magnitude of the electric field are investigated by using TCAD simulation. It is found that compared with conventional TTFET and TTFET with gate-drain overlap(GDO) structure, GDS-TTFET not only has the minimum ambipolar current but also can suppress the ambipolar current under a more extensive bias range. Furthermore, the analog/RF performances of GDS-TTFET are also investigated in terms of transconductance, gate-source capacitance, gate-drain capacitance, cutoff frequency, and gain bandwidth production. By inserting a low-κ spacer layer between the gate electrode and the gate dielectric, the GDS structure can effectively reduce parasitic capacitances between the gate and the source/drain, which leads to better performance in term of cutoff frequency and gain bandwidth production. Finally, the thickness of the gate dielectric spacer is optimized for better ambipolar current suppression and improved analog/RF performance.

关键词： tunneling field effect transistor T-shaped tunnel field-effect transistor gate dielectric spacer ambipolar current analog/RF performance

Ferromagnetism in an Electron Gas Obeying Fractional Statistics

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Chinese Physics Letters 2001年第7期18卷 868-869页

作者： YANG Kai-Hua han ru-Shan WANG Yu-Peng Department of Physics Peking UniversityBeijing 100871 Institute of Physics and Center for Condensed Matter Physics Chinese Academy of SciencesBeijing 100080

We study an ideal electron gas obeying fractional *** parameters for exclusion statistics are given by the strength of the repulsive *** some parameter regions,it is found the system shows itinerant ferromagnetism.

关键词： Electron fractional system

Effect of Sample Thickness on Magneto-Optic Imaging for Vortex Fully Penetrated Square-Shaped Superconductors

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Chinese Physics Letters 1998年第1期15卷 65-67页

作者： LIU Yun GAO Zheng-xiang TAO Jing han ru-shan Department of Physics Peking UniversityBeijing 100871

A significant effect of sample thickness on three components of the magnetic flux density distribution on square-shaped superconductor surface is shown,and the critical current density jc of the superconductor from th... 详细信息

关键词： superconductor Vortex Superconductor

微生态制剂在南美白对虾养殖中的应用研究进展

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饲料研究 2024年第9期47卷 157-161页

作者：蔡树东赵龙飞李文司天桃韩煜茹罗生金哈密市畜牧工作站新疆哈密839000

微生态制剂是一种新型的饲用添加剂,具有绿色、生态、无毒、无残留、不产生抗性、作用范围广等特点,具有调节肠道菌群平衡、抑制有害菌群生长、增强机体免疫力、净化水质、提高饲料利用率、促进水产动物生长发育等作用,在水产养殖中得... 详细信息

微生态制剂是一种新型的饲用添加剂,具有绿色、生态、无毒、无残留、不产生抗性、作用范围广等特点,具有调节肠道菌群平衡、抑制有害菌群生长、增强机体免疫力、净化水质、提高饲料利用率、促进水产动物生长发育等作用,在水产养殖中得到了广泛应用。近年来,微生态制剂在南美白对虾养殖中的应用研究取得了较大进展,尤其在南美白对虾的生长性能、免疫功能、抗病力等方面发挥了积极的作用。文章就微生态制剂的分类、作用机制及其在南美白对虾养殖中的应用效果进行了综述,为微生态制剂的研究及其在南美白对虾养殖中的合理应用提供参考,进一步促进南美白对虾养殖业的高效、健康发展。

关键词：微生态制剂作用机制南美白对虾

大骨鸡公鸡各生长阶段不同生长速度对血清生化指标的影响

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饲料研究 2024年第9期47卷 71-76页

作者：韩雪茹刘朋邵彩梅朱弘焱田玉民苏玉虹锦州医科大学畜牧兽医学院辽宁锦州121000 禾丰食品股份有限公司辽宁沈阳110000 锦州医科大学基础医学院辽宁锦州121000 锦州医科大学食品与健康学院辽宁锦州121000

试验旨在研究大骨鸡公鸡血清生化指标变化规律,分析不同生长速度间的血清生化指标差异。试验将1日龄263羽公鸡饲养至24周龄,自第3周开始,每单周末随机选5只鸡采血,测定血清生化指标。第12周龄,随机取高(H组)、低(L组)体重鸡各12只,准确... 详细信息

试验旨在研究大骨鸡公鸡血清生化指标变化规律,分析不同生长速度间的血清生化指标差异。试验将1日龄263羽公鸡饲养至24周龄,自第3周开始,每单周末随机选5只鸡采血,测定血清生化指标。第12周龄,随机取高(H组)、低(L组)体重鸡各12只,准确计量体重并采血测定血清生化指标。结果显示:各周龄公鸡血清白蛋白、球蛋白、总二氧化碳、钙、总胆红素、尿素氮与周龄呈显著或极显著正相关(P0.05)外,各饲养阶段其他血清指标均有显著差异(P<0.05)。12周龄H组血清中总胆汁酸含量显著高于L组(P<0.05),葡萄糖含量极显著低于L组(P<0.01),体重与血清中总胆汁酸、脂肪酶和葡萄糖呈显著(P<0.05)或极显著(P<0.01)相关。研究表明,试验确定了大骨鸡公鸡各饲养阶段的血清生化指标含量及差异,明确第12周龄大骨鸡公鸡体重与血清中胆汁酸、葡萄糖和脂肪酶有关,并可用数学模型估测体重。

关键词：大骨鸡公鸡血清生化指标生长体重

慢性心力衰竭不同中医证型与客观指标相关性临床研究

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河北中医 2024年第6期46卷 889-892页

作者：周纳纳雷瑗琳陈晋玉韩茹陕西省西安市中医医院心内科陕西西安710000 陕西省安康市中医医院心内科陕西安康725000

目的观察慢性心力衰竭(CHF)不同中医证型与脑钠肽(BNP)和左心室射血分数(LVEF)的相关性。方法收集CHF患者240例,所有病例均进行中医辨证分型,其中阳气亏虚血瘀型32例(13.33%),气阴两虚血瘀型34例(14.17%),气虚血瘀型174例(72.50%),兼痰... 详细信息

目的观察慢性心力衰竭(CHF)不同中医证型与脑钠肽(BNP)和左心室射血分数(LVEF)的相关性。方法收集CHF患者240例,所有病例均进行中医辨证分型,其中阳气亏虚血瘀型32例(13.33%),气阴两虚血瘀型34例(14.17%),气虚血瘀型174例(72.50%),兼痰饮70例。比较不同中医证型的BNP和LVEF,并分析各中医证型与BNP和LVEF的相关性。结果阳气亏虚血瘀型与气阴两虚血瘀型、气虚血瘀型患者BNP水平比较差异有统计学意义(P0.05);阳气亏虚血瘀型患者与气阴两虚血瘀型、气虚血瘀型患者LVEF水平比较差异有统计学意义(P0.05)。CHF中医证型与BNP、LVEF有一定相关性。结论CHF早期,中医证型为气虚血瘀证、气阴两虚血瘀证,晚期为阳气亏虚血瘀证。在阳气亏虚血瘀证阶段,BNP升高,LVEF值下降,在CHF晚期患者中有着同步性变化,故BNP、LVEF值可作为CHF阳气亏虚血瘀证的客观诊断指标。

关键词：心力衰竭中医证型脑钠肽左心室射血分数