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Rare earth element-modified MOF materials:synthesis and photocatalytic applications in environmental remediation

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Rare Metals 2024年第4期43卷 1390-1406页

作者： Shu-Kun Le Qi-jie Jin Jia-Ao han Hua-Cong Zhou Quan-Sheng liu Fu Yang jie Miao Pei-Pei liu Cheng-zhang Zhu hai-Tao Xu Inner Mongolia Key Laboratory of High-Value Functional Utilization of Low Rank Carbon Resources Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot010050China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing210009China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212100China Institut National de la Recherche Scientifique-Énergie Matériaux et Télécommunications MontrealQCJ3X 1P7Canada

Metal-organic framework-like materials(MOFs)have been developed in the fields of photocatalysis for their excellent optical properties and physicochemical properties,including environmental remediation,CO_(2)photoreduction,water splitting,and so *** their important roles in various fields,rare earth elements have received growing interests from *** MOFs with rare earth elements for modification allows broadening the absorption spectrum,while the active electrons on their empty 4f orbitals can act as traps to capture photoexcited carriers to inhibit the recombination of electron-hole pairs,thus promoting photocatalytic ***,rare earth elements modified MOFs provide an attractive way to achieve their high value *** this mini-review,the synthesis of rare earth element-modified MOFs photocatalysts and corresponding applications in the removal of antibiotics,CO_(2)reduction,and hydrogen production are constructively summarized and ***,the latest advancements and current difficulties of these materials as well as the application prospects are also provided.

关键词： Rare earth metals MOFs Photocatalytic CO_(2) reduction Environmental remediation Water splitting

Long-and short-term outcomes for resectable gallbladder carcinoma patients treated with curative-intent laparoscopic versus open resection:a multicenter propensity score-matched comparative study

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 788-800,I0002页

作者： Zhi-Peng liu Xing-Xing Su Long-Fei Chen Xue-Lei li Yi-shi Yang Zhi-Long You Xiao-lin zhao Fan Huang Chao yu zhao-Ping Wu Wei Chen Jin-Xue Zhou Wei Guo da-Long Yin Ping yue Rui Ding Yi Zhu Wei Chen Yan Jiang jie Bai Jing-Jing Wang Yan-Qi zhang Dong zhang hai-Su dai Wan Yee Lau Zhi-yu Chen The Biliary Surgery Branch of Elite Group of Chinese Digestive Surgery(EGCDS) Department of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Hepato-pancreato-biliary Center Tsinghua Changgung HospitalTsinghua UniversityBeijingChina Department of General Surgery Third Affiliated Hospital of Zunyi Medical UniversityZunyiChina Department of General Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiChina Department of Hepatobiliary Surgery Affiliated Hospital of Guizhou Medical UniversityGuiyangChina Department of Hepatopancreatobiliary Surgery Jiujiang First People’s HospitalJiujiangChina Department of Hepatopancreatobiliary Surgery First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Hepatopancreatobiliary Surgery Henan Provincial Tumor HospitalZhengzhouChina Department of General Surgery Capital Medical University Affiliated Beijing Friendship HospitalBeijingChina Department of Hepatobiliary Surgery First Affiliated Hospital of USTCHefeiChina Department of General Surgery Lanzhou University First Affiliated HospitalLanzhouChina Department of Hepatopancreatobiliary Surgery First Affiliated Hospital of Air Force Medical UniversityXi’anChina Department of Hepatopancreatobiliary Surgery The Second Affiliated Hospital Zhejiang University School of MedicineHangzhouChina Department of Health Statistics College of Military Preventive MedicineThird Military Medical University(Army Medical University)ChongqingChina Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Faculty of Medicine the Chinese University of Hong KongHong KongChina 不详

Background:Gallbladder cancer(GBC)was once considered a contraindication for laparoscopic surgery,but it is becoming more common to use laparoscopic surgery for GBC *** aim of this study was to analyze the long-and short-term outcomes of patients with more advanced T-staged GBC treated with curative intent as defined by the National Comprehensive Cancer Network(NCCN)after laparoscopic resection(LR)versus open resection(OR).Methods:A multicenter database was used to select consecutive GBC patients treated with curative-intent resection as defined by the NCCN between 2016 and *** patients were divided into the LR group and the OR *** score matching(PSM)was used to eliminate selection *** endpoints were overall survival(OS),progression-free survival(PFS),and short-term *** factors that were independently associated with OS and PFS were ***:Of 626 GBC patients treated with curative-intent resection,after PSM,51 patients were in the LR group and 153 patients were in the OR *** LR group had more patients who were suitable to receive adjuvant chemotherapy(AC),a longer operation time,more harvested lymph nodes,and a lower overall morbidity *** rates of OS and PFS were not significantly different between the two *** was independently associated with better OS and ***:The overall morbidity of GBC patients after LR was lower,but the long-term outcomes between LR and OR were not significantly *** GBC patients treated with LR were more likely to receive AC,and the use of AC after curative-intent resection of GBC helped achieve better long-term survival outcomes.

关键词： Gallbladder cancer(GBC) laparoscopic resection(LR) morbidity survival adjuvant chemotherapy(AC)

Association of serum interleukin-6 with negative symptoms in stable early-onset schizophrenia

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World Journal of Psychiatry 2024年第6期14卷 794-803页

作者： Peng Chen hai-Dong Yang Jun-jie Wang Zhen-Hua Zhu Hui-Min zhao Xu-yuan Yin yuan Cai Hong-liangZhu Jia-lin Fu Xin-Zhu zhang Wen-Xi Sun li Hui Xiao-Bin zhang Suzhou Medical College of Soochow University Suzhou 215123Jiangsu ProvinceChina Department of Psychiatry Suzhou Psychiatric HospitalInstitute of Mental HealthThe Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Psychiatry The Fourth People’s Hospital of LianyungangThe Affiliated Kangda College of Nanjing Medical UniversityLianyungang 222003Jiangsu ProvinceChina Research Center of Biological Psychiatry Suzhou Psychiatric HospitalInstitute of Mental HealthThe Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Neurology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215002Jiangsu ProvinceChina

BACKGROUND Accumulating evidence suggests that the inflammatory cytokine interleukin-6(IL-6)contributes to the pathophysiology of psychiatric ***,there was no study concerning the relationship between IL-6 concentrations and clinical features in the chronic phase of early-onset schizophrenia(EOS).AIM To investigate the relationship between serum IL-6 concentration and the clinical features of *** We measured serum IL-6 Levels from 74 patients with chronic schizophrenia,including 33 with age at onsethan healthy controls(F=22.32,P0.05)after controlling for age,body mass index,and other *** symptom scores were higher in the EOS group than the AOS group(F=6.199,P=0.015).Serum IL-6 concentrations in the EOS group were negatively correlated with both total PANSS-negative symptom score(r=-0.389,P=0.032)and avolition/asociality subscore(r=-0.387,P=0.026).CONCLUSION Patients with EOS may have more severe negative symptoms than those with adult-onset schizophrenia during the chronic phase of the ***-6 signaling may regulate negative symptoms and its avolition/asociality subsymptoms among the early-onset chronic schizophrenic patients.

关键词： Early-onset schizophrenia Interleukin 6 Negative symptoms Avolition Asociality

Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits

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Plant Communications 2024年第6期5卷 173-192页

作者： Xue-Mei Lu Xiao-Fen yu Guo-Qiang li Ming-Hao Qu Huan Wang Chuang liu yu-Ping Man Xiao-han Jiang Mu-Zi li Jian Wang Qi-Qi Chen Rui Lei Cheng-Cheng zhao yun-Qiu Zhou Zheng-Wang Jiang Zuo-Zhou li Shang Zheng Chang Dong Bai-lin Wang Yan-Xiang Sun Hui-Qin zhang jie-Wei li Quan-Hui Mo Ying zhang Xin Lou hai-Xu Peng Ya-Ting Yi He-Xin Wang Xiu-Jun zhang Yi-Bo Wang dan Wang li li Qiong zhang Wen-Xia Wang yongbo liu Lei Gao Jin-Hu Wu Yan-Chang Wang CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubeiChina Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansuChina College of life Sciences University of Chinese Academy of SciencesBeijingChina Wuhan Frasergen Bioinformatics Co. LtdWuhanHubeiChina Institute of Soil and Fertilizer Anhui Academy of Agricultural SciencesHefeiChina College of Agricultural Sciences Xichang UniversityXichangSichuanChina Department of Horticulture Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiangChina College of life Sciences Langfang Normal UniversityLangfangHebeiChina Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiangChina Guangxi Institute of Botany Chinese Academy of SciencesGuilinGuangxiChina Xi’an Botanical Garden of Shaanxi Province Institute of Botany of Shaanxi ProvinceXi’anShaanxiChina Institute of Modern Agricultural Research Dalian UniversityDalianLiaoningChina Bioinformatics Center College of Plant Science and TechnologyBeijing University of AgricultureBeijingChina College of Agriculture Eastern Liaoning UniversityDandongLiaoningChina dalian Institute of Chemical Physics Chinese Academy of SciencesDalianLiaoningChina State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijingChina Hubei Hongshan Laboratory WuhanHubeiChina The New Zealand Institute for Plant and Food Research limited AucklandNew Zealand

Actinidia arguta,the most widely distributed Actinidia species and the second cultivated species in the genus,can be distinguished from the currently cultivated Actinidia chinensis on the basis of its small and smooth fruit,rapid softening,and excellent cold *** evolution of tetraploid Actinidia species and the genetic basis of their important agronomic traits are still ***,we generated a chromosome-scale genome assembly of an autotetraploid male *** *** genome assembly was 2.77 Gb in length with a contig N50 of 9.97 Mb and was anchored onto 116 *** and clustering of 101 geographically representative accessions showed that they could be divided into two geographic groups,Southern and Northern,which first diverged 12.9 million years *** underwent two prominent expansions and one demographic bottleneck from the midPleistocene climate transition to the late *** genomics studies using paleoclimate data enabled us to discern the evolution of the species’adaptation to different historical *** genes(AaCEL1,AaPME1,and AaDOF1)related to flesh softening were identified by multi-omics analysis,and their ability to accelerate flesh softening was verified through transient expression assays.A set of genes that characteristically regulate sexual dimorphism located on the sex chromosome(Chr3)or autosomal chromosomes showed biased expression during stamen or carpel *** chromosome-level assembly of the autotetraploid *** genome and the genes related to important agronomic traits will facilitate future functional genomics research and improvement of ***.

关键词： kiwiberry dioecism adaptive evolution paleoclimate GEA rapid softening

Clinical guidelines for indications,techniques,and complications of autogenous bone grafting

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Chinese Medical Journal 2024年第1期137卷 5-7页

作者： Jianzheng zhang Shaoguang li Hongying He li han Simeng zhang lin Yang Wenxing han Xiaowei Wang jie Gao Jianwen zhao Weidong shi Zhuo Wu Hao Wang Zhicheng zhang licheng zhang Wei Chen Qingtang Zhu Tiansheng Sun Peifu Tang Yingze zhang Senior Department of Orthopedics PLA General HospitalBeijing 100048China The National Clinical Research Center for Orthopedics Sports Medicine&RehabilitationBeijing 100048China The Trauma Orthopedic Branch of Chinese Orthopedic Association ShijiazhuangHebei 050051China Department of Orthopedic Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei 050051China Department of Microsurgical Trauma The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China

Autogenous bone grafts have long been considered the“gold standard”and most effective material in bone regeneration procedures.[1]Autogenous bone grafts are used to repair bone defects caused by nonunion,infection,tumor resection,and spinal and joint fusion.[2]It has been reported that more than 200,000 autologous bone grafts are performed in the United States each year.[3]Although there are no specific statistics on the annual number of bone grafts performed in China,autologous bone grafting is the most common surgical technique in *** iliac crest remains the most common donor site,along with the fibula,ribs,tibial metaphysis,proximal humerus,distal radius,and greater trochanter.[4,5]Various bone-graft options provide different amounts and qualities of cortical,cancellous,and corticocancellous bone.[6,7]Autogenous bone graft is osteogenic,histocompatible,provides structural support.

关键词： grafting graft union

Potential efficacy and mechanism of medicinal plants on chronic kidney disease-associated vascular calcification:a review

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Traditional Medicine Research 2024年第9期9卷 21-31页

作者： han-Qing zhang Shuang Wu Xin Chen Ya-Xuan Fang Qiu-Mei Lan Zi-Jun Zhou Yan-Heng Qiao jie li Yan-Ru zhao Ming Pei Bo Yang Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China

Vascular calcification is a crucial risk factor that affects the incidence and mortality of cardiovascular disease in chronic kidney disease *** medicine relies on calcium-phosphorus binding agents,calcium mimetics,active vitamin D,and hemodialysis to prevent and treat vascular calcification,however,their efficacy is unsatisfactory and adverse reactions often *** plant therapy can act as an integrative regulator in patients with chronic kidney disease-associated vascular calcification,which can significantly improve patients’symptoms,but its specific mechanism has not been fully elucidated *** this paper,we reviewed the domestic and international theoretical studies on the pathogenesis mechanism of chronic kidney disease-associated vascular calcification in recent years,summarized eight active ingredients of medicinal plants as well as four compound formulas for improving chronic kidney disease-associated vascular calcification,and explored the mechanism of action of herbal medicine,which will provide a new strategy for promoting the prevention and treatment of vascular calcification.

关键词： chronic kidney disease chronic kidney disease-mineral and bone disorder(CKD-MBD) vascular calcification medicinal plants herbal monomers

What Can Topology Bring to Chemistry?

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CCS Chemistry 2024年第9期6卷 2084-2109页

作者： Wei Wang Songtao Zhou Xiujun yu Qing-Hui Guo Yanhang Ma jie Song liang zhang Xuzhou Yan Lu han Qing liao Xiaopeng li Wen-Bin zhang Yiyong Mai Shaodong zhang Shunai Che hai-Bo Yang Xuefeng Fu Mei-Xiang Wang School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200062 hangzhou Institute of Medicine Chinese Academy of SciencesHangzhou 310022Zhejiang College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060Guangdong MOE Key Laboratory of Bioorganic Phosphorous and Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 School of Physical Science and Technology and Shanghai Key Laboratory of High-Resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210 School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesState Key Laboratory of Composite MaterialsShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240 School of Chemical Science and Engineering Tongji UniversityShanghai 200092 Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048 Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871 Department of Chemical Sciences National Natural Science Foundation of ChinaBeijing 10085

The unique mathematical perspectives and principal concepts of topology have not only promoted the development of other branches of mathematics but have also deeply influenced other subjects,particularly physics and *** minireview aims to elucidate the substantial influence of topology on chemistry by critically examining both the contributions of topology to current chemical science and its potential future *** will discuss the topology of molecular structures and assemblies across various scales—from small molecules and mechanically interlocked molecules to polymers,biomacromolecules,and supramolecular *** discussion will include an exploration of cutting-edge techniques for characterizing topological features,underscoring the role of topology as a novel paradigm for the design and synthesis of new molecular ***,a critical analysis of topology’s role in the development of functional materials—such as photonic materials,polymers,biomacromolecules,and chiral materials—will demonstrate its emerging significance as a crucial parameter in unveiling novel properties and *** topology’s formidable potential,it is anticipated to be used increasingly to address pivotal challenges within chemistry and adjacent disciplines.

关键词： chemical topology topological invariants molecular graphs links and knots structureproperty relationship

A discovery of two slow pulsars with FAST:“Ronin”from the globular cluster M15

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 166-180页

作者： Dengke Zhou Pei Wang Di li Jianhua Fang Chenchen Miao Paulo CCFreire Lei zhang dandan zhang Huaxi Chen Yi Feng Yifan Xiao Jintao Xie Xu zhang Chenwu Jin han Wang Yinan Ke Xuerong Guo Rushuang zhao Chenhui Niu Weiwei Zhu Mengyao Xue Yabiao Wang Jiafu Wu Zhenye Gan Zhongyi Sun Chengjie Wang jie zhang Junshuo zhang Jinhuang Cao Wanjin Lu Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China University of Chinese Academy of Sciences Beijing 100049China New Cornerstone Science Laboratory Shenzhen 518054China Max Planck Institut f¨ur Radioastronomie Bonn 53121Germany Centre for Astrophysics and Supercomputing Swinburne University of TechnologyHawthorn 3122Australia School of Mathematical Sciences School of Physics and Electronic SciencesGuizhou Normal UniversityGuiyang 550001China Guizhou Provincial Key Laboratory of Radio Astronomy and data Processing Guiyang 550001China School of Physics and Electronic Engineering Qilu Normal UniversityJinan 250200China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China College of Physical Science and Technology Central China Normal UniversityWuhan 430079China Tencent Youtu Lab Shanghai 201103China

Globular clusters harbor numerous millisecond pulsars,but long-period pulsars(P 100 ms)are rarely *** this study,we employed a fast folding algorithm to analyze observational data from multiple globular clusters obtained by the Five-hundredmeter Aperture Spherical radio Telescope(FAST),aiming to detect the existence of long-period *** estimated the impact of the median filtering algorithm in eliminating red noise on the minimum detectable flux density(S_(min))of ***,we successfully discovered two isolated long-period pulsars in M15 with periods approximately equal to 1.928451 and3.960716 s,*** the P-˙P diagram,both pulsars are positioned below the spin-up line,suggesting a possible history of partial recycling in X-ray binary systems disrupted by dynamical encounters later *** to timing results,these two pulsars exhibit remarkably strong magnetic *** the magnetic fields were weakened during the accretion process,then a short duration of accretion might explain the strong magnetic fields of these pulsars.

关键词： pulsar globular cluster FAST

Updated overall survival and circulating tumor DNA analysis of ensartinib for crizotinib-refractory ALK-positive NSCLC from a phase II study

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Cancer Communications 2024年第4期44卷 455-468页

作者： Jing Zheng Tao Wang yunpeng Yang jie Huang Jifeng Feng Wu Zhuang Jianhua Chen Jun zhao Wei Zhong Yanqiu zhao Yiping zhang yong Song Yi Hu Zhuang yu Youling Gong yuan Chen Feng Ye Shucai zhang Lejie Cao yun Fan Gang Wu yubiao Guo Chengzhi Zhou Kewei Ma Jian Fang Weineng Feng yunpeng liu Zhendong Zheng Gaofeng li Huijie Wang Shundong Cang Ning Wu Wei Song Xiaoqing liu shijun zhao lieming Ding Giovanni Selvaggi Yang Wang Shanshan Xiao Qian Wang Zhilin Shen Jianya Zhou Jianying Zhou li zhang Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityZhejiang Provincial Clinical Research Center for Respiratory DiseaseHangzhouZhejiangP.R.China hangzhou Repugene Technology Co. LtdHangzhouZhejiangP.R.China Department of Medical Oncology Sun Yat-sen University Cancer Cen-terState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China Department of Thoracic Oncology Fujian Provincial Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Department of Medical Oncology-Chest Hunan Cancer HospitalChangshaHunanP.R.China Department of Thoracic Oncology Beijing Cancer HospitalBeijingP.R.China Department of Pulmonary Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingP.R.China Respiratory Department of Internal Medicine Henan Provincial Can-cer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Thoracic Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Division of Respiratory Medicine Jinling HospitalNanjing University School of MedicineNanjingJiangsuP.R.China Department of Oncology Chinese People’s Liberation Army(PLA)General HospitalBeijingP.R.China Department of Oncology The Affiliated Hospital of Qingdao UniversityQingdaoShandongP.R.China Department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanP.R.China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology Cancer HospitalThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityTeaching Hospital of

Background:The initial phase II stuty(NCT03215693)demonstrated that ensartinib has shown clinical activity in patients with advanced crizotinib-refractory,anaplastic lymphoma kinase(ALK)-positive non-small cell lung cancer(NSCLC).Herein,we reported the updated data on overall survival(OS)and molecular profiling from the initial phase Ⅱ ***:In this study,180 patients received 225 mg of ensartinib orally once daily until disease progression,death or *** was estimated by Kaplan‒Meier methods with two-sided 95%confidence intervals(CIs).Next-generation sequencing was employed to explore prognostic biomarkers based on plasma samples collected at baseline and after initiating *** tumor DNA(ctDNA)was detected to dynamically monitor the genomic alterna-tions during treatment and indicate the existence of molecular residual disease,facilitating improvement of clinical ***:At the data cut-off date(August 31,2022),with a median follow-up time of 53.2 months,97 of 180(53.9%)patients had *** median OS was 42.8 months(95%CI:29.3-53.2 months).A total of 333 plasma samples from 168 patients were included for ctDNA *** inferior OS correlated sig-nificantly with baseline ALK or tumor protein 53(TP53)*** addition,patients with concurrent TP53 mutations had shorter OS than those without con-current TP53 *** ctDNA levels evaluated by variant allele frequency(VAF)and haploid genome equivalents per milliliter of plasma(hGE/mL)at baseline were associated with poor ***,patients with ctDNA clear-ance at 6 weeks and slow ascent growth had dramatically longer OS than those with ctDNA residual and fast ascent growth,***,patients who had a lower tumor burden,as evaluated by the diameter of target lesions,had a longer *** Cox regression analysis further uncovered the independent prognostic values of bone metastases,higher hGE,and elevated ALK mutation abundance at 6 we

关键词： anaplastic lymphoma kinase ctDNA ensartinib non-small cell lung cancer overall survival