检索结果-南通市图书馆

Synthesis and Herbicidal Activities of 3-(Substituted phenyl)isoxazole Derivatives

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2003年第9期14卷 897-900页

作者： Yu han ZHOU, wei rong MIAO, Lu Bai CHEN State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012 State Key Lab. of Fine Chemicals Dalian University of Technology Dalian 116012 China

Several novel 3-(substituted phenyl)isoxazole derivatives were prepared from phenyl butan-1,3-dione. Their structures were confirmed by 1H NMR, IR, and CIMS. Preliminary bioassay showed that some of them exhibited goo... 详细信息

关键词： Protox-inhibitor isoxazole derivatives herbicidal activity.

国家自然科学基金资助非编码RNAs与肿瘤研究

在线全文

学校读者我要写书评

暂无评论

生命科学 2018年第2期30卷 222-232页

作者：石嵘韩卫东洪微国家自然科学基金委员会医学科学部北京100085 浙江大学医学院附属邵逸夫医院肿瘤内科杭州310016

现总结2010—2017年国家自然科学基金委员会医学科学部肿瘤学代码下非编码RNAs(non-coding RNAs,ncRNAs)相关研究的申请、资助情况;展示自然科学基金资助下,中国在ncRNAs与肿瘤研究领域的现状和发展趋势;分析ncRNAs在肿瘤领域的前沿科... 详细信息

现总结2010—2017年国家自然科学基金委员会医学科学部肿瘤学代码下非编码RNAs(non-coding RNAs,ncRNAs)相关研究的申请、资助情况;展示自然科学基金资助下,中国在ncRNAs与肿瘤研究领域的现状和发展趋势;分析ncRNAs在肿瘤领域的前沿科学方向以及存在的问题。

关键词：肿瘤非编码RNAs 项目受理项目资助国家自然科学基金

在线全文

学校读者我要写书评

暂无评论

7-羟基黄酮糖苷的合成研究

化学试剂 2008年第2期30卷 123-124,134页

作者：郭瑞霞李伟韩卫荣石家庄学院化工学院河北石家庄050035 南京中医药大学中医药学院江苏南京210029

对传统的合成黄酮糖苷的方法进行了改进,以溴代乙酰糖和7-羟基黄酮为原料,四丁基溴化铵为相转移催化剂,以K2CO3为除酸剂,采用固-液相转移催化法合成了7-羟基黄酮葡萄糖苷和7-羟基黄酮阿拉伯糖苷。另外,还研究了反应方式、温度、糖的种... 详细信息

对传统的合成黄酮糖苷的方法进行了改进,以溴代乙酰糖和7-羟基黄酮为原料,四丁基溴化铵为相转移催化剂,以K2CO3为除酸剂,采用固-液相转移催化法合成了7-羟基黄酮葡萄糖苷和7-羟基黄酮阿拉伯糖苷。另外,还研究了反应方式、温度、糖的种类等因素对收率的影响。

关键词：固-液相转移催化黄酮糖苷合成

在线全文

学校读者我要写书评

暂无评论

PA6/云母复合材料界面改性研究

塑料工业 2011年第6期39卷 24-26页

作者：高岩磊韩卫荣牟微石家庄学院化工学院河北石家庄050035

采用熔融共混法制备出了PA6/PA6接枝马来酸酐/云母复合材料,研究了PA6接枝马来酸酐对PA6/云母复合材料力学性能和热性能的影响。结果表明,PA6接枝马来酸酐的加入量(质量分数)为6%时,PA6/PA6接枝马来酸酐/云母复合材料的综合力学性能较好... 详细信息

采用熔融共混法制备出了PA6/PA6接枝马来酸酐/云母复合材料,研究了PA6接枝马来酸酐对PA6/云母复合材料力学性能和热性能的影响。结果表明,PA6接枝马来酸酐的加入量(质量分数)为6%时,PA6/PA6接枝马来酸酐/云母复合材料的综合力学性能较好;PA6接枝马来酸酐的加入有助于提高PA6/云母复合材料的热稳定性。

关键词：尼龙6 云母界面改性性能

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man han Deyang Zeng wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： ronglin han Lanxin Luo Caiyan wei Yaru Qiao Jiming Xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 225-234页

作者： wei ZhanG weiCHENG WANG RUI WANG XIAO han LIJUN ZHU WENJIE GUO YANHONG GU Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210029China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing210023China Department of Oncology The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou225300China

Background:As a novel blocker of vascular endothelial growth factor receptor(VEGFR),fruquintinib has been approved for treating colorectal cancer(CRC).However,its dosage and therapeutic efficacy are limited by its widespread adverse ***,recognized as the initial inhibitor of B-cell lymphoma protein 2(BCL2),has shown potential in boosting the effectiveness of immunotherapy against *** study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating *** and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against *** we employed various techniques to evaluate different aspects of the experimental *** was used to detect cell proliferation and angiogenesis in tumor *** blot analysis was utilized to examine the occurrence of cell apoptosis,and flow cytometry to quantitate immune cells within the tumor ***,immunofluorescence was employed to measure cytokine ***:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax,as opposed to individual drug *** was found to amplify the impact of fruquintinib,leading to decreased cancer cell proliferation,increased cancer cell apoptosis,lowered angiogenesis,better vascular structure normalization,and improved immune cell ***:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune *** study presents the justification for utilizing the fruquintinib and venetoclax combination in treating *** holds promise in being assimilated into anticancer medications for CRC.

关键词： Colorectal cancer(CRC) B-cell lymphoma protein 2(BCL2) Venetoclax Vascular endothelial growth factor receptor(VEGFR) Fruquintinib Anti-angiogenesis Immunotherapy

三乙酰基三苄基六氮杂异伍兹烷(TATBIW·0.5H_2O)的合成及晶体结构

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

有机化学 2005年第10期25卷 1259-1264页

作者：韩卫荣欧育湘刘进全陈博仁北京理工大学材料科学与工程学院

通过控制六苄基六氮杂异伍兹烷(HBIW)的氢解程度,成功制备了其氢解反应过程中一个重要的中间体三乙酰基三苄基六氮杂异伍兹烷(TATBIW),并对其单晶结构(TATBIW·0.5H_2O)进行了测定,它属三斜晶系,空间群为P-1,a=0.9893(2)nm,b=1.2624(3)n... 详细信息

通过控制六苄基六氮杂异伍兹烷(HBIW)的氢解程度,成功制备了其氢解反应过程中一个重要的中间体三乙酰基三苄基六氮杂异伍兹烷(TATBIW),并对其单晶结构(TATBIW·0.5H_2O)进行了测定,它属三斜晶系,空间群为P-1,a=0.9893(2)nm,b=1.2624(3)nm,c=1.3396(3)nm;V=1.5963(6)nm3,Z=2,Dc=1.194g·cm-3,该化合物的单晶数据未见文献报道.TATBIW的制备有助于我们进一步了解HBIW的氢解反应机理,提高氢解产品得率.

关键词：三乙酰基三苄基六氮杂异伍兹烷氢解晶体结构合成六苄基六氮杂异伍兹烷乙酰基单晶结构反应过程三斜晶系反应机理

在线全文

学校读者我要写书评

暂无评论

TATBIW与TADBIW的氢解反应特性

含能材料 2008年第2期16卷 153-155页

作者：韩卫荣欧育湘张雪红黄兴牟微高岩磊石家庄学院化工学院河北石家庄050035 北京理工大学材料科学与工程学院北京100081

研究了六苄基六氮杂异伍兹烷(HBIW)的氢解不完全产物三乙酰基三苄基六氮杂异伍兹烷(TATBIW)对氢解产品四乙酰基二苄基六氮杂异伍兹烷(TADBIW)的二次氢解反应产生的影响。结果表明,TATBIW较TADBIW稳定性差,在甲酸介质中易于破笼,且易引... 详细信息

研究了六苄基六氮杂异伍兹烷(HBIW)的氢解不完全产物三乙酰基三苄基六氮杂异伍兹烷(TATBIW)对氢解产品四乙酰基二苄基六氮杂异伍兹烷(TADBIW)的二次氢解反应产生的影响。结果表明,TATBIW较TADBIW稳定性差,在甲酸介质中易于破笼,且易引起二次氢解催化剂中毒;但当催化剂用量加大到1%时,仍可得到TATBIW氢解完全的产物三乙酰基三甲酰基六氮杂异伍兹烷(TATFIW)。

关键词：有机化学四乙酰基二苄基六氮杂异伍兹烷(TADBIW) 三乙酰基三苄基六氮杂异伍兹烷(TATBIW) 氢解催化剂