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Do tensile and shear forces exerted on cells influence mechanotransduction through stored energy considerations?

BIOCELL 2024年第4期48卷 525-540页

作者： FREDERICK h.SILVER TANMAY DEShMUKh Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical SchoolRutgersThe State University of New JerseyPiscatawayNJ 08854USA OptoVibronex LLC.Ben Franklin Tech PartnersBethlehemPA 18015USA

All tissues in the body are subjected externally to gravity and internally by collagenﬁbril and cellular retractive forces that create stress and energy equilibrium required for *** involves mechanical work(force through a distance)and energy storage as kinetic and potential *** leads to changes in cell mitosis or apoptosis and the synthesis or loss of tissue *** involves the application of energy directly to cells through integrin-mediated processes,cell-cell connections,stretching of the cell cytoplasm,and activation of the cell nucleus via yes-associated protein(YAP)and transcriptional coactivator with PDZ-motif(TAZ).These processes involve numerous complexes,intermediate molecules,and multiple *** pathways have been identiﬁed from research studies on vertebrate cell culture and from studies in *** pathways involve mechanosensors and other molecules that activate the *** review discusses the mitogen-activated protein kinase(MAPK)family,hippo,hedgehog,and Wingless-related integration site(WNT)/βcatenin signaling *** mediators covered includeβcatenin,ion channels,growth factors,hormone receptors,members of the Ras superfamily,and components of the linker of nucleoskeleton and cytoskeleton(LINC)***,the interrelationship among the different pathways remains to be clariﬁ***-mediated mechanotransduction involves direct tensile loading and energy applied to the cell membrane via collagenﬁbril *** energy is transferred between cells by stretching the cell-cell connections involving cadherins and the WNT/βcatenin *** alterations induce changes in intracellular events in the cytoskeleton and nuclear skeleton caused by the release of YAP and *** coactivators then penetrate through the nuclear pores and inﬂuence nuclear cell *** in the balance of forces and energy applied to cells and tissues is hypothesized to shift th

关键词： MAPK family hippo hedgehog WNT pathway βcatenin Ion channels Growth factor receptors hormone receptors Ras superfamily LINC complex Collagen Cadherins

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Neurological consequences of human calmodulin mutations

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Neural Regeneration Research 2024年第5期19卷 943-944页

作者： helene h.Jensen Anders Olsen Medical Biotechnology Department of Chemistry and BiosciencesAalborg UniversityAalborgDenmark

When calcium ions enter the cytosol,it is a stimulatory signal for cellular *** calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream interaction *** this way,calmodulin affects cellular processes such as fertilization,muscle contraction,neuronal firing,and *** is,calmodulin is involved in(nearly)everything!The significance of calmodulin is emphasized by the fact that we all carry three different genes(CALM1,2,3)on different chromosomes that encode the exact same calmodulin protein,and these are all expressed in all cell ***,throughout vertebrate evolution,the protein sequence has remained completely unchanged.

关键词： consequences unchanged calmodulin

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Evaluating mechanism of banana pseudo-stem retting using seawater:A cost-effective surface pre-treatment approach

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Journal of Bioresources and Bioproducts 2024年第3期9卷 322-335页

作者： Prince hotor Ahmed h.hassanin Osbert Akatwijuka Mohamed A.h.Gepreel Mitsuo Yamamoto Yukie Saito Ahmed Abdel-Mawgood Egypt-Japan University of Science and Technology Biotechnology ProgramAlexandria GovernorateNew Borg Al Arab 21934Egypt Alexandria University Department of Textile EngineeringAlexandria GovernorateBab Sharqi 5424041Egypt Egypt-Japan University of Science and Technology Material Science and EngineeringAlexandria GovernorateNew Borg Al Arab 21934Egypt Graduate School of Agricultural and Life Sciences The University of TokyoBunkyo-KuTokyo 113-8657Japan

Retting has been employed to extract natural fibers from agricultural wastes as a biological and cost-effective approach for *** its global abundance,banana pseudo-stem is a promising agro-waste for lignocellulosic fiber *** this study,fibers were extracted from the pseudo-stems after being pre-treated under four conditions using seawater at room temperature for up to 35 d Bacterial isolation from the fresh seawater sample and screening for ligninolytic ability were *** load as well as laccase and manganese peroxidase enzyme activity profile assay during the retting duration were *** transform infrared(FT-IR)and X-day diffraction(XRD)analyses were also examined for both pre-treated and untreated extracted *** results shows that six out of the eight bacterial isolates had the ability to degrade *** treatments(Raw stem+Raw seawater)and(Autoclaved stem+Raw seawater)recorded the highest viable bacterial load of 9.24×102 and 4.46×102 CFU,respectively,on the 14th day of the retting ***,the highest laccase and manganese peroxidase enzymes activity was recorded for(Raw stem+Raw seawater)and(Autoclaved stem+Raw seawater)treatments in the second to the third *** FT-IR spectra of the pre-treated fibers revealed relative reductions in peaks attributed to polysaccharides and other amorphous substances for all retting *** XRD diffractogram revealed that the crystallinity index(CI)of pre-treated fibers increased in all seawater retting treatment ***,the CI for fibers pre-treated under enzymatic conditions were enhanced even after five *** analysis for selected bacterial isolates showed homology to sequences of Bacillus velezensis,Shewanella sp.L8–5,and Citrobacter amalonaticus and Bacillus subtilis j8 *** these findings,it was suggested that physical,biological,and chemical actions were collectively involved in the seawater retting process of banana ps

关键词： Seawater retting Banana pseudo-stem Natural fiber Enzyme activity Colony forming unit

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B-cell and antibody responses to SARS-CoV-2:infection,vaccination,and hybrid immunity

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Cellular & Molecular Immunology 2024年第2期21卷 144-158页

作者： Dennis Lapuente Thomas h.Winkler Matthias Tenbusch Institut für klinische und molekulare Virologie Universitätsklinikum Erlangen und Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossgarten 491054 ErlangenGermany Department of Biology Division of GeneticsNikolaus-Fiebiger-Center for Molecular MedicineFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Medical Immunology Campus Erlangen Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossplatz 191054 ErlangenGermany

The emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 prompted scientific,medical,and biotech communities to investigate infection-and vaccine-induced immune responses in the context of this pathogen.B-cell and antibody responses are at the center of these investigations,as neutralizing antibodies(nAbs)are an important correlate of protection(COP)from infection and the primary target of SARS-CoV-2 vaccine *** addition to absolute levels,nAb longevity,neutralization breadth,immunoglobulin isotype and subtype composition,and presence at mucosal sites have become important topics for scientists and health policy *** recent pandemic was and still is a unique setting in which to study de novo and memory B-cell(MBC)and antibody responses in the dynamic interplay of infection-and vaccine-induced *** also provided an opportunity to explore new vaccine platforms,such as mRNA or adenoviral vector vaccines,in unprecedented cohort *** with the technological advances of recent years,this situation has provided detailed mechanistic insights into the development of B-cell and antibody responses but also revealed some unexpected *** this review,we summarize the key findings of the last 2.5 years regarding infection-and vaccine-induced B-cell immunity,which we believe are of significant value not only in the context of SARS-CoV-2 but also for future vaccination approaches in endemic and pandemic settings.

关键词： SARS-CoV-2 neutralizing antibodies memory responses vaccines IgG4

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Gut microbial regulation of innate and adaptive immunity after traumatic brain injury

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Neural Regeneration Research 2024年第2期19卷 272-276页

作者： Marta Celorrio Kirill Shumilov Stuart h.Friess Department of Pediatrics Washington University in St.Louis School of MedicineSt.LouisMOUSA

Acute care management of traumatic brain injury is focused on the prevention and reduction of secondary insults such as hypotension,hypoxia,intracranial hypertension,and detrimental ***,the imperative to balance multiple clinical concerns simultaneously often results in therapeutic strategies targeted to address one clinical concern causing unintended effects in other remote organ *** the bidirectional communication between the gastrointestinal tract and the brain has been shown to influence both the central nervous system and gastrointestinal tract homeostasis in health and disease.A critical component of this axis is the microorganisms of the gut known as the gut *** in gut microbial populations in the setting of central nervous system disease,including traumatic brain injury,have been reported in both humans and experimental animal models and can be further disrupted by off-target effects of patient *** this review article,we will explore the important role gut microbial populations play in regulating brain-resident and peripheral immune cell responses after traumatic brain *** will discuss the role of bacterial metabolites in gut microbial regulation of neuroinflammation and their potential as an avenue for therapeutic intervention in the setting of traumatic brain injury.

关键词： gut microbiome gut microbiota gut-brain axis macrophage microglia monocyte neuroinflammation short-chain fatty acids T cell traumatic brain injury

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Experimental study of corner separation and unsteady characteristics in linear compressor cascades with and without sweeping jet actuator

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Propulsion and Power Research 2024年第3期13卷 360-374页

作者： S.W.Chen W.h.Li C.Xu Q.h.Meng School of Energy Science and Engineering Harbin Institute of TechnologyHarbinHeilongjiang 150001China AVIC Shenyang Aircraft Design and Research Institute Shenyang 110035China

Sweeping jet actuator(SJA)has been widely applied for activeflow control in *** this paper,the SJA character in compressor cascade and its performance for separation control in innerflows are ***-averaged and transientflowfield measurement,together with visualization methods are *** is found that endwall effects are important for both SJA behaviors and SJA performance for separation control in compressor *** is a maximum of 12.7%total pressure loss reduction with SJA placed near the separation position,close to the endwall and under *** characteristic frequencies in theflowfield contribute to the capture of influence regions of vortices and excitation *** concentrated shedding vortices and SJA jets impact region helped to judge that SJA energizes low momentumfluids in a large region and matches the high loss core *** be concrete,theflow separation control mechanism of SJA lies on the interruption of the blade suction surface boundary layer development and the restriction of the lifting of the boundary layer from end-wall towards blade suction surface.

关键词： Compressor cascade Activeflow control Sweeping jet actuator Corner separation Oilflow visualization

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Data-Driven Fault Detection of Multiple Open-Circuit Faults for MMC Systems Based on Long Short-Term Memory Networks

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1563-1574页

作者： Chenxi Fan Kaishun Xiahou Lei Wang Q.h.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China

This paper presents a long short-term memory(LSTM)-based fault detection method to detect the multiple open-circuit switch faults of modular multilevel converter(MMC)systems with full-bridge sub-modules(FB-SMs).Eighteen sensor signals of grid voltages,grid currents and capacitance voltages of MMC for single and multi-switch faults are collected as sampling *** output signal characteristics of four types of single switch faults of FB-SM,as well as double switch faults in the same and different phases of MMC,are analyzed under the conditions of load variations and control command changes.A multi-layer LSTM network is devised to deeply extract the fault characteristics of MMC under different faults and operation conditions,and a Softmax layer detects the fault *** results have confirmed that the proposed LSTM-based method has better detection performance compared with three other methods:K-nearest neighbor(KNN),naive bayes(NB)and recurrent neural network(RNN).In addition,it is highly robust to model uncertainties and Gaussian *** validity of the proposed method is further demonstrated by experiment studies conducted on a hardware-in-the-loop(hIL)testing platform.

关键词： Fault detection long short-term memory(LSTM) modular multilevel converter(MMC) open circuit fault

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Morphology-Tailored Dynamic State Transition in Active-Passive Colloidal Assemblies

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Research 2024年第3期2024卷 751-760页

作者： Nan Yu Zameer h.Shah Mingcheng Yang Yongxiang Gao Institute for Advanced Study Shenzhen University518060ShenzhenChina Key Laboratory of Optoelectronic Device and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen University518060ShenzhenChina Beijing National Laboratory for Condensed Matter Physics and Laboratory of Soft Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory DongguanGuangdong 523808China.

Mixtures of active self-propelled and passive colloidal particles promise rich assembly and dynamic states that are beyond reach via equilibrium ***,controllable transition between different dynamic states remains ***,we reveal a plethora of dynamic behaviors emerging in assemblies of chemically propelled snowman-like active colloids and passive spherical particles as the particle shape,size,and composition are *** example,assembles of one or more active colloids with one passive particle exhibit distinct translating or orbiting states while those composed of one active colloid with 2 passive particles display persistent“8”-like cyclic motion or hopping between circling states around one passive particle in the plane and around the waist of 2 passive ones out of the plane,controlled by the shape of the active colloid and the size of the passive particles,*** morphology-tailored dynamic transitions are in excellent agreement with state diagrams predicted by mesoscale dynamics *** work discloses new dynamic states and corresponding transition strategies,which promise new applications of active systems such as micromachines with functions that are otherwise impossible.

关键词： Transition otherwise transitions

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Tau in the pancreas:understanding the link between type 2 diabetes mellitus and Alzheimer's disease

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Signal Transduction and Targeted Therapy 2024年第1期9卷 6-7页

作者： Wenlu Li Steffen Tiedt Eng h.Lo Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA Consortium International pour la Recherche Circadienne sur l’AVC(CIRCA) BostonUSA Institute for Stroke and Dementia Research LMU University HospitalLMU MunichMunichGermany

A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to decreased insulin production in individuals with type 2 diabetes mellitus(T2DM).1 Using a combination of cell culture experiments,animal models and studies in T2DM patients,the authors show that an up-regulation of tau inβ-islet cells can inhibit pancreatic insulin secretion through changes in microtubule assembly.

关键词： T2DM Alzheimer tau

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The multi-impurity system in CdSe nanoplatelets:electronic structure and thermodynamic properties

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Communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： D A Baghdasaryan V A harutynyan E M Kazaryan h A Sarkisyan Russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically studies the impurity states and the effects of impurity concentration and configuration on the optical,electrical,and statistical properties of CdSe nanoplatelets(NPLs).An image charge-based model of electron-impurity interaction is *** charge-carrier energy spectra and corresponding wave functions depending on the impurity number and configuration are *** electron binding energies are calculated for different NPL *** is shown that the image charge-based interaction potential that arises due to the dielectric constants mismatch is much stronger than the interaction potential that does not take such a mismatch into ***,it is demonstrated that the binding energies are increasing with the number of *** calculate the canonical partition function using the energy levels of the electron,which in turn is used to obtain the mean energy,heat capacity,and entropy of the non-interacting electron *** thermodynamic properties of the non-interacting electron gas that depend on the geometric parameters of the NPL,impurity number,configuration,and temperature are studied.

关键词： nanoplateletes thermodynamic properties impurity states

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