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Formation of intermetallic phases in unrefined and refined AA6082 Al alloys investigated by using SEM-based ultramicrotomy tomography

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Journal of Materials Science & Technology 2022年第25期120卷 118-128页

作者： J.M.Yu T.hashimoto h.T.Li N.Wanderka Z.Zhang C.Cai X.L.Zhong J.Qin Q.P.Dong h.nagaumi X.N.Wang Shagang School of Iron and Steel and high-Performance Metal Structural Materials Research Institute Soochow UniversitySuzhou 215137China School of Materials The University of ManchesterSackville StreetManchester M139PLUK Chinalco Materials Application Research Institute Co.Ltd. Beijing 102200China helmholtz-Zentrum Berlin Für Materialien und Energie Hahn-Meitner-Platz 1Berlin 14109Germany Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China

The spatial arrangement,distribution and morphology of Fe-bearing intermetallics in AA6082 alloys depends on the manufacturing process of the alloy and thus influences the macroscopic ***,the microstructure of a near industrial scale casting AA6082 Al alloy fabricated by:(a)direct chill casting,(b)Al-5 Ti-1 B grain refiner addition and(c)intensive melt shearing has been investigated by threedimensional visualization using SEM-based serial ultra microtomy *** formation sequence of phases in AA6082 alloys is generally categorized into four stages:formation ofα-Al grains,Fe-bearing intermetallics,Mg_(2)Si phase,and eutectic *** of three-dimensional visualization of the microstructure indicated that TiBparticles not only could nucleate Fe-bearingβ-intermetallics,but also could provide substrate for the formation of Fe-bearingα-intermetallics and Mg_(2)Si.A further deep analysis reveals that the essential condition for the formation of secondary phases such as Fe-bearing intermetallics and Mg_(2)Si phase is the build-up of a supersaturated solute front at theα-Al solid-liquid interface irrespective of the specific nucleation *** addition,the results indicate that grain refinement processing causes the severe interconnectivity of Fe-bearingα-***,the intensive melt shearing is a better manufacturing process because the intermetallics are more evenly distributed and refined than with the addition of the grain refiner,thereby improving the properties of the alloy.

关键词： Al-Si-Mg alloy Grain refinement Al-Fe-Si intermetallic phase Tomography Ultramicrotomy Mg2Si

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

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Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

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Numerical simulation of macrosegregation in billet continuous casting influenced by electromagnetic stirring

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Journal of Iron and Steel Research International 2022年第4期29卷 612-627页

作者： Qi-peng Dong Jiong-ming Zhang Yan-bin Yin hiromi nagaumi School of Iron and Steel High-Performance Metal Structural Materials Research InstituteSoochow UniversitySuzhou 215021JiangsuChina State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

A three-dimensional numerical model coupling the macrosegregation and magnetohydrodynamic simulations was developed to investigate the effects of electromagnetic stirring(EMS)on the *** results show that a significant swirling flow was induced by the in-mold EMS,which further changed the shape of the solidification shell and homogenized the solute elements in ***,the effects were only confined to the initial billet *** improvement in centerline segregation was observed with the usage of the final EMS(F-EMS),which led to the forced convection at the final solidification *** solute elements in the mushy zone were significantly even,with the maximum segregation degree of solute C reducing from 1.311 to *** addition,the effects of the stirrer positions and currents of F-EMS on the macrosegregation alleviation were numerically *** values of centerline segregation were predicted with various stirrer positions and currents,and there is an optimum stirrer parameter to obtain the best macrosegregation *** the experimental conditions,the optimum position was about 7 m away from meniscus,and the optimum current was 300 A.

关键词： Numerical simulation Macrosegregation Electromagnetic stirring Continuous casting

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Enhanced creep resistance in Mg-Y-Nd alloy via regulating prior thermo-mechanical treatment

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Journal of Magnesium and Alloys 2024年第7期12卷 2766-2782页

作者： Zhirou Zhang Qinghuan huo Yuxiu Zhang Gantao Zhao hiromi nagaumi Xuyue Yang School of Materials Science and Engineering Central South UniversityChangsha 410083China Advanced Metals Division Korean Institute of Material ScienceChangwon 51508Republic of Korea School of Iron and Steel Soochow UniversitySuzhou 215100China

In this study,the tensile creep behavior of a hot-rolled Mg-4Y-3.5Nd alloy subjected to different prior thermo-mechanical treatments was investigated at 220℃.Five groups of samples were prepared using different combinations of the solid solution(S),aging treatment at 220℃ for 30 h(A),and hot compression at 490℃ to a true strain of 0.25(C).The abbreviations for the samples are S,SA,SC,SAC,and *** examining the yield strength and creep resistance,it was found that creep resistance could not be directly predicted by the yield *** stability of the deformation bands(DBs)induced by prior thermo-mechanical treatment plays an important role in determining the creep *** dislocation of the DBs and demonstrated the best creep resistance in the SAC sample,which were prepared using a solid solution,aging treatment,and subsequent hot ***,despite the highest yield strength,frequent dislocation motions destroyed the stability of the DBs and deteriorated the creep resistance of the SCA sample,which were prepared using a solid solution,hot compression,and subsequent aging *** the thermo-mechanical treatments used in this study,the application of aging treatment was important to obtain the resultant creep *** the aging treatment was performed prior to hot compression,the creep resistance could be further enhanced based only on hot ***,the sequence from the strongest to the weakest creep resistance was SAC>SC>S>SCA>SA.

关键词： Mg-Y-Nd alloy Microstructure Deformation bands Creep Precipitation Dislocation

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Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

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Distinguished roles of static aging and strain aging in the microstructure and creep resistance of Mg-4Y-3.5Nd alloy

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Journal of Materials Science & Technology 2024年第14期181卷 20-40页

作者： Zhirou Zhang Qinghuan huo Yuxiu Zhang Byung-joo Kim hiromi nagaumi Xuyue Yang School of Materials Science and Engineering Central South UniversityChangsha 410083China Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea School of Iron and Steel Soochow UniversitySuzhou 215100China

This work concerns the distinguished roles of static aging and strain aging in the creep resistance of a hot-rolled Mg-4Y-3.5Nd *** solution-treated sample is named AS while the peak-aged sample ob-tained from static aging at 220℃ is named *** strain aging(creep loading)was performed for both AS and AA samples at 220,250 and 280℃,*** results showed that the creep resistance of both samples was closely related to the width of precipitate-free zones(PFZs).Under low stress,the dislocation cross-slip was effectively delayed by the precipitates and the existing PFZs widened slowly in the AA sample,leading to its stronger creep resistance compared to the AS ***,under high stress,pyramidalslip was more frequently activated,which could not be delayed by the coars-ened ***,the widening rate of PFZs became fast and the creep resistance became weaker in the AA *** the above-mentioned results,this work provides a novel guide for using Mg alloys with rare-earth *** the temperature range of 220-280℃,static aging is positive for creep resistance under low stress,while directly performing strain aging without static aging is recom-mended for creep resistance under high stress.

关键词： Magnesium Microstructure Creep Precipitation Dislocation slip

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Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

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Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： Stress concentration

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The novel strategy for enhancing mechanical properties and corrosion resistance via regulating multi-scale microstructure characteristics in Al-Si-Cu-Mg-Zr cast alloy

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Journal of Materials Science & Technology 2024年第13期180卷 102-117页

作者： Rui Wang Dongtao Wang hiromi nagaumi Minghe Zhang Xinzhong Li Zibin Wu Xiaozu Zhang Pengfei Zhou Bo Zhang high-Performance Metal Structural Materials Research Institute Soochow UniversitySuzhou 215021China School of Iron and Steel Soochow UniversitySuzhou 215021China School of Materials Science and Engineering Liaoning University of TechnologyJinzhou 121001China Shandong Weiqiao Aluminum&Electricity Co. Ltd.Binzhou 256200China

high strength and low corrosion resistance are always the contradiction in Al-Si-Cu-Mg cast alloy due to introducing high Cu and Mg *** this work,the new strategy was achieved for enhancing corrosion resistance and mechanical properties by regulating multi-scale microstructure characteristics in Al-9Si-4.2Cu-0.25Mg-Zr *** and corrosion morphology results indicate that the addition of Zr significantly enhances the corrosion resistance of the *** grain refinement inhibits the charge transfer process between cathode phases and the matrix is the main reason at the Zr level of less than 0.15%.When the Zr level is up to 0.3%,the multi-scale synergistic effect of grain refinement and passive film enhancement significantly inhibits the corrosion ***,0.3%Zr addition increases the yield strength to 419 MPa,tensile strength to 490 MPa,and the acceptable fracture elongation to 3.8%.The strengthening of mechanical and corrosion properties originates from the nano-Al3Zr precipitates after T6 *** study provides a novel micro-mechanism and design strategy for simultaneously improving corrosion resistance and enhancing the mechanical properties of Al-Si-Cu-Mg cast alloy.

关键词： Al-Si-Cu-Mg alloy Zr addition Corrosion behavior Passive film

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