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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo Liang Chao Wang Yunhong Zhang Hong Liu Yu Zhang Lin han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie Mao Zhimin Zhang han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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利用SFE-MD技术分离提纯玫瑰精油及其成分分析

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精细化工 2006年第6期23卷 553-557页

作者：韩荣伟庄桂东安桂香于忠娜段元斐张军迟玉森江苏大学生物与环境工程学院江苏镇江212013 莱阳农学院食品科学与工程学院山东青岛266109

用超临界CO2流体萃取技术（SFE）萃取平阴玫瑰浸膏,用分子蒸馏技术（MD）进行精制,所得玫瑰精油呈淡黄色,质量标准达到FCC（2004）,得率由传统水蒸气蒸馏法的0.03%提高到0.1%.超临界CO2流体萃取最佳工艺条件为：萃取压力25 MPa,温度50 ... 详细信息

用超临界CO2流体萃取技术（SFE）萃取平阴玫瑰浸膏,用分子蒸馏技术（MD）进行精制,所得玫瑰精油呈淡黄色,质量标准达到FCC（2004）,得率由传统水蒸气蒸馏法的0.03%提高到0.1%.超临界CO2流体萃取最佳工艺条件为：萃取压力25 MPa,温度50 ℃,CO2流量25 kg/h,萃取时间2.5 h;分子蒸馏温度为80～120 ℃;所得精油GC-MS分析,检测出63种成分,主体呈香成分为酯类物质,质量分数超过50%,相对分子质量主要集中在200～250.

关键词：玫瑰油超临界CO2萃取分子蒸馏

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A bi-population immune algorithm for weapon transportation support scheduling problem with pickup and delivery on aircraft carrier deck

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Defence Technology（防务技术） 2023年第4期22卷 119-134页

作者： Fang Guo wei han Xi-chao Su Yu-jie Liu rong-wei Cui Naval Aviation University No.188Ermalu RoadZhifu DistrictYantai264001Shandong ProvinceChina

The weapon transportation support scheduling problem on aircraft carrier deck is the key to restricting the sortie rate and combat capability of carrier-based *** paper studies the problem and presents a novel solution *** the interference of the carrier-based aircraft deck layout on the weapon transportation route and precedence constraint into consideration,a mixed integer formulation is established to minimize the total objective,which is constituted of makespan,load variance and accumulative transfer time of support *** approach is developed for the ***,based on modeling the carrier aircraft parked on deck as convex obstacles,the path library of weapon transportation is constructed through visibility graph and Warshall-Floyd *** then propose a bi-population immune algorithm in which a population-based forward/backward scheduling technique,local search schemes and a chaotic catastrophe operator are ***,the randomkey solution representation and serial scheduling generation scheme are adopted to conveniently obtain a better *** Taguchi method is additionally employed to determine key parameters of the ***,on a set of generated realistic instances,we demonstrate that the proposed algorithm outperforms all compared algorithms designed for similar optimization problems and can significantly improve the efficiency,and that the established model and the bi-population immune algorithm can effectively respond to the weapon support requirements of carrier-based aircraft under different sortie missions.

关键词： Carrier-based aircraft Weapon transportation support scheduling Pickup and delivery Bi-population immune algorithm

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Influence of bottom blowing oxygen on dust emission in converter steelmaking

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Journal of Iron and Steel Research International 2021年第9期28卷 1105-1113页

作者： wei-feng Li rong Zhu Chao Feng Bao-chen han Guang-sheng wei School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Research Center of Special Melting and Preparation of High-end Metal Materials University of Science and Technology BeijingBeijing 100083China

With the importance of the steelmaking industry in the economy and its negative impacts on the environment,reducing dust emissions is a vital focus in this ***,the theory of dust generation in converter steelmaking process was analyzed and the influence of bottom blowing oxygen on dust generation was obtained through experimental *** industrial test was carried out in a 120-t bottom combined blown O_(2)–CaO steelmaking *** results show that lowering the lance position can reduce the amount of *** emission rate of the converter is also found to be in direct proportion to the decarburization *** a result,the proposed bottom blowing O_(2)–CaO steelmaking converter can technically reduce the amount of dust and improve the recovery rate of *** more bottom blowing oxygen,the dust content is lower with the dust peak appearing *** evaporation theory,followed by the bubble theory,plays the primary role in the dust generation of bottom blowing oxygen *** points out the direction for the technology research and development of reducing dust generation.

关键词： Steelmaking converter Dust emission Bottom blowing O_(2)-CaO Evaporation theory Bubble theory

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Effects and complications of placement of motility coupling post in porous polyethylene orbital implants

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 464-469页

作者： Hong-guang CUI rong-rong HU Hui-yan LI wei han Department of Ophthalmology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To investigate the effects and complications of primary and secondary placements of motility coupling post （MCP） in the unwrapped porous polyethylene orbital implant （PPOI） following enucleation. Methods： We investigated 198 patients who received PPOI implantation following the standard enucleation procedure in the First Affiliated Hospital, School of Medicine, Zhejiang University, hangzhou, China, from 2002 to 2004. These patients were subgrouped into PPOI-only patients （112 cases, received PPOI following enucleation）, primary MCP patients （46 cases, received primary placement of MCP during PPOI operation）, and secondary MCP patients （40 cases, received secondary placement ofMCP 6 months after the initial surgery）. Effects and complications among these three groups were compared. Results： The PPOI-only patients took shorter treatment course when compared with other two MCP groups （P〈0.001）, without significant difference noted between the two MCP groups. However, the two MCP groups had better prosthetic motility than PPOI-only group （P〈0.001）, without significant difference between the two MCP groups. In the early stage, 2 eyes in the PPOI-only group and l eye in the primary MCP group had PPOI infection. In PPOI-only group, 3 （2.68%） eyes had PPOI exposure, which occurred after fitting the prostheses; 4 eyes （8.70%） in primary MCP group and 1 eye （2.50%） in secondary MCP had PPOI exposure, which occurred before fitting the prostheses. After prosthesis was fit successfully, the excessive discharge and granuloma were 33.9% and 1.79% in PPOI group-only, 53.3% and 8.9% in primary MCP group, and 52.5% and 7.5% in secondary MCP group, respectively. Conclusion： Both primary and secondary placements of MCP into the PPOI following enucleation can help patients to obtain desirable prosthetic motility, but may be associated with more complications. The primary placement of MCP with skilled operation in selected patients is more recommendable than secondary placemen

关键词： Porous polyethylene orbital implant (PPOI) Motility coupling post (MCP)

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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu Ying han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

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不同母乳低聚糖对肠道LS174T杯状细胞黏蛋白分泌相关基因表达的影响

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食品安全质量检测学报 2022年第22期13卷 7438-7445页

作者：许文君姚倩倩高亚男郑楠韩荣伟王加启青岛农业大学食品科学与工程学院青岛266109 中国农业科学院北京畜牧兽医研究所农业农村部奶及奶制品质量安全控制重点实验室北京100193 中国农业科学院北京畜牧兽医研究所农业农村部奶产品质量安全风险评估实验室北京100193

目的分析不同母乳低聚糖对肠道LS174T杯状细胞黏蛋白分泌相关基因表达的影响。方法以人肠道LS174T细胞为研究对象,将2’-岩藻糖基乳糖(2’-fucosyllactose,2’-FL)、3’-唾液酸乳糖(3’-sialyllactose,3’-SL)和低聚半乳糖(galactooligo... 详细信息

目的分析不同母乳低聚糖对肠道LS174T杯状细胞黏蛋白分泌相关基因表达的影响。方法以人肠道LS174T细胞为研究对象,将2’-岩藻糖基乳糖(2’-fucosyllactose,2’-FL)、3’-唾液酸乳糖(3’-sialyllactose,3’-SL)和低聚半乳糖(galactooligosaccharide,GOS)3种低聚糖和乳糖对细胞的作用时间分成24 h组和48 h组,分别在细胞稳态和细胞炎症状态下,以黏蛋白2(mucin 2,MUC2)及其相关基因[三叶因子-3(trefoil factor 3,TFF3)、抵抗素样蛋白B(recombinant resistinlike beta,RETNLB)、碳水化合物磺基转移酶5(carbohydrate sulfotransferase 5,CHST5)、半乳糖-3-O-磺基转移酶2(galactose-3-O-sulfotransferase 2,GAL3ST2)]的表达水平为评价指标,通过实时荧光定量多聚核苷酸链式反应(real time-quantitative polymerase chain reaction,RT-qPCR)试验确定影响肠道LS174T杯状细胞黏蛋白分泌相关基因表达的母乳低聚糖。结果在正常状态下,GOS作用后,MUC2及黏蛋白分泌相关基因表达量无显著变化(P>0.05);作用48 h时,3’-SL可显著提高RETNLB基因表达量(P<0.05);在炎症状态下,2’-FL和GOS可极显著促进MUC2、CHST5和TFF3的表达(P<0.01),表明在炎症状态下,2’-FL和GOS可促进杯状细胞分泌黏蛋白。结论在细胞炎症状态下,2’-FL和GOS可提高肠道LS174T杯状细胞黏蛋白分泌相关基因的表达量。

关键词：母乳低聚糖 LS174T杯状细胞 2’-岩藻糖基乳糖 3’-唾液酸乳糖低聚半乳糖黏蛋白2 黏蛋白分泌相关基因

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High Open-circuit Voltage and Low Voltage Loss in All-polymer Solar Cell with a Poly(coronenediimide-vinylene)Acceptor

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Chinese Journal of Polymer Science 2020年第11期38卷 1157-1163,I0005页

作者： han han Fu-Jin Bai rong wei han Yu Yi-Kun Guo He Yan Da-Hui Zhao Beijing National Laboratory for Molecular Sciences Centre for the Soft Matter Science and EngineeringThe Key Laboratory of Polymer Chemistry and Physics of the Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration&Reconstruction Hong Kong University of Science and Technology(HKUST)Clear Water BayKowloonHong Kong 999077China

Reducing the voltage loss(Vloss)is a critical factor in optimizing the open-circuit voltage(Voc)and overall power-c on version efficie ncy(PCE)of polymer solar *** the current work,by designing a novel electron-accepting unit of coronenediimide(CDI)and using it as the main functional building block,a new polymer acceptor CDI-V is developed and applied to fabricate all-polymer solar *** with the perylenediimide-based polymer acceptors we previously reported,the current CDI-V polymer possesses a noticeably elevated lowest unoccupied molecular orbital(LUMO).Thereby,by virtue of the enlarged energy gap between the donor HOMO and acceptor LUMO,a high Voc value of 1.05 V is achieved by the all-polymer photovolatic device,along with an impressively low Vloss of 0.55 *** remarkably,in spite of an extremely small LUMO level offset of 0.01 eV exhibited by the donor and acceptor polymers,effective charge separation still takes place in the allpolymer device,as evidenced by a proper short-circuit current(Jsc)of 9.5 mA·cm^-2 and a decent PCE of 4.63%.

关键词： All-polymer solar cell Coronenediimide Voltage loss Acceptors

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Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期68卷 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong Liang weipeng Li Chengjian Zhu Jie han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词： gold catalysis peptide alkylation C-C coupling radical

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