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Orexin-a regulates body temperature in coordination with control of arousal state

中国病理生理杂志 2001年第8期 77-78页

作者： G.Yoshimichi h.yoshimatsu T.Masaki T.Sakata Department of Internal Medicine I School of Medicine Oita Medical University Oita Japan

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Music effect on pain threshold evaluated with current perception threshold

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中国病理生理杂志 2001年第8期 78-79页

作者： T.Fukagawa K.Fukagawa K.Goto h.yoshimatsu T.Sakata First Department of Internal Medicine Oita Medical University Oita-gun Oita 879-5593 Japan

AIM: Music relieves anxiety and psychotic tension. This effect of music is applied to surgical operation in the hospital and dental office. It is still unclear whether this music effect is only limited to the psychological aspect but not to the physical aspect or whether its music effect is influenced by the mood or emotion of audience. To elucidate these issues, we evaluated the music effect on pain threshold by current perception threshold (CPT) and profile of mood states (POMC) test. METhODS: healthy 30 subjects (12 men, 18 women, 25-49 years old, mean age 34.9) were tested. (1)After POMC test, all subjects were evaluated pain threshold with CPT by Neurometer (Radionics, USA) under 6 conditions, silence, listening to the slow tempo classic music, nursery music, hard rock music, classic paino music and relaxation music with 30 seconds interval. (2)After Stroop color word test as the stresser, pain threshold was evaluated with CPT under 2 conditions, silence and listening to the slow tempo classic music. RESULTS: Under litening to the music, CPT sores increased, especially 2 000 hz level related with compression, warm and pain sensation. Type of music, preference of music and stress also affected CPT score. CONCLUSION: The present study demonstrated that the concentration on the music raise the pain threshold and that stress and mood influence the music effect on pain threshold.

关键词： Music effect on pain threshold evaluated with current perception threshold

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Anti-obesity and anti-diabetic actions of histamine neurons

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中国病理生理杂志 2001年第9期17卷 923-923页

作者： T.Sakata T.Masaki h.yoshimatsu

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Orexin -Aregulates body temperature in coordination with control of arousal state

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中国病理生理杂志 2001年第9期17卷 925-925页

作者： G.Yoshimichi h.yoshimatsu T.Masaki T.Sakata

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Neuronal histamine decreases fat accumulation and up-regulates UCP family in db/db obese mice

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中国病理生理杂志 2001年第8期 71-71页

作者： D.Tajima T.Masaki h.yoshimatsu T.Sakata Department of Internal Medicine I School of Medicine Oita Medical University Oita Japan

To examine anti-obesity and-diabetic effects of neuronal histamine especially in leptin resistant states, we investigated the effects of chronic central treatment with histamine on lipid, glucose and energy metabolism of db/db obese mice, which are genetically leptin receptor mutated mice. Chronic centrally treatment with histamine (0.05 μmol*g-1 body weight*d-1 for 7 days) decreased body weight, food intake in db/db obese mice, and decreased body fat weight, serum concentration of glucose compared with pair-fed db/db obese mice. Neuronal histamine also suppressed ob　mRNA in the white adipose tissue (WAT), serum leptin and increased UCPs mRNA expression in brown adipose tissue (BAT) and in WAT compared with pair-fed controls. These above effects of the histamine were attenuated in these mice with combination of targeted disruption of the histamine h1 receptor gene. In conclusion, neuronal histamine can regulate body fat deposition, serum glucose, leptin, BAT and WAT UCPs expression even in leptin insensitive db/db obese mice.

关键词： UCP Neuronal histamine decreases fat accumulation and up-regulates UCP family in db/db obese mice

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Troglitazone prevented the development of fatty liver under obese and diabetic condition in Otsuka Long-Evans Tokushima fatty rats

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中国病理生理杂志 2001年第8期 70-70页

作者： h.Sakino M.Ookuma S.Fukuchi S.hidaka h.yoshimatsu T.Sakata T.Okeda Department of Internal Medicine I Gerontological Nursing Oita Medical University Oita Japan

We aimed to clarify the effects of troglitazone to prevent the development of fatty liver in Otsuka Long-Evans Tokushima fatty (OLETF) rats, an obese type2 diabetes model. Treatment of 0.2% troglitazone for 16 weeks significantly decreased blood glucose, serum insulin and free fatty acid (FFA) concentration (P＜0.05 for each) in the OLETF rats leaving their food intake, body weight and general fat pad weight unaffected compared with those of their lean littermates, Long-Evans Tokushima Otsuka (LETO) rats. Troglitazone restored increase in liver weight and hepatic triglyceride(TG) content of the OLETF rats (P＜0.05 for each). These findings were accertained by histological examination which showed that fat deposition, necrosis and vacuolization of hepatocyte, markers for fatty liver, were diminished by troglitazone treatment. Messenger RNA expression of microsomal triglyceride transfer protein in the liver, a marker for hepatic TG output, was not significantly different between OLETF and LETO rats with or without troglitazone treatment. Fatty acid composition such as C18∶1(oleic acid) showed no remarkable change after troglitazone treatment in OLETF rats, indicating no dietary influence to hepatic lipogenesis. These indicate that reduction in circulating FFA level may be one of the main mechanisms for troglitazone to prevent the development of insulin resistance and fatty liver.

关键词： Long

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The feeding behavior of cross-intestine parabiotic rats are modulated by brain histamine

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中国病理生理杂志 2001年第8期 77-77页

作者： h.Noguchi h.Koopmans h Tanaka T.Fukagawa K.Goto K.Fukagawa h.yoshimatsu T.Sakata Department of Internal Medicine Oita Medical University Hasoma Oita 879-5593 Japan

To clarify the mechanism in which signals to regulate food intake are transmitted from the gastro-intestinal system to the brain, we analyzed changes in hypothalamic neuronal histamine using cross-intestine parabiotic rats. Pairs of weight matched Lewis rats were sewn together in such a way as to form a common abdominal cavity. The small intestines of rats were transected and reconnected so that food eaten by one rat passed through a segment of its partner's intestine before returning to the intestine of the first rat. Concentrations of neuronal histamine were measured in microdissected hypothalami using radioimmnoassay. Sustained alteration of food intake were observed in both rats, one rat eating an average of 2.2 times (SE 0.15) as much as the other, without development of any significant difference in body weight after seven weeks. We found significant increase in hypothalamic neuronal histamine concentrations in the arcuate and tublomamelary nuclei of the hypophagic *** results are supportive of the theory that histamine acts in response to signals from the gut to regulate food intake.

关键词： The feeding behavior of cross-intestine parabiotic rats are modulated by brain histamine

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The feeding behavior of cross -intestine parabiotic rats are modulated by brain histamine

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中国病理生理杂志 2001年第9期17卷 927-927页

作者： h.Noguchi h.Koopmans h.Tanaka T.Fukagawa K.Goto K.Fukagawa h.yoshimatsu T.Sakata

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hyperleptinemia in A~y/a mice up-regulates arcuate cocaine -and amphetamine-regulated transcript expression

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中国病理生理杂志 2001年第9期 111-111页

作者： Tsuruta Y yoshimatsu h

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Anti-obesity and anti-diabetic actions of histamine neurons

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中国病理生理杂志 2001年第8期 66-66页

作者： T.Sakata T Masaki h.yoshimatsu Department of Internal Medicine School of Medicine Oita University Hasama Oita 879-5593 Japan

The present study aimed to examine roles of histamine neurons in leptin signaling pathways and leptin resistant states. h1-receptor knockout (h1KO) mice showed no change in daily food intake, adiposity, growth curve, basal expression of hypothalamic neuropeptides, uncoupling proteins (UCPs) or ob gene. however, h1KO mice fed with high fat diet increased fat deposition and ob gene expression more excessively. Leptin-induced feeding suppression was attenuated in h1KO mice. Chronic leptin treatment decreased visceral fat and up-regulated UCPs expression in brown and white fat. These effects of leptin were attenuated in pair-fed h1KO mice. Chronic histamine or histidine treatment decreased body weight, body fat deposition, and serum glucose and insulin in diet-induced obese, ob/ob and db/db mice. Activation of histamine neurons suppressed ob gene expression in the fat tissue together with elevation of seurm leptin and UCPs mRNA. These actions of neuronal histamine were attenuated in the double knockout mice, i.e., db/db mice with h1KO. Taken together, h1KO mice, a novel leptin resistant model, elucidate essential roles of h1-R in energy intake and expenditure as a down-stream-signaling message of leptin actions in the brain. The anti-obesity and anti-diabetic effects of histamine neurons provide a new insight into therapeutic strategies on human obesity and diabetes with leptin resistance.

关键词： Anti-obesity and anti-diabetic actions of histamine neurons

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