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Increase of peripheral Th17 lymphocytes during acute cellular rejection in liver transplant recipients

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Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 606-611页

作者： Hua Fan, Li-Xin Li, Dong-Dong han, jian-Tao Kou, ping Li, Qiang He Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China Department of Hepatobiliary Surgery Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

BACKGROUND: Although many human inflammatory and autoimmune diseases were previously considered to be mediated by T helper type 1 (Th1) cells, the recently described Th17 cells play dominant roles in several of these diseases. We and others speculated that allograft rejection after organ transplantation may also involve Th17 cells. Episodes of acute rejection occur in 30% of liver transplants. This study aimed to determine the frequency of circulating Th17 cells in patients who had received liver transplants for benign end-stage liver disease and to identify any association between acute rejection episodes and levels of Th17 cells in the peripheral blood. METHODS: A prospective study compared Th17 cells from 76 consecutive benign end-stage liver disease patients who had undergone orthotopic liver transplantation from 2007 to 2011 with those from 20 age-matched healthy individuals. Peripheral blood samples were collected at different time points within one year after transplant. Blood samples and liver biopsies were also collected at the diagnosis of acute rejection. Percentages of circulating CD4+ IL-17+ cells were measured by flow cytometry The transplant patients were classified into two groups: a rejection group consisting of 17 patients who had an episode of acute rejection, and a non-rejection group comprising the remaining 59 patients with no acute rejection episodes Percentages of circulating Th17 cells were compared between the two groups and controls. RESULTS: The levels of circulating CD4+ IL-17+ T cells in the rejection group were higher during acute rejection than those in the non-rejection group (2.56±0.43% versus 1.79±0.44% P<0.001). The frequency of CD4+ IL-17+ cells in peripheral blood was positively correlated with the rejection activity index (r=0.79, P=0.0002).CONCLUSION: Circulating Th17 cells may be useful as a surrogate marker for predicting acute rejection in liver transplant recipients.

关键词： liver transplantation Th17 cells acute cellular rejection transplant immunology

Lateral-torsional buckling of box beam with corrugated steel webs

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Journal of Central South University 2019年第7期26卷 1946-1957页

作者： FENG Yu-lin jianG Li-zhong ZHOU Wang-bao han jian-ping School of Civil Engineering Central South University Changsha 410075 China National Engineering Laboratory for High Speed Railway Construction Central South University Changsha 410075 China Key Laboratory of Disaster Prevention and Mitigation in Civil Engineering of Gansu Province Lanzhou University of Technology Lanzhou 730050 China

Corrugated steel web is folded along the longitudinal direction and has the mechanical properties such as axial compression stiffness corrugation effect, shear modulus corrugation effect, similar to that of an accordion. In order to study the lateral-torsional buckling of box beams with corrugated steel webs (BBCSW) under the action of bending moment load, the neutral equilibrium equation of BBCSW under the action of bending moment load is derived through the stationary value theory of total potential energy and further, along with taking Kollbrunner-Hajdin correction method and the mechanical properties of the corrugated web into consideration. The analytical calculation formula of lateral-torsional buckling critical bending moment of BBCSW is then obtained. The lateral-torsional buckling critical bending moment of 96 BBCSW test specimens with different geometry dimensions are then calculated using both the analytical calculation method and ANSYS finite element method. The results show that the analytical calculation results agree well with the numerical calculation results using ANSYS, thus proving the accuracy of the analytical calculation method and model simplification hypothesis proposed in this paper. Also, compared with the box beams with flat steel webs (BBFSW) with the same geometry dimensions as BBCSW, within the common range of web space-depth ratio and web span-depth ratio, BBCSW’s lateral-torsional buckling critical bending moment is larger than that of BBFSW. Moreover, the advantages of BBCSW’s stability are even more significant with the increase of web space-depth ratio and web depth-thickness ratio.

关键词： box beams with corrugated steel webs lateral-torsional buckling analytical solution accordion effect Kollbrunner-Hajdin method

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新型自复位黏弹性阻尼支撑力学性能研究

Clinical application of BVS5000 left ventricular assist device in heart failure patients

工程力学 2021年第1期38卷 195-204页

作者：韩建平章全才兰州理工大学甘肃省土木工程防灾减灾重点实验室甘肃兰州 730050 兰州理工大学防震减灾研究所甘肃兰州 730050

提出了一种新型的自复位黏弹性阻尼支撑(self-centering viscoelastic damping brace,SCVEDB),该支撑利用形状记忆合金的拉伸变形和黏弹性材料的剪切变形共同耗散能量,同时利用形状记忆合金的超弹性特性复位.设计和加工了SCVEDB最基本... 详细信息

提出了一种新型的自复位黏弹性阻尼支撑(self-centering viscoelastic damping brace,SCVEDB),该支撑利用形状记忆合金的拉伸变形和黏弹性材料的剪切变形共同耗散能量,同时利用形状记忆合金的超弹性特性复位.设计和加工了SCVEDB最基本的模型,对该支撑试件进行了循环往复荷载作用下的力学性能试验,研究了位移幅值、加载速率、SMA丝数量、黏弹性材料的厚度对其性能的影响,同时通过割线刚度、耗散能量、等效阻尼比、自复位比4个参数量化分析了SCVEDB的力学性能.对SMA丝进行了循环拉伸试验,利用OpenSees平台建立了SMA的材料本构数值模型,然后将其与模拟黏弹性材料的Bouc-Wen模型并联,建立了该支撑的力学模型,进而模拟了支撑的力学性能,数值模拟结果与试验结果吻合较好.

关键词：自复位黏弹性阻尼支撑 SMA 超弹性黏弹性材料力学试验数值模拟

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Chinese Medical Journal 2008年第10期121卷 877-880页

作者： LUO Xin-jin HU Sheng-shou SUN han-song XU jian-ping LIU ping ZHENG Zhe MA Wei-guo ZhanG Yan Department of Cardiovascular Surgery Fu Wai Hospital PekingUnion Medical College Beijing 100037 China

Background Mechanical ventricular assistance is an important therapeutic method for severe heart failure patients. A variety of ventricular assist devices have been designed for use, The purpose of this report was to describe the experience of using Abiomed BVS5000 as a means of left ventricular support as a clinical treatment for heart failure patients. Methods From February 2004 to April 2006, 12 male patients were supported with Abiomed BVS5000 left ventricular assist device （LVAD） at Fu Wai Hospital. The average age was （55.2±9.6） years （range 39 to 68 years）. The mean body surface area was （1.76±0.1） m^2 （range 1.6 to 1.9 m^2 ）. Devices were inserted for post-cardiotomy shock after coronary artery bypass graft in 11 patients （92%） and in 1 dilated cardiomyopathy patient for acute cardiogenic shock. Modified cannulation methods by inserting the arterial cannulae in femoral artery and inserting the venous cannula in left atrium through a segment of bovine jugular vein were used in 7 patients. In this way, the device could be taken off without re-sternotomy when support was finished. A comparison was made between the modified method and routine left atrium-to-ascending aorta cannulating method. Results The median duration of support was 5 （3-43） days, with support flow rate of 3.8-4.5 L/min. There were 9 （75%） patients weaned from support and 8 （67%） patients discharged from the hospital. Four （33%） patients were dead. The most common morbidity was adverse neurological events. There is no statistical difference between modified and routine method on average in BVS5000 support duration, in assisted flow rate, in mechanical ventilation duration, in the intensive care unit stay and thoracic drainage. Conclusions The Abiomed BVS5000 is valuable to support patients with acute cardiogenic shock for short-term use. By the modified cannulating method, the weaning procedure can be effectively simplified. Optimization of inserting indication remains challenging and attr

关键词： heart failure surgical treatment left ventricular assist devices

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电气火灾智能监控技术应用与探讨

消防科学与技术 2012年第9期31卷 971-974页

作者：韩建平河南省消防总队河南郑州450008

电气火灾监测与报警已能够准确、全天候监测电气线路中的漏电、温度等各项参数的变化,但其智能化水平偏低。基于数字化、功能一体化、智能化的设计思路,采用高速交流采样技术、无线射频识别技术、分布式光纤测温技术、智能传感及分析技... 详细信息

电气火灾监测与报警已能够准确、全天候监测电气线路中的漏电、温度等各项参数的变化,但其智能化水平偏低。基于数字化、功能一体化、智能化的设计思路,采用高速交流采样技术、无线射频识别技术、分布式光纤测温技术、智能传感及分析技术、信息可视化技术构建智能化监控系统,并成功应用于实际工程项目。

关键词：电气火灾智能监控智能化

煤矿井下无人值守变电所远程智能监控系统升级改造

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煤炭工程 2022年第10期54卷 90-94页

作者：韩建萍山西能源学院山西晋中030600

为了提高煤矿井下变电所系统的稳定性和可靠性,实现井下变电所的无人值守,加快智慧矿山的建设,对潞安集团司马煤业有限公司二采区无人值守变电所系统进行了改造升级。通过更新井下电力监控分站,增添级联综合保护器等设备,组建光纤环网,... 详细信息

为了提高煤矿井下变电所系统的稳定性和可靠性,实现井下变电所的无人值守,加快智慧矿山的建设,对潞安集团司马煤业有限公司二采区无人值守变电所系统进行了改造升级。通过更新井下电力监控分站,增添级联综合保护器等设备,组建光纤环网,改进软件系统等措施,提高了信号传递的实时性和可靠性,解决了工作人员井下现场作业时安全没保障、矿井电网发生大面积停电时复电慢、各煤矿井下变电所远程监控系统信息不能共享等问题。实现了防越级跳闸、地面监控中心远程智能监控及无人值守的目的。

关键词：井下变电所无人值守防越级跳闸远程智能监控

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应用型大学电气自动化专业方向定位研究

教育理论与实践 2015年第3期35卷 6-7页

作者：韩建萍山西能源学院(筹)电气工程系

应用型大学电气自动化专业方向定位要面向社会需求、适应区域经济特点以及结合地方经济发展规划。在进行专业方向定位时,要按照学科分类进行,通过比较各大院校的专业方向定位方法,选择适合自己的定位,同时要结合学校自身的办学条件,细... 详细信息

应用型大学电气自动化专业方向定位要面向社会需求、适应区域经济特点以及结合地方经济发展规划。在进行专业方向定位时,要按照学科分类进行,通过比较各大院校的专业方向定位方法,选择适合自己的定位,同时要结合学校自身的办学条件,细化专业方向。

关键词：应用型大学电气自动化专业专业方向定位

基于不同规范设计的现役RC框架损伤分析及可修复性能评估

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工程力学 2023年第3期40卷 117-128页

作者：孙小云韩建平黄林杰南京交通职业技术学院南京211188 兰州理工大学甘肃省土木工程防灾减灾重点实验室兰州730050 南京林业大学土木工程学院南京210037

我国现役大多数钢筋混凝土(RC)框架是基于GBJ 11-1989、GB 50011-2001和GB 50011-2010三次抗震设计规范所设计,由于建筑功能的需求,常见框架结构的首层层高明显高于其它层,易导致结构层间变形集中。选择底层层高明显高于其它层的三栋现... 详细信息

我国现役大多数钢筋混凝土(RC)框架是基于GBJ 11-1989、GB 50011-2001和GB 50011-2010三次抗震设计规范所设计,由于建筑功能的需求,常见框架结构的首层层高明显高于其它层,易导致结构层间变形集中。选择底层层高明显高于其它层的三栋现役RC框架为分析算例,综合考虑填充墙面外变形、节点区剪切变形、柱内钢筋粘结滑移等因素,利用OpenSees有限元分析软件,分别建立其三维空间有限元模型。对三个模型进行了低周往复加载分析和大量地震动激励下的动力时程分析,研究了结构在中震、大震和特大震三个水准下的损伤程度、层间变形的分布模式及可修复性能。结果表明:相对于GBJ 11-1989和GB 50011-2001,基于GB 50011-2010抗震设计规范设计的结构损伤最小,对于潜在薄弱层的加强效果更加明显;中、大震水平,三次规范设计结构发生倒塌的概率均较低,但基于GBJ 11-1989抗震设计规范设计的结构损伤较严重,较难修复;特大震水平,基于GBJ 11-1989和GB 50011-2001抗震设计规范设计的结构倒塌风险较大,基于GB50011-2010抗震设计规范设计的结构倒塌概率相对较低,但其修复需较大的经济投入。经过规范的依次修订,在特大震水平,基于GBJ 11-1989至GB50011-2010抗震设计规范设计的结构中结构构件的失效率逐渐降低;基于GB 50011-2001和GB 50011-2010抗震设计规范设计的结构中,柱以延性破坏为主,但基于GBJ11-1989抗震设计规范设计的结构中,柱发生明显的脆性破坏。

关键词：抗震规范钢筋混凝土框架动力分析特大震损伤可修复性能

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考虑填充墙平面内外相互作用评估RC框架-填充墙结构抗整体性倒塌能力

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工程力学 2016年第9期33卷 146-154页

作者：韩建平黄林杰孙小云兰州理工大学甘肃省土木工程防灾减灾重点实验室甘肃兰州730050 兰州理工大学防震减灾研究所甘肃兰州730050

首先简要阐述了可模拟填充墙平面内外相互作用的纤维离散化梁-柱单元模型。其次,基于Open Sees分析软件,对某倒塌试验的4层钢筋混凝土框架-填充墙结构进行了数值模拟,数值模拟结果与试验结果的对比表明考虑平面内外相互作用的纤维离散化... 详细信息

首先简要阐述了可模拟填充墙平面内外相互作用的纤维离散化梁-柱单元模型。其次,基于Open Sees分析软件,对某倒塌试验的4层钢筋混凝土框架-填充墙结构进行了数值模拟,数值模拟结果与试验结果的对比表明考虑平面内外相互作用的纤维离散化梁-柱单元模型模拟框架-填充墙结构中的填充墙是有效的。最后,基于校准后的数值分析模型,利用Open Sees分析软件对某钢筋混凝土框架-填充墙结构教学楼,区分考虑和不考虑填充墙平面内外相互作用两种情况,分别建立三维空间模型,进行了静力推覆分析和增量动力分析,进而利用24条地震动记录输入下的增量动力分析结果,给出了具有50%倒塌概率的结构抗整体性倒塌能力。分析结果对比表明不考虑填充墙平面内外相互作用会明显低估结构的抗倒塌能力。

关键词：平面内与平面外相互作用填充墙多层RC框架-填充墙增量动力分析抗整体性倒塌能力