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Theoretical and Experimental Study of the Reaction of 2-Guanidinobenzimidazole on a Series of meta-Substituted Benzaldehydes

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Chemical Research in Chinese Universities 2017年第5期33卷 765-772页

作者： MONIA chebbi hammouda chebbi HEDI M'rabet YOUS SEF Arfaoui Unit of Physical Chemistry of Condensed Materials Laboratory of Materials Crystallochemistry and Applied Thermodynamic Laboratory of Organic and Heterocyclic Synthesis Department of Chemistry Faculty of Sciences University of Tunis EI-Manar 2092 Tunisia

The syntheses of a variety of 1,3,5-triazinebenzimidazoles obtained by the cyclocondensafion reaction of 2-guanidinobenzimidazole with a series of meta-substituted benzaldehydes were reported. The prepared compounds were fully characterized by IR and NMR spectroscopies. Based on the density functional theory（DFT） calculations method, quantum chemical calculations were performed by Gaussian 09 set of programs. All possible transition states, reactants and products were fully optimized at the hybrid density functional B3LYP level using the 6-311＋G（d,p）. The geometries of five possible tautomers of 2-amino-4-aryl[1,3,5]triazino[1,2-a]benzimidazoles were optimized in ethanol, using conductor like polarizable confinuum（CPCM） in the gas phase. The energetic diagrams of tautomeric equilibrium showed that form A is the most stable tautomer which proved to be in accordance with the X-ray diffraction structure analysis. In order to interpret the reaction mechanism, the chemical reactivity was studied using local and global reactivity indexes.

关键词： 2-Amino-4-aryltriazino[1,2-a]benzimidazole 2-Guanidinobenzimidazole Density functional theory Tautomeric equilibrium Reaction mechanism X-Ray diffraction analysis

反应器选择和排序的优化:费用最少/体积最小(英文)

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Chinese Journal of Chemical Engineering 2014年第6期22卷 651-656页

作者： Rachid chebbi Department of Chemical Engineering American University of Sharjah

The present investigation targets minimum cost of reactors in series for the case of one single chemical reaction, considering plug flow and stirred tank reactor(s) in the sequence of flow reactors. Using Guthrie's cost correlations three typical cases were considered based on the profile of the reaction rate reciprocal versus conversion. Significant differences were found compared to the classical approach targeting minimum total reactor volume.

关键词：最低成本反应器小体积排序优化化学反应典型案例反应速度

Extranodal Tuberculosis of Head and Neck: A Series of 29 Cases

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Journal of Tuberculosis Research 2019年第3期7卷 148-158页

作者： Sameh Mezri Ghassen chebbi Manel chebbi Sabrine Maamouri Rania Ben Mhamed Khemaies Akkari ENT Department Military Hospital of Tunis Tunis Tunisia

Background: Despite a re-increase in the incidence of tuberculosis, extranodal location on head and neck remains rare. Clinical symptomatology is non-specific and even data from paraclinical explorations often pose the problem of differential diagnosis with tumor pathology. Methods: We report a series of 29 cases of extranodal tuberculosis collected over a period of 32 years [1986-2018] in ENT department of the military hospital of Tunis. Results: Rhinosinusopharyngeal involvement was predominant (45%) followed by glandular involvement (14%). Diagnosis was histopathological in most cases. Concomitant pulmonary tuberculosis was detected in two cases and spinal lumbar in one case. Treatment was medical in all cases. Conclusion: Clinical presentation of extranodal tuberculosis is various and non-specific. Neoplastic pathology is the main differential diagnosis. However, diagnosis should be systematically raised in endemic countries. Treatment is essentially medical.

关键词： Tuberculosis ENT Extranodal

Complicated sinusitis in children:18 cases report

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World Journal of Otorhinolaryngology 2015年第1期5卷 30-36页

作者： Ali Mardassi Nabil Mathlouthi Hajer Mbarek Chiraz Halouani Sameh Mezri Cyrine Zgolli Ghassen chebbi Rania Ben Mhamed Khemaies Akkari Sonia Benzarti ENT Department Military Hospital

AIM: To precise the clinical characteristics of rhinosinusitis in pediatric population, their complications and therapeutic ***: All infants younger than 15 years adm-itted to the Ear, Nose and Throat Department of the Military Hospital of Tunis, Tunisia for a complicated rhinosinusitis between 2006 and 2013 were evaluated. Data related to patients and the disease were collected and analyzed: past medical history, complaints, clinical examination, radiologic findings, therapeutic management and evolution. RESULTS: Eighteen cases were identified with a mean age of 5.1 years(5 mo to 13 years)(SD ± 3.1). A male preponderance was noted in 72% of the cases. Rhinorrhea and fever were the most common presenting symptoms. Radiological explorations(computed tomography-scan ± magnetic resonance imaging) have been practiced for all of our patients. Orbital involvement was found in 77% of the cases associated with meningitis in 2 cases. Antibiotherapy was prescribed to all our patients. Surgical procedures were performed in 8 cases: endoscopic sinus surgery and/or external drainage of orbital abscess. After an average follow-up period of 2.5 years, 3 of our patients were lost. The ophthalmic sequelae noted in 3 cases(16%) were permanent and caused important functional and social problems. A favourable outcome has been noted in the rest of our patients. CONCLUSION: Rhinosinusitis can be extremely severe in children requiring urgent radiological imaging and aggressive treatment to avoid orbital and intracranial complications.

关键词： Rhinosinusitis Children Imaging Orbit Meningitis Antibiotherapy Surgery

Nasopharyngeal carcinoma: Long term follow-up of 83 patients

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World Journal of Otorhinolaryngology 2015年第2期5卷 65-70页

作者： Ali Mardassi Nabil Mathlouthi Nawel Hlila Chiraz Halouani Sameh Mezri Cyrine Zgolli Ghassen chebbi Rania Ben Mhamed Khemaies Akkari Sonia Benzarti ENT Department Military Hospital of Tunis

AIM: To analyzes the clinical, paraclinical, therapeutical and evolutive features of nasopharyngeal carcinoma(NPC).METHODS: All the patients treated for a nasopharyngeal carcinoma between 2000 and 2013 in the Ear-NoseThroat Department of the Military Hospital of Tunis, Tunisia were collected in this study. Eighty-three patients signed a written consent prior to study enrollment. The gender ratio(M/W) was 6.5 with a median age of 49 years(range 16-85). The median follow up time was 37 mo(18 to 108 mo). The evolution, during and after the end of therapy, was assessed on clinical biological and radiological exams. Different parameters were analyzed and compared to other series: complications of chemo and radiotherapy, recurrence of the disease, metastasis and overall survival ***: Of the 83 patients of our study, 15% had T1 tumors, 20% had T2, 23% had T3 and 41% had T4 disease. At the time of diagnosis, 14% of the patients had a cranial nerve deficit. Only 12 patients had exclusive radiotherapy and the remaining of our patients had concomitant radio chemotherapy. Iatrogenic complications were diagnosed in 53% of the cases: radioepithelitis(28%), radiodermatitis(9%), xerostomia(17%), osteoradionecrosis(3%), cerebral radionecrosis(1%) and a pancytopenia(17%). The follow-up period varied from 18 to 108 mo(average: 37 mo). During the first six months after treatment, a persistence of the disease was found in 11% of patients, while a recurrence of the cancer was diagnosed in 6% and distant metastasis developed in 14% of the patients. Fifteen patients needed remedial chemotherapy for a relapse or metastasis and five had palliative chemotherapy for very advanced cases. We report 3 cases of death during the follow-up. CONCLUSION: Despite its excellent radio-chemotherapy response, and general good prognosis, a careful follow-up of patients with NPC is necessary to detect and manage any iatrogenic complication, locoregional recurrence or metastasis of the disease.

关键词： Nasopharyngeal carcinoma Cranial nerve Radiotherapy Chemotherapy Metastasis

Infrathyroidian hydatid cyst: Diagnostic difficulties and therapeutic management, a case report

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World Journal of Otorhinolaryngology 2015年第2期5卷 78-81页

作者： Ali Mardassi Nabil Mathlouthi Hajer Mbarek Chiraz Halouani Sameh Mezri Cyrine Zgolli Ghassen chebbi Rania Ben Mhamed Khemaies Akkari Sonia Benzarti Ear Nose and Throat Department of the Military Hospital

Hydatidosis is a cosmopolitan anthropozoonose common to humans and many mammals. The cervical localization is rare even in endemic countries. We report a case of cervical hydatidosis located in the infra-thyroidian region. The diagnosis was suspected on clinical and radiological examinations(Ultrasonography, computed tomography-scan). The surgical removal of the cyst was difficult because of the inflammatory tissue around the mass. The confirmation of the diagnosis was obtained by the histopathological examination. During the followup, a local recurrence of the disease was diagnosed after 9 mo treated successfully by surgery.

关键词： Hydatidosis Anthropozoonose Cervical localization Ultrasonography Surgery Histopathology

Synchronous carcinoma of head and neck: 2 cases report

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World Journal of Otorhinolaryngology 2015年第2期5卷 74-77页

作者： Ali Mardassi Nabil Mathlouthi Nawel Hlila Chiraz Halouani Sameh Mezri Cyrine Zgolli Ghassen chebbi Rania Ben Mhamed Khemaies Akkari Sonia Benzarti Ear Nose and Throat Department the Military Hospital Tunis

Multiple primary cancers are becoming an increasingly frequent situation and are often the source of many diagnostic and therapeutic difficulties. We report the case of two patients diagnosed with head and neck synchronous carcinomas. The first case is a 33-yearold man with a history of a keratinizing squamous cell carcinoma of the eye lid and who was operated 4 mo later from a mucoepidermoid carcinoma of thesubmandibular salivary gland. The second case is a 71-year-old woman who underwent a total parotidectomy for a mucoepidermod carcinoma of the left parotid gland and who consulted 2 mo later for epistaxis. The explorations concluded to a squamous cell carcinoma of the nasopharynx. The patient had a complementary radiotherapy. No local neither distant recurrence of the two tumors has been detected after a follow-up of 36 mo in the first case and 24 mo in the second one.

关键词： Carcinoma Submandibular gland Parotid gland Nasopharynx Radiotherapy