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本科层次畜牧兽医专业职教课程体系构建探索与研究

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职业技术 2021年第12期20卷 7-13页

作者：闫伟李巨银刘海霞朱爱文韩大勇江苏农牧科技职业学院动物科技学院江苏泰州225300

本科层次职业教育对加快建设我国现代职业教育体系意义重大,江苏农牧科技职业学院在入选国家"双高计划"高水平学校的基础上申请合并转设为本科层次职业技术大学,积极探索构建本科层次畜牧兽医专业职教课程体系。文章在分析畜牧兽医专业... 详细信息

本科层次职业教育对加快建设我国现代职业教育体系意义重大,江苏农牧科技职业学院在入选国家"双高计划"高水平学校的基础上申请合并转设为本科层次职业技术大学,积极探索构建本科层次畜牧兽医专业职教课程体系。文章在分析畜牧兽医专业岗位发展及专业人才能力需求的基础上,提出构建能力("专业能力+综合能力+智慧信息能力")与特色课程("共享课程、模块课程和畜牧产业课程")匹配的主干课程体系,及"课程思政+创新创业素养"互融的配套课程体系,实现"1+X"证书、职业资格、技能等级培训与课程体系的融通,可以为后续本科层次畜牧兽医专业建设提供参考。

关键词：本科层次职业教育岗位能力课程体系

Comparison of the corrosion behavior of AM60 Mg alloy with and without self-healing coating in atmospheric environment

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Journal of Magnesium and Alloys 2021年第4期9卷 1224-1237页

作者： Yingwei Song Dan Liu Weineng Tang Kaihui Dong dayong Shan En-Hou han Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China Baosteel Central Research Institute(R&D Center) China Baowu Group655 Fujin RoadShanghai 201900China

Coatings on the surface of Mg alloys are inevitably damaged during their practical applications,and corrosion can easily initiate from the damaged areas to accelerate the failure of Mg parts.A dual self-healing coating has already been developed to solve this problem in our previous *** the practical application of this coating,it is necessary to investigate its service behavior in atmospheric ***,the corrosion behavior of AM60 Mg substrate with and without the self-healing coating was compared in Shenyang industrial atmospheric *** results show that the enrichment of sediments and rainwater on the scratch areas can accelerate the corrosion of the exposed Mg *** inhibitors can be released from the damaged coating to inhibit *** dual self-healing coating shows better inhibition ability to narrow scratches due to the higher inhibitor concentration and less ***,the coating with wide scratches displays enough inhibition ability as *** dual self-healing coating is a good alternative for Mg alloy parts in the practical applications.

关键词： Self-healing coating Micro-arc oxidation(mao)film Atmospheric corrosion Mg alloy Inhibitor Sediments

深部高构造应力巷道冲击地压发生临界应力及影响因素研究

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中国安全生产科学技术 2023年第9期19卷 83-88页

作者：宋义敏邓文良张苑玉赵亚周许海亮安栋张军徽韩大永北方工业大学土木工程学院北京100144 沈阳焦煤股份有限公司红阳三矿辽宁辽阳111300

为研究深部高构造应力巷道中构造应力对冲击地压发生的影响,采用层滑结构失稳力学模型,获得冲击地压发生临界条件,分析巷道尺寸、煤性质、构造应力等因素对冲击地压发生的影响。研究结果表明:冲击地压受巷道尺寸、煤性质、构造应力、煤... 详细信息

为研究深部高构造应力巷道中构造应力对冲击地压发生的影响,采用层滑结构失稳力学模型,获得冲击地压发生临界条件,分析巷道尺寸、煤性质、构造应力等因素对冲击地压发生的影响。研究结果表明:冲击地压受巷道尺寸、煤性质、构造应力、煤岩厚度和煤岩界面摩擦影响,临界载荷随巷道宽度、构造应力和煤岩界面摩擦系数增大而减小,随煤峰值前后模量比、煤层厚度和顶板厚度增大而增大;临界塑性活动区长度随巷道宽度、煤峰值前后模量比、构造应力、煤层厚度和顶板厚度增大而增大,随煤岩界面摩擦系数增大而减小。研究结果可为高水平构造应力巷道冲击地压发生临界条件及冲击地压发生影响因素的研究提供理论参考。

关键词：冲击地压构造应力层滑结构失稳

Influence of yttrium element on the corrosion behaviors of Mg-Y binary magnesium alloy

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Journal of Magnesium and Alloys 2017年第1期5卷 26-34页

作者： Xianbin Liu dayong Shan Yingwei Song En-hou han National Engineering Center for Corrosion Control Institute of Metal ResearchChinese Academy of Sciences62 Wencui RoadShenyang 110016China

The influence of yttrium on the corrosion behavior of Mg–Y alloys has been investigated by electrochemical measurements,scanning electron microscope(SEM)observation,X-ray diffraction(XRD),and X-ray photoelectron spectroscopy(XPS)analysis in NaCl *** corrosion resistance decreased with increasing Y content due to increasing Y-rich *** solid-dissolved Y improved the chemical activity of the substrate which promoted the corrosion reaction by forming *** corrosion resistance was improved by increasing the Y concentration of matrix and proper net Y-rich *** sample has the best corrosion resistance when all the Y element was dissolved into the matrix of Mg–5Y in 0.1 M NaCl.

关键词： Mg-Y alloys Corrosion behavior Yttrium element Solid-dissolved Y

姜曲海猪mtDNA D-loop序列遗传多样性研究

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天津农业科学 2022年第1期28卷 20-22,34页

作者：韩大勇赵旭庭周春宝陈章言倪黎刚江苏农牧科技职业学院江苏泰州225300 江苏姜曲海种猪场江苏泰州225300

为研究姜曲海猪保种群线粒体DNA遗传多样性及种质特性,选取姜曲海猪保种群中58个体进行mtDNA D-loop高变区序列扩增测序,获得的长度为427 bp有效序列基因片段,然后对有效序列遗传多样性进行了分析。结果表明:(1)姜曲海猪的mtDNA D-loop... 详细信息

为研究姜曲海猪保种群线粒体DNA遗传多样性及种质特性,选取姜曲海猪保种群中58个体进行mtDNA D-loop高变区序列扩增测序,获得的长度为427 bp有效序列基因片段,然后对有效序列遗传多样性进行了分析。结果表明:(1)姜曲海猪的mtDNA D-loop高变区扩增测序的有效序列基因片段中,碱基A+T含量为63.2%,G+C含量为36.8%,碱基A+T含量明显高于G+C含量;(2)在58个序列中共有15个变异位点,其中T/C转换10次、G/A转换3次、A/T颠换1次、C/A颠换1次;(3)检测出单倍型3个,总的单倍型多样性和核苷酸多样性指数分别为0.686和0.0052,表明姜曲海猪种群遗传多样性偏低,姜曲海猪保种群母系来源单一;(4)单倍型间遗传距离计算结果表明,种群内3个单倍型之间的平均遗传距离在0.003~0.005之间,单倍体间的遗传距离较近,表明保种群近交的情况比较严重。

关键词：线粒体DNA控制区遗传多样性种质资源保护姜曲海猪

Effect of corrosive media on galvanic corrosion of complicated tri-metallic couples of 2024 Al alloy/Q235 mild steel/304 stainless steel

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Journal of Materials Science & Technology 2019年第9期35卷 1886-1893页

作者： Linjun Shi Xiuying Yang Yingwei Song Dan Liua Kaihui Dong dayong Shan En-Hou han Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology o f ChinaHefei 230026China Shenyang Institute of Technology Fushun 113122China

Galvanic corrosion of tri-metallic couples is more complicated than that of bi-metallic couples. In this study, the effect of the pH of corrosive media on the galvanic corrosion of 2024 A1 alloy/Q235 mild steel/304 stainless steel tri-metallic couples was investigated using potentiodynamic polarization, scanning electron microscopy, scanning vibrating electrode technique and a multi-channel galvanic corrosion meter. The results show that 2024 always acts as the only anode in 3.5 wt% NaCl at pH 5.56,9.72 and 12.0, while both Q235 and 2024 act as anodes at pH 2.39 in the initial stage and then the role of Q235 changes at longer coupling time, which can be attributed to the effect of pH on the surface film of 2024. It is also found that the galvanic current density of a tri-metallic couple is the superposition of two bi-metallic couples when cathodic reactions are controlled by the diffusion of oxygen, otherwise it is smaller than that of the sum of two bi-metallic couples. The localized corrosion instead of uniform corrosion of anodic metal is accelerated by galvanic corrosion.

关键词： Galvanic corrosion Tri-metallic couples Corrosive media Scanning vibrating electrode technique Zero resistance ammeter

Crystallographic and NMR studies on sterols from green alga Chaetomorpha basiretorsa Setchell

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Acta Oceanologica Sinica 2008年第1期27卷 147-151页

作者： SHI dayong XU Feng HE Juan SHI Jiangong FAN Xiao han Lijun Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Institute of Materia Medica Chinese Academy of Medical Sciences and Beijing Union Medical College Beijing 100050 China Affiliated Hospital of Medical College Qingdao University Qingdao 266003 China

Chemical investigation of the ethanol extract of the marine green alga Chaetomorpha basiretorsa Setchell led to the isolation of a new sterol stigmast-4,28-dien-3α,6β-diol 1 in addition to the five known sterols of β-lawsaritol 2, saringosterol 3, 24-hydroperoxy-24-vinyl - cholesterol 4, β-stigmasterol 5, 29-hydroxystigmasta-5, 24 （28） -dien-3β-ol 6. Compounds were isolated by normal phase silica gel and Sephadex LH - 20 gel colum chromatography, reverse phase HPLC and recrystalization. Their structures were elucidated by spectroscopic methods including MS, IR 1D/2D NMR and X-ray analysis. Cytotoxicity of compounds was screened by using the standard MTF method. All these compounds were isolated from the green alga Chaetomorpha basiretorsa Setchell for the first time and they were inactive （50% inhibitory concentration was greater than 10 μg/cm^3） against KB, Bel -7402, PC - 3M, Ketr 3 and MCF-7 cell lines.

关键词： green alga sterol X-ray crystal structure

Emerging roles of Aurora-A kinase in cancer therapy resistance

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Acta Pharmaceutica Sinica B 2023年第7期13卷 2826-2843页

作者： dayong Zheng Jun Li han Yan Gang Zhang Wei Li Edward Chu Ning Wei School of Pharmacy North China University of Science and TechnologyTangshan 063210China Basic Medical Science College Liaoning University of Traditional Chinese MedicineShenyang 110032China Division of Biology and Biological Engineering California Institute of TechnologyPasadenaCA 91125USA Department of Oncology and Cancer Therapeutics Program Montefiore Einstein Cancer CenterAlbert Einstein College of MedicineBronxNY 10461USA

Aurora kinase A(Aurora-A),a serine/threonine kinase,plays a pivotal role in various cellular processes,including mitotic entry,centrosome maturation and spindle *** or gene-amplification/mutation of Aurora-A kinase occurs in different types of cancer,including lung cancer,colorectal cancer,and breast *** of Aurora-A impacts multiple cancer hallmarks,especially,immortalization,energy metabolism,immune escape and cell death resistance which are involved in cancer progression and *** review highlights the most recent advances in the oncogenic roles and related multiple cancer hallmarks of Aurora-A kinase-driving cancer therapy resistance,including chemoresistance(taxanes,cisplatin,cyclophosphamide),targeted therapy resistance(osimertinib,imatinib,sorafenib,etc.),endocrine therapy resistance(tamoxifen,fulvestrant) and ***,the mechanisms of Aurora-A kinase promote acquired resistance through modulating DNA damage repair,feedback activation bypass pathways,resistance to apoptosis,necroptosis and autophagy,metastasis,and ***,our review also summarizes the promising synthetic lethality strategy for Aurora-A inhibitors in RB1,ARID1A and MYC gene mutation tumors,and potential synergistic strategy for m TOR,PAK1,MDM2,MEK inhibitors or PD-L1 antibodies combined with targeting Aurora-A *** addition,we discuss the design and development of the novel class of Aurora-A inhibitors in precision medicine for cancer treatment.

关键词： Aurora-A Therapy resistance Chemoresistance Targeted therapy Radioresistance Synthetic lethality Alisertib PROTAC

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基于现场矿压显现的微震预警指标研究

煤炭与化工 2023年第6期46卷 82-84,88页

作者：王志坚芦盛亮李钢查颖蔡宏伟韩大永潞安化工集团余吾煤业公司山西长治046000 沈阳市汽车工程学校辽宁沈阳110000 吉林省能源投资集团有限责任公司吉林长春130000 沈阳焦煤股份有限公司红阳三矿辽宁沈阳110000

在工作面回采过程中,矿压显现对于一些灾害起着诱导作用,因此需要对矿压显现进行预警。本文结合余吾煤矿N1100工作面回采过程中的微震监测情况和现场矿压监测情况,分析了矿压显现的微震预警指标。结果表明,该矿在日微震频次40次,日累积... 详细信息

在工作面回采过程中,矿压显现对于一些灾害起着诱导作用,因此需要对矿压显现进行预警。本文结合余吾煤矿N1100工作面回采过程中的微震监测情况和现场矿压监测情况,分析了矿压显现的微震预警指标。结果表明,该矿在日微震频次40次,日累积微震总能量5×10^(4)J,单个微震事件最大能量为1×10^(4)J时会出现矿压显现,为利用微震监测矿压显现提供一定的参考。

关键词：煤矿开采矿压显现微震监测预警指标