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Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

Nano-Micro Letters 2025年第1期17卷 361-377页

作者： feng He Sitong Chen Ruili Zhou hanyu Diao Yangyang han Xiaodong Wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue tong Shi Chenhui han Heng Zhang Fenrong Liu Haorun Li Yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Nanorods

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牛性别决定新基因Fgf9的克隆及生物信息学分析

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中国生物工程杂志 2009年第8期29卷 45-50页

作者：廖冰吴宁韩凤桐林秀坤中国农业科学院北京畜牧兽医研究所北京100193 中国科学院海洋研究所青岛266071 东北农业大学哈尔滨150030

Fgf9基因是脊椎动物性别决定中重要的信号因子,它在睾丸发育过程中参与Sertoli细胞的增殖和睾丸索的形成。基于表达序列标签(expressed sequence tags,ESTs)克隆原理,采用序列拼接和RT-PCR方法获得了荷斯坦奶牛Fgf9基因的cDNA序列,并对... 详细信息

Fgf9基因是脊椎动物性别决定中重要的信号因子,它在睾丸发育过程中参与Sertoli细胞的增殖和睾丸索的形成。基于表达序列标签(expressed sequence tags,ESTs)克隆原理,采用序列拼接和RT-PCR方法获得了荷斯坦奶牛Fgf9基因的cDNA序列,并对其组织表达特征进行分析。利用生物信息学方法对Fgf9基因序列和蛋白结构进行分析。结果显示:Fgf9基因定位于牛12号染色体上,cDNA全长为697bp,开放阅读框为627bp,编码208个氨基酸,分子量23.38245kDa,等电点7.0600。RT-PCR证实该开放阅读框正确,在牛的各组织中均有表达,且与牛其他cDNA无同源性,获得GenBank登陆号为:EU693028。功能结构分析显示Fgf9蛋白具有典型的FGF家族保守结构域,包括受体相互作用位点和肝素结合位点。信号肽预测显示牛Fgf9蛋白可能不存在信号肽序列。

关键词： Fej9 性别决定基因克隆生物信息学

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Inflammation inhibitory effects of sirolimus and paclitaxel-eluting stents on interleukin-1β-induced coronary artery in-stent restenosis in pigs

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Chinese Medical Journal 2010年第17期123卷 2405-2409页

作者： ZHOU Xu-chen HUANG Rong-chong ZhanG Bo YIN Da LIANG Bin WANG Shao-peng GUAN Qi-gang SUN Xi-zhuo MIAO Zhi-lin HE Xue-zhi han feng-tong CHENG Ying ZhanG Li ZENG Ding-yin Department of Cardiology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Cardiology First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Cardiology Dalian Central Hospital Dalian Liaoning 116000 China

Background Coronary artery in-stent restenosis （ISR） and late stent thrombosis remain as important complications of stenting. The inflammation reactions to sirolimus and paclitaxel-eluting stents were investigated in a swine stenosis model induced by interleukin （IL）-1β.Methods Mini pigs （n=12; 2-3 months old and weighing 25-30 kg） were subjected to thoracotomy. Segments （10 mm）of the mid left anterior descending coronary artery and left circumflex coronary artery were exposed and aseptically wrapped with a cotton mesh soaked with IL-1β （5 μg）. After 2 weeks, the animals were anesthetized and quantitative coronary arteriography （QCA） was performed. The stenosis sites were randomized into three groups for stent insertion： a sirolimus-eluting stent （SES） group （FirebirdTM, n=7）, a paclitaxel-eluting stent （PES） group （TAXUSTM, n=9）, and a bare-metal stent （BMS） group （YINYITM, Dalian Yinyi Biomaterials Development Co., Ltd, China, n=8）. The three different stents were randomly implanted into stenosis segments. Expression of monocyte chemoattractant protein-1 （MCP-1）, tumor necrosis factor-alpha （TNF-α）, P-selectin and vascular cell adhesion molecule-1 （VCAM-1） was determined by reverse transcription-coupled polymerase chain reaction （RT-PCR）.Results QCA showed severe stenosis in IL-1β treated segments. The SES and PES groups showed lower 1-month angiographic late lumen loss （LLL） within the stent and the lesion compared with BMS （P 〈0.05） by follow-up QCA. The SES showed lower LLL than that of PES in reducing 1-month inflammation lesions in pigs by follow-up QCA （（0.15±0.06）mm vs. （0.33±0.01） mm, P 〈0.0001）. The neointimal hyperplasia areas in SES and PES showed lower than those of BMS （SES （11.6±1.7） mm2, PES （27.2±1.6） mm2 vs. BMS （76.2±1.3） mm2, P 〈0.0001）. The mRNA expression of MCP-1 by RT-PCR in SES and PES showed lower than that of BMS at 30 days after stenting （SES 0.20±0.03, PES 0.48±0.49 *** 0.58±0.07, P 〈0.05）. Levels of VCAM-1 in SES were significantly

关键词： interleukin-1β sirolimus paclitaxel drug-eluting stent inflammation in-stent restenosis

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牛Sry启动子调控序列的鉴定

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中国农业科学 2010年第14期43卷 2996-3004页

作者：韩凤桐林秀坤刘娣吴宁廖冰哈尔滨工业大学基础与交叉科学研究院生命医学工程研究中心中国农业科学院北京畜牧兽医研究所黑龙江省农业科学院

【目的】Sry是大多数哺乳动物雄性性别发育的决定基因,但人们仍未找到其表达的调控规律,本试验对牛Sry5′端调控序列作了初步的研究,为深入研究牛Sry的表达调控奠定了基础。【方法】克隆牛Sry5′端侧翼1056bp长的DNA序列,利用生物信息... 详细信息

【目的】Sry是大多数哺乳动物雄性性别发育的决定基因,但人们仍未找到其表达的调控规律,本试验对牛Sry5′端调控序列作了初步的研究,为深入研究牛Sry的表达调控奠定了基础。【方法】克隆牛Sry5′端侧翼1056bp长的DNA序列,利用生物信息学方法对这一区域内潜在的转录起始位点进行了预测,并构建了10个不同长度的缺失牛Sry5′部分侧翼序列的报告基因载体;进一步分离了胎牛生殖嵴,进行生殖嵴细胞的原代培养,并对胎牛生殖嵴细胞进行了性别和特征鉴定;最后利用荧光素酶双报告基因分析系统,在生殖嵴细胞内检测了牛Sry核心启动子区域的位置。【结果】体外培养的生殖嵴细胞可以表达雄性生殖嵴细胞的特征基因Sry、Sox9、Sf-1和Dax1,牛Sry5′端-93、-419和-722处存在3个潜在的转录起始位点(TSS),-599—-565区域35bp内存在控制Sry基础转录活性的顺式调控元件,其中存在多个潜在的转录因子结合位点。【结论】牛Sry5′端UTR区-599—-565bp区域35bp存在部分调控序列。

关键词：牛 Sry 核心启动子双荧光素酶报告基因分析系统

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牛Sry亚细胞定位及其对Sox9基因表达的影响

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动物学报 2008年第5期54卷 890-896页

作者：韩凤桐吴宁廖冰林秀坤刘娣中国农业科学院北京畜牧兽医研究所黑龙江省农业科学院

为鉴别牛Sry基因的下游目的基因,并确定Sry蛋白在细胞内的定位区域,本试验构建pcDNA3.1-Sry表达载体和pEGFP-N1-Sry亚细胞定位表达载体,在原代培养的生殖嵴细胞和卵巢颗粒细胞中进行Sry过表达,并对性别控制相关基因在Sry过表达前后的表... 详细信息

为鉴别牛Sry基因的下游目的基因,并确定Sry蛋白在细胞内的定位区域,本试验构建pcDNA3.1-Sry表达载体和pEGFP-N1-Sry亚细胞定位表达载体,在原代培养的生殖嵴细胞和卵巢颗粒细胞中进行Sry过表达,并对性别控制相关基因在Sry过表达前后的表达水平变化进行检测,包括Sf1(Steroidogenic fator-1)、Gata4(GATA binding protein 4)、Wt1(Wilms tumor gene)、Sox9(Sry-related HMG box-9)、Amh(Anti Mullerian Hormone)和Dax1(Dosage sensitive sex reversal locus-1);并在两种细胞中进行了Sry亚细胞定位研究。Sry在两种细胞中过表达后,在生殖嵴细胞中Sox9的表达水平被显著上调,但在卵巢颗粒细胞中未观察到Sox9基因被上调,而其他几个基因的表达水平未受Sry影响;亚细胞定位结果表明牛Sry主要分布在细胞核内。本试验说明牛Sry可能间接调控Sox9表达,或存在其他不需要Sry参与的调控通路调控Sox9表达;牛Sry蛋白起转录因子作用。

关键词：牛 Sry 过表达亚细胞定位 Sox9

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Modeling and control of a rigid-flexible coupling robot for narrow space manipulations

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Science China Technological Sciences 2025年

作者： Kuangda CHEN Huan ZHAO Jiexin ZhanG Mei feng Yiwei WANG Jinliang WANG han DING State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and Technology Key Laboratory of CNC Equipment Reliability Ministry of Education Jilin University School of Medical Equipment Science and Engineering Huazhong University of Science and Technology

Narrow space manipulations are crucial for equipment maintenance, as they eliminate the need for disassembly, thus reducing costs and increasing efficiency. Cable-driven flexible robots possess exceptional capabilities in maneuvering through narrow spaces, thanks to their interaction compliance and distal dexterity. However, their inherent low stiffness causes a decline in the location accuracy of the robot and could even lead to manipulation failure. To address this challenge, this paper proposes a novel type of rigid-flexible coupling robot, which increases the stiffness of the robot while ensuring the reachability within a narrow space. To achieve high-accuracy location in a narrow space, kinematic and control methods are proposed. Specifically,the robot forward kinematics are uniformly represented, and the closed-form inverse kinematics solution is derived. Furthermore, in cases where the robot?s structure fails to align with Pieper?s solution, a two-stage search strategy is utilized to solve the inverse kinematics, resulting in a high success rate of 99.1%. Based on the proposed kinematics, a rigid-dominated control method is then proposed to facilitate localization and pose alignment of target objects in narrow spaces. The practical comparative experiments show that the proposed robot has the capability of high accuracy control in narrow spaces.

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配子水平上对家畜性别控制的研究进展

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畜牧兽医杂志 2005年第5期24卷 26-28页

作者：韩凤桐李武东北农业大学动物科学技术学院黑龙江哈尔滨150030

实现对家畜性别的控制是生物学中重要的研究课题,依据畜牧业生产中不同的需要来决定不同家畜的性别在人类健康及畜牧业生产上有巨大的应用价值,实现对动物性别的控制一直是人类期望达到的目标之一。本文从配子角度出发对家畜性别决定原... 详细信息

实现对家畜性别的控制是生物学中重要的研究课题,依据畜牧业生产中不同的需要来决定不同家畜的性别在人类健康及畜牧业生产上有巨大的应用价值,实现对动物性别的控制一直是人类期望达到的目标之一。本文从配子角度出发对家畜性别决定原理机制、性别控制的生物学依据及各种性别控制方法作了简述,并着重对不同方法的理论基础、特点、实践应用价值以及这些方法存在的问题进行了综述。

关键词：性别控制精子性别精子分离

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Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

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Science China Chemistry 2025年第1期68卷 35-45页

作者： Xinyu Peng Qian Ma Da han School of Life Science Shanghai University Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine State Key Laboratory of Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Department of Research and Development Intellinosis Biotechnologies Co.Ltd.

Gastric cancer(GC) is a prevalent and lethal malignancy worldwide, and the 5-year survival rate is less than 30%. The absence of distinctive symptoms often leads to late-stage diagnosis, contributing to a grim prognosis. Early detection is pivotal for improving the survival rates and outcomes of GC patients. Traditional diagnostic methods, including gastroscopy and histopathological examination, are restricted in the early diagnosis of GC. Conventional protein biomarkers, such as carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), and carbohydrate antigen 72-4(CA72-4), exhibit insufficient sensitivity and specificity for GC screening, which diminishes their clinical value. Recently, novel circulating biomarkers, such as circulating tumor cells(CTCs), circulating tumor cell DNA(ct DNA), and circulating free RNA(cf RNA), have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and specificity. This review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

关键词： gastric cancer early diagnosis blood

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Secure beamforming and deployment design for rate-splitting multiple access-based UAV communications

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Science China(Information Sciences) 2025年第1期68卷 342-356页

作者： Bing WANG Xiaofeng TAO Shujun han Huici WU Kai YANG Zhu han National Engineering Research Center of Mobile Network Technologies Beijing University of Posts and Telecommunications Peng Cheng Laboratory Department of Electrical and Computer Engineering University of Houston

Rate-splitting multiple access(RSMA) has recently gained attention as a potential robust multiple access(MA)scheme for upcoming wireless networks. Given its ability to efficiently utilize wireless resources and design interference management strategies, it can be applied to unmanned aerial vehicle(UAV) networks to provide convenient services for large-scale access ground users. However, due to the line-of-sight(LoS) broadcast nature of UAV transmission, information is susceptible to eavesdropping in RSMA-based UAV networks. Moreover, the superposition of signals at the receiver in such networks becomes complicated. To cope with the challenge, we propose a two-user multi-input single-output(MISO) RSMA-based UAV secure transmission framework in downlink communication networks. In a passive eavesdropping scenario, our goal is to maximize the sum secrecy rate by optimizing the transmit beamforming and deployment location of the UAV-base station(UAV-BS),while considering quality-of-service(QoS) constraints, maximum transmit power, and flight space limitations. To address the non-convexity of the proposed problem, the optimization problem is first decoupled into two subproblems. Then, the successive convex approximation(SCA) method is employed to solve each subproblem using different propositions. In addition, an alternating optimization(AO)-based location RSMA(L-RSMA) beamforming algorithm is developed to implement joint optimization to obtain the suboptimal solution. Numerical results demonstrate that(1) the proposed L-RSMA scheme yields a28.97% higher sum secrecy rate than the baseline L-space division multiple access(SDMA) scheme;(2) the proposed L-RSMA scheme improves the security performance by 42.61% compared to the L-non-orthogonal multiple access(NOMA) scheme.

关键词： rate-splitting multiple access UAV communication precoding optimization deployment location physical layer security

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