检索结果-南通市图书馆

复合碳化物强化超细WC-Co硬质合金烧结工艺研究

在线全文

学校读者我要写书评

暂无评论

稀有金属与硬质合金 2025年第1期53卷 112-118页

作者：秦琴张可罗琳昆彭一桐鲁韩宇米鑫陈宇钦成都锦城学院智能制造学院四川成都611731 成都大学机械工程学院四川成都610106

分别采用真空烧结和低压烧结工艺制备了复合碳化物强化超细WC-8Co和WC-6Co硬质合金,研究了烧结方式及烧结温度对合金性能及微观组织的影响。结果表明:与真空烧结合金相比,低压烧结合金具有更少的孔隙数量和更高的密度、硬度和抗弯强度;... 详细信息

分别采用真空烧结和低压烧结工艺制备了复合碳化物强化超细WC-8Co和WC-6Co硬质合金,研究了烧结方式及烧结温度对合金性能及微观组织的影响。结果表明:与真空烧结合金相比,低压烧结合金具有更少的孔隙数量和更高的密度、硬度和抗弯强度;随着低压烧结温度的升高,合金的密度、硬度和抗弯强度均提高,但低压烧结温度过高会导致WC晶粒异常长大。

关键词：超细WC-Co硬质合金复合碳化物强化真空烧结低压烧结烧结温度微观组织性能

1998-2023年长江口南槽河床演变特征及其影响因素

在线全文

学校读者我要写书评

暂无评论

水利水运工程学报 2025年第1期 37-46页

作者：刘汝兰李俊花程海峰顾峰峰王珍珍韩露上海海事大学海洋科学与工程学院上海201306 上海河口海岸科学研究中心河口海岸交通运输行业重点实验室上海201201

南槽作为长江口的入海汊道之一,其河床演变动态受到广泛关注。基于长江口南槽1998年以来长序列水下地形、水沙观测数据和大型涉水工程实施情况,分析南槽近期河床冲淤变化过程,从流域减沙和工程建设两方面探讨河床演变特征及影响过程。... 详细信息

南槽作为长江口的入海汊道之一,其河床演变动态受到广泛关注。基于长江口南槽1998年以来长序列水下地形、水沙观测数据和大型涉水工程实施情况,分析南槽近期河床冲淤变化过程,从流域减沙和工程建设两方面探讨河床演变特征及影响过程。结果表明:近25年,南槽河床演变总体呈现“缓慢冲刷-趋于平衡-加速冲刷”的三阶段变化特征,其中第一阶段的“缓慢冲刷”主要受工程建设影响,流域减沙则是第三阶段“加速冲刷”的主要因素之一。未来,在稳定河床边界和较低含沙量条件下,南槽短期内仍将延续冲刷态势,直至趋于新的平衡。

关键词：南槽河床演变水沙变化涉水工程

维普期刊数据库博看期刊

同方期刊数据库

BRD4通过HMGB1/TGF-β1/Smad通路参与调控肺泡上皮细胞间质转化

在线全文

学校读者我要写书评

暂无评论

安徽医科大学学报 2025年第2期60卷 247-254页

作者：陈茹茹韩璐何海兰郝小惠刘和亮郭灵丽华北理工大学公共卫生学院唐山063210 河北省器官纤维化重点实验室唐山063210 成都中医药大学医学技术学院成都610075

目的探究溴结构域蛋白4(BRD4)在转化生长因子-β1(TGF-β1)诱导的肺泡Ⅱ型上皮细胞间质转化中的作用机制。方法采用不同浓度(5、10 ng/ml)的TGF-β1刺激MLE-12细胞48 h建立上皮间质转化(EMT)细胞模型,并对细胞予以50 nmol/L BRD4抑制剂J... 详细信息

目的探究溴结构域蛋白4(BRD4)在转化生长因子-β1(TGF-β1)诱导的肺泡Ⅱ型上皮细胞间质转化中的作用机制。方法采用不同浓度(5、10 ng/ml)的TGF-β1刺激MLE-12细胞48 h建立上皮间质转化(EMT)细胞模型,并对细胞予以50 nmol/L BRD4抑制剂JQ-1,100μmol/L高迁移率族蛋白B1(HMGB1)抑制剂甘草甜素(GA)和3μg/ml的重组高迁移率族蛋白1(rHMGB1)预处理。实验分组为:对照组、TGF-β1组、JQ-1组、JQ-1+TGF-β1组、GA组、GA+TGF-β1组、JQ-1+TGF-β1+rHMGB1组。采用CCK-8法检测JQ-1对细胞活力的影响;采用Western blot检测CDH1、ZO-1、Vimentin、α-SMA、BRD4、HMGB1、TGF-β1及Smad2/3、p-Smad2/3的蛋白表达水平;通过划痕实验检测细胞迁移能力。结果与对照组比较,TGF-β1组Vimentin、α-SMA蛋白表达增加,CDH1和ZO-1蛋白表达降低,提示EMT模型构建成功。在该模型中,BRD4、HMGB1的表达明显增加。不同浓度的JQ-1均可抑制MLE-12的细胞活力,且呈浓度依赖性。JQ-1和GA均可缓解TGF-β1诱导的EMT的发生,并抑制由TGF-β1引起的HMGB1表达的增加和TGF-β1/Smad2/3通路的激活,而采用rHMGB1上调HMGB1的表达可以减少JQ-1对EMT和TGF-β1/Smad2/3通路的影响。此外,JQ-1和GA均可以有效降低TGF-β1诱导的细胞迁移;而rHMGB1可以缓解JQ-1对细胞迁移速率的抑制作用。结论BRD4可通过影响HMGB1/TGF-β1/Smad2/3信号通路调控肺泡Ⅱ型上皮细胞向间质转化过程,且BRD4可能成为抑制肺纤维化的一个潜在靶点。

关键词：溴结构域蛋白4 高迁移率族蛋白1 TGF-β1/Smad2/3 上皮间质转化纤维化 JQ-1

同方期刊数据库

Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2024年第1期22卷 83-92页

作者： lu-lu han Xin Zhang Hui Zhang Ting Li Yi-chen Zhao Ming-hui Tian Feng-lei Sun Bo Feng Department of Neurology Three The Fifth People’s Hospital of JinanJinan 250013Shandong ProvinceChina Department of Gastroenterology Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina The First Clinical Medical College Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Geriatrics the First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital)Jinan 250014Shandong ProvinceChina Chinese Medicine Culture and Literature Research Institute Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of General Medicine Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Traditional Chinese Medicine the Second People’s Hospital of Haibei PrefectureZangzu Autonomous Prefecture of Haibei810300Qinghai ProvinceChina

Objective Obesity is a global health concern with management strategies encompassing bariatric surgery and anti-obesity drugs;however,concerns regarding complexities and side effects persist,driving research for more effective,low-risk *** promotion of white adipose tissue(WAT)browning has emerged as a promising ***,alisol B 23-acetate(AB23A)has demonstrated efficacy in addressing metabolic disorders,suggesting its potential as a therapeutic agent in obesity ***,in this study,we aimed to investigate the therapeutic potential of AB23A for mitigating obesity by regulating metabolic phenotypes and lipid distribution in mice fed a high-fat diet(HFD).Methods An obesity mouse model was established by administration of an *** and insulin metabolism were assessed via glucose and insulin tolerance *** size was determined using hematoxylin and eosin *** expression of browning markers in WAT was evaluated using Western blotting and quantitative real-time polymerase chain *** cage monitoring involved the assessment of various parameters,including food and water intake,energy metabolism,respiratory exchange rates,and physical ***,oil red O staining was used to evaluate intracellular lipid accumulation.A bioinformatic analysis tool for identifying the molecular mechanisms of traditional Chinese medicine was used to examine AB23A targets and associated signaling *** AB23A administration significantly reduced the weight of obese mice,decreased the mass of inguinal WAT,epididymal WAT,and perirenal adipose tissue,improved glucose and insulin metabolism,and reduced adipocyte ***,treatment with AB23A promoted the expression of browning markers in WAT,enhanced overall energy metabolism in mice,and had no discernible effect on food intake,water consumption,or physical *** 3T3-L1 cells,AB23A inhibited lipid accumulation,and both AB23A and rapamycin inhibited t

关键词： Obesity Alisol B 23-acetate Adipose tissue mTOR-SREBP1 High-fat diet

Spin selectivity of chiral mesostructured diamagnetic BiOBr films

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第8期16卷 11444-11449页

作者： Kun Ding Jing Ai Hao Chen Zhibei Qu Peizhao Liu lu han Shunai Che Yingying Duan Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power Shanghai University of Electric PowerShanghai 200090China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesState Key Laboratory of Matrix CompositeShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China School of Chemical Science and Engineering Tongji University1239 Siping RoadShanghai 200092China Department of Medicinal Chemistry School of PharmacyFudan University826 Zhangheng RoadShanghai 201203China

The chirality-induced spin selectivity(CISS)has been found in the antiferromagnetic and paramagnetic chiral inorganic materials with unpaired electrons,while rarely reported in the spin-paired diamagnetic inorganic materials with spin-pairing ***,we report the CISS in the spin-paired diamagnetic BiOBr endowed with three levels of chiral *** mesostructured BiOBr films(CMBFs)were fabricated through a sugar alcohol-induced hydrothermal *** antipodal CMBFs exhibited chirality-dependent,magnetic field-independent magnetic circular dichroism(MCD)signals,which indicates the existence of spin *** spin selectivity of CMBFs was speculated to be the result of the competing effect between the externally applied magnetic field and the effective magnetic field arisen from the spin electron motions in chiral *** chirality-induced effective magnetic field acts on the magnetic moment of electrons,potentially overcoming the spin-pairing energy and producing opposite energy changes for spin-down and spin-up electrons.

关键词： chiral mesostructures diamagnetic material chiral-induced spin selectivity(CISS) magnetic circular dichroism(MCD)

The Effect of By-pass Current on the Accuracy of Resistivity Measurement in a Diamond Anvil Cell

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2013年第6期30卷 53-55页

作者： YANG Jie PENG Gang LIU Cai-Long lu han han Yong-Hao GAO Chun-Xiao Department of Fundamental Aviation University of AirforceChangchun 130012 State Key Laboratory of Superhard Materials Jilin UniversityChangchun 130012

We report a quantitative analysis of by-pass current effect on the accuracy of resistivity measurement in a diamond anvil *** to the by-pass current,the sample resistivity calculated by the van der Pauw method is obviously smaller than the actual value and the problem becomes more serious for a high-resistivity *** the consideration of high accuracy of resistivity measurement,a method is presented that the inside wall of the sample chamber should be covered by a polymethylmethane *** this highly insulating layer,the by-pass current is effectively prevented and the current density distribution inside the sample is very close to the ideal case.

关键词： resistivity Diamond Resistivity

Effect of Contact Pressure during Quenching on Microstructures and Mechanical Properties of Hot-stamping Parts

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2015年第12期22卷 1138-1143页

作者： Zheng-wei GU Meng-meng L Guan-han lu Xin LI Hong XU State Key Laboratory of Automobile Materials Jilin University Department of Materials Science and Engineering Jilin University

An experimental apparatus with cooling system and pressure-adjustment assembly for simulating quench- ing was constructed to investigate the effect of contact pressure on the microstructures and mechanical properties of hot stamping parts. Qualitative and quantitative analyses of the microstructures of the as quenched parts were con- ducted; moreover, hardness and tensile tests were performed to measure their mechanical properties. The results in- dicated that contact pressure during quenching strongly affected the structures and performances of hot-stamping components. An excessive low contact pressure led to insufficient martensitic transformation. The critical contact pressure for complete martensitic transformation for 4.0 mm 22MnB5 steel was 0.4 MPa when the temperature of the coolant was 20 ℃. However, in consideration of the efficiency of practical production, a contact pressure higher than 1.25 MPa is recommended.

关键词： hot stamping quenching contact pressure microstructure mechanical property

Chiral hierarchical structure of bone minerals

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第2期15卷 1295-1302页

作者： Chao Zhou Xueliang Zhang Jing Ai Ting Ji Masaya Nagai Yingying Duan Shunai Che lu han School of Chemistry and Chemical Engineering State Key Laboratory of Composite MaterialsShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China School of Chemical Science and Engineering Tongji University1239 Siping RoadShanghai 200092 China Graduate School of Engineering Science Osaka University1-3 MachikaneyamaToyonakaOsaka 5608531Japan

Chirality is an indispensable integral of biological *** an important part of organisms,chiral organic structure of bone has been extensively ***,the chirality of bone minerals is unclear and not fully ***,we report nine levels of fractal-like chirality of bone minerals by combining electron microscopic and spectrometric *** primary helically twisted acicular apatite crystals inside collagen fibrils and between fibrils merge laterally to form secondary helical *** chiral arrangement of several subplatelets forms tertiary spiral mineral *** coherent stepwise stacking of mineral platelets with collagen fibrils leads to quaternary to ninth levels,which reconciled the previous conflicting *** optical activities in the UV-visible,infrared and terahertz regions demonstrated chirality from atomic to macroscopic scales based on circularly selective absorption and Bragg resonance at different levels of *** findings provide new insight into the structural integrity of bone,osteology,forensic medicine and archaeology and inspire the design of novel biomaterials.

关键词： chiral hierarchical structure fractal-like chirality chirality of organisms bone bone minerals

A Fluorescent Probe for Hg2＋ Based on Gold（I） Complex with An Aggregation-Induced Emission Feature

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2015年第9期33卷 1064-1068页

作者： Xie han Xiaoyi lu Zhao Chen Guangao Yu Jun Yin Shenghua Liu Key Laboratory of Pesticide and Chemical Biology Ministry of Education College of Chemistry Central China Normal University Wuhan Hubei 430079 China

A gold（I） complex that exhibited aggregation-induced emission in acetonitrile-water mixtures was designed. It showed high selectivity and sensitivity for Hg2＋ in acetonitrile-H20 （1 ：1, V ： V） solution. Dynamic light scatter-ing measurements were conducted to verify that the addition of Hg2 changed the particle size and induced fluorescence quenching.

关键词： gold(1) complex aggregation-induced emission (ALE) mercuric ion fluorescent sensor