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Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

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Science China(Life Sciences) 2024年第9期67卷 1849-1866页

作者： Kumar Ganesan Cong Xu Jianming Wu Bing Du Qingqing Liu Yue Sui Cailu Song Jinhui Zhang hailin tang Jianping Chen School of Chinese Medicine LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Pharmacy Southwest Medical UniversityEducation Ministry Key Laboratory of Medical ElectrophysiologySichuan Key Medical Laboratory of New Drug Discovery and Druggability EvaluationLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSouthwest Medical UniversityLuzhou 646000China College of Food Science South China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510080China

The spreading of cancer cells from the primary tumor site to other parts of the body,known as metastasis,is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC).Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70%of TNBC *** is crucial for promoting tumor metastasis and associated with poor ***,it is vital to identify effective therapeutic strategies targeting EGFR ***,an isoflavonoid found in various plants,such as clover and soybeans,has been shown to have anticancer properties in several *** the present study,we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular *** used various assays,including cell viability,colony formation,Transwell,wound healing,ELISA,Western blotting,and staining techniques,to achieve this *** results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis,as evidenced by the cell viability assay,colony formation assay,and expression of apoptosis markers,and reduced the metastatic capabilities of TNBC *** effects were achieved through the direct suppression of cell adhesion,invasiveness and ***,in TNBC xenograft lung metastatic models,ononin treatment significantly reduced tumor growth and lung ***,ononin reversed the epithelial-mesenchymal transition(EMT)by downregulating the expression of EMT markers and matrix metalloproteinases,as confirmed by Western blot ***,ononin treatment reduced EGFR phosphorylation and suppressed the PI3K,Akt,and m TOR signaling pathways,which was further confirmed using EGFR agonists or ***,ononin treatment did not exert any toxic effects on liver or kidney *** conclusion,our findings suggest that ononin is a safe and potentially therapeutic treatment for TNBC metastasis that targets the EGFRm

关键词： ononin TNBC breast cancer lung metastasis EGFR PI3k/Akt EMT therapeutic effect

CircMYBL2 facilitates hepatocellular carcinoma progression by regulating E2F1 expression

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Oncology Research 2024年第6期32卷 1129-1139页

作者： JUNZHE YI BINBIN LI XIAOMIN YIN LINGRUI LIU CAILU SONG YING ZHAO MANBO CAI hailin tang DONG CHEN NING LYU State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou510060China Department of Medical Oncology The Third People’s Hospital of YongzhouYongzhou425000China Department of Radiotherapy The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang421001China Center of Hepato-Pancreato-Biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China

Circular RNAs(circRNAs)have been recognized as pivotal regulators in tumorigenesis,yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma(HCC)remain *** sought to unveil the expression profile and biological role of circMYBL2 in *** microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells,and qRT‒PCR analysis was then performed in HCC cell lines and tissues,revealing significant upregulation of *** experiments were conducted to evaluate the biological function of circMYBL2 in HCC ***,bioinformatics analysis,qRT‒PCR analysis,luciferase reporter assays,and western blot analysis were employed to investigate the interplay among circMYBL2,miR-1205,and ***2 was found to exhibit marked upregulation in tumor tissues as well as HCC cell *** expression of circMYBL2 increased the proliferation and migration of HCC cells,whereas circMYBL2 knockdown elicited contrasting ***,our results indicated that circMYBL2 promoted E2F1 expression and facilitated HCC progression by sponging *** findings revealed that circMYBL2 contributed to HCC progression through the circMYBL2/miR-1205/E2F1 axis,suggesting the potential of circMYBL2 as a novel target for HCC treatment or a prognostic biomarker for HCC.

关键词： Circular RNAs circMYBL2 miR-1205 E2F1 Hepatocellular carcinoma

The burgeoning importance of PIWI-interacting RNAs in cancer progression

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Science China(Life Sciences) 2024年第4期67卷 653-662页

作者： Xinpei Deng Tianle Liao Jindong Xie Da Kang Yiwei He Yuying Sun Zhangling Wang Yongluo Jiang Xuan Miao Yixuan Yan hailin tang Lewei Zhu Yutian Zou Peng Liu State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Medicine Sun Yat-sen UniversityShenzhen 518107China Key Laboratory of Cardiovascular and Cerebrovascular Medicine Nanjing Medical UniversityNanjing 211166China Guanghua School of Stomatology Sun Yat-sen UniversityGuangzhou 510062China The First People’s Hospital of Foshan Foshan 528000China

PIWI-interacting RNAs(pi RNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ *** studies have found that pi RNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and ***,the atypical manifestation of pi RNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of ***,the precise functions of pi RNAs in cancer progression and their underlying mechanisms have yet to be fully *** review aims to examine current research on the biogenesis and functions of pi RNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of pi RNAs and piwi proteins in the management and treatment of advanced cancer.

关键词： PIWI-interacting RNAs/piRNAs cancer progression metastasis chemoresistance stemness

Effects of Alexithymia to Stigma of Patients with Lymphedema

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Journal of Cancer Therapy 2024年第4期15卷 201-211页

作者： Qiaoling Zhong Huizhen Zhang Liping Zhang Qinghua Luo Huiting Zhang Feng Liu hailin tang Na Li Lijuan Zhang State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center Guangzhou China

BACKGROUND: Secondary lymphedema is one of the common complications after malignant tumor surgery. It is a chronic and complex disease. Once lymphedema occurs, there will be discomfort such as limb swelling, pain, numbness and tension, which will eventually lead to changes in the appearance of the affected limb and will seriously affect the quality of life and require lifelong treatment and psychosocial support. This study investigated the current situation of stigma and alexithymia in patients with lymphedema, and discussed the impact of alexithymia on stigma in patients with lymphedema. AIMS: To understand the current situation of stigma and alexithymia in patients with lymphedema, and to analyze the influence of alexithymia on stigma. METHODS: 195 patients with lymphedema in a hospital were selected by convenient sampling. General information questionnaire, Toronto Alexithymia Scale and social impact scale were used to investigate respectively, to study the general situation, stigma and alexithymia of the respondents. RESULTS: The results showed that the total score of stigma in 195 patients with lymphedema was (60.36 ± 11.08), and the total score of alexithymia was (56.53 ± 8.43). Multiple linear regression analysis showed that alexithymia and family relationship were the influencing factors of stigma in patients with lymphedema. CONCLUSIONS: The patients with lymphedema have obvious stigma, and alexithymia and family relationship are the influencing factors.

关键词： Alexithymia Lymphedema Stigma Influence Factor

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环状RNA在三阴乳腺癌中的研究进展

中南医学科学杂志 2024年第1期52卷 1-5页

作者：吴松唐海林中山大学肿瘤防治中心广东广州510060

三阴乳腺癌(TNBC)是乳腺癌中恶性程度最高的亚型,其特征为不表达雌激素受体、孕激素受体和人表皮生长因子受体2。TNBC具有易侵袭和转移、预后不良、对常规化疗或靶向治疗效果不佳的临床特点。研究表明,环状RNA(circRNA)在TNBC组织表达异... 详细信息

三阴乳腺癌(TNBC)是乳腺癌中恶性程度最高的亚型,其特征为不表达雌激素受体、孕激素受体和人表皮生长因子受体2。TNBC具有易侵袭和转移、预后不良、对常规化疗或靶向治疗效果不佳的临床特点。研究表明,环状RNA(circRNA)在TNBC组织表达异常,并与TNBC患者的临床病理特征和预后相关。circRNA可通过调控转录和剪接、作为微小RNA海绵、与蛋白质结合以及作为翻译模板,参与TNBC肿瘤细胞增殖、转移和耐药过程。因此,circRNA在TNBC的早期诊断、临床治疗和预后监测方面有广泛的应用前景。本文阐述了circRNA的形成和作用机制,并总结了circRNA在TNBC中的生物学功能和临床意义。

关键词：三阴乳腺癌环状RNA 生物标志物

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基于若依开源框架的低代码开发

现代计算机 2024年第14期30卷 112-116页

作者：蒋谨汤海林广东白云学院大数据与计算机学院广州510450

在合适场景选用低代码开发,不仅可以节约成本,还可以提升效率。若依是完全开源的架构,允许企业或者个人商用。通过运用若依开源架构实现了中华人民共和国民事诉讼法的数字化开发,向读者介绍和推荐了若依开源框架,为公司和个人的项目开发... 详细信息

在合适场景选用低代码开发,不仅可以节约成本,还可以提升效率。若依是完全开源的架构,允许企业或者个人商用。通过运用若依开源架构实现了中华人民共和国民事诉讼法的数字化开发,向读者介绍和推荐了若依开源框架,为公司和个人的项目开发,提供了一种低代码实现的参考途径。

关键词：若依开源框架低代码微服务前后端分离

基于大语言模型的水工程调度知识图谱的构建与应用

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计算机科学与探索 2024年第6期18卷 1637-1647页

作者：冯钧畅阳红陆佳民唐海麟吕志鹏邱钰淳河海大学计算机与软件学院南京211100

随着水利事业的发展和信息化需求的增加,处理和表示海量水利数据变得复杂而繁琐。特别是调度文本数据通常以自然语言的形式存在,缺乏明确的结构和规范,并且处理和应用这些多样性的数据需要具备广泛的领域知识和专业背景。为此,提出了基... 详细信息

随着水利事业的发展和信息化需求的增加,处理和表示海量水利数据变得复杂而繁琐。特别是调度文本数据通常以自然语言的形式存在,缺乏明确的结构和规范,并且处理和应用这些多样性的数据需要具备广泛的领域知识和专业背景。为此,提出了基于大语言模型的水工程调度知识图谱的构建方法。通过数据层的调度规则数据收集与预处理,再利用大语言模型挖掘和抽取数据中蕴藏的知识,完成概念层本体构建和实例层“三步法”提示策略抽取。在数据层、概念层、实例层的相互作用下,实现了规则文本的高性能抽取,完成了数据集和知识图谱的构建。实验结果表明,大语言模型抽取方法F1值达到85.5%,且通过消融实验验证了模型各模块的有效性和合理性。构建的水工程调度知识图谱整合了分散的水利规则信息,有效处理非结构化文本数据,并提供可视化查询和功能追溯功能。这有助于领域从业人员判断来水情况并选择适当的调度方案,为水利决策和智能推荐等提供了重要支持。

关键词：知识图谱大语言模型(LLM) 本体构建知识抽取水工程调度

基于Java Web技术的校园论坛网页的设计与实现

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现代信息科技 2024年第15期8卷 74-77页

作者：庄丽君汤海林广东白云学院广东广州510450

随着网络技术的快速发展,校园论坛打破了传统人与人之间的交流方式,可为广大师生提供更为丰富、自由、便捷的交流与沟通渠道,用户可以在校园论坛上自由分享、交流互动等。文章设计并实现一个基于Java Web技术的校园论坛网页,以方便广大... 详细信息

随着网络技术的快速发展,校园论坛打破了传统人与人之间的交流方式,可为广大师生提供更为丰富、自由、便捷的交流与沟通渠道,用户可以在校园论坛上自由分享、交流互动等。文章设计并实现一个基于Java Web技术的校园论坛网页,以方便广大师生进行学术交流和社交互动。该校园论坛基于Java Web技术而开发,采用B/S设计模式,使用JSP+CSS技术设计美化界面,运用JDBC连接关系型数据库MySQL。实现了登录注册模块、用户交流模块、帖子模块、用户管理模块、校园互助管理模块等。经过严格的测试和验证,该校园论坛在各项功能上均达到了预期目标,安全性和实用性俱佳,能够为广大师生提供一个良好的在线交流虚拟社交平台。

关键词： Java Web 校园论坛网页设计

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心肌梗死后侧壁心肌夹层瘤超声表现1例

中华超声影像学杂志 2024年第2期33卷 176-178页

作者：胡晚育赵博文王蓓李世岩唐海林蒋晨阳浙江大学医学院附属邵逸夫医院超声医学科杭州310016 浙江大学医学院附属邵逸夫医院心内科杭州310016

患者男, 65岁, 3 d前出现进食后上腹不适, 伴恶心感, 未重视未就诊。9 h前下地干活时突发晕厥, 摔倒在地, 数秒后意识恢复, 伴胸闷、恶心, 3 h前至当地医院就诊, 查肌钙蛋白I 26 μg/L(参考区间25 000 μg/L(参考区间0~54 μg/L), 氨基... 详细信息

患者男, 65岁, 3 d前出现进食后上腹不适, 伴恶心感, 未重视未就诊。9 h前下地干活时突发晕厥, 摔倒在地, 数秒后意识恢复, 伴胸闷、恶心, 3 h前至当地医院就诊, 查肌钙蛋白I 26 μg/L(参考区间25 000 μg/L(参考区间0~54 μg/L), 氨基末端pro脑钠肽4.82 μg/L(参考区间<0.9 μg/L), 肌酸激酶520 U/L(参考区间50~320 U/L), 丙氨酸转氨酶803 U/L(参考区间9~50 U/L), 天冬氨酸转氨酶1 449 U/L(参考区间15~40 U/L), 肌酐174 μmol/L(参考区间57~111 μmol/L), 尿素10.3 mmol/L(参考区间3.6~9.5 mmol/L)。初步诊断:急性心肌梗死, 肝肾功能异常。

关键词：急性心肌梗死参考区间意识恢复肝肾功能异常丙氨酸转氨酶肌钙蛋白I 天冬氨酸转氨酶肌酸激酶