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Methyl Groups Pendant on Triphenylmethane Toward Modulating Thermal Stability and Dielectric Properties of the Crosslinkable Fluorinated Polyimide Films with High Transparency

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Chinese Journal of Polymer Science 2025年第2期43卷 316-327页

作者： Wen Yang Liang Yuan Kai gong Ruo-han Zhang Lan Lei Hui Li School of Chemistry and Chemical Engineering Shandong Key Laboratory of Fluorine Chemistry and Chemical Engineering MaterialsUniversity of JinanJinan250022China School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350China

It is urgent to develop high-performance polyimide(PI)films that simultaneously exhibit high transparency,exceptional thermal stability,mechanical robustness,and low dielectric to fulfil the requirements of flexible display ***,a series of fluorinated polyimide films(FPIs)were fabricated by the condensation of 5,5′-(perfluoropropane-2,2-diyl)bis(isobenzofuran-1,3-dione)(6FDA)and the fluorinated triphenylmethane diamine monomer(EDA,MEDA and DMEDA)with heat-crosslinkable tetrafluorostyrene side groups,which was incorporated by different numbers of methyl groups pendant in the ortho position of amino ***,the FPI films underwent heating to produce crosslinking FPIs(C-FPIs)through the self-crosslinking of double bonds in the *** transparency,solvent resistance,thermal stability,mechanical robustness and dielectric properties of FPI and C-FPI films can be tuned by the number of methyl groups and crosslinking,which were deeply investigated by virtue of molecular dynamics(MD)simulations and density functional theory(DFT).As a result,all the films exhibited exceptional optically colorless and transparent,with transmittance in the visible region of 450-700 nm exceeding 79.9%,and the cut-off wavelengths(λ_(off))were nearly 350 *** thermal decomposition temperatures at 5% weight loss(T_(d5%))for all samples exceeded 504℃.These films exhibited a wide range of tunable tensile strength(46.5-75.1 MPa).Significantly,they showed exceptional dielectric properties with the dielectric constant of 2.3-2.5 at full frequency(10^(7)-20 Hz).This study not only highlights the relationship between the polymer molecular structure and properties,but offer insights for balancing optical transparency,heat resistance and low dielectric constant in PI films.

关键词： Crosslinkable fluorinated polyimide Methyl group Triphenylmethane Transparency Thermal stability Low dielectric constant

When Software Security Meets Large Language Models:A Survey

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 317-334页

作者： Xiaogang Zhu Wei Zhou qing-Long han Wanlun Ma Sheng Wen Yang Xiang IEEE the School of Computer and Mathematical Sciences the University of Adelaide the School of Science Computing and Engineering Technologies Swinburne University of Technology

Software security poses substantial risks to our society because software has become part of our life. Numerous techniques have been proposed to resolve or mitigate the impact of software security issues. Among them, software testing and analysis are two of the critical methods, which significantly benefit from the advancements in deep learning technologies. Due to the successful use of deep learning in software security, recently,researchers have explored the potential of using large language models(LLMs) in this area. In this paper, we systematically review the results focusing on LLMs in software security. We analyze the topics of fuzzing, unit test, program repair, bug reproduction, data-driven bug detection, and bug triage. We deconstruct these techniques into several stages and analyze how LLMs can be used in the stages. We also discuss the future directions of using LLMs in software security, including the future directions for the existing use of LLMs and extensions from conventional deep learning research.

关键词： Large language models (LLMs) software analysis software security software testing

Bacterial indole-3-propionic acid inhibits macrophage IL-1β production through targeting methionine metabolism

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Science China Life Sciences 2025年

作者： Ziyi han Jian Fu Aiyan gong Wenkai Ren State Key Laboratory of Livestock and Poultry Breeding College of Animal Science South China Agricultural University Animal Disease-resistant Nutrition Key Laboratory of Sichuan Province Sichuan Agricultural University China Institute of Veterinary Drug Control

The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites, like indole derivatives from tryptophan. However, the direct role of these indole derivatives in macrophage fate decision and the underlying mechanism remains unknown. Here, we found that bacterial indole-3-propionic acid(IPA) downregulates interleukin-1beta(IL-1β) production in M1 macrophages through inhibition of nuclear factor-kappa B(NF-κB) signaling. Mechanistically, IPA binds specifically with methionine adenosyltransferase 2A(MAT2A) to promote S-adenosylmethionine(SAM) synthesis, which facilitates the DNA methylation of ubiquitin-specific peptidase 16(USP16, a deubiquitinase), and in turn promotes Toll-like receptor 4(TLR4) ubiquitination and NF-κB inhibition. Furthermore,IPA administration attenuates sepsis in mouse models induced by lipopolysaccharides(LPS), showcasing its potential as a microbial-derived adjunct in alleviating inflammation. Collectively, our findings reveal a newly found microbial metabolite-immune system regulatory pathway mediated by IPA.

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The Security of Using Large Language Models:A Survey With Emphasis on ChatGPT

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 1-26页

作者： Wei Zhou Xiaogang Zhu qing-Long han Lin Li Xiao Chen Sheng Wen Yang Xiang the School of Science Computing and Engineering Technologies Swinburne University of Technology IEEE the School of Computer and Mathematical Sciences the University of Adelaide Adelaide the Faculty of Science and Engineering Southern Cross University the School of Information and Physical Sciences the University of Newcastle

ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential security risks that need to be carefully evaluated and addressed. In this survey, we provide an overview of the current state of research on security of using ChatGPT, with aspects of bias, disinformation, ethics, misuse,attacks and privacy. We review and discuss the literature on these topics and highlight open research questions and future *** this survey, we aim to contribute to the academic discourse on AI security, enriching the understanding of potential risks and mitigations. We anticipate that this survey will be valuable for various stakeholders involved in AI development and usage, including AI researchers, developers, policy makers, and end-users.

关键词： Artificial intelligence (AI) ChatGPT large language models (LLMs) security

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期68卷 249-256页

作者： qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsChemistry and Biomedicine Innovation Center(ChemBIC)School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 211198China

Selective modification of peptides has always been a challenging *** selective alkylation of peptides can alter the biological activity and physical properties of molecules,and it has gained significant research *** herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis.A wide range of structurally diverse primary,secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with theα-C(sp^(3))–H in glycine residue of *** protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups.A series of relay transformations to construct cyclic peptides,to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic *** addition,mechanistic studies and density functional theory(DFT)calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET)mechanism.

关键词： gold catalysis peptide alkylation C-C coupling radical

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When Embodied AI Meets Industry 5.0:Human-Centered Smart Manufacturing

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IEEE/CAA Journal of Automatica Sinica 2025年第3期12卷 485-501页

作者： Jing Xu Qiyu Sun qing-Long han Yang Tang IEEE the Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of Education East China University of Science and Technology the School of Science Computing and Engineering Technologies Swinburne University of Technology

As embodied intelligence(EI), large language models(LLMs), and cloud computing continue to advance, Industry5.0 facilitates the development of industrial artificial intelligence(Ind AI) through cyber-physical-social systems(CPSSs) with a human-centric focus. These technologies are organized by the system-wide approach of Industry 5.0, in order to empower the manufacturing industry to achieve broader societal goals of job creation, economic growth, and green production. This survey first provides a general framework of smart manufacturing in the context of Industry 5.0. Wherein, the embodied agents, like robots, sensors, and actuators, are the carriers for Ind AI, facilitating the development of the self-learning intelligence in individual entities, the collaborative intelligence in production lines and factories(smart systems), and the swarm intelligence within industrial clusters(systems of smart systems). Through the framework of CPSSs, the key technologies and their possible applications for supporting the single-agent, multi-agent and swarm-agent embodied Ind AI have been reviewed, such as the embodied perception, interaction, scheduling, multi-mode large language models, and collaborative training. Finally, to stimulate future research in this area, the open challenges and opportunities of applying Industry 5.0 to smart manufacturing are identified and discussed. The perspective of Industry 5.0-driven manufacturing industry aims to enhance operational productivity and efficiency by seamlessly integrating the virtual and physical worlds in a human-centered manner, thereby fostering an intelligent, sustainable, and resilient industrial landscape.

关键词： Embodied AI human-centered manufacturing Industry 5.0 internet of things large multi-mode language models

Folding encapsulation toward Lindqvist polyoxometalates within adaptive coordination cages for catalysis

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Science China Chemistry 2025年第2期68卷 561-569页

作者： Ying-Mei Zhong Jin-Jin Xuan Xujie Qin han Xiao Zi-Jun Xia Li-Peng Zhou Xiao-qing Guo Yu-hang Hu Lu Zhang Chunsen Li Li-Xuan Cai qing-Fu Sun State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China

In nature,enzymes at specific folded conformations exhibit high substrate complementarity,enabling them to efficiently and selectively catalyze biochemical *** by enzymes,coordination cages with conformational dynamics have been designed and are receiving increasing attention due to their versatile applications in allosteric guest binding and *** present here two enzyme-mimicking adaptive macrocycle-based coordination cages,Pd_(2)L_(2)^(1) and Pd_(2)L_(2)^(2),from macrocycle-based ligands(L^(1) and L^(2))and the encapsulation and stabilization of Lindqvist polyoxometalates anions M6O192−(M=W or Mo)in neutral aqueous solution.X-ray crystallographic studies have verified the formation of 1:1 host-guest complexes of two Pd_(2)L_(2) cages and the W6O192−anion,via an induced-fit folding *** with the free host,Pd_(2)L_(2)^(1) exhibited an induced-fit semi-folded conformation in the inclusion complex,while Pd_(2)L_(2)^(2) adopted an induced-fit fully-folded ***,the Mo_(6)O_(19)⊂Pd_(2)L_(2) host-guest complexes demonstrate high yield and selectivity in the oxidative decontamination reaction of the sulfur mustard simulant,2-chloroethyl ethyl *** work not only sheds light on the importance of conformational adaptability in enzyme-like systems but also paves the way for protecting labile POM clusters via host-guest encapsulation toward enhanced catalytic performance in aqueous solution.

关键词： coordination cage induced-fit polyoxometalates host-guest chemistry supramolecular catalysis

2010年5月与2013年6月黄、渤海大型底栖动物群落组成和结构的比较研究

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海洋学研究 2017年第1期35卷 86-94页

作者：李帅吕腾腾韩庆功郑俊勇韩庆喜宁波大学海洋学院浙江宁波315211

基于2010年5月和2013年6月采集的黄、渤海海域的大型底栖动物数据,对该海域大型底栖动物的种类组成和群落结构等进行了研究,对该海域大型底栖动物群落结构的时间和空间差异进行了分析,并利用AMBI和m-AMBI生物指数对各站位的生态质量状... 详细信息

基于2010年5月和2013年6月采集的黄、渤海海域的大型底栖动物数据,对该海域大型底栖动物的种类组成和群落结构等进行了研究,对该海域大型底栖动物群落结构的时间和空间差异进行了分析,并利用AMBI和m-AMBI生物指数对各站位的生态质量状况进行了评估。研究结果表明:在2010年5月和2013年6月所采站位的大型底栖动物共有131种,其中软体动物和甲壳动物占据了较大比例的物种数量,分别为51种和42种;其次为鱼类、多毛类和棘皮动物。该海域的优势物种为日本鼓虾Alpheus japonicus、日本褐虾Crangon hakodatei、司氏盖蛇尾Stegophiura sladeni和奇异指纹蛤Acila mirabilis,其中司氏盖蛇尾具有最大的丰度和优势度。生物指数(AMBI和m-AMBI)的结果显示黄、渤海区域底栖生态环境仍相对稳定,但与历史资料比较得知,该海域大型底栖动物生存环境整体趋于恶化。

关键词：大型底栖动物黄、渤海群落组成和结构年际变化

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低盐低硝红肠保质期的研究

肉类工业 2011年第2期 21-25页

作者：韩功卿哈尔滨大众肉联食品有限公司黑龙江哈尔滨150137

研究以氯化钾替代部分食盐氯化钠,以山梨酸钾和红曲米部分代替亚硝酸钠,加工低盐低硝酸盐的红肠制品,分别从感官指标、pH值、细菌总数、脂质过氧化值等几方面对其保质期进行测定。结果表明:采用上述替代方法加工出的红肠产品的保质期能... 详细信息

研究以氯化钾替代部分食盐氯化钠,以山梨酸钾和红曲米部分代替亚硝酸钠,加工低盐低硝酸盐的红肠制品,分别从感官指标、pH值、细菌总数、脂质过氧化值等几方面对其保质期进行测定。结果表明:采用上述替代方法加工出的红肠产品的保质期能够达到24d,与没有进行替代的产品无显著差异,其中最佳替代方案为氯化钾7.2g/kg,氯化钠28.8g/kg,亚硝酸钠0.12g/kg,山梨酸钾1.60g/kg,红曲米2.0g/kg。

关键词：低盐低硝酸盐红肠保质期