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SRy-Box transcription factor 9 triggers yAP nuclear entry via direct interaction in tumors

Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： hui Qian Chen-hong Ding fang Liu Shi-Jie Chen Chen-Kai huang Meng-Chao Xiao Xia-Lu hong Ming-Chen Wang fang-Zhi yan Kai Ding ya-Lu Cui Bai-Nan Zheng Jin Ding Cheng Luo Xin Zhang Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of yAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of yAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of yAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of yAP is essential for SOX9-yAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of yAP at Arg-124(yAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between yAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and yAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits yAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving yAP nuclear translocation and presents a potential therapeutic strategy for yAP-driven human cancers by targeting SOX9-yAP interaction.

关键词： interaction interaction precise

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Innovative Mn3-xO4-y@NCA design:Leveraging Mn/O vacancies and amorphous architecture for enhanced sodium-ion storage

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Journal of Energy Chemistry 2024年第10期97卷 747-756页

作者： Kaijun Xie Xin Liu Kai Xia Lipeng Diao Ping Lu Mengmeng Wang Long fang yihui Zou Dongjiang yang Xiaodong Zhang College of Chemistry and Chemical Engineering College of Environmental Science and Engineering State Key Laboratory of Bio-fibers and Eco-textiles Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological Textiles Institute of Marine Biobased Materials Qingdao University Institute of Micro/Nano Materials and Devices Ningbo University of Technology

Manganese-based oxide electrode materials suffer from severe Jahn-Teller（J-T） distortion,leading to severe cycle instability in sodium ion ***,it is difficult to adjust the electron at d orbitals exactly to a low spin state to eliminate orbital degeneracy and suppress J-T distortion *** article constructed concentration-controllable Mn/O coupled vacancy and amorphous network in Mn3O4and coated it with nitrogen-doped carbon aerogel(Mn3-xO4-y@NCA).The existence of Mn/O vacancies has been confirmed by scanning transmission electron microscopy（STEM） and positron annihilation lifetime spectroscopy（PALS）.Atomic absorption spectroscopy（AAS） and X-ray photoelectron spectroscopy（XPS） determine the most optimal ratio of Mn/O vacancies for sodium ion storage is 1:*** functional theory（DFT） calculations prove that Mn/O coupled vacancies with the ratio of 1:2could exactly induce a low spin states and a d4electron configuration of Mn,suppressing the J-T distortion *** abundant amorphous regions can shorten the transport distance of sodium ions,increase the electrochemically active sites and improve the pseudocapacitance *** the synergetic effect of Mn/O coupled vacancies and amorphous regions,Mn3-xO4-y@NCA exhibits an energy density of 37.5 W h kg-1and an ultra-high power density of 563 W kg-1in an asymmetric *** sodium-ion batteries,it demonstrates high reversible capacity and exceptional cycling *** research presents a new method to improve the Na+storage performance in manganese-based oxide,which is expected to be generalized to other structural distortion.

关键词： Amorphous network Concentration-controllable Mn/O coupled vacancies Manganese-based metal oxide Sodium ion battery Sodium ion supercapacitor

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Defect and nanostructure engineering of polymeric carbon nitride for visible-light-driven CO2 reduction

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结构化学 2024年第3期43卷 10-18页

作者： Ziruo Zhou Wenyu Guo Tingyu yang Dandan Zheng yuanxing fang Xiahui Lin yidong hou Guigang Zhang Sibo Wang State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou350116China College of Environment and Safety Engineering Fuzhou UniversityFuzhou350108China

Sunlight-induced photocatalytic carbon dioxide(CO2)reduction to energy-rich chemicals by metal-free polymeric carbon nitride(CN)semiconductor is a promising tactic for sustained solar fuel ***,the reaction efficiency of CO2 photoreduction is restrained seriously by the rapid recombination of photogenerated carriers on CN ***,we incorporate 2-aminopyridine molecule with strong electron-withdrawing group into the skeleton edge of CN layers through a facile one-pot thermal polymerization strategy using urea as the precursor,which renders a modified carbon nitride(ACN)with extended optical harvesting,abundant nitrogen defects and ultrathin nanosheet ***,the ACN photocatalyst with desirable structural features attains enhanced separation and migration of photoexcited charge *** visible light irradiation with Co(bpy)32+as a cocatalyst,the optimized ACN sample manifests a high CO2 deoxygnative reduction activity and high sta-bility,providing a CO yielding rate of 17 μmol h-1,which is significantly higher than that of pristine *** key intermediates engaged in CO2 photoreduction reaction are determined by the in situ diffuse reflectance infrared Fourier transform spectroscopy,which sponsors the construction of the possible photocatalytic CO2 reduction mechanism on ACN nanosheets.

关键词： Carbon nitride Photocatalysis CO_2 reduction Nitrogen defects Nanosheets

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Boosting rate performance of layered lithium-rich cathode materials by oxygen vacancy induced surface multicomponent integration

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Journal of Energy Chemistry 2024年第5期92卷 250-262页

作者： youyou fang yuefeng Su Jinyang Dong Jiayu Zhao haoyu Wang yun Lu Bin Zhang hua yan Feng Wu Lai Chen Beijing Key Laboratory of Environmental Science and Engineering School of Material Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Chongqing Innovation Center Beijing Institute of TechnologyChongqing 401120China yibin Libode New Materials Co. Ltd.Yibin 64400SichuanChina School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083HunanChina

The rapid development of electric vehicles and portable energy storage systems demands improvements in the energy density and cost-effectiveness of lithium-ion batteries,a domain in which Lithium-rich layered cathode(LLO)materials inherently ***,these materials face practical challenges,such as low initial Coulombic efficiency,inferior cycle/rate performance,and voltage decline during cycling,which limit practical *** study introduces a surface multi-component integration strategy that incorporates oxygen vacancies into the pristine LLO material Li1.2Mn_(0.6)Ni_(0.2)O_(2).This process involves a brief citric acid treatment followed by calcination,aiming to explore rate-dependent degradation *** induced surface oxygen vacancies can reduce surface oxygen partial pressure and diminish the generation of O_(2)and other highly reactive oxygen species on the surface,thereby facilitating the activation of Li ions trapped in tetrahedral sites while overcoming transport ***,the formation of a spinel-like phase with 3D Li+diffusion channels significantly improves Li^(+)diffusion kinetics and stabilizes the surface *** optimally modified sample boasts a discharge capacity of 299.5 mA h g^(-1)at a 0.1 C and 251.6 mA h g^(-1)at a 1 C during the initial activation cycle,with an impressive capacity of 222.1 mA h g^(-1)at a 5 *** notably,it retained nearly 70%of its capacity after 300 cycles at this elevated *** straightforward,effective,and highly viable modification strategy provides a crucial resolution for overcoming challenges associated with LLO materials,making them more suitable for practical application.

关键词： Lithium-ion battery Layered lithium rich cathode Surface multicomponent integration Rate-dependent degradation and Li^(+) diffusion kinetics

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Preparation and Performance of Organically Modified Montmorillonite Composite Separation Membrane

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1100-1107页

作者： LIU Peng BI yuanyuan ChEN Shaowei WAN ye yU yunwu fang yanfeng GU yaxin LI Feihong TANG Ning LI Xiangyu School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China

A new composite separation membrane was developed by using organically modified montmorillonite(OMMT)as an *** effects of OMMT on the modification and properties of PVDF composite membranes were *** is found that different kinds and amounts of OMMT into the casting solution can obviously change the pure water flux,separation performance and hydrophilicity of composite membrane in varying *** the TA/PDA-MMT was 0.5 wt%,the pure water flux of the membrane reached the maximum,which was 584.7 L/(m^(2)·h),about 6 times that of the original *** OMMT/PVDF composite membrane had good hydrophilicity and stability in the treatment of oily *** development of novel OMMT/PVDF composite membrane will provide a new idea for solving the problem of oily wastewater treatment.

关键词： membrane montmorillonite composite wastewater

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Boosting hydrogen production of ammonia decomposition via the construction of metal-oxide interfaces

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结构化学 2024年第2期43卷 49-59页

作者： Jiangping Chen hongju Ren Kai Wu huihuang fang Chongqi Chen Li Lin yu Luo Lilong Jiang National Engineering Research Center for Chemical Fertilizer Catalyst(NERC-CFC) School of Chemical EngineeringFuzhou UniversityFuzhou350002China National Engineering Research Center for Chemical Fertilizer Catalyst(NERC-CFC) School of Chemical EngineeringFuzhou UniversityFuzhou350002China Qingyuan Innovation Laboratory QuanzhouFujian362801China

The ammonia decomposition for the production of carbon-free hydrogen has triggered great attention yet still remains challenging due to its sluggish kinetics,posting the importance of precise design of efficient catalysts for ammonia decomposition under low *** the metal-support interaction and interface is one of the most important strategies for promoting *** this work,by coating ceria onto the Ni nanoparticles(NPs),we discover that the Ni-CeO2 interfaces create an exceptional effect to enhance the catalytic decomposition of ammonia by over 10 folds,compared with the pristine *** kinetic analysis demonstrates that the recombinative N2 desorption is the rate-determining step(RDS)and the Ni-CeO2 interface greatly increases the *** on these understandings,a strategy to fabricate the Ni/CeO2 catalyst with abundant Ni-Ce-O in-terfaces via one-pot sol-gel method was employed(hereafter denoted to s-Ni/CeC2).The s-Ni/CeO2 catalyst shows a high activity for ammonia decomposition,achieving a h2 formation rate of 10.5 mmol gcat1 min-1 at 550 ℃.Combined with a series of characterizations,the relationship between the catalyst structure and the performance was investigated for further understanding the effect of metal-oxide interfaces.

关键词： Metal-support interaction Ammonia decomposition Nickel Cerium oxide Metal-oxide interfaces

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Constructing highly safe and long-life calcium ion batteries based on hydratedvanadium oxide cathodes featuring a pillar structure

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Rare Metals 2024年第6期43卷 2597-2612页

作者： Chun-fang Wang Shi-Wei Zhang Lan huang yuan-Min Zhu Feng Liu Jian-Chuan Wang Li-Ming Tan Chun-yi Zhi Cui-Ping han Powder Metallurgy Research Institute Central South UniversityChangsha410083China Songshan Lake Materials Laboratory Dongguan 523808China Research Institute of Interdisciplinary Science and School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Faculty of Materials Science and Energy Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Calcium-ion batteries(CIBs)have generated intense interest due to the growing demand for safer,cheaper,and large-scale energy storage ***,their development is still in its infancy,owing to the lack of suitable cathodes for sustaining reversiblc Ca^(2+)intercalation/***,layered h_(2)V_(3)O_(8)(hVO)with Zn^(2+)pre-insertion(ZhVO)is reported as a high-rate and highly durable cathode material for *** existence of Zn^(2+)and h_(2)O pillars could expand the interlayer spacing up to 1.8 nm,which is favorable for the diffusion of bulky Ca^(2+).The formation of Zn-O bonds facilitates electron transfer and enhances electrical ***,the ZhVO cathode achieves superior capacity performance(213.9 mAh·g^(-1)at 0.2 A·g^(-1))and long lifespan(78.3%for 1,000 cycles at 5 A·g^(-1))compared to pristine *** functional theory(DFT)calculations revealed that Zn^(2+)moved during Ca^(2+)intercalation,thereby reducing the diffusion energy barrier and facilitating Ca^(2+)***,a safe aqueous calcium ion cell was successfully assembled.

关键词： Multivalent batteries Calcium-ion batteries Layered structure Vanadium oxide Cathode materials

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Synergetic PVA degradation and h2 evolution in photocatalytic fuel cells using Ag@Fe_(2)O_(3) cathode

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Frontiers of Chemical Science and Engineering 2024年第1期18卷 85-93页

作者： Likun Sun Kesi Xiong Baoning Zhang Jinghong fang yingchao he Min Wang Zhixing Gan fanglin Du Qiong Sun Liyan yu Lifeng Dong College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Center for Future Optoelectronic Functional Materials School of Computer and Electronic InformationNanjing Normal UniversityNanjing 210023China Department of Physics Hamline UniversitySt.Paul 55104USA

In a dual-chamber photocatalytic fuel cell device,polyvinyl alcohol degradation and h2 evolution were concurrently *** setup involved commercial P25 as the photoanode and Ag@Fe_(2)O_(3) nanoparticles as the ***,the feasibility of a Fentonlike reaction in the cathode,utilizing Fe^(2+)ions and pumped O_(2),was *** cathode materials,polyvinyl alcohol types,and ph values’effects were assessed on device *** tests highlighted photoinduced holes(h+)and Oh·radicals as pivotal contributions to polyvinyl alcohol ***-term stability of the device was established through cycling experiments.

关键词： photocatalytic fuel cell PVA Ag@Fe_(2)O_(3) cathode materials Fenton-like reaction

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Bibliometric analysis of hotspots and trends of global myopia research

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 940-950页

作者： Xing-yang Wu hui-hui fang yan-Wu Xu yan-Ling Zhang Shao-Chong Zhang Wei-hua yang Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina School of Future Technology South China University of TechnologyGuangzhou 510641Guangdong ProvinceChina

AIM:To gain insights into the global research hotspots and trends of ***:Articles were downloaded from January 1,2013 to December 31,2022 from the Science Core Database website and were mainly statistically analyzed by bibliometrics ***:A total of 444 institutions in 87 countries published 4124 *** 2013 and 2022,China had the highest number of publications(n=1865)and the highest h-index(61).Sun yat-sen University had the highest number of publications(n=229)and the highest h-index(33).Ophthalmology is the main category in related *** from 2020 to 2022 highlight keywords of options and reference,child health(pediatrics),myopic traction mechanism,public health,and machine learning,which represent research ***:Myopia has become a hot research *** and Chinese institutions have the strongest academic influence in the field from 2013 to *** main driver of myopic research is still medical or *** study highlights the importance of public health in addressing the global rise in myopia,especially its impact on children’s *** present,a unified theoretical system is still *** surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive *** addition,the benefits of artificial intelligence(AI)models are also reflected in disease monitoring and prediction.

关键词： bibliometric analysis myopia global trends

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Continuous microflow visible-light photocatalytic N-formylation of piperidine and its kinetic study

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Chinese Chemical Letters 2024年第1期35卷 285-289页

作者： yangyang Xu fang Zhao Xuhong Guo State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China International Joint Research Center of Green Energy Chemical Engineering Shanghai 200237China

N-formylation of amines,a class of synthetically important reactions,is typically conducted using metal catalysts that are relatively expensive or not readily available and usually needs harsh conditions to increase the reaction ***,an efficient continuous microflow strategy was developed for the gas-liquid visible-light photocatalytic N-formylation of piperidine,which achieved a reaction yield of 82.97%and a selectivity of>99%at 12 min using cheap organic dye photocatalyst under mild reaction *** influence of essential parameters,including light intensity,temperature and equivalents of the gas,additive and photocatalyst,on the reaction yield was systematically ***,kinetic investigations were conducted,exhibiting the dependence of reaction rate and equilibrium yield of N-formylpiperidine on light intensity,temperature and photocatalyst *** microflow photocatalytic approach established in this work,which realized a markedly higher space-time yield than the conventional batch method(37.9 vs.0.212 mmol h-1 L-1),paves the way for the continuous,green and efficient synthesis of N-formamides.

关键词： Microflow Visible-light photocatalysis N-Formylation Piperidine Kinetics

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