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Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

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A modified averaging scheme with application to the secondary hopf bifurcation of a delayed van der Pol oscillator

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Acta Mechanica Sinica 2008年第4期24卷 449-454页

作者： z.h.Wang h.y.hu Institute of Sciences PLA University of Science and Technology Nanjing 211101 China Institute of Vibration Engineering Research Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

In this paper, a modified averaging scheme is presented for a class of time-delayed vibration systems with slow variables. The new scheme is a combination of the averaging techniques proposed by hale and by Lehman and Weibel, respectively. The averaged equation obtained from the modified scheme is simple enough but it retains the required information for the local nonlinear dynamics around an equilibrium. As an application of the present method, the delay value for which a secondary hopf bifurcation occurs is successfully located for a delayed van der Pol oscillator.

关键词： Time delay ·Secondary hopf bifurcation·The averaging technique van der Pol oscillator

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A hOMOTOPy METhOD OF SWITChING SOLUTION BRANChES AT ThE PITChFORK BIFURCATION POINT

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Journal of Computational Mathematics 2001年第3期19卷 299-308页

作者： Cong, y.-h. zhu, z.-y. College of Mathematical Sciences Shanghai Teachers University Shanghai 200234 China

Provides information on a study which proposed a continuation method for switching solution branches at a pitchfork point. Problem of the standard pitchfork; Information on the systems of equations; Numerical examples... 详细信息

关键词： homotopy method switching solution branches pitchfork point

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Synthesis of self-assembled nanorod vanadium oxide bundles by sonochemical treatment

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Journal of Natural Gas Chemistry 2009年第3期18卷 312-318页

作者： y.h.Taufiq-yap y.C.Wong z.zainal M.z.hussein Centre of Excellence for Catalysis Science and Technology Faculty of ScienceUniversiti Putra Malaysia Department of Chemistry Faculty of ScienceUniversiti Putra Malaysia

Self-assembled nanorod of vanadium oxide bundles were synthesized by treating bulk V2O5 with high intensity sonochemical technique. The synthesized materials were characterized by X-ray diffraction （XRD）, scanning electron microscope （SEM）, transmission electron microscope （TEM） and temperature-programmed reduction （TPR） in h2. Catalytic behaviour of the materials over anaerobic n-butane oxidation was studied through temperature-programmed reaction （TPRn）. Catalytic evaluation of the sonochemical treated V2O5 products was also studied on microreactor. XRD patterns of all the vanadium samples were perfectly indexed to V2O5. The morphologies of the nanorod vanadium oxides as shown in SEM and TEM depended on the duration of the ultrasound irradiation. Prolonging the ultrasound irradiation duration resulted in materials with uniform, well defined shapes and surface structures and smaller size of nanorod vanadium oxide bundles. h2-TPR profiles showed that larger amount of oxygen species were removed from the nanorod V2O5 compared to the bulk. Furthermore, the nanorod vanadium oxide bundles, which were produced after 90, 120 and 180 min of sonochemical treatment, showed an additional reduction peak at lower temperature （-850 K）, suggesting the presence of some highly active oxygen species. TPRn in n-butane/he over these materials showed that the nanorod V2O5 with highly active oxygen species showed markedly higher activity than the bulk material, which was further proven by catalytic oxidation of n-butane.

关键词： nanorod vanadium oxide sonochemical treatment butane oxidation

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Rational design of AgGaS/znS/znS quantum dots with a near-unity photoluminescence quantum yield via double shelling scheme

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Journal of Materials Science & Technology 2024年第2期169卷 235-242页

作者： h.X.Lu h.Liu z.z.Fu y.y.Chen h.Q.Dai z.hu W.L.zhang R.Q.Guo Institute for Electric Light Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future Lighting Academy for Engineering and TechnologyFudan UniversityShanghai 200433China yiwu Research Institute of Fudan University YiwuZhejiang 322000China zhongshan-Fudan Joint Innovation Center Zhongshan 528437China

In this study,a two-step method was used to synthesize highly luminescent AgGaS/znS/znS quantum dots(QDs).In the first step,an inner znS shell was formed via a one-pot method,which resulted in a smaller lattice mismatch between the AgGaS core and the outer znS shell,thereby facilitating the formation of a thick outer *** the two-step shelling process,the synthesized AgGaS/znS/znS QDs showed an excellent photoluminescence quantum yield(PLQy)of 96.4%with a peak wavelength of 508 nm,repre-senting the highest PLQy reported thus far for AgGaS ***,the effect of halogen ions in zn precursors on the shelling process was *** was proposed that the capacity of halogen ions to coordinate with the QDs influenced the balance between zn cation diffusion and znS shelling ***,the znS shelling reaction was dominant when znCl_(2)was employed,while zn cation diffusion was the dominant process under the I^(−)-rich *** work provides insights into the interfacial restructuring during the znS shelling and offers a clear map for the tailored synthesis of core/shell QDs.

关键词： AgGaS Quantum dots Photoluminescence Core/shell Alloyed core/shell interface

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INVESTIGATION OF LASER BEAM WELDING PROCESS OF Az61 MAGNESIUM-BASED ALLOy

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Acta Metallurgica Sinica(English Letters) 2006年第4期19卷 287-294页

作者： h.y. Wang z.J. Li Industrial Center Shenzhen Polytechnic Shenzhen 518055 China

Laser welling process of Az61 magnesium alloys is investigated using a special CO2 laser experimental system. The effect of processing parameters including laser power, welling speed, and protection gas flow at the top and bottom is researched. The results show that an ideal well bead can be formed by choosing the processing parameters properly. An optimized parameter range is obtained by a large number of experiments. Among them, laser power and welling speed are the two main parameters that determine the well width and dimensions. The protect gas flow rate has a slight effect on the well width, but it directly effects the surface color of the well. The test results for typical welds indicate that the microhardness and tensile strength of the well zone are better than that of the base metal A fine-grained well region has been observed and no obvious heat-affected zone is found. The well zone mainly consists of small α-Mg phase, （α ＋ Al12Mg17）, and other eutectic phases. The small grains and the eutectic phases in the joint are believed to play an important role in the increase of the strength of wells for Az61 magnesium alloys.

关键词： magnesium alloy laser beam welding laser power welling speed

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Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS heterojunction with photothermal effect for efficient photocatalytic hydrogen production

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Journal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.y.huang z.yang S.y.yang z.h.Dai y.J.Liu J.h.Liao G.y.zhong z.J.Xie y.P.Fang S.S.zhang Key Laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic *** photocatalysts with full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heterojunction catalyst is obtained by in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous *** unique 2D/2D structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the ***,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite catalyst with photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS *** study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.

关键词： Two-dimensional structure heterostructure Photothermal effect Photocatalyst hydrogen evolution

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Dispersion and Damage of Carbon Nanotubes in Carbon Nanotube/7055Al Composites During high-Energy Ball Milling Process

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Acta Metallurgica Sinica(English Letters) 2021年第2期34卷 196-204页

作者： S.Bi B.L.Xiao z.h.Ji B.S.Liu z.y.Liu z.y.Ma Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of Material Science and Engineering University of Science and Technology of China72 Wenhua RoadShenyang 110016China AVIC Manufacturing Technology Institute Beijing 100024China

high-energy ball milling(hEBM)combined with powder metallurgy route was used to fabricate carbon nanotube(CNT)reinforced 7055 Al *** powder morphology evolution processes(hEBM-1 and hEBM-2)were designed to investigate the dispersion and damage of CNTs during hEBM ***-1 evolution process involved powder fl attening,cold-welding and fracture,while hEBM-2 evolution process consisted of powder fl attening and *** hEBM-1,the repetitive fracture and cold-welding process was effective for dispersing ***,the powder fl attening process in hEBM-2 was unsuccessful in dispersing CNTs due to two reasons:(1)the thickness of fl aky Al powders exceeded the critical value,and(2)the clustered CNTs embedded in fl aky Al powders could not be *** of the broadening of D band and the appearance of a new defect-related D’band,product of I D/I G and full width half maximum of D band,rather than I D/I G,was used to evaluate the actual damage of *** indicates that the damage of CNTs was severe in powder fl attening and fracture stages,while the damage of CNTs was small in powder cold-welding stage.

关键词： Metal matrix composites Carbon nanotubes Powder evolution Dispersion and damage Powder metallurgy

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Reactive destabilization and bidirectional catalyzation for reversible hydrogen storage of LiBh_(4) by novel waxberry-like nano-additive assembled from ultrafine Fe_(3)O_(4) particles

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Journal of Materials Science & Technology 2024年第6期173卷 63-71页

作者： S.Wang M.h.Wu y.y.zhu z.L.Li y.X.yang y.z.Li h.F.Liu M.X.Gao Department of Material Science Shenzhen MSU-BIT UniversityShenzhen 518172China State Key Laboratory of Silicon and Advanced Semiconductor Materials&School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Institute of Resources Utilization and Rare Earth Development State Key Laboratory of Rare Metals Separation and Comprehensive UtilizationGuangdong Provincial Key Laboratory of Rare Earth Development and ApplicationGuangdong Academy of SciencesGuangzhou 510650China Institute of Science and Technology for New Energy Xi’an Technological UniversityXi’an 710021China National Supercomputing Center in Shenzhen Shenzhen 518055China

LiBh_(4) containing 18.5 wt.%h_(2) is an attractive high-capacity hydrogen storage material,however,it suffers from high operation temperature and poor ***,a novel and low-cost bifunctional additive,waxberry-like Fe_(3)O_(4) secondary nanospheres assembled from ultrafine primary Fe_(3)O_(4) nanoparticles,is synthesized,which exhibits significant destabilization and bidirectional catalyzation towards(de)hydrogenation of LiBh_(4).With an optimized addition of 30 wt.% waxberry-like Fe_(3)O_(4),the system initiated dehydrogenation below 100℃ and released a total of 8.1 wt.%h_(2) to 400℃.After 10 cycles,a capacity retention of 70% was achieved,greatly superior to previously reported oxides-modified *** destabilizing and catalyzing mechanisms of waxberry-like Fe_(3)O_(4) on LiBh_(4) were systematically analyzed by phase and microstructural evolutions during dehydrogenation and hydrogenation cycling as well as density functional theory(DFT)*** present work provides new insights in developing advanced nano-additives with unique structural and multifunctional designs towards LiBh4 hydrogen storage.

关键词： LiBh_(4) hydrogen storage Waxberry-like Fe_(3)O_(4) Destabilization Catalysis

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Enhancing strength and ductility of AlSi10Mg fabricated by selective laser melting by TiB_(2)nanoparticles

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Journal of Materials Science & Technology 2022年第14期109卷 254-266页

作者： y.K.Xiao h.Chen z.y.Bian T.T.Sun h.Ding Q.yang y.Wu Q.Lian z.Chen h.W.Wang State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240China School of Materials Science&Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In the metallic components fabricated by the emerging selective laser melting(SLM)technology,most strategies used for strengthening the materials sacrifice the ductility,leading to the so-called strengthductility *** the present study,we report that the strength and ductility of materials can be enhanced simultaneously by introducing nanoparticles,which can break the trade-off of the metallic *** the case of in-situ nano-TiB_(2)decorated AlSi10Mg composites,the introduced nanoparticles lead to columnar-to-equiaxed transition,grain refinement and texture *** increasing content of nanoparticles,the strength increases ***,the ductility first increases and then *** results show that the ductility is controlled by the competition between the crack-induced catastrophic fracture and ductile fracture associated with dislocation *** first increase of ductility is mainly attributed to the suppression of crack-induced catastrophic fracture when TiB_(2)nanoparticles *** the further increase of TiB_(2)nanoparticles,the subsequent decrease of ductility is mainly controlled by dislocation ***,the materials will exhibit the optimum strength and ductility combination in a certain range of TiB_(2)*** study clarifies the physical mechanism controlling ductility for nano-TiB_(2)decorated Al Si10Mg composites,which provides the insights for the design of structural materials.

关键词： Selective laser melting Aluminium matrix composites Ductility Mechanical behavior Dislocations Cracks

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