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Exosomes in viral infection:Effects for pathogenesis and treatment strategies

BIOCELL 2023年第12期47卷 2597-2608页

作者： FATEMEH HEIDARI REIHANEH SEYEDEBRAHIMI PIAO YANG MOHSEN ESLAMI FARSANI SHIMA ABABZADEH NASER KALHOR hamed manoochehri MOHSEN SHEYKHHASAN MARYAM AZIMZADEH Anatomy Department Faculty of MedicineQom University of Medical SciencesQomIran Cellular and Molecular Research Center Qom University of Medical SciencesQomIran Department of Molecular Genetics College of Arts and SciencesThe Ohio State UniversityColumbusOH43210USA Tissue Engineering Department Faculty of MedicineQom University of Medical SciencesQomIran Department of Mesenchymal Stem Cells Academic Center for EducationCultureand Research(ACECR)Qom BranchQomIran The Persian Gulf Marine Biotechnology Research Center The Persian Gulf Biomedical Sciences Research InstituteBushehr University of Medical SciencesBushehrIran Department of Molecular Medicine and Genetics Research Center for Molecular MedicineHamadan University of Medical SciencesHamadanIran Department of Medical Laboratory Sciences Khomein University of Medical SciencesKhomeinIran Molecular and Medicine Research Center Khomein University of Medical SciencesKhomeinIran

Exosomes are small vesicles that carry molecules from one cell to *** have many features that make them interesting for research,such as their stability,low immunogenicity,size of the nanoscale,toxicity,and selective *** can also interact with viruses in diverse *** research highlights the significant role of exosomes in viral infections,particularly in the context of diseases like COVID-19,HIV,HBV and *** the intricate interplay between exosomes and the human immune system holds great promise for the development of effective antiviral *** important aspect is gaining clarity on how exosomes influence the immune system and enhance viral infectivity through their inherent *** leveraging the innate properties of exosomes,viruses exploit the machinery involved in exosome biogenesis to set replication,facilitate the spread of infection,and eliminate immune *** can either help or hinder viral infection by modulating the immune *** review summarizes the recent findings on how exosomes mediate viral infection and how they can be used for diagnosis or *** could lead to new clinical applications of exosomes in disease management.

关键词： Exosomes Viral infection COVID-19 HIV HBV HCV

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