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Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 65-82页

作者： Xiaojian JIANG Lihong LEI Weilian SUN Yingming WEI jiayin han Shuaiqi ZHONG Xianyan YANG Zhongru GOU Lili CHEN Department of Oral Medicine the Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009China Bio-nanomaterials and Regenerative Medicine Research Division Zhejiang–California International Nanosystem InstituteZhejiang UniversityHangzhou310058China

Magnesium-doped calcium silicate(CS)bioceramic scaffolds have unique advantages in mandibular defect repair;however,they lack antibacterial properties to cope with the complex oral ***,for the first time,the CS scaffold was functionally modified with a novel copper-containing polydopamine(PDA(Cu^(2+)))rapid deposition method,to construct internally modified(*P),externally modified(@PDA),and dually modified(*P@PDA)*** morphology,degradation behavior,and mechanical properties of the obtained scaffolds were evaluated in *** results showed that the CS*P@PDA had a unique micro-/nano-structural surface and appreciable mechanical *** the prolonged immersion stage,the release of copper ions from the CS*P@PDA scaffolds was rapid in the early stage and exhibited long-term sustained *** in vitro evaluation revealed that the release behavior of copper ions ascribed an excellent antibacterial effect to the CS*P@PDA,while the scaffolds retained good cytocompatibility with improved osteogenesis and angiogenesis ***,the PDA(Cu^(2+))-modified scaffolds showed effective early bone regeneration in a critical-size rabbit mandibular defect ***,it was indicated that considerable antibacterial property along with the enhancement of alveolar bone regeneration can be imparted to the scaffold by the two-step PDA(Cu^(2+))modification,and the convenience and wide applicability of this technique make it a promising strategy to avoid bacterial infections on implants.

关键词： Copper-containing polydopamine Modification Antibacterial property Bone regeneration Angiogenesis Bioceramic scaffold

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补骨脂肝损伤实验研究及网络毒理学预测研究进展

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中国实验方剂学杂志 2024年第2期30卷 179-189页

作者：唐璇韩佳寅潘辰张宇实梁爱华中国中医科学院中药研究所北京100700

补骨脂是传统的无毒中药,但近年来出现了一些关于其造成药物性肝损伤的报道,使得其用药安全问题引起了社会的广泛关注。目前,仅根据动物实验和体外实验研究补骨脂肝损伤的毒性机制及相关作用靶点和有毒成分与临床出现的补骨脂药物性肝... 详细信息

补骨脂是传统的无毒中药,但近年来出现了一些关于其造成药物性肝损伤的报道,使得其用药安全问题引起了社会的广泛关注。目前,仅根据动物实验和体外实验研究补骨脂肝损伤的毒性机制及相关作用靶点和有毒成分与临床出现的补骨脂药物性肝损伤实际情况存在一定的差距,这说明尚有一些补骨脂的潜在肝损伤成分及毒性靶点未被发现。随着系统生物学技术的不断发展,利用网络毒理学方法构建药物性肝损伤和肝损伤预测模型,能够大大降低实验成本,有效提高毒性预测效率,为挖掘潜在毒性成分及相关毒性靶点提供新的工具。为了更系统地阐释补骨脂应用过程中出现的肝损伤的特点,挖掘补骨脂潜在肝损伤成分及相关靶点,进而阐释其毒性机制,该文首先对1962—2021年中国知网、万方、维普、PubMed数据库收录的有关补骨脂肝损伤的文献报道进行整理和统计,分析临床上补骨脂肝损伤的特点和影响因素;进而对文献中报道的补骨脂的物质成分和入血成分进行总结;并对临床前体内、体外实验发现的补骨脂肝损伤机制、靶点、相关成分进行梳理,总结目前已知的补骨脂中可能具有肝损伤的化合物;最后对目前采用网络毒理学构建的补骨脂肝损伤预测模型获取的补骨脂肝损伤成分及靶点预测结果进行总结。从临床肝损伤特点、临床前肝损伤研究、计算机网络预测3方面阐释补骨脂肝损伤发生可能的相关因素,为补骨脂肝损伤研究和风险提示提供参考。

关键词：补骨脂肝损伤毒性机制毒性靶点网络毒理学

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全胚胎培养技术及其应用研究进展

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中国中药杂志 2010年第5期35卷 549-553页

作者：韩佳寅梁爱华首都医科大学中医药学院北京100069 中国中医科学院中药研究所北京100700

体外全胚胎培养技术是以体外胚胎替代整体动物进行实验的技术,主要用于研究早期器官的生长发育和化学物质的胚胎毒性及造成胚胎毒性的机制等。本文就大鼠和小鼠的全胚胎培养技术及其应用进行综述,着重介绍了全胚胎培养技术的发展概况,... 详细信息

体外全胚胎培养技术是以体外胚胎替代整体动物进行实验的技术,主要用于研究早期器官的生长发育和化学物质的胚胎毒性及造成胚胎毒性的机制等。本文就大鼠和小鼠的全胚胎培养技术及其应用进行综述,着重介绍了全胚胎培养技术的发展概况,应用全胚胎培养技术的注意事项及全胚胎培养技术在生长发育研究、环境污染物和重金属的胚胎毒性研究、药物安全性评价、中药的胚胎毒性及其机制研究领域的应用,并就该技术在中药生殖毒性研究中的应用前景进行了讨论。

关键词：全胚胎培养胚胎发育生殖毒性安全性评价

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倒千里光碱对小鼠体外培养胚胎的发育毒性研究

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中国中药杂志 2011年第14期36卷 1901-1904页

作者：韩佳寅梁爱华易艳首都医科大学中医药学院北京100069 中国中医科学院中药研究所北京100700

目的:探讨倒千里光碱的胚胎发育毒性。方法:采用小鼠全胚胎培养模型,将8.5 d小鼠胚胎在含有倒千里光碱的即刻离心血清中培养48 h(倒千里光碱的终浓度分别为12.5,25,50,100 mg.L-1),观察倒千里光碱对胚胎生长发育(卵黄囊直径、颅臀长、... 详细信息

目的:探讨倒千里光碱的胚胎发育毒性。方法:采用小鼠全胚胎培养模型,将8.5 d小鼠胚胎在含有倒千里光碱的即刻离心血清中培养48 h(倒千里光碱的终浓度分别为12.5,25,50,100 mg.L-1),观察倒千里光碱对胚胎生长发育(卵黄囊直径、颅臀长、头长、体节数)和组织器官形态分化(卵黄囊循环、尿囊、翻转、心、脑、尾神经管、视听嗅系统、腮弓、颌突、肢芽)的影响。结果:倒千里光碱对胚胎的生长发育和形态分化均具有明显的毒性影响。随倒千里光碱浓度的增加,胚胎的生长发育和组织器官形态分化指标影响越来越严重,其中听嗅系统、腮弓、上下颌突、前后肢芽的影响最为明显。结论:倒千里光碱对体外培养的小鼠胚胎有明显的毒性作用,提示妊娠期暴露于该化合物对胎儿具有潜在的毒性。

关键词：倒千里光碱全胚胎培养发育毒性生殖毒性胚胎毒性

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Cloudy Sky Conditions Promote Net Ecosystem CO_2 Exchange in a Subtropical Coniferous Plantation across Seasons

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Journal of Resources and Ecology 2019年第2期10卷 137-146页

作者： han jiayin YE Shu GUO Chuying ZhanG Leiming LI Shenggong WANG Huimin Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academyof Sciences Beijing 100101 China College of Resources and Environment University of Chinese Academy of Sciences Beijing 100190 China

Dynamic changes in solar radiation have an important influence on ecosystem carbon sequestration,but the effects of changes caused by sky conditions on net ecosystem CO2 exchange(NEE)are *** study analyzed the effects of sunny,cloudy,and overcast sky conditions on NEE using carbon flux and meteorological data for a subtropical coniferous plantation in *** on one-year data,we found no seasonal variation in the light response curve under various sky *** with sunny sky conditions,the apparent quantum yield(α)and potential photosynthetic rate at a light intensity of 150 and 750 W m^-2(P150 and P750)under cloudy sky conditions increased by an average of 82.3%,217.7%,and 22.5%;αand P150 under overcast sky conditions increased by 118.5%and 301%on *** radiation conditions were more favorable for maximum NEE,while low radiation conditions inhibited *** most cases,when the sunny NEE was used as a baseline for comparison,the relative change in NEE(%NEE)was positive under cloudy sky conditions and negative under overcast sky *** average maximal%NEE under cloudy sky conditions was 42.4% in spring,34.1% in summer,1.6% in autumn and –87.3% in *** study indicates that cloudy sky conditions promote photosynthetic rates and NEE in subtropical coniferous plantations.

关键词： eddy covariance sky conditions diffuse radiation clearness index NEE

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Modelling Soil Greenhouse Gas Fluxes from a Broad-leaved Korean Pine Forest in Changbai Mountain: Forest-DNDC Model Validation

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Journal of Resources and Ecology 2019年第2期10卷 127-136页

作者： YE Shu GUO Chuying han jiayin ZhanG Leiming DAI Guanhua WEN Xuefa YU Guirui Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academyof Sciences Beijing 100101 China College of Resources and Environment University of Chinese Academy of Sciences Beijing 100190 China Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China

Fluctuations in soil greenhouse gas(GHG)are an important part of the terrestrial ecosystem carbon-nitrogen cycle,but uncertainties remain about the dynamic change and budget assessment of soil GHG *** high frequency and consecutive soil GHG fluxes measured with an automatic dynamic chamber system,we tested the applicability of the current Forest-DNDC model in simulating soil CH4,CO2 and N2O fluxes in a temperate broad-leaved Korean pine forest at Changbai *** results showed that the Forest-DNDC model reproduced general patterns of environmental variables,however,simulated seasonal variation in soil temperature,snow melt processes and soil moisture partly deviated from measured variables,especially during the non-growing *** modeled CH4 flux was close to the field measurement and co-varied mainly with soil temperature and *** modeled soil CO2 flux had the same seasonal trend to that of the observation along with variation in temperature,however,simulated CO2 flux in the growing season was *** modeled N2O flux attained a peak in summer due to the influence of temperature,which was apparently different from the observed peak of N2O flux in the freeze-thaw ***,both modeled CO2 flux and N2O flux were dampened by rainfall *** from consistent estimation of annual soil CH4 flux,the annual accumulation of CO2 and N2O was *** is still necessary to further optimize model parameters and processes using long-term high-frequency observation data,especially transference of heat and water in soil and GHG producing *** work will improve modeling,ecosystem carbon-nitrogen budget assessment and estimation of soil GHGs flux from the site to the region.

关键词： soil GHGs flux dynamic chamber method forest-DNDC temperate forest

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含吡咯里西啶生物碱植物的特殊毒性及致毒机制研究进展

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中国中药杂志 2011年第10期36卷 1397-1401页

作者：韩佳寅梁爱华高双荣首都医科大学中医药学院北京100069 中国中医科学院中药研究所北京100700

吡咯里西啶类生物碱(pyrrolizidine alkaloids,PAs)是一类在植物中广泛分布的成分,含有吡咯里西啶类生物碱的植物在民间被作为草药和植物茶饮品应用的现象极为普遍。然而,研究发现吡咯里西啶类生物碱具有明确的毒性作用,其中的肝毒性早... 详细信息

吡咯里西啶类生物碱(pyrrolizidine alkaloids,PAs)是一类在植物中广泛分布的成分,含有吡咯里西啶类生物碱的植物在民间被作为草药和植物茶饮品应用的现象极为普遍。然而,研究发现吡咯里西啶类生物碱具有明确的毒性作用,其中的肝毒性早已引起人们的关注,而生殖毒性、致突变和致癌性方面的毒性却研究较少。本文主要就PAs的生殖毒性、致突变和致癌方面的特殊毒性进行综述,主要总结了20世纪50年代以来关于PAs特殊毒性的临床报道及动物实验研究,并对现有研究所认为的影响PAs特殊毒性的因素及PAs特殊毒性产生的机制进行了归纳。

关键词：吡咯里西啶类生物碱生殖毒性致突变致癌

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Physicochemical principles of hydrogen metallurgy in blast furnace

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Journal of Iron and Steel Research International 2024年第1期31卷 46-63页

作者： han-jie Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China

Based on the stoichiometric method and the free energy minimization method,an ideal model for the reduction of iron oxides by carbon and hydrogen under blast furnace conditions was established,and the reduction efficiency and theoretical energy consumption of the all-carbon blast furnace and the hydrogen-rich blast furnace were *** results show that after the reduction reaction is completed at the bottom of the blast furnace,the gas produced by reduction at 1600℃still has a certain excessive reduction capacity,which is due to the hydrogen brought in by the hydrogen-rich blast as well as the excess carbon monoxide generated by the reaction of the coke and the oxygen brought in by the *** the process of the gas with excessive reduction capacity rising from the bottom of the blast furnace and gas reduction process,the excessive reduction capacity of the gas gradually decreases with the increase in the dydrogen content in the *** the all-carbon blast furnace,the excess gas reduction capacity is the strongest,and the total energy consumption per ton of iron reduction is the *** shows that,for the current operation mode of the blast furnace,adding hydrogen in the blast furnace cannot reduce the consumption of carbon required for reduction per ton of iron,but rather increases the consumption of carbon.

关键词： Hydrogen metallurgy Excess gas reduction capacity Theoretical energy consumption Hydrogen-rich blast furnace Thermodynamic model Gibbs minimum free energy method

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Engineered plant extracellular vesicles for autoimmune diseases therapy

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Nano Research 2024年第4期17卷 2857-2873页

作者： Ruina han Yan Wu Yafei han Xiangfei Liu han Liu Jiacan Su Institute of Translational Medicine Shanghai UniversityShanghai 200444China Organoid Research Center Shanghai UniversityShanghai 200444China National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghai 200444China Department of Orthopedics Shanghai Zhongye HospitalShanghai 200941China Department of Orthopedics Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China

Autoimmune diseases(AID)encompass a diverse array of conditions characterized by immune system dysregulation,resulting in aberrant responses of B cells and T cells against the body’s own healthy *** extracellular vesicles(PEVs)are nanoscale particles enclosed by phospholipid bilayers,secreted by plant cells,which facilitate intercellular communication by transporting various bioactive *** to their nanoscale structure,safety,abundant sources,low immunogenicity,high yield,biocompatibility,and effective targeting of the colon and liver,PEVs are regarded as a promising platform for the treatment of *** review provides a comprehensive summary of PEV biogenesis,physicochemical and biological properties,internalization mechanisms,isolation methods,and their applications in various diseases,with a specific focus on their potential roles in ***,we propose engineering approaches and administration methods for ***,we present an overview of the advantages and challenges associated with utilizing PEVs for the treatment of *** gaining a comprehensive understanding of PEVs,we anticipate the development of innovative therapeutic strategies for *** and engineered PEVs hold substantial promise as a valuable resource for innovative technologies in AID treatment.

关键词： autoimmune diseases plant extracellular vesicles extracellular vesicles engineering modification

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FAST unveils a new era in the discovery of long-period pulsars in globular clusters

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 185-186页

作者： Zhanwen han International Centre of Supernovae Yunnan Key LaboratoryYunnan ObservatoriesChinese Academy of SciencesKunming 650011China

Globular clusters(GC)are among the oldest celestial bodies in the Milky *** possessing millions of stars and have been going through abundant stellar interactions,GCs are futile ground for hunting for compact objects,particularly,neutron stars.A significant number of fast-spinning millisecond pulsars(MSPs)have been discovered,comprising the majority of known GC pulsars.

关键词： stars pulsars abundant

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