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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina hromada Patrick heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes c.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department Life Science engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGcs). however, the use of tNGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGcs and compared the various features of these improved silk^(+) tNGcs with the tubes without holes(silk^(–) tNGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Estimates for the Maximal Bilinear Singular Integral Operators

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Acta Mathematica Sinica,english Series 2015年第5期31卷 847-862页

作者： Guo en hU Department of Applied Mathematics Zhengzhou Information Science and Technology Institute

In this paper, the behavior on the product of Lebesgue spaces is considered for the maximal operators associated with the bilinear singular integral operators whose kernels satisfy certain minimal regularity conditions.

关键词： Bilinear singular integral operator maximal operator multilinear interpolation calderon-Zygmund decomposition

MAO Ze-dong's View on Traditional chinese Medicine and Its Modern Significance

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chinese Journal of Integrative Medicine 2020年第6期26卷 469-472页

作者： LI en-chang Wenzhou Medical University WenzhouZhejiang Province(325035)China

MAO Ze-dong's view on traditional chinese medicine(TcM)can be divided into the scientific view on TcM,the development view on TcM and the future view on *** core of MAO Ze-dong's view on TcM lies in its scientific *** basic content of MAO Ze-dong's development view on TcM includes unity of TcM and Western medicine(WM),advocating the multi-angle development of TcM from the height of chinese national dignity,independence and *** Ze-dong's future view on TcM is targeted at WM learning from TcM,integrating TcM and WM and establishing new chinese *** contemporary enlightenment of MAO Ze-dong's view on TcM is to start from reforming the medical education system before establishing new chinese medicine.

关键词： MAO Ze-dong view on traditional chinese medicine(TcM) scientific view on TcM development view on TcM future view on TcM Western medicine learning from TcM

Solitary Excitations of Dipolar Bosons in Optical Lattice under Magnetic Fields

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communications in Theoretical Physics 2006年第2X期46卷 233-238页

作者： WANG Shi-en Department of Physics Honghe University Mengzi 661100 China Department of Materials Tsinghua University Beijing 100084 China Department of Physics Wenshang Normal Academy Wenshaag 663000 China Department of Physics Beijing Normal University Beijing 100875 China

We obtain the multisolitary solutions of the extended Bose-hubbard model which describes dipolar Bose- Einstein condensates in optical lattices under time-dependent magnetic fields, and indicate that the nonlinearity is due to both on-site short-range interactions and also （long-range） dipole-dipole interactions which can act between neighboring sites. The discrete breathers as nonlinear excitations are always oscillatory in time and can also be spatially localized, while the oscillatory frequencies are determined by an external field. We show that these excitations will be observable and discuss how the parameters can be tuned in future experiments.

关键词： solitary excitation extended Bose-hubbard model bosons optical lattice

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： hauser sclerosis damage

On the Variation of a Metric and Its Application

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Acta Mathematica Sinica,english Series 2010年第10期26卷 2003-2014页

作者： Fa en WU Department of Mathematics School of Science Beijing Jiaotong University Beijing 100044 P. R. China

Some of the variation formulas of a metric were derived in the literatures by using the local coordinates system, In this paper, We give the first and the second variation formulas of the Riemannian curvature tensor, Ricci curvature tensor and scalar curvature of a metric by using the moving frame method. We establish a relation between the variation of the volume of a metric and that of a submanifold. We find that the latter is a consequence of the former. Finally we give an application of these formulas to the variations of heat invariants. We prove that a conformally flat metric g is a critical point of the third heat invariant functional for a compact 4-dimensional manifold M, then （M, g） is either scalar flat or a space form.

关键词： Riemannian functional variation of a metric volume variation space form heat invariant

Effects of heat Treatment and Thermal cycling on Martensitic Transformation Behavior of Ni_(59)Al_(11)Mn_(30) high Temperature Shape Memory Alloy

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材料热处理学报 2004年第5期25卷 147-151页

作者： heZhi-rong ZhouJing-en ShaanxiUniversityofTechnology Hanzhong723003China Xi＇anJiaotongUniversity Xi＇an710049China

A reversible martensitic transformation (MT) takes place during cooling and heating in the solution quenched and the solution quenched plus aged Ni59AlhMn30 alloy The MT temperature increases with increasing solution temperature. The excellent MT characteristics can be obtained from a process of lOOcTc solution quenched plus 400 °c aged. Follow this process, the MT start temperature (Ms) and the reverse MT finish temperature (Af) are 469*c and 548"c, respectively. The martensitic stabilization effect in the solution quenched and aged Ni59AlnMn3o alloy is observed as an increase in the Af temperature of the first reverse MT during thermal cycles. This stabilization effect vanishes from the second thermal cycle. Thermal cycling can enhance the stability of the reversible MT. The microstructure of the quenched NisgAlnMnjo alloy consists of martensite (M) and gamma phase. The volume fraction of gamma phase is about 40%. The substructure of M and gamma phase is twins and dislocations, respectively. The hardness of M is higher than that of gamma phase. After aging treatment the basic phases of alloy do not change, but the hardness of the phases increases.

关键词：热处理马氏体转变形状记忆合金热循环 Ni59Al11Mn30

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MScs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSc *** increasing number of pre-clinical studies suggest that delivering in vivo an MSc-conditioned medium(i.e.,the medium collected from MSc cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

A Unified and Explicit construction of N-Soliton Solutions for the Nonlinear Schrfdinger Equation

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communications in Theoretical Physics 2001年第10期36卷 401-404页

作者： FAN en-Gui Institute of Mathematics Fudan University Shanghai 200433 China

An explicit N-fold Darboux transformation with multiparameters for nonlinear Schrodinger equation is constructed with the help of its Lax pairs and a reduction technique. According to this Darboux transformation, the solutions of the nonlinear Schrfdinger equation are reduced to solving a linear algebraic system, from which a unified and explicit formulation of N-soliton solutions with multiparameters for the nonlinear Schrfdinger equation is given.

关键词： Schrodinger equation, N-fold Darboux transformation, N-soliton solutions