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蒙药白益母草化学成分研究

中药材 2015年第8期38卷 1668-1670页

作者：邵彩云王青虎吴荣君吴杰斯韩那仁朝克图代那音台内蒙古民族大学蒙医药学院内蒙古通辽028000

目的：研究白益母草乙酸乙酯部位的化学成分。方法：采用硅胶柱色谱法对白益母草乙酸乙酯部位进行分离,利用波谱数据解析化合物结构。结果：从白益母草乙酸乙酯部位中分离鉴定了9个化合物,分别为：7-甲氧基香豆素（1）、异鼠李素（2）... 详细信息

目的：研究白益母草乙酸乙酯部位的化学成分。方法：采用硅胶柱色谱法对白益母草乙酸乙酯部位进行分离,利用波谱数据解析化合物结构。结果：从白益母草乙酸乙酯部位中分离鉴定了9个化合物,分别为：7-甲氧基香豆素（1）、异鼠李素（2）、咖啡酸（3）、5-羟基-7,3＇,4＇-三甲氧基黄酮（4）、5-羟基-7,4＇-二甲氧基黄酮（5）、山柰酚（6）、异鼠李素-3-O-β-D-葡萄糖苷（7）、山柰酚-3-O-β-D-葡萄糖苷（8）、异鼠李素-3-O-β-D-葡萄糖基-（1→6）-O-α-L-鼠李糖苷（9）。结论：其中,化合物1～4、6、7和9为首次从该植物中分离得到。

关键词：白益母草化学成分香豆素黄酮

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蒙药白益母草定性定量方法研究

药物分析杂志 2015年第10期35卷 1846-1851页

作者：王青虎吴荣君包宝乐尔代那音台韩那仁朝克图吴杰斯内蒙古民族大学蒙医药学院通辽028000

目的：建立白益母草定性定量方法,以多指标成分综合评价白益母草质量。方法：采用化学和薄层色谱法对白益母草中黄酮类化合物进行定性鉴别;运用高效液相色谱法对其进行定量分析,采用Inertsil ODS-SP（250 mm×4.6 mm,5μm）色谱柱,以乙... 详细信息

目的：建立白益母草定性定量方法,以多指标成分综合评价白益母草质量。方法：采用化学和薄层色谱法对白益母草中黄酮类化合物进行定性鉴别;运用高效液相色谱法对其进行定量分析,采用Inertsil ODS-SP（250 mm×4.6 mm,5μm）色谱柱,以乙腈-水为流动相梯度洗脱,检测波长为261 nm,柱温为35℃。结果：白益母草供试品溶液盐酸-镁粉反应阳性,灵敏度高;薄层鉴别斑点清晰,重现性好;HPLC分析,异鼠李素-3-O-芸香糖苷（S1）、5,6,7,4＇-四羟基黄酮-7-O-（6＂-O-[E]-咖啡酰基）-葡萄糖苷（S2）、5,6,7,4＇-四羟基黄酮-7-O-（6＂-O-[E]-香豆酰基）-葡萄糖苷（S3）、异鼠李素-3-O-葡萄糖苷（S4）、金丝桃苷（S5）、芹菜素-7-O-葡萄糖苷（S6）和7,4＇-二甲氧基芹菜素（S7）质量浓度分别在100.00～500.00（r=0.999 7）、20.00～100.00（r=0.999 9）、10.00～50.00（r=0.999 9）、5.00～25.00（r=0.999 5）、2.00～10.00（r=0.999 5）、1.00～5.00（r=0.999 7）和1.00～5.00μg·m L-1（r=0.999 4）范围内具有良好的线性关系,平均回收率（n=6）分别为98.67%（RSD=1.20%）、97.42%（RSD=1.45%）、98.32%（RSD=2.08%）、96.85%（RSD=1.27%）、97.23%（RSD=1.95%）、96.37%（RSD=1.40%）、96.54%（RSD=1.63%）,8批样品中上述7种成分平均含量范围分别为5142.0～5714.0、1332.0～1465.0、724.0～802.0、302.4～330.8、113.4～132.4、58.69～62.08、58.75～62.57μg·g-1。结论：通过实验研究,建立了白益母草定性和定量分析方法,为药材质量检测提供依据。

关键词：白益母草黄酮定性鉴别定量测定薄层色谱法高效液相色谱法质量控制

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie na han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine Peking University People’s HospitalBeijingChina key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

蒙药铁杆蒿石油醚提取物中6个萜类化合物的分离与鉴定

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中国药物化学杂志 2016年第2期26卷 142-145页

作者：玉华王青虎韩那仁朝克图图布新布仁满达内蒙古民族大学蒙医药学院内蒙古通辽028000

目的了解铁杆蒿石油醚提取物的化学成分。方法采用硅胶柱色谱和薄层色谱进行分离,采用核磁共振谱鉴定化学结构。结果分离鉴定了6个萜类化合物,分别为3,5,8a-三甲基-3a,6,7,8a,9a,9b-四氢-3H,4H-萘[2,3b]呋喃-2,8-二酮(1)、硫华菊醛(2)、... 详细信息

目的了解铁杆蒿石油醚提取物的化学成分。方法采用硅胶柱色谱和薄层色谱进行分离,采用核磁共振谱鉴定化学结构。结果分离鉴定了6个萜类化合物,分别为3,5,8a-三甲基-3a,6,7,8a,9a,9b-四氢-3H,4H-萘[2,3b]呋喃-2,8-二酮(1)、硫华菊醛(2)、15-非杜松烷-2-烯-5,9-二醇(3)、肋柱花素B(4)、肋柱花素A(5)、14-非桉烷-3-羟基-3-烯-2,9-二酮(6)。结论所有化合物均为首次从该植物中分离得到。

关键词：铁杆蒿化学成分单萜倍半萜

Inner limiting membrane peeling prevents secondary epiretinal membrane after vitrectomy for proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1496-1501页

作者： Rong-han Wu Ming-na Xu ke Lin Ming-Xue ren han Wen ke-Mi Feng Hong-Jia Zhou Nived Moonasar Zhong Lin Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina national Clinical Research Center for Ocular Diseases Wenzhou 325027Zhejiang ProvinceChina Caribbean Eye Institute ValsaynTrinidad and Tobago

·AIM:To evaluate the role of internal limiting membrane(ILM)peeling in preventing secondary epiretinal membrane(ERM)formation in pars plana vitrectomy(PPV)for proliferative diabetic retinopathy(PDR).·METHODS:This retrospective study analyzed the medical records of patients who underwent PPV for PDR and were followed up for minimum 3 *** peeling was performed based on the intraoperative surgeons’*** was assessed by optical coherence tomography *** relationship between ILM peeling and postoperative ERM was analyzed.·RESULTS:In total,212 eyes from 197 patients were included in this *** incidence of secondary ERM in the ILM non-peeling group was significantly higher than that in the ILM peeling group(37.0%vs 14.0%;Pnal surgeons.

关键词： internal limiting membrane secondary epiretinal membrane proliferative diabetic retinopathy

The role of crm-1 in ionizing radiation-induced nervous system dysfunction in Caenorhabditis elegans

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Neural Regeneration Research 2023年第6期18卷 1386-1392页

作者： Hui-Qiang Long Jin Gao Shu-Qing He Jian-Fang han Yu tu na Chen Suzhou Medical College of Soochow University SuzhouJiangsu ProvinceChina State key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhouJiangsu ProvinceChina Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions SuzhouJiangsu ProvinceChina

Ionizing radiation can cause changes in nervous system ***,the underlying mechanism remains *** this study,Coenorhabditis elegans(***)was irradiated with 75 Gy of ^(60)Co whole-body γ *** indicators(head thrashes,touch avoidance,and foraging),and the development of dopaminergic neurons related to behavioral function,were evaluated to assess the effects of ionizing radiation on nervous system function in *** behaviors were impaired after whole-body irradiation and degeneration of dopamine neurons was *** suggests that 75 Gy of γ radiation is sufficient to induce nervous system *** genes nhr-76 and crm-1,which are reported to be related to nervous system function in human and mouse,were screened by transcriptome sequencing and bioinformatics analysis after irradiation or sham *** expression levels of these two genes were increased after ***,Rnai technology was used to inhibit the expression of crm-1,a gene whose homologs are associated with motor neuron development in other *** of crm-1 expression effectively alleviated the deleterious effects of ionizing radiation on head thrashes and touch *** was also found that the expression level of crm-1 was regulated by the nuclear receptor gene *** results of this study suggest that knocking down the expression level of nhr-76 can reduce the expression level of crm-1,while down-regulating the expression level of crm-1 can alleviate behavioral disorders induced by ionizing ***,inhibition of crm-1 may be of interest as a potential therapeutic target for ionizing radiation-induced neurological dysfunction.

关键词： behavior Caenorhabditis elegans degeneration disorder dysfunction nerve injury nervous system neurodevelopment neuron radiation

Effect of seepage on soil arching effect in deep shield tunnel

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Underground Space 2023年第5期12卷 218-233页

作者： Xu Song Fan-Yan Meng ren-Peng Chen han-Lin Wang Huai-na Wu Research Center for Advanced Underground Space Technologies of Hunan University Changsha 410082China key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education Hunan UniversityChangsha 410082China College of Civil Engineering Hunan UniversityChangsha 410082China

Shield tunneling and post-tunneling steady seepage are accompanied by stress and displacement variations,which could induce and influence the soil arching *** there are many studies on the tunneling-induced soil arching effect,the research about the effect of seepage on soil arching effect is extremely *** this study,a numerical model is firstly established and verified by field ***,a series of numerical models,whose simulation method of steady seepage is verified by adopting the conformal mapping technique,are established to study the soil arching evolution of deep-buried tunneling and post-construction steady *** results indicate that seepage leads to an increase in effective vertical stress,which is consistent with the existing *** seepage weakens the soil arching effect resulting in the height of the arch zone reducing from 2.38D(D is the tunnel diameter)to *** seepage leads to the further development of ground consolidation settlement,but the differential displacement in the soil mass *** ground reaction curve in the steady seepage condition shows a bigger value than that after *** is reasonable to control the ground loss ratio in the range of 0.5–1.0%,which can minimize overburden pressure with moderate ground deformation.

关键词： Soil arching effect Steady seepage Numerical simulation Deep shield tunnel Stress change

Coset Structure of Spin Group

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Communications in Theoretical Physics 2007年第6期47卷 987-994页

作者： WANG na WU ke School of Mathematical Science Capital Normal University Beijing 100037 China key Laboratory of Mathematics Mechanization The Chinese Academy of Sciences Beijing 100080 China

This article considers One example is also given to take a the coset structure closer look at what of spin group via analyzing the expression of its representation. the coset and the subgroup are.

关键词： spin group group representation coset structure

Radiofrequency ablation,heat shock protein 70 and potential anti-tumor immunity in hepatic and pancreatic cancers:a minireview

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Hepatobiliary & Pancreatic Diseases International 2010年第4期9卷 361-365页

作者： Teng, Li-Song Jin, ke-Tao han, na Cao, Jiang Zhejiang Univ Sch Med Ctr Canc Affiliated Hosp 1 Hangzhou 310003 Zhejiang Peoples R China Zhejiang Univ Sir Run Run Shaw Inst Clin Med Key Lab Biotherapy Zhejiang Prov Hangzhou 310016 Zhejiang Peoples R China

BACKGROUND: Radiofrequency ablation (RFA) is a minimally invasive surgical procedure which has widespread popularity in the treatment of hepatic and pancreatic cancers. Increased evidence indicates that RFA stimulates anti-tumor immunity, possibly through the induction heat shock protein 70 (HSP70) expression. HSP70 has the capacity to affect the immunogenicity of tumor cells, to chaperone antigenic peptides and deliver these into antigen presentation pathways within antigen-presenting cells, and to activate and regulate innate and adaptive immunity, which makes it useful in immunotherapeutic strategies for the treatment of cancers. DATA SOURCES: An English-language literature search was conducted using MEDLINE (1991-2010) on anti-tumor immunity, heat shock protein 70, radiofrequency ablation, hepatic cancer, pancreatic cancer, and other related subjects. RESULTS: RFA has an increasing application in the surgical treatment of hepatic and pancreatic cancers. Increased evidence indicates that RFA can induce the expression of HSP70 which possesses properties that enable it to influence a variety of immunological processes. tumor-derived HSP70 is regarded as a potent adjuvant facilitating presentation of tumor antigens and induction of anti-tumor immunity. CONCLUSIONS: This review addresses the potential association of RFA, HSP70, and anti-tumor immunity in treatment of hepatic and pancreatic cancers. To establish direct evidence of a potential association of RFA, HSP70, and anti-tumor immunity in hepatic and pancreatic cancers, further investigations should be conducted.

关键词： anti-tumor immunity heat shock protein 70 hepatic cancer pancreatic cancer radiofrequency ablation