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FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer

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World Journal of Clinical Oncology 2018年第5期9卷 110-118页

作者： CANDice Carola Fran?ois Ghiringhelli Stefano Kim Thierry ANDré Juliette Barlet Le?la Bengrine-Lefevre hélène marijon marie-Line garcia-Larnicol Christophe Borg Linda Dainese Nils Steuer hubert Richa magdalena Benetkiewicz Annette K Larsen Aimery de Gramont Benoist Chibaudel Department of medical Oncology Franco-British Institute Department of medical Oncology Centre George Fran?ois Leclerc Department of medical Oncology CHU Besan?on Department of medical Oncology Saint-Antoine Hospital and Sorbonne Universités UMPC Department of Anatomy-Pathology Paris Pathology Institute Department of Gastrointestinal Surgery Franco-British Institute Fondation ARCAD Cancer Biology and Therapeutics Centre de Recherche Saint-Antoine INSERM U938 Faculté de Médecine Sorbonne Université

AIm To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal *** This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3(day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m^2, irinotecan 90 mg/m^2, 5-fluorouracil infusion 2400 mg/m^2 per 46 h; day 3: irinotecan 90 mg/m^2) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate(ORR). Secondary endpoints were disease control rate(DCR), progression-free survival(PFS), overall survival(OS), and *** Among 74 patients treated in four French centers, nine were excluded due to prior use of aflibercept(n = 3), more than one prior treatment line in irinotecanna?ve patients(n = 3), and inadequate liver function(n = 3). In the "irinotecan-na?ve" patients(n = 30), ORR was 43.3% and DCR was 76.7%. median PFS and OS were 11.3 mo(95%CI: 6.1-29.0) and 17.0 mo(95%CI: 13.0-17.3), respectively. The most common(> 5%) grade 3-4 adverse events were diarrhea(37.9%), neutropenia(14.3%), stomatitis and anemia(10.4%), and hypertension(6.7%). In the "pre-exposed irinotecan" patients(n = 35), 20(57.1%) received ≥ 2 prior lines of treatment. ORR was 34.3% and DCR was 60.0%. median PFS and OS were 5.7 mo(95%CI: 3.9-10.4) and 14.3 mo(95%CI: 12.8-19.5), *** minimally modified FOLFIRI has improvement dramatically the FOLFIRI3-aflibercept efficacy, whatever prior use of irinotecan. A prospective randomized trial is warranted to compare FOLFIRI-aflibercept to FOLFIRI3-aflibercept.

关键词： Chemotherapy Irinotecan Aflibercept Second-line Colorectal cancer

Incidenee and time-varying predictors of hIV and sexually transmitted infections among male sex workers in mexico City

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Infectious Diseases of Poverty 2021年第1期10卷 36-45页

作者： Karla Y.Ganley marta Wilson-Barthes Andrew R.Zullo Sandra G.Sosa-Rubi Carlos J.Conde-Glez Santa garcia-Cisneros mark N.Lurie Brandon D.L.marshall Don Operario Kenneth h.mayer Omar Galarraga Department of Narrative medicine Columbia UniversityNew YorkNYUSA Department of Epidemiology School of Public HealthBrown UniversityProvide neeRlUSA Department of health Services Policyand PracticeSchool of Public HealthBrown University121 South Main StreetBox G-121S-2ProvidenceRl 02912USA National Institute of Public health(INSP) CuernavacaMorelosMexico Department of Behavioral and Social Science School of Public HealthBrown UniversityProvidenceRlUSA Fenway health and harvard University BostonMAUSA.

Background:male sex workers are at high-risk for acquisition of sexually transmitted infections(STIs),including human immunodeficiency virus(hIV).We quantified incidence rates of STIs and identified their time-varying predictors among male sex workers in mexico ***:From January 2012 to may 2014,male sex workers recruited from the largest hIV clinic and community sites in mexico City were tested for chlamydia,gonorrhea,syphilis,hepatitis,and hIV at baseline,6-months,and *** nee rates with 95%bootstrapped confide nee limits were *** examined potential timevarying predictors using generalized estimating equations for a population averaged ***:Among 227 male sex workers,median age was 24 and baseline hIV prevalence was 32%.Incidence rates(per 100 person-years)were as follows:hIV[5.23;95%confidence interval(CI):2.15-10.31],chlamydia(5.15;95%CI:2.58-9.34),gonorrhea(3.93;95%CI:1.88-7.83),syphilis(13.04;95%CI:8.24-19.94),hepatitis B(2.11;95%CI:0.53-4.89),hepatitis C(0.95;95%CI:0.00-3.16),any STI except hIV(30.99;95%CI:21.73-40.26),and any STI including hIV(50.08;95%CI:37.6062.55).In the multivariable-adjusted model,incident STI(excluding hIV)were lower among those who reported consistently using condoms during anal and vaginal intercourse(odds ratio=0.03,95%CI:0.00-0.68)compared to those who reported inconsistently using condoms during anal and vaginal ***:Incidence of STIs is high among male sex workers in mexico *** condom use is an important protective factor for STIs,and should be an important comp on ent of interventions to prevent incide nt infect i ons.

关键词： male sex worker men who have sex with men hIV Sexually transmitted infection Transmission Risk factor mexico

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mutations in foregut SOX2^+ cells induce efficient proliferation via CXCR2 pathway

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Protein & Cell 2019年第7期10卷 485-495页

作者： Tomoaki hishida Eric Vazquez-Ferrer Yuriko hishida-Nozaki Ignacio Sancho-martinez Yuta Takahashi Fumiyuki hatanaka Jun Wu Alejandro Ocampo Pradeep Reddy min-Zu Wu Laurie Gerken Reuben J. Shaw Concepcion Rodriguez Esteban Christopher Benner hiroshi Nakagawa Pedro Guillen garcia Estrella Nunez Delicado Antoni Castells Josep m. Campistol Guang-hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Advaneed Innovation Center for human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical University Beijing 100053 China National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of the Chinese Academy of Sciences Beijing 100049 China Insitute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101 China Beijing Institute for Brain Disorder Beijing 100069 China Universidad Catolica San Antonio de Murcia Campus de los Jeronimos 135 Guadalupe 30107 Spain molecular and Cell Biology Laboratory Dulbecco Center for Cancer Research Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA howard hughes medical Institute Dulbecco Center for Cancer Research Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Integrative Genomics Core Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Division of Gastroenterology Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Abramson Cancer Center University of Pennsylvania Philadelphia PA 19104 USA Department of Traumatology and Research Unit Clinica CEMTRO Av. Ventisquero de la Condesa 42 Madrid 28035 Spain Gastroenterology Department Hospital Clinic University of Barcelona IDIBAPS CIBEREHD Barcelona 08036 Spain

Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. here, we demonstrate that SOX2^+ foregut epithelial cells are prone to oncogenic transformation upon mutagenic insults, such as Kras^G12D and p53 deletion. GFP-based lineage-tracing experiments indicate that SOX2^+ cells are the cells-of-origin of esophagus and stomach hyperplasia. Our observations indicate distinct roles for oncogenic KRAS mutation and P53 deletion. p53 homozygous deletion is required for the acquisition of an invasive potential, and Kras^G12D expression, but not p53 deletion, suffices for tumor formation. Global gene expression analysis reveals secreting factors upregulated in the hyperplasia induced by oncogenic KRAS and highlights a crucial role for the CXCR2 pathway in driving hyperplasia. Collectively, the array of genetic models presented here demonstrate that stratified epithelial cells are susceptible to oncogenic insults, which may lead to a better understanding of tumor initiation and aid in the design of new cancer therapeutics.

关键词： Sox2 tumor CXCR2 stratified epithelia

Plasmid instability when the hsp60 gene promoter is used to express the protective non-toxic fragment B of the diphtheria toxin in recombinant BCG

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American Journal of molecular Biology 2013年第2期3卷 81-86页

作者： Dilzamar V.Nascimento Odir A.Dellagostin Raphael hirata Jr Geraldo m.B.Pereira Ana Luiza mattos-Guaraldi Geraldo R.garcia Armoa Faculdade de Ciencias médicas Universidade do Estado do Rio de JaneiroRio de JaneiroBrazil Centro de Biotecnologia Universidade Federal de PelotasCampus UniversitárioPelotasBrazil Instituto Oswaldo Cruz Fundacao Oswaldo CruzRio de JaneiroBrazil

The genetic modification of the live attenuated mycobacterium bovis BCG to deliver a protective Corynebacterium diphtheriae antigen in vivo could be a safer and less costly alternative to the new and more expensive DTP vaccines available today, in particular to third world-countries. The stability of expression of heterologous antigens in BCG, however, is a major challenge to the use of live recombinant bacteria in vaccine development and appears to be dependent to a certain extent, on a genetic compatibility between the expression cassette within the plasmid construct and the mycobacterium host. In the quest for the best recombinant BCG transformant to express the dtb gene of C. diphtheriae we generated two new rBCG strains by transforming the moreau substrain of BCG with the mycobacterial expression vectors pUS973 and pUS977, each one carrying a different promoter to drive the expression of the target antigen. After transformation recombinant BCG clones were selected on middlebrook 7h10 kanamycin Agar plates, expanded in middlebrook 7h9 kanamycin Broth and analyzed by agarose gel electrophoresis and immunoblotting. rBCGs transformed with the construct carrying the weak PAN promoter from m. paratuberculosis stably expressed the dtb gene. Conversely, rBCGs transformed with the construct carrying the strong mycobacterium hsp60 promoter were unstable and consequently unfit for the expression of the C. diphtheriae gene.

关键词： BCG Vaccine Recombinant BCG Fragment B of Diphtheria Toxin Anti-Diphtheria Vaccine

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溴甲烷熏蒸被地中海实蝇为害的草莓

植物检疫 1986年第2期 72-73页

作者： J.W.Armstrong E.L.Schneider D.L.garcia h.m.Couey 王跃进

就世界范围而言,地中海实蝇Ceratitis capitata (Wiedemann)被人们认为是温带和热带地区为害性最大的一种害虫。地中海实蝇虽然不喜欢寄生草莓。但草莓是它的一个寄主。美国农业部地中海实蝇扑灭计划报告(美国农业部,1930年)、Thiem(19... 详细信息

就世界范围而言,地中海实蝇Ceratitis capitata (Wiedemann)被人们认为是温带和热带地区为害性最大的一种害虫。地中海实蝇虽然不喜欢寄生草莓。但草莓是它的一个寄主。美国农业部地中海实蝇扑灭计划报告(美国农业部,1930年)、Thiem(1923)、Bohm(1958)和Baas(1959)、Kobayashi和Fujimoto(1975)等都报道过地中海实蝇为害草莓的情况。

关键词：地中海实蝇甲烷经过沼气烷烃熏蒸处理纤维板板材(木材)

A Study of Eruca vesicaria, Bromelia hemisphaerica and Erythrina americana as Green Corrosion Inhibitors for Carbon Steel in Sulfuric Acid

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Advances in materials Physics and Chemistry 2016年第2期6卷 9-20页

作者： m. J. garcia-Ramirez G. F. Dominguez Patiño J. G. Gonzalez-Rodriguez m. L. Dominguez-Patiño J. A. Dominguez-Patiño Centre for Engineering and Applied Science Morelos State Autonomous University Cuernavaca Mexico Faculty of Biological Sciences Morelos State Autonomous University Cuernavaca Mexico Faculty of Chemistry and Engineering Morelos State Autonomous University Cuernavaca Mexico

A study of Eruca vesicaria, Bromelia hemisphaerica and Erythrina americana as eco-friendly corrosion inhibitors for 1018 carbon steel in 0.5 m h2SO4 has been carried out by using weight loss tests, potentiodynamic polarization curves and electrochemical impedance spectroscopy measuremnts. Results have shown that the three extracts performed as good corrosion inhibitors, but the Eruca vesicaria exhibited the best performance followed by Erythrina americana. The three inhibitors formed a protective, passive film which protected the steel from corrosion. This was because they contain antioxidants present in their molecular structure with heteroatoms such as N, C and O like phenols, amino acids, etc., which react with metal and environment to form the protective film.

关键词： Acid Corrosion Green Inhibitors Electrochemical Techniques

Search for the doubly heavy baryons Ωbc0 and Ξbc0 decaying to Λc+π- and Ξc+π-

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Chinese Physics C 2021年第9期45卷 14-25页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva m.Adinolfi h.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio m.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov m.Andreotti F.Archilli A.Artamonov m.Artuso K.Arzymatov E.Aslanides m.Atzeni B.Audurier S.Bachmann m.Bachmayer J.J.Back P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista Leite R.J.Barlow S.Barsuk W.Barter m.Bartolini F.Baryshnikov J.m.Basels G.Bassi B.Batsukh A.Battig A.Bay m.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-haim A.Berezhnoy *** D.Berninghoff h.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian m.S.Bieker S.Bifani P.Billoir m.Birch F.C.R.Bishop A.Bitadze A.Bizzeti m.Bj?rn m.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi m.Borisyak m.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi m.J.Bradley S.Braun A.Brea Rodriguez m.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu h.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine m.Calvi m.Calvo Gomez P.Camargo magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse m.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick m.G.Chapman m.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas m.Chefdeville C.Chen S.Chen A.Chernov V.Chobanova S.Cholak m.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone m.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke m.Clemencic h.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.m.Costa Sobral B.Couturier D.C.Craik J.Crkovská m.Cruz Torres R.Currie C.L.Da Silva E.Dall'Occo J.Dalseno C.D'Amb University of Edinburgh horia hulubei National Institute of Physics and Nuclear Engineering INFN Sezione di Bari Università di Bari Los Alamos National Laboratory (LANL) Van Swinderen Institute University of Groningen Universiteit maastricht AGh-University of Science and Technology Faculty of Physics and Applied Computer Science Université Clermont Auvergne Università di Cagliari Institute for Nuclear Research of the National Academy of Sciences (KINR) School of Physics University College Dublin NSC Kharkiv Institute of Physics and Technology (NSC KIPT) INFN Sezione di Perugia STFC Rutherford Appleton Laboratory School of Physics and Astronomy monash University Novosibirsk State University CNRS/IN2P3 Department of Physics and Astronomy Uppsala University Università di Genova School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University National Center for Nuclear Research (NCBJ) Università di Roma Tor Vergata Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio) Universidade Federal do Triangulo mineiro (UFTm) Institute of Particle Physics LPC Central China Normal University hangzhou Institute for Advanced Study UCAS Instituto de Fisica Corpuscular Centro mixto Universidad de Valencia-CSIC Nikhef National Institute for Subatomic Physics and VU University Amsterdam National Research Tomsk Polytechnic University AGh-University of Science and Technology Faculty of Computer Science Electronics and Telecommunications University of michigan Università di Siena Università di Padova Scuola Normale Superiore National Research Centre Kurchatov Institute Università degli Studi di milano mSU-Iligan Institute of Technology (mSU-IIT) Università di Firenze INFN Sezione di Roma La Sapienza Institut für Physik Universit?t Rostock INFN Sezione di milano Departamento de Fisica Universidad Nacional de Colombia Universit?t Bonn-helmholtz-Institut für Strahlen und Kernphysik hanoi University of Science Università di Pisa P.N. Lebedev Physical Institute Russian Academy of Science (LPI RAS) Università

The first search for the doubly heavy Ωbc0baryon and a search for the Ξbc0baryon are performed using pp collision data collected via the LhCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 *** baryons are reconstructed via their decays to ∧c+π-andΞc+π-.No significant excess is found for invariant masses between 6700 and 7300 meV/c2,in a rapidity range from2.0 to 4.5 and a transverse momentum range from 2 to 20 meV/*** limits are set on the ratio of the Ωbc0andΞbc0production cross-section times the branching fraction to ∧c+π-（Ξc+π-） relative to that of the ∧b0（Ξb0） baryon,for different lifetime hypotheses,at 95% confidence *** upper limits range from 0.5×10-4to 2.5×10-4for theΩbc0→∧c+π-(Ξbc0→∧c+π-) decay,and from 1.4×10-3to 6.9×10-3for the Ωbc0→Ξc+π-(Ξbc0→Ξc+π-) decay,depending on the considered mass and lifetime of the Ωbc0(Ξbc0) baryon.

关键词： B physics quarkonium spectroscopy heavy quark production

measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

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Chinese Physics C 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg h.Aihara N.Akopov A.Aloisio F.Ameli L.Andricek N.Anh Ky D.m.Asner h.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.m.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal m.Barrett J.Baudot A.Beaulieu J.Becker P.K.Behera J.V.Bennett E.Bernieri F.U.Bernlochner m.Bertemes m.Bessner S.Bettarini V.Bhardwaj F.Bianchi T.Bilka S.Bilokin D.Biswas G.Bonvicini A.Bozek m.Bračko P.Branchini N.Braun T.E.Browder A.Budano S.Bussino m.Campajola L.Cao G.Casarosa C.Cecchi D.Červenkov m.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin h.-E.Cho K.Cho S.Cho S.-K.Choi S.Choudhury D.Cinabro L.Corona L.m.Cremaldi S.Cunliffe T.Czank F.Dattola E.De La Cruz-Burelo G.De Nardo m.De Nuccio G.De Pietro R.de Sangro m.Destefanis S.Dey A.De Yta-hernandez F.Di Capua S.Di Carlo J.Dingfelder Z.Doležal I.Domínguez Jiménez T.V.Dong K.Dort S.Dubey S.Duell S.Eidelman m.Eliachevitch T.Ferber D.Ferlewicz G.Finocchiaro S.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom m.Gabriel E.Ganiev m.garcia-hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich J.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald C.hadjivasiliou S.halder K.hara T.hara O.hartbrich K.hayasaka h.hayashii C.hearty m.T.hedges I.heredia de la Cruz m.hernández Villanueva A.hershenhorn T.higuchi E.C.hill h.hirata m.hoek S.hollitt T.hotta C.-L.hsu Y.hu K.huang T.Iijima K.Inami G.Inguglia J.Irakkathil Jabbar A.Ishikawa R.Itoh m.Iwasaki Y.Iwasaki S.Iwata P.Jackson W.W.Jacobs D.E.Jaffe E.-J.Jang h.B.Jeon S.Jia Y.Jin C.Joo J.Kahn h.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki h.Kichimi C.Kiesling B.h.Kim C.-h.Kim D.Y.Kim S.-h.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno S.Korpar D.Kotchetkov N.Kovalchuk T.m.G.Kraetzschmar P.Križan R.Kroeger J.F.Krohn P.Krokovny W.Kuehn T.Kuhr m.Kumar R.Kumar K.Kumara S.Kurz A.Kuzmin Y.-J.Kwon S.Lacaprara Y.-T.Lai C.La Licata K.Lalwani L.Lanceri J.S.Lange K.Lautenbach I.-S.Le Beihang University Beijing 100191 Brookhaven National Laboratory UptonNew York 11973 Budker Institute of Nuclear Physics SB RAS Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 Faculty of mathematics and Physics Charles University12116 Prague Chiba University Chiba 263-8522 Consejo Nacional de Ciencia y Tecnología Mexico City 03940 Deutsches Elektronen–Synchrotron 22607 Hamburg Duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum Jülich 52425 Jülich Department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of Nuclear Physics and Ion-beam Application(mOE)and Institute of modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced Studies(SOKENDAI) Hayama 240-0193 Gyeongsang National University Jinju 52828 Department of Physics and Institute of Natural Sciences Hanyang UniversitySeoul 04763 high Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 J-PARC Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and Research mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology hyderabad Telangana 502285 Indian Institute of Technology madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for high Energy Physics Protvino 142281 Institute of high Energy Physics Vienna 1050 Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica Corpuscular Paterna 46980 INFN Laboratori Nazionali di Frascati I-00044 Frascati INFN Sezione di Napoli I-80126 Napoli INFN Sezione di Padova I-35131 Padova INFN Sezione di Perugia I-06123 Perugia

From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

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对完成最初化疗方案后6～12个月内复发的卵巢癌患者进行卡培他滨治疗的Ⅱ期临床试验,并探讨TS、DDP、TP与治疗的关系:妇科肿瘤组的一项研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 42-43页

作者： garcia A.A. Blessing J.A. Lenz h.-J. 王婷婷 Breast Cancer Program Cedars Sinai Medical Center Women' s Cancer Research Institute 8700 Beverly Boulevard Los Angeles CA 90048 United States

Purpose. A phase II trial was conducted to evaluate the antitumor activity and adverse effects of capecitabine in women with measurable platinum- sensitive ovarian cancer or platinum- sensitive primary peritoneal cancer and to explore the ability of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and thymidine phosphorylase (TP) to predict response and toxicities. Experimental design. Patients were treated with a daily starting dose of 2500 mg/m2/day (divided in two doses given every 12 h) for 14 days of each 21- day cycle. Genotyping in the 5′ and 3′ ends of TS was performed in DNA from 23/23 pre- treatment blood specimens. Relative gene expression of TS, DPD, and TP was quantified in 18/21 paraffin- embedded tumor specimens. Results. Of the 27 patients enrolled on study, 2 were never treated leaving 25 patients evaluable. Two patients (8.0% ) achieved a partial response, 13 (52% ) exhibited stable disease, 5 (20% ) displayed increasing disease, and response could not be assessed in 5 (20% ). The median time to progression and survival was 3.9 and 21.2 months, respectively. The most common serious toxicities were nausea/vomiting, gastrointestinal, and dermatological. There was one treatment- related death. TS expression was associated with severe nausea/vomiting (P = 0.039), but not with other severe toxicities. TS genotype or expression of DPD or TP was not associated with any of the severe toxicities. Conclusions. Based on the low response rate, this trial was closed after the first stage of accrual, the drug was not selected for further study in this patient population, and biomarker associations with response could not be assessed.

关键词：妇科肿瘤卡培他滨 DDP TP TS Ⅱ期临床试验肿瘤标本毒性反应生物学指标磷酸化酶

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