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Effects of target pre-heating and expansion on terahertz radiation production from intense laser-solid interactions

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high Power Laser Science and Engineering 2014年第1期2卷 13-17页

作者： X.h.Yuan Y.Fang D.C.Carroll D.A.MacLellan F.Du N.Booth M.Burza M.Chen R.J.Gray Y.F.Jin Y.T.Li Y.Liu D.Neely h.powell G.Scott C.-G.Wahlstrm J.Zhang P.McKenna Z.M.Sheng Key Laboratory for Laser Plasmas (Ministry of Education) and Department of Physics and Astronomy Shanghai Jiao Tong University Beijing National Laboratory of Condensed Matter Physics Institute of Physics Chinese Academy of Sciences SUPA Department of Physics University of Strathclyde Central Laser Facility Rutherford Appleton Laboratory Department of Physics Lund University

The first experimental measurements of intense(～7 × 1019 W cm-2) laser-driven terahertz(Thz) radiation from a solid target which is preheated by an intense pulse of laser-accelerated protons is reported. The total energy of the Thz radiation is found to decrease by approximately a factor of 2 compared to a cold target reference. This is attributed to an increase in the scale length of the preformed plasma, driven by proton heating, at the front surface of the target,where the Thz radiation is generated. The results show the importance of controlling the preplasma scale length for Thz production.

关键词： target heating terahertz radiation

Effect of salinity and acidity on bioleaching activity of mesophilic and extremely thermophilic bacteria

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中国有色金属学会会刊：英文版 2008年第3期18卷 714-721页

作者： h.DEVECI M.A.JORDAN N.powell I.ALP Department of Mining Engineering Karadeniz Technical UniversityTrabzon 61080Turkey Camborne School of Mines UECTremough CampusPenrynCornwallTR109EZUK

The effects of bacterial strain, salinity and ph on the bioleaching of a complex ore using mesophilic and extremely thermophilic bacteria were investigated and the statistical analysis of the results was performed using ERGUN’s test. The extreme thermophiles were shown to display superior kinetics of dissolution of zinc compared with the mesophiles as confirmed by the statistical analysis. Bioleaching performance of the extreme thermophiles is found to improve in response to the increase in acidity (ph from 2.0 to 1.0) whilst the activity of the mesophiles is adversely affected by decreasing ph. Statistical analysis of the bioleaching data indicates that the effect of ph is insignificant in the range of ph 1.0-1.2 for the extreme thermophiles and ph 1.4-2.0 for the mesophiles. Salinity is shown to have a suppressing effect on the mesophiles. however, the extreme thermophiles appear to be halophilic in character as they could operate efficiently under saline conditions (1%-4%Cl- (w/v)).

关键词：细菌生物浸取盐度 ph 硫化物

A Ring-Reinforced Right Ventricle to Pulmonary Artery Conduit Is Associated with Better Regional Mechanics after Stage I Norwood Operation

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Congenital heart Disease 2022年第5期17卷 591-603页

作者： Benjamin Zielonka David M.harrild Sunil J.Ghelani Eleni G.Elia Christopher W.Baird Andrew J.powell Rahul h.Rathod Department of Cardiology Boston Children’s HospitalBostonUSA Department of Pediatrics Harvard Medical SchoolBostonUSA Department of Cardiothoracic Surgery Boston Children’s HospitalBostonUSA Department of Surgery Harvard Medical SchoolBostonUSA

Background:The right ventricle to pulmonary artery conduit(RVPAC)may impair right ventricular(RV)function in patients with functional single right *** of the RVPAC using a ring-reinforced end with dunked insertion into the RV through a limited ventriculotomy may reduce the impact on RV *** compared RV segmental strain between patients with a traditional RVPAC and ring-reinforced RVPAC using feature tracking cardiovascular magnetic resonance(CMR)***:Patients with CMR examinations after Stage I operation with RVPAC between 2000 and 2018 were *** mass,volumes,late gadolinium enhancement(LGE),and peak radial and circumferential strain of the 4 segments near the RVPAC insertion site were ***:The study included 71 CMR examinations in 61 patients(30 traditional RVPAC,31 ring-reinforced RVPAC).Prior to Stage II,the ring-reinforced RVPAC group had better peak radial strain and circumferential strain in 1 of 4 segments proximal to the RVPAC insertion site compared to the traditional RVPAC *** to Stage III operation,the ring-reinforced group had better peak radial and circumferential strain in 2 of 4 *** at the RVPAC insertion site was observed in 97%of patients before Stage II and 95%of patients before Stage *** type and regional strain were not associated with transplant-free survival during a median follow-up of 6.3 ***:Compared to a traditional RVPAC,the ring-reinforced RVPAC is associated with improved regional mechanics at the conduit insertion *** investigation of long-term outcomes after ring-reinforced RVPAC is warranted.

关键词： Single ventricle hypoplastic left heart syndrome cardiovascular magnetic resonance feature tracking

Involvement of CRF2 signaling in enterocyte differentiation

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World Journal of Gastroenterology 2017年第28期23卷 5127-5145页

作者： Benjamin Ducarouge Marjolaine Pelissier-Rota Rebecca powell Alain Buisson Bruno Bonaz Muriel Jacquier-Sarlin Equipe de l’apoptose du cancer et du développementCentre Léon Bérard Equipes des"Neuro-pathologies et Dysfonctions synaptiques"et du"Stress et des interactions neurodigestives" UniversitéGrenoble Alpes Equipes des"Neuropathologies et dysfonctions synaptiques"et du"Stress et des interactions neurodigestives" Université Grenoble Alpes and Grenoble Institut des Neurosciences-Inserm U1216 Service d’hépato-gastroentérologie Centre Hospitalier Universitaire de Grenoble

To determine the role of corticotropin releasing factor receptor (CRF2) in epithelial permeability and enterocyte cell *** this purpose, we used rat Sprague Dawley and various colon carcinoma cell lines (SW620, hCT8R, hT-29 and Caco-2 cell lines). Expression of CRF2 protein was analyzed by fluorescent immunolabeling in normal rat colon and then by western blot in dissociated colonic epithelial cells and in the lysates of colon carcinoma cell lines or during the early differentiation of hT-29 cells (ten first days). To assess the impact of CRF2 signaling on colonic cell differentiation, hT-29 and Caco-2 cells were exposed to Urocortin 3 recombinant proteins (Ucn3, 100 nmol/L). In some experiments, cells were pre-exposed to the astressin 2b (A2b) a CRF2 antagonist in order to inhibit the action of Ucn3. Intestinal cell differentiation was first analyzed by functional assays: the trans-cellular permeability and the para-cellular permeability were determined by Dextran-FITC intake and measure of the transepithelial electrical resistance respectively. Morphological modifications associated to epithelial dysfunction were analyzed by confocal microscopy after fluorescent labeling of actin (phaloidin-TRITC) and intercellular adhesion proteins such as E-cadherin, p120ctn, occludin and ZO-1. The establishment of mature adherens junctions (AJ) was monitored by following the distribution of AJ proteins in lipid raft fractions, after separation of cell lysates on sucrose gradients. Finally, the mRNA and the protein expression levels of characteristic markers of intestinal epithelial cell (IEC) differentiation such as the transcriptional factor krüppel-like factor 4 (KLF4) or the dipeptidyl peptidase IV (DPPIV) were performed by RT-PCR and western blot respectively. The specific activities of DPPIV and alkaline phosphatase (AP) enzymes were determined by a colorimetric ***2 protein is preferentially expressed in undifferentiated epithelial cel

关键词： Urocortin3 Colon carcinoma cell lines Intercellular adhesion complexes Cell permeability Epithelial cell differentiation Corticotrophin releasing factor 2

Calculated Phase Relations in the System Na2O-CaO-K2O-FeO-MgO-Ai2O3-SiO2-h2O with Applications to UhP Eclogites and Whiteschists

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Calculated Phase Relations in the System Na2O-CaO-K2O-FeO-Mg...

Transcriptomic Profiling of human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time

中国科学院地质与地球物理研究所2006学术年会

作者： Roger powell School of Earth Sciences The University of MelbourneParkvilleVictoria 3010MelbourneAustralia

Pressure-temperature grids in the system Na2O-CaO-K2O-FeO-MgO- Al2O3-SiO2-h2O and its subsystems have been calculated in the ranges of 15-45 kbar and 550-900℃,using an internally consistent thermodynamic dataset and new thermodynamic models for amphibole,white mica,and clinopyroxene,with the software ThERMOCALC. Minerals considered for the grids include garnet,omphacite,diopside,jadeite,hornblende, actinolite,glaucophane,zoisite,lawsonite,kyanite,coesite,quartz,talc,muscovite,paragonite, biotite,chlorite,and *** diagrams are used to illustrate the phase relationships in the ***-bearing eclogites and a whiteschist from China are used to demonstrate the ability of pseudosections to model phase relationships in natural ultrahigh-pressure metamorphic *** water-saturated conditions,chlorite-bearing assemblages in Mg and Al-rich eclogites are stable at lower temperatures than in Fe-rich eclogites. The relative temperature stability of the three amphiboles is hornblende > actinolite > glaucophane (amphibole names used sensu lato).Talc-bearing assemblages are stable only at low temperature and high pressure in Mg and Al-rich *** most eclogite compositions,talc coexists with lawsonite,but not zoisite,in the stability field of *** content contouring of pressure-temperature pseudosections along with appropriate geotherms provides new constraints concerning dehydration of such rocks in subducting *** and lawsonite are two important h2O-carriers in subducting *** on bulk composition and pressure-temperature path,amphibole may or may not be a major h2O-carrier to *** most cases,dehydration to make ultrahigh-pressure eclogites takes place gradually,with h2O content controlled by divariant or higher variance ***,fluid fluxes in subduction zones are likely to be continuous,with the rate of dehydration changing with changing pressure and ***,eclogites of different

关键词： dehydration eclogites phase relations ThERMOCALC UhP metamorphism whiteschists

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Genomics, Proteomics & Bioinformatics 2021年第2期19卷 223-242页

作者： Grace E.Lidgerwood Anne Senabouth Casey J.A.Smith-Anttila Vikkitharan Gnanasambandapillai Dominik C.Kaczorowski Daniela Amann-Zalcenstein Erica L.Fletcher Shalin h.Naik Alex W.hewitt Joseph E.powell Alice Pebay Department of Anatomy and Neuroscience The University of MelbourneParkvilleVIC 3010Australia Department of Surgery The University of MelbourneParkvilleVIC 3010Australia Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVIC 3002Australia Garvan Weizmann Centre for Cellular Genomics Garvan Institute of Medical ResearchThe Kinghorn Cancer CentreDarlinghurstNSW 2010Australia Single Cell Open Research Endeavour The Walter and Eliza Hall Institute of Medical ResearchParkvilleVIC 3052Australia Immunology Division The Walter and Eliza Hall Institute of Medical ResearchParkvilleVIC 3052Australia Department of Medical Biology The University of MelbourneParkvilleVIC 3010Australia School of Medicine Menzies Institute for Medical ResearchUniversity of TasmaniaHobartTAS 7005Australia UNSW Cellular Genomics Futures Institute School of Medical SciencesUniversity of New South WalesSydneyNSW 2052Australia

human pluripotent stem cell(h PSC)-derived progenies are immature versions of cells,presenting a potential limitation to the accurate modelling of diseases associated with maturity or ***,it is important to characterise how closely cells used in culture resemble their native *** order to select appropriate time points of retinal pigment epithelium(RPE)cultures that reflect native counterparts,we characterised the transcriptomic profiles of the h PSC-derived RPE cells from 1-and 12-month *** differentiated the human embryonic stem cell line h9 into RPE cells,performed single-cell RNA-sequencing of a total of 16,576 cells to assess themolecular changes of the RPE cells across these two culture time *** results indicate the stability of the RPE transcriptomic signature,with no evidence of an epithelial–mesenchymal transition,and with the maturing populations of the RPE observed with time in *** of Gene Ontology pathways revealed that as the cultures age,RPE cells upregulate expression of genes involved in metal binding and antioxidant *** might reflect an increased ability to handle oxidative stress as cells *** with native human RPE data confirms a maturing transcriptional profile of RPE cells in *** results suggest that long-term in vitro culture of RPE cells allows the modelling of specific phenotypes observed in native mature *** work highlights the transcriptional landscape of h PSC-derived RPE cells as they age in culture,which provides a reference for native and patient samples to be benchmarked against.

关键词： human embryonic stem cell human pluripotent stem cell Retinal pigment epithelium Single-cell RNA sequencing Ageing

Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis

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World Journal of Gastroenterology 2017年第40期23卷 7321-7331页

作者： Kelly L hayward Patricia C Valery Jennifer h Martin Antara Karmakar Preya J Patel Leigh U horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E powell W Neil Cottrell Pharmacy Department Princess Al-exandra Hospital The Centre for Liver Disease Research Translational Research Institute The University of Queensland Cancer and Chronic Disease Research Group QIMR Berghofer Medical Research Institute School of Medicine and Public health The University of Newcastle The Centre for Liver Disease Research Translational Research Institute The University of Queensland Department of Gastroenterology and hepatology Princess Alexandra Hospital The Centre for Liver Disease Research Translational Research Institute The University of Queensland Department of Gastroenterology and hepatology Princess Alexandra Hospital Statistics Unit QIMR Berghofer Medical Research Institute School of Pharmacy The University of Queensland

AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated *** One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = *** Medication adherence was " high " in 42 % o f participants, "Medium" in 37%, and "Low" in 21%. Compared to patients with "high" adherence, those with "Medium" or "Low" adherence were more likely to report difficulty affording their medications(P helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with "Low" adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of "Low"*** The association between "Low" adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explor

关键词： Medication adherence Medication beliefs Illness perceptions Quality of life Liver cirrhosis

Design Optimization of a Micro-Combustor for Lean, Premixed Fuel-Air Mixtures

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Journal of Power and Energy Engineering 2016年第6期4卷 13-26页

作者： Leigh T. powell Ralph C. Aldredge Department of Mechanical and Aerospace Engineering University of California-Davis Davis CA USA

Present technology has been shifting towards miniaturization of devices for energy production for portable electronics. Micro-combustors, when incorporated into a micro-power generation system, create the energy desired in the form of hot gases to power such technology. This creates the need for a design optimization of the micro-combustor in terms of geometry, fuel choice, and material selection. A total of five micro-combustor geometries, three fuels, and three materials were computationally simulated in different configurations in order to determine the optimal micro-combustor design for highest efficiency. Inlet velocity, equivalence ratio, and wall heat transfer coefficient were varied in order to test a comprehensive range of micro-combustor parameters. All simulations completed for the optimization study used ANSYS Fluent v16.1 and post-processing of the data was done in CFD Post v16.1. It was found that for lean, premixed fuel-air mixtures (φ= 0.6 - 0.9) ethane (C2h6) provided the highest flame temperatures when ignited within the micro-combustor geometries. An aluminum oxide converging micro-combustor burning ethane and air at an equivalence ratio of 0.9, an inlet velocity of 0.5 m/s, and heat transfer coefficient of 5 W/m2-K was found to produce the highest combustor efficiency, making it the optimal choice for a micro-combustor design. It is proposed that this geometry be experimentally and computationally investigated further in order to determine if additional optimization can be achieved.

关键词： Micro-Combustor Combustion Computational Fluid Dynamics Ethane Efficiency

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磷处理粉煤灰可作农业土壤磷源

地学前缘 2008年第6期15卷 112-117页

作者：申俊峰 M.A.powell D.B.hayden 中国地质大学(北京)地球科学与资源学院北京100083 环境地质咨询公司西安大略大学生物系

粉煤灰(简称CCP或ash)具有改良土壤,增加植物产量的功能。此外,由于它特殊的多孔结构,也可用作吸纳并承载植物养分的载体。用Nah2PO4配制成含磷0.10mol/L浓度的溶液,对采自加拿大西安大略省Sarnia地区Lambton电厂的底灰(bottomash)进行... 详细信息

粉煤灰(简称CCP或ash)具有改良土壤,增加植物产量的功能。此外,由于它特殊的多孔结构,也可用作吸纳并承载植物养分的载体。用Nah2PO4配制成含磷0.10mol/L浓度的溶液,对采自加拿大西安大略省Sarnia地区Lambton电厂的底灰(bottomash)进行振荡浸渍处理。结果表明,振荡浸渍66h后的粉煤灰中磷含量可达784×10-6。以磷处理粉煤灰、未进行磷处理的粉煤灰和石英砂按比例混合,作为基本生长介质进行玉米种植实验,其中实验配方设计为生长介质中含磷量分别为标准含磷浓度(50×10-6)的10%、25%、50%、75%和100%。生长26、34和46d后分别与不含磷的空白配方、施加含氮-磷-钾为0-20-0标准磷肥并控制磷含量为标准浓度(50×10-6)配方进行生物产量对比。生长实验结果表明,以磷处理粉煤灰供磷的生长介质,当含磷量为标准浓度的25%至100%时,其植物生长量就比添加标准浓度磷肥的配方好。种植46d后的生物生长量统计结果显示,含磷分别为标准浓度50%、75%和100%的实验介质中,玉米杆的鲜重较施标准磷肥介质中玉米分别增长39.46%、42.73%和46.13%;玉米杆干重依次增加29.71%、13.39%和28.87%;根鲜重平均增加16.62%;根干重平均增加14.03%。上述实验结果启示,粉煤灰可以很好地吸纳承载磷养分,并持续供给植物吸收生长,如果采用吸纳磷(或其他养分)的粉煤灰改良砂质土壤将有重要意义。

关键词：粉煤灰磷载体植物生长量砂土改良