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Modeling and Simulation of an Invasive Mild Hypothermic Blood Cooling System

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Chinese Journal of Mechanical Engineering 2021年第1期34卷 45-53页

作者： Na wang Qinghua Liu Yan Shi Shijun wang Xianzhi Zhang Chengwei han Yixuan wang Maolin Cai xunming Ji Engineering Training Center Beihang UniversityBeijing 100191China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144China People's Hospital of Juye County Heze 274900China Department of Mechanical Engineering Kingston Univer sityLondonUK. Department of Neurosurgery and Cerebrovascular Diseases Research In stitute Xuanwu HospitalCapital Medical UniversityBeijingChina

Nowadays,mild hypothermia is widely used in the fields of post-cardiac arrest resuscitation,stroke,cerebral hemorrhage,large-scale cerebral infarction,and craniocerebral *** this paper,a locally mixed sub-low temperature device is designed,and the cold and hot water mixing experiment is used to simulate the human blood transfer *** set a foundation for the optimization of the heat transfer system,the static characteristics are analyzed by building the mathematic model and setting up the experimental *** addition,the affection of several key structure parameters is *** experimental and simulation studies,it can be concluded that,firstly,the mathematical model proved to be ***,the results of simulation experiments show that 14.52℃ refrigeration can reduce the original temperature of 33.42℃ to 32.02℃,and the temperature of refrigerated blood rises to 18.64℃,and the average error is about 0.3℃.Thirdly,as the thermal conductivity of the vascular sheath increases,the efficiency of the heat exchange system also increases ***,as the input cold blood flow rate increases,the mass increases and the temperature of the mixed blood temperature *** provides a research basis for subsequent research on local fixed-point sub-low temperature control technology.

关键词： Therapeutic hypothermia Invasive blood cooling Static character Heat transfer

Change in summer daily precipitation and its relation with air temperature in Northwest China during 1957–2016

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Research in Cold and Arid Regions 2018年第4期10卷 317-325页

作者： CaiXia Zhang xunming wang YongZhong Su zhiwen han ZhengCai Zhang Ting Hua Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences

On the basis of the summer daily-precipitation meteorological data collected from weather stations across Northwest China from 1957 to 2016, this study evaluated the trends in 12-daily precipitation indices in the summer season and their relations with air temperature. Precipitation-event intensity, which was averaged over the total study area, increased in recent decades although the total precipitation continuously decreased. In particular, intensity generally decreased in the northern and eastern parts and increased in the southern and western parts of the study area. None of the 12 precipitation indices was significantly correlated with temperature in Xinjiang; R95 N(number of events with precipitation greater than the long-term95 th percentile), RX1 day(greatest 1-day total precipitation), PI(simple daily intensity), and R10(number of heavy-precipitation days) were significantly and positively correlated with temperature in Qinghai–Gansu. However, low correlation coefficients were observed. In the Loess Plateau, P(total precipitation), WS(maximum number of consecutive wet days),R95 N, and WD(number of wet days) were significantly and negatively correlated with temperature, whereas Gini(gini concentration index) and DS(maximum number of consecutive dry days) were significantly and positively correlated with temperature. Results of the study suggested that climate shift was evident in terms of daily precipitation, and the study area faced new challenges involving precipitation-event intensity increasing in the southwestern part and unevenly dispersing in the northwest.

关键词： summer daily precipitation temperature China

Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum

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Chinese Science Bulletin 2013年第23期58卷 2775-2783页

作者： LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG han dong LiNa ZHUO HaiXin YU KaiFeng MASON Joseph wang XiaoYong CHEN YingYong LU Qi WU Bo dong zhibao QU JianJun wang xunming GUO ZhengTang School of Geographic and Oceanographic Sciences Institute for Climate and Global Change Research Nanjing University College of Tourism and Environment Shaanxi Normal University Department of Geography University of Wisconsin Madison Institute of Desertification Studies Chinese Academy of Forestry Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Institute of Geology and Geophysics Chinese Academy of Sciences

The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human a

关键词：沙漠环境中国北部适宜期全新世末次冰期末次盛冰期库姆塔格沙漠干旱地区

Loss of Wip1 aggravates brain injury after ischaemia/reperfusion by overactivating microglia

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Stroke & Vascular Neurology 2021年第3期6卷 344-351页

作者： Feng Yan Xiang Cheng Ming Zhao Shenghui Gong Ying han Liping Ding Di Wu Yumin Luo Wei Zuo Lingling Zhu Ming Fan xunming Ji Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersCapital Medical UniversityBeijingChina Cerebrovascular Disease Research Laboratory Xuanwu HospitalBeijingChina Institute of Military Cognition and Brain Sciences Academy of Military Medical SciencesBeijingChina Department of Pharmacy Peking Union Medical College HospitalDongcheng-quBeijingChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongChina

Background and purpose The inflammatory response mediated by microglia/macrophages is closely related to cerebral ischaemia/reperfusion ***-type p53-induced protein phosphatase 1(Wip1),a serine/threonine phosphatase,is expressed in various tissues.A growing number of reports have suggested that Wip1 is a negative regulator of inflammation in peripheral tissue;however,its role in the central nervous system(CNS)remains *** study aimed to clarify whether Wip1 can inhibit CNS inflammation by regulating microglia/macrophage functions after ischaemic *** A model of middle cerebral artery occlusion and reperfusion was established in *** inflammation was simulated by lipopolysaccharide treatment of primary *** speckle imaging was used to monitor regional cerebral blood *** outcomes were assessed with a TreadScan gait analysis *** staining was used to evaluate the infarct volume,and western blotting and immunofluorescence staining were applied to detect the phenotypical transformation of *** was performed to detect the levels of inflammatory *** Wip1 expression was increased after ischaemia/***1-knockout(KO)mice displayed more severe brain injury than wild-type mice,as indicated by aggravated motor dysfunction,greater brain infarct volumes and higher expression of inflammatory cytokines(interleukin-6 and tumour necrosis factor alpha)in the *** also found that Wip1 depletion increased microglial/macrophage activation in both in vitro and in vivo models,which all showed activation of microglia/***-Ppm1d reversed the injury induced by *** Our results suggest that Wip1 may inhibit neuroinflammation by inhibiting microglial/macrophage activation after brain ischaemia/reperfusion injury.

关键词： inflammation reperfusion Wip1

基于最优功率分配因子的插电式混合动力汽车实时能量管理策略研究

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机械工程学报 2019年第4期55卷 91-101页

作者：刘辉李训明王伟达韩立金闫正军北京理工大学机械与车辆学院北京100081 北京理工大学车辆传动国家重点实验室北京100081

插电式混合动力汽车兼顾传统混合动力汽车和纯电动汽车的优点,即具有较长的续驶里程又具有较好的燃油经济性,插电式混合动力汽车的实时能量管理策略是发挥节能潜力的关键技术。为解决具有手动行驶模式选择功能的P2构型插电式混合动力汽... 详细信息

插电式混合动力汽车兼顾传统混合动力汽车和纯电动汽车的优点,即具有较长的续驶里程又具有较好的燃油经济性,插电式混合动力汽车的实时能量管理策略是发挥节能潜力的关键技术。为解决具有手动行驶模式选择功能的P2构型插电式混合动力汽车的能量管理实时优化问题,定义发动机和电机功率分配因子,在任何SOC下从电量消耗模式切换到电量维持模式时,提出通过功率分配因子动态调整发动机最优工作曲线获得最佳的燃油经济性的实时能量管理策略。建立功率分配因子全局优化模型,利用自适应模拟退火算法离线优化功率分配因子,研究功率分配因子和SOC对整车燃油经济性的影响规律,得到在不同SOC的最优功率分配因子控制线。从而建立基于最优功率分配因子控制线的插电式混合动力汽车实时控制能量管理策略。在多个循环工况下对比仿真分析不同SOC下的燃油经济性,结果表明基于最优功率分配因子的能量管理策略使得燃油经济性改善幅度最大可达16.99%。

关键词：插电式混合动力汽车能量管理策略功率分配因子全局优化模型实时控制

Perspectives on mechanisms underlying remote ischemic conditioning against ischemic stroke

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Journal of Translational Neuroscience 2019年第1期4卷 1-14页

作者： Changqing Xia xunming Ji Department of Hematology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Ischemic stroke is a major neurological disease with limited effective therapeutic options except for thrombolysis and thrombectomy. Remote ischemic conditioning (RIC) is an approach that promises an alternative to the current treatment portfolio. As an easy-handled, non-invasive regimen, it takes advantage of transient ischemia (currently often made through inflation and deflation of limb blood pressure cuff) to enhance the tolerance of vital organs to ischemia. RIC can be executed before, during and after the onset of stroke. The mechanisms of action of RIC employed at different stroke stages are similar and may involve humoral, neurological and inflammatory pathways. As new mechanisms underlying RIC-induced neuroprotection continue to be revealed, we review in this article some of the latest development in this field, including:① RIC and RIC-induced fundamental change, hypoxia, as well as the role of hypoxia inducible factors against stroke;② Potential role of RIC-induced extracellular vesicles in neuroprotection;③ RIC-induced metabolic changes in tissue protection;④ Potential effect of RIC on red blood cells (RBC) oxygen delivery;and ⑤ RIC and its anti-inflammatory potential.

关键词： remote ischemic conditioning (RIC) stroke hypoxia inducible factors (HIF) exosome oxygen delivery inflammation metabolomics microRNA

多指标综合评价法在城市湖泊补水中的应用——以南京玄武湖为例

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环境保护科学 2018年第6期44卷 56-61页

作者：王磊韩龙喜张奕陈清王训明河海大学环境学院江苏南京210098 河海大学浅水湖泊综合治理与资源开发教育部重点实验室江苏南京210098 江苏三水建设工程有限公司江苏扬州225500

补水是城市湖泊治理的有效手段。为合理地比选城市湖泊补水方案,提出了集水质、水力以及经济指标为一体的多指标综合评价体系,并运用层次分析法(APH)明确了各指标权重,从而进一步构建了补水多指标综合评价法。该法将湖泊补水的各项指标... 详细信息

补水是城市湖泊治理的有效手段。为合理地比选城市湖泊补水方案,提出了集水质、水力以及经济指标为一体的多指标综合评价体系,并运用层次分析法(APH)明确了各指标权重,从而进一步构建了补水多指标综合评价法。该法将湖泊补水的各项指标无量纲化处理,消除各指标间的不可公度性,使其能直观地反应各补水方案的优劣性。以南京玄武湖为例,建立了玄武湖指标权重体系,同时运用二维水动力—水质耦合模型计算得到不同补水方案对应的水质、水力指标值,最后利用已建立的多指标综合评价法得到相对较优的补水方案。

关键词：湖泊补水数值模拟评价指标权重体系多指标综合评价

IMPACT OF WIDE BANDGAP P-TYPE NC-SI ON THE PERFORMANCE OF A-SI SOLAR CELLS

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IMPACT OF WIDE BANDGAP P-TYPE NC-SI ON THE PERFORMANCE OF A-...

中国太阳能学会2001年学术会议

作者： Xianbo Liao, xunming Deng,Xianbi Xiang, Wenjing wang, Shijin han, Henry Povolny, and Wenhui DuDepartment of Physics and Astronomy, University of Toledo, Toledo, OH 43606State Laboratory for Surface Physics, Institute of Semiconductors, and Center for Condensed Matter Physics, Chinese Academy of Sciences, Beijing 100083

This paper reports the impact of a wide bandgap p-type hydrogenatednanocrystalline silicon(nc-Si:H) on the performances of hydrogenated amorphoussilicon (a-Si:H) based solar *** p-layer is composed of nanometer-sized Sicrystallites embedded in a-SiHx matrix and the widening of its bandgap is mainly dueto the quantum size-confinement effect(QSE).By employing this p-layer we have obtained high performances of a-Si:H topcells with Voc1.036V and FF=72.5%,much improved a-SiGe:H mid and bottomcells,and also the spectral splitting triple-junction solar cells deposited on stainlesssteel (SS) substrate with the initial active area conversion efficiency of 12.7%(confirmed 12.5% by NREL) and stable efficiency of 10.5%.We have studied the problems associated with the p-i interface and the I-Vrollover behavior,and found that one cause for a poor interface is the mismatch of thevalance band edge *** using AMPS model developed by the Pernn StateUniversity supports our arguments.

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来源： cnki会议评论

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液压混合动力公交车制动性能仿真与试验分析

汽车技术 2014年第9期 48-52页

作者：曲金玉李训明任传波韩尔樑刘林山东理工大学潍柴动力股份有限公司

针对城市公交车运行特点和在城市运行工况下燃油经济性差的问题,提出一种新型液压混合动力系统,并建立制动回收过程动力学模型、能量再生过程动力学模型和柴油机液压起动模型等,对其制动性能进行仿真,最后进行了样机台架、实车道路试验... 详细信息

针对城市公交车运行特点和在城市运行工况下燃油经济性差的问题,提出一种新型液压混合动力系统,并建立制动回收过程动力学模型、能量再生过程动力学模型和柴油机液压起动模型等,对其制动性能进行仿真,最后进行了样机台架、实车道路试验。试验结果表明,该液压混合动力公交车可实现汽车制动能量回收等功能,在典型城市循环工况下制动能量回收率为69.7%,制动能量再生率为32.8%,液压起动发动机时间为1.7 s。

关键词：液压混合动力公交车制动性能仿真试验