检索结果-南通市图书馆

Network analyses:Inhibition of androgen receptor signaling reduces inflammation in the lung through Ar-mAF-IL6 signaling axes

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 140-143页

作者： Albert r.Wang Andrew m.Baschnagel Zijian Ni Sean r.brennan hypatia K.Newton Darya Buehler Christina Kendziorski randall j.Kimple Gopal lyer Department of human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin Carbone Cancer Center MadisonWI 53705USA Department of Biostatistics and medical Informatics University of Wisconsin-MadisonMadisonWI 53706USA Department of Biology Tufts UniversityMedfordMA 02155USA Department of Pathology and Laboratory medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Androgen receptor(Ar)is a major transcription factor that plays a role in inflammatory response including interleukin-6(IL6)signaling.1 While Ar regulation through paracrine loop signaling in prostate tissue is well-studied,its impact through an IL6 autocrine loop in the lung has not been wellstudied despite the organ's response to respiratory viral *** inhibition and rNA knockdown of Ar identified a bZIP transcription factor mAF to be a common target of inflammation using these perturbations in lung cells.

关键词： inflammation lung respiratory

Evidence for particle acceleration approaching PeV energies in the W51 complex

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2024年第18期69卷 2833-2841页

作者： LhAASO Collaboration Zhen Cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.j.Bi Y.j.Bi W.Bian A.V.Bukevich Q.Cao W.Y.Cao Zhe Cao j.Chang j.F.Chang A.m.Chen E.S.Chen h.X.Chen Liang Chen Lin Chen Long Chen m.j.Chen m.L.Chen Q.h.Chen S.Chen S.h.Chen S.Z.Chen T.L.Chen Y.Chen N.Cheng Y.D.Cheng m.Y.Cui S.W.Cui X.h.Cui Y.D.Cui B.Z.Dai h.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan j.h.Fan Y.Z.Fan j.Fang j.h.Fang K.Fang C.F.Feng h.Feng L.Feng S.h.Feng X.T.Feng Y.Feng Y.L.Feng S.Gabici B.Gao C.D.Gao Q.Gao W.Gao W.K.Gao m.m.Ge L.S.Geng G.Giacinti G.h.Gong Q.B.Gou m.h.Gu F.L.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.han m.hasan h.h.he h.N.he j.Y.he Y.he Y.K.hor B.W.hou C.hou X.hou h.B.hu Q.hu S.C.hu D.h.huang T.Q.huang W.j.huang X.T.huang X.Y.huang Y.huang X.L.ji h.Y.jia K.jia K.jiang X.W.jiang Z.j.jiang m.jin m.m.Kang I.Karpikov D.Kuleshov K.Kurinov B.B.Li C.m.Li Cheng Li Cong Li D.Li F.Li h.B.Li h.C.Li jian Li jie Li K.Li S.D.Li W.L.Li W.L.Li X.r.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.j.Lin B.Liu C.Liu D.Liu D.B.Liu h.Liu h.D.Liu j.Liu j.L.Liu m.Y.Liu r.Y.Liu S.m.Liu W.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo h.K.Lv B.Q.ma L.L.ma X.h.ma j.r.mao Z.min W.mitthumsiri h.j.mu Y.C.Nan A.Neronov L.j.Ou P.Pattarakijwanich Z.Y.Pei j.C.Qi m.Y.Qi B.Q.Qiao j.j.Qin A.raza D.ruffolo A.Sáiz m.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu h.C.Song Yu.V.Stenkin V.Stepanov Y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun j.Takata P.h.T.Tam Q.W.Tang r.Tang Z.B.Tang W.W.Tian C.Wang C.B.Wang G.W.Wang h.G.Wang h.h.Wang j.C.Wang Kai Wang Kai Wang L.P.Wang L.Y.Wang P.h.Wang r.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.j.Wang Z.h.Wang Z.X.Wang Zhen Wang Zheng Wang D.m.Wei j.j.Wei Y.j.Wei T.Wen C.Y.Wu h.r.Wu Q.W.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi j.Xia G.m.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.r.Xiong Z.Xiong D.L.Xu r.F.Xu r.X.Xu W.L.Xu L.Xue D.h.Yan j.Z.Yan T.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang m.j.Yang r.Z.Yang W.X.Yang Y.h.Yao Z.G.Yao L.Q.Yin N.Yin X.h.You Z.Y.You Y.h.Yu Q.Yuan h.Yue h.D.Zeng T.X.Zeng W.Zeng m.Zha B.B.Zhang F.Zhang h.Zhang 不详 Key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic ray research Center ChengduChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear research of russian Academy of Sciences Moscow 117312Russia hebei Normal University Shijiazhuang 050024China University of Science and Technology of China Hefei 230026China State Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark matter and Space Astronomy&Key Laboratory of radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China Key Laboratory for research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Physics and Astronomy Yunnan UniversityKunming 650091China Key Laboratory of Cosmic rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays(Crs)accelerated by the shock of supernova remnant(SNr)W51C and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of W51C for Crs remains *** on observations conducted with the Large high Altitude Air Shower Observatory(LhAASO),we report a significant detection ofγrays emanating from the W51 complex,with energies from 2 to 200 *** LhAASO measurements,for the first time,extend theγ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 TeV or a power-law break at~200 TeV in the Cr proton spectrum,most likely providing the first evidence of SNrs serving as Cr accelerators approaching the PeV ***,two young star clusters within W51B could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme Cr accelerators within the W51 complex and provide new insights into the origin of Galactic Crs.

关键词： UhE c-ray Cosmic rays SNr W51C Star clusters

On an isotropic porous solid cylinder:the analytical solution and sensitivity analysis of the pressure

在线全文

学校读者我要写书评

暂无评论

Applied mathematics and mechanics(English Edition) 2024年第9期45卷 1499-1522页

作者： h.ASGhArI L.mILLEr r.PENTA j.mErODIO Departamento de matematica Aplicada a las TIC ETS de Ingenieria de Sistemas InformaticosUniversidad Politecnica de MadridMadrid 28031Spain School of mathematics and Statistics University of GlasgowGlasgow G128QQU.K.

Within this work,we perform a sensitivity analysis to determine the influence of the material input parameters on the pressure in an isotropic porous solid *** provide a step-by-step guide to obtain the analytical solution for a porous isotropic elastic cylinder in terms of the pressure,stresses,and elastic *** obtain the solution by performing a Laplace transform on the governing equations,which are those of Biot's poroelasticity in cylindrical polar *** enforce radial boundary conditions and obtain the solution in the Laplace transformed domain before reverting back to the time *** sensitivity analysis is then carried out,considering only the derived pressure *** analysis finds that the time t,Biot's modulus m,and Poisson's ratio ν have the highest influence on the pressure whereas the initial value of pressure P_(0) plays a very little role.

关键词： sensitivity analysis Laplace transform cylindrical polar coordinate Biot's modulus cylinder

由超拍电子伏特加速器产生的超高能伽马射线气泡

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2024年第4期69卷 449-457页

作者： LhAASO Collaboration Zhen Cao Chuandong Gao Cong Li ruo-Yu Liu ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic ray research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UhE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UhEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

光驱动rh/InGaN_(1-x)O_(x)纳米组装体甲烷干重整制合成气

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2024年第10期69卷 1400-1409页

作者：李亦昕李景林俞天奇邱亮 Syed m.Najib hasan 姚琳潘虎 Shamsul Arafin Sharif md.Sadaf 朱磊周宝文 Key Laboratory for Power machinery and Engineering of ministry of Education Research Center for Renewable Synthetic FuelSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China China-UK Low Carbon College Shanghai Jiao Tong UniversityShanghai 201306China Centre Energie Matériaux et TélécommunicationsInstitut National de la Recherche Scientifique(INRS)-Universitédu QuébecVarennes J3X 1E4Canada Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOH43210USA

Light-driven dry reforming of methane toward syngas presents a proper solution for alleviating climate change and for the sustainable supply of transportation fuels and ***,rh/InGaN_(1-x)O_(x) nanowires supported by silicon wafer are explored as an ideal platform for loading rh nanoparticles,thus assembling a new nanoarchitecture for this grand *** combination with the remarkable photothermal synergy,the O atoms in rh/InGaN_(1-x)O_(x) can significantly lower the apparent activation energy of dry reforming of methane from 2.96 eV downward to 1.70 *** as-designed rh/InGaN_(1-x)O_(x) NWs nanoarchitecture thus demonstrates a measurable syngas evolution rate of 180.9 mmol g_(cat)^(-1) h^(-1) with a marked selectivity of 96.3% under concentrated light illumination of 6 W cm^(-2).What is more,a high turnover number(TON)of 4182 mol syngas per mole rh has been realized after six reuse cycles without obvious activity *** correlative 18O isotope labeling experiments,in-situ irradiated X-ray photoelectron spectroscopy(ISI-XPS)and in-situ diffuse reflectance Fourier transform infrared spectroscopy characterizations,as well as density functional theory calculations reveal that under light illumination,rh/InGaN_(1-x)O_(x) NWs facilitate releasing^(*)Ch_(3) and h^(+)from Ch_(4) by holes,followed by h_(2) evolution from h^(+)reduction with ***,the O atoms in rh/InGaN_(1-x)O_(x) can directly participate in CO generation by reacting with the ^(*)C species from Ch_(4) dehydrogenation and contributes to the coke elimination,in concurrent formation of O *** resultant O vacancies are then replenished by CO_(2),showing an ideal chemical *** work presents a green strategy for syngas production via light-driven dry reforming of methane.

关键词： Dry reforming of methane Photo-thermal catalysis rh/InGaN_(1-x)O_(x)nanowires

modelling dynamic pantograph loads with combined numerical analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

railway Engineering Science 2024年第1期32卷 81-94页

作者： F.F.jackson r.mishra j.m.rebelo j.Santos P.Antunes j.Pombo h.magalhaes L.Wills m.Askill School of Computing and Engineering University of HuddersfieldHuddersfieldUK School of Computing and Engineering Institute of Railway ResearchUniversity of HuddersfieldHuddersfieldUK IDmEC Instituto Superior TecnicoUniversidade de LisboaLisbonPortugal ISEL Instituto Politecnico de LisboaLisbonPortugal hitachi rail Newton AycliffeUK Wabtec/Brecknell Willis ChardUK

Appropriate interaction between pantograph and catenary is imperative for smooth operation of electric *** heights of overhead lines to accommodate level crossings,overbridges,and tunnels pose significant challenges in maintaining consistent current collection performance as the pantograph aerodynamic profile,and thus aerodynamic load changes significantly with operational *** research aims to analyse the global flow characteristics and aerodynamic forces acting on individual components of an hSX pantograph operating in different configurations and orientations,such that the results can be combined with multibody simulations to obtain accurate dynamic insight into contact ***,computational fluid dynamics simulations are used to investigate the pantograph component loads in a representative setting,such as that of the recessed cavity on a Class 800 *** an aerodynamic perspective,this study indicates that the total drag force acting on non-fixed components of the pantograph is larger for the knuckle-leading orientation rather than the knuckle-trailing,although the difference between the two is found to reduce with increasing pantograph *** the aerodynamic loads acting on individual components with multibody tools allows for realistic dynamic insight into the pantograph *** results obtained show how considering aerodynamic forces enhance the realism of the models,leading to behaviour of the pantograph-catenary contact forces closely matching that seen in experimental tests.

关键词： Pantograph-catenary interaction Pantograph aerodynamics Computational fluid dynamics Pantograph loads Current collection performance

Greatly enhanced corrosion/wear resistances of epoxy coating for mg alloy through a synergistic effect between functionalized graphene and insulated blocking layer

在线全文

学校读者我要写书评

暂无评论

journal of magnesium and Alloys 2024年第1期12卷 332-344页

作者： Z.Y.Xue X.j.Li j.h.Chu m.m.Li D.N.Zou L.B.Tong School of metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Advanced Design and manufacturing for Vehicle Body Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of mg alloys seriously limit their potential applications in various *** conventional epoxy coating easily forms many intrinsic defects during the solidification process,which cannot provide sufficient *** the current study,we design a double-layer epoxy composite coating on mg alloy with enhanced anti-corrosion/wear properties,via the spin-assisted assembly *** outer layer is functionalized graphene(FG)in waterborne epoxy resin(WEP)and the inner layer is Ce-based conversion(Ce)*** FG sheets can be homogeneously dispersed within the epoxy matrix to fill the intrinsic defects and improve the barrier *** Ce film connects the outer layer with the substrate,showing the transition *** corrosion rate of Ce/WEP/FG composite coating is 2131 times lower than that of bare mg alloy,and the wear rate is decreased by~90%.The improved corrosion resistance is attributed to the labyrinth effect(hindering the penetration of corrosive medium)and the obstruction of galvanic coupling *** synergistic effect derived from the FG sheet and blocking layer exhibits great potential in realizing the improvement of multi-functional integration,which will open up a new avenue for the development of novel composite protection coatings of mg alloys.

关键词： mg alloy Functionalized graphene Epoxy coating Corrosion/wear resistance Blocking layer

miniSCIDOm: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches

在线全文

学校读者我要写书评

暂无评论

high Power Laser Science and Engineering 2024年第2期12卷 41-50页

作者： A.Corvino m.reimold E.Beyreuther F.-E.Brack F.Kroll j.Pawelke j.D.Schilz m.Schneider U.Schramm m.E.P.Umlandt K.Zeil T.Ziegler j.metzkes-Ng helmholtz-Zentrum Dresden–rossendorf DresdenGermany Technische Universität Dresden DresdenGermany Oncoray–National Center for radiation research in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Current affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Current affiliation:Universitätsklinikum Freiburg FreiburgGermany

Laser plasma accelerators(LPAs)enable the generation of intense and short proton bunches on a micrometre scale,thus offering new experimental capabilities to research fields such as ultra-high dose rate radiobiology or material *** spectrally broadband,laser-accelerated proton bunches allow for tailored volumetric dose deposition in a sample via single bunches to excite or probe specific sample *** rising number of such experiments indicates a need for diagnostics providing spatially resolved characterization of dose distributions with volumes of approximately 1 cm^(3) for single proton bunches to allow for fast online *** we present the scintillator-based miniSCIDOm detector for online single-bunch tomographic reconstruction of dose distributions in volumes of up to approximately 1 cm^(3).The detector achieves a spatial resolution below 500μm and a sensitivity of 100 *** detector performance is tested at a proton therapy cyclotron and an LPA proton *** experiments’primary focus is the characterization of the scintillator’s ionization quenching behaviour.

关键词： beam monitoring detectors laser-driven proton beams scintillator-based diagnostics ultra-high dose rate

微生物菌肥和腐植酸复合肥对百合生长和光合特性的影响

在线全文

学校读者我要写书评

暂无评论

中国农业科技导报 2024年

作者：吴小丹高丽巩天耕孔祥凤姜雨舟贾桂霞北京林业大学园林学院花卉种质创新与分子育种北京市重点实验室国家花卉工程技术研究中心城乡生态环境北京实验室林木花卉遗传育种教育部重点实验室北京花乡花木集团有限公司

为探索微生物菌肥和腐植酸复合肥对百合生长、光合特性及鳞茎品质的影响，并筛选适宜的施肥用量，以百合组培苗为材料，通过田间微区试验，设置8种处理，包括腐植酸复合肥10(F-1)、30(F-2)、50 g·m-2(F-3)，微生物菌肥30(j-1)、60(j-2)... 详细信息

为探索微生物菌肥和腐植酸复合肥对百合生长、光合特性及鳞茎品质的影响，并筛选适宜的施肥用量，以百合组培苗为材料，通过田间微区试验，设置8种处理，包括腐植酸复合肥10(F-1)、30(F-2)、50 g·m-2(F-3)，微生物菌肥30(j-1)、60(j-2)、90 g·m-2(j-3)，腐植酸复合肥30 g·m-2+微生物菌肥30 g·m-2(h)和清水对照（CK），对比分析不同处理对百合植株生长和光合特性的影响。结果表明，与CK相比，微生物菌肥和腐植酸复合肥不同程度地促进了百合地上和地下部分的生长发育，其中h处理显著增加了百合小鳞茎的周径、鲜重、根长、须根数和抽茎后植株的茎粗，分别是CK的1.76、3.78、1.61、1.85和1.58倍；施用微生物菌肥和腐植酸复合肥可显著提高百合叶片叶绿素含量和净光合速率（net photosynthetic rate,Pn），其中h处理的叶绿素a和叶绿素b含量最高，分别是CK的2.31和2.64倍，j-2和j-3处理的Pn最大，分别较CK高148.72%、172.96%；微生物菌肥处理的气孔导度（stomatalconductance,Gs）、蒸腾速率（transpirationrate,Tr）和水分利用率（wateruse efficiency,WUE）显著高于CK，而胞间CO2浓度（intercellular CO2 concentration,Ci）显著降低，其中，j-2处理的Gs和Tr最高，分别较CK高50.00%和65.47%。施加微生物菌肥和腐植酸复合肥可有效提高百合鳞茎的蔗糖、淀粉和可溶性蛋白质含量，其中F-3处理的蔗糖和蛋白质含量最高，j-3处理的淀粉含量最高，分别较CK增加17.97%、15.41%和9.20%。通过主成分分析和隶属函数得出，h处理下百合各指标的综合评价最好。综上所述，微生物菌肥和腐植酸复合肥可有效促进百合的生长发育和光合速率，提高鳞茎的产量和品质，二者配施对百合的生长效果最佳。研究结果为百合种球培育的施肥方法提供了理论依据和技术支撑。

关键词：百合微生物菌肥腐植酸复合肥鳞茎生长光合特性