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Constructal optimization for h-shaped multi-scale heat exchanger based on entransy theory

Science China(Technological Sciences) 2013年第2期56卷 299-307页

作者： FENG huiJun ChEN LinGen xIE Zhihui sun FengRui College of Power Engineering Naval University of Engineering

Analogizing with the definition of thermal efficiency of a heat exchanger,the entransy dissipation efficiency of a heat exchanger is defined as the ratio of dimensionless entransy dissipation rate to dimensionless pumping power of the heat *** the constraints of the total tube volume and total tube surface area of the heat exchanger,the constructal optimization of an h-shaped multi-scale heat exchanger is carried out by taking entransy dissipation efficiency maximization as optimization objective,and the optimal construct of the h-shaped multi-scale heat exchanger with maximum entransy dissipation efficiency is *** results show that for the specified total tube volume of the heat exchanger,the optimal constructs of the first order T-shaped heat exchanger based on the maximizations of the thermal efficiency and entransy dissipation efficiency are obviously different with the lower mass flow rates of the cold and hot *** the h-shaped multi-scale heat exchanger,the entransy dissipation efficiency decreases with the increase in mass flow rate when the heat exchanger order is fixed;for the specified dimensionless mass flow rate M(Mhe entransy dissipation efficiency decreases with the increase in the heat exchanger *** performance of the multi-scale heat exchanger is obviously improved compared with that of the single-scale heat ***,the heat exchanger subjected to the total tube surface area constraint is also discussed in the *** optimization results obtained in this paper can provide a great compromise between the heat transfer and flow performances of the heat exchanger,provide some guidelines for the optimal designs of heat exchangers,and also enrich the connotation of entransy theory.

关键词： constructal theory thermal efficiency entransy dissipation efficiency h-shaped multi-scale heat exchanger generalizedthermodynamic optimization

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Preferential gene retention increases the robustness of cold regulation in Brassicaceae and other plants after polyploidization

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horticulture Research 2020年第1期7卷 2514-2528页

作者： xiao-Ming Song Jin-Peng Wang Peng-Chuan sun xiao Ma Qi-hang Yang Jing-Jing hu Sang-Rong sun Yu-xian Li Ji-Gao Yu Shu-Yan Feng Qiao-Ying Pei Tong Yu Nan-Shan Yang Yin-Zhe Liu xiu-Qing Li Andrew h.Paterson xi-Yin Wang School of Life Science North China University of Science and TechnologyTangshan 063210China Center for Genomics and Computational Biology North China University of Science and TechnologyTangshan 063210China Library North China University of Science and TechnologyTangshan 063210China Fredericton Research and Development Centre Agriculture and Agri-Food CanadaFrederictonNew Brunswick E3B 4Z7Canada Plant Genome Mapping Laboratory University of GeorgiaAthensGA 30605USA

Cold stress profoundly affects plant growth and development and is a key factor affecting the geographic distribution and evolution of *** have evolved adaptive mechanisms to cope with cold ***,through the genomic analysis of Arabidopsis,three Brassica species and 17 other representative species,we found that both cold-related genes(CRGs)and their collinearity were preferentially retained after polyploidization followed by genome instability,while genome-wide gene sets exhibited a variety of other expansion *** coldrelated regulatory network was increased in Brassicaceae genomes,which were recursively affected by *** combining our findings regarding the selective retention of CRGs from this ecological genomics study with the available knowledge of cold-induced chromosome doubling,we hypothesize that cold stress may have contributed to the success of polyploid plants through both increasing polyploidization and selectively maintaining CRGs during *** hypothesis requires further biological and ecological exploration to obtain solid supporting evidence,which will potentially contribute to understanding the generation of polyploids and to the field of ecological genomics.

关键词： evolution retention doubling

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医疗失效模式与效应分析在临床试验方案偏离管理中的应用

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医药导报 2024年第10期43卷 1645-1650页

作者：邱博杨浩天杜润璇宋浩静孙雪丁琮洋白万军董占军河北省人民医院药学部石家庄050051 河北省临床药学重点实验室石家庄050051 河北省人民医院生殖遗传科石家庄050051

目的规范临床试验的管理,降低方案偏离的发生率,为提高临床试验的质量提供参考。方法运用医疗失效模式与效应分析方法(hFMEA)确定目前方案偏离发生的潜在失效模式,量化并评估失效模式发生频率、严重程度及可探测度,计算风险优先数(RPN)... 详细信息

目的规范临床试验的管理,降低方案偏离的发生率,为提高临床试验的质量提供参考。方法运用医疗失效模式与效应分析方法(hFMEA)确定目前方案偏离发生的潜在失效模式,量化并评估失效模式发生频率、严重程度及可探测度,计算风险优先数(RPN),提出相应的改进措施,统计分析hFMEA实施前后RPN值,评估改进效果。结果开展hFMEA活动后,14项潜在失效模式的RPN值明显下降(PhFMEA小组成员在发现问题和解决问题能力、沟通配合等方面得到了显著提高。结论hFMEA活动的实施有助于临床试验方案偏离的管理,可有效降低方案偏离的发生,为提高药物临床试验质量提供经验。

关键词：临床试验方案偏离医疗失效模式与效应分析

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Stable all-solid-state Li-Te battery with Li_(3)TbBr_(6) superionic conductor

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Nano Research 2023年第7期16卷 9344-9351页

作者： Zhichao Zeng xiaomeng Shi Mingzi sun hongtu Zhang Wei Luo Yunhui huang Bolong huang Yaping Du Chun-hua Yan Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional MaterialsHaihe Laboratory of Sustainable Chemical TransformationsSmart Sensing Interdisciplinary Science CenterSchool of Materials Science and EngineeringNational Institute for Advanced MaterialsNankai UniversityTianjin 300350China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China Institute of New Energy for Vehicles School of Materials Science and EngineeringTongji UniversityShanghai 201804China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth MaterialsChemistry and ApplicationsPKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China College of Chemistry and Chemical Engineering Lanzhou UniversityLanzhou 730000China

Rare-earth(RE)halide solid electrolytes(hSEs)have been an emerging research area due to their good electrochemical and mechanical properties for all-solid-state lithium batteries(ASSBs).however,only very limited types of hSEs have been reported with high *** this work,tens of grams of RE-hSE Li_(3)TbBr_(6)(LTbB)was synthesized by a vacuum evaporationassisted *** as-prepared LTbB displays a high ionic conductivity of 1.7 mS·cm^(-1),a wide electrochemical window,and good ***,the assembled solid lithium-tellurium(Li-Te)battery based on the LTbB hSE exhibits excellent cycling stability up to 600 cycles,which is superior to most previous *** processes and the chemicals during the discharge/charge of Li-Te batteries have been studied by various in situ and ex situ *** calculations have demonstrated the dominant conductivity contributions of the direct[octahedral]-[octahedral]([Oct]-[Oct])pathway for Li ion migrations in the *** Tb sites guarantee efficient electron transfer while the Li 2s orbitals are not affected during migration,leading to a low activation ***,this successful fabrication and application of LTbB have offered a highly competitive solution for solid electrolytes in ASSBs,indicating the great potential of RE-based hSEs in energy devices.

关键词： rare-earth halide solid electrolytes all-solid-state lithium batteries superionic conductor Li-Te solid battery

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Exceptional thermal stability and enhanced hardness in a nanostructured Mg-Gd-Y-Zn-Zr alloy processed by high pressure torsion

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Journal of Magnesium and Alloys 2023年第12期11卷 4589-4602页

作者： Wanting sun Yang he xiaoguang Qiao xiaojun Zhao houwen Chen Nong Gao Marco J.Starink Mingyi Zheng School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Materials Research Group School of EngineeringUniversity of SouthamptonSouthampton SO171BJUnited Kingdom Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150001China Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHung HomHong KongChina

A Mg-8.2Gd-3.8Y-1.0Zn-0.4Zr(wt.%) alloy is processed by solution treatment and high pressure torsion(hPT) at room temperature to produce a nanostructured light material with high hardness. The stability of this alloy is subsequently tested through isochronal annealing for 0.5 h at 373 K to 673 K. The results reveal a thermal stability that is vastly superior to that of conventional Mg-based alloys processed by severe plastic deformation: the grain size remains at around 50 nm on heating to 573 K, and as the temperature is increased to 673 K,grain growth is restricted to within 500 nm. The stability of grain refinement of the present alloy/processing combination allowing grain size to be limited to 55 nm after exposure at 573 K, appears to be nearly one order of magnitude better than for the other SPD processed Mg-RE type alloys, and 2 orders of magnitude better than those of SPD processed RE-free Mg alloys. This superior thermal stability is attributed to formation of co-clusters near and segregation at grain boundaries, which cause a thermodynamic stabilization of grain size, as well as formation of β-Mg_(5)RE equilibrium phase at grain boundaries, which impede grain growth by the Zener pinning effect. The hardness of the nanostructured Mg-Gd-Y-Zn-Zr alloy increases with increasing annealing temperature up to 573 K, which is quite different from the other SPD-processed Mg-based alloys. The high hardness of 136 hV after annealing at 573 K is mainly due to solute segregation and solute clustering at or near grain boundaries.

关键词： Mg-RE alloy high pressure torsion Thermal stability Grain growth Solute segregation Phase transformation

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马尾松和米槠林下外生菌根真菌对宿主的选择性

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福建农业学报 2024年第1期39卷 93-104页

作者：张小慧谢荣樟张锦燕满家银孙代珍邓宗杰魏丽花练春兰福建农林大学林学院/森林共生生物学国际联合实验室福建福州350002 三明市三元区林业局福建三明365000 福建省清流国有林场福建三明365000 东京大学亚洲自然环境科学中心东京文京188-0002

【目的】探究森林土壤中外生菌根真菌(Ectomycorrhizal fungi,ECMF)对宿主的选择性。【方法】采用不同的土壤菌源(马尾松土壤Pinus massoniana soil,PmS和米槠土壤Castanopsis carlesii soil,CcS),分别对马尾松(Pinus massoniana,Pm)和鳞苞锥(Castanopsis uraiana,Cu)进行接种试验(Pm-PmS、Pm-CcS、Cu-PmS、CuCcS)。培育6个月后,采用ITS进行菌根鉴定,检测并计算不同土壤菌源下马尾松和鳞苞锥根中ECM出现的频率、侵染率、相对丰度、相对频率、丰富度和多样性,并测定苗木生长指标以及土壤理化性质。【结果】米槠土壤ph值、全磷含量、全碳含量、有效磷含量显著高于马尾松土壤,且接种苗木后幼苗的地上干重和根长均显著高于马尾松土壤。两种土壤中共检测到19个OTUs的ECMF,分别属于7科和10属,Cenococum geophilum、Rhizopogon boninensis和Tomentella sp.2为两种土壤共有。马尾松林下土壤鉴定到的13种ECMF中,能侵染马尾松的有8种,能侵染鳞苞锥的有6种。米槠林下土壤鉴定到的9种ECMF中,能侵染马尾松的有4种,能侵染鳞苞锥的有7种。***和Sebacina sp.2均能与马尾松和鳞苞锥建立共生关系;而hyaloscyphaceae sp.、Lactarius inconspicuous、***、***、Tomentella sp.1、Tomentella sp.3和Tomentellopsis submollis只侵染马尾松;Athelia sp.、Amanita sp.、***、Russula minor、Russula sp.、Sebacina sp.1、Thelephora sp.1、Thelephora sp.2和Tomentella sp.4只侵染鳞苞锥。马尾松土壤的ECMF丰富度指数(IV)、Shannon多样性指数(h′)、Simpson优势度指数(D)高于米槠土壤;但马尾松土壤接种不同宿主植物后的Sorensen相似性指数(0.14)低于米槠土壤(0.36)。部分ECMF的侵染率与寄主的生理生态指标密切相关。【结论】ECM是经过长期与树种共同进化而建立的共生关系,因此马尾松土壤中的ECMF更倾向于侵染马尾松,而米槠土壤的ECMF更倾向于侵染同为壳斗科的鳞苞锥;马尾松林下土壤的ECMF相对于米槠土壤,对寄主植物选择性的更强。虽然土壤理化性质在一定程度上影响了侵染率,但是ECMF的定殖主要受宿主植物的影响。

关键词：马尾松鳞苞锥外生菌根真菌宿主选择共进化

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highly efficient base editing in human tripronuclear zygotes

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Protein & Cell 2017年第10期8卷 772-775页

作者： Changyang Zhou Meiling Zhang Yu Wei Yidi sun Yun sun hong Pan Ning Yao Wanxia Zhong Yixue Li Weiping Li3 hui Yang Zi-jiang Chen Institute of Neuroscience State Key Laboratory of Neuroscience Key Laboratory of Primate Neurobiology CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China College of Life Sciences University of Chinese Academy of Sciences Beijing 100049 China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Center for Reproductive Medicine Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China Center for Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong University National Research Center for Assisted Reproductive Technology and Reproductive Genetics The Key laboratory for Reproductive Endocrinology of Ministry of Education Jinan 250021 China Key Lab of Computational Biology CAS-MPG Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Institute of Biomedical Sciences Fudan University Medical College Shanghai 200032 China Shanghai Center for Bioinformation Technology Shanghai Industrial Technology Institute Shanghai 201203 China State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresource Guangxi University Nanning 530004 China

There are hundreds of disease-causing single-gene mutations, mainly caused by single-nucleotide substitutions or point mutations rather than small insertions/deletions （in- dels）, and often there are no cures for th... 详细信息

关键词： ONE-STEP GENERATION MOUSE MICE

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姜黄素纳米晶注射液联合损伤控制性外科对高原寒冷环境腹部火器伤救治的实验研究

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医学研究与战创伤救治 2024年第3期37卷 246-253页

作者：孙赳杨雪李佳佳屈金权杨欣悦郑爱萍刘江伟新疆医科大学研究生学院乌鲁木齐830054 新疆军区总医院新疆特殊环境医学重点实验室乌鲁木齐830000 军事科学院军事医学研究院毒物药物研究所北京100850

目的观察姜黄素纳米晶注射液(CNI)、损伤控制性外科(DCS)和CNI联合DCS治疗对模拟高原寒冷环境下猪腹部肠管火器贯通伤的救治效果。方法40只健康长白仔猪,随机数字表法分为4组,每组10只,对照组为高原致伤组(hI),实验组分别为高原致伤+CN... 详细信息

目的观察姜黄素纳米晶注射液(CNI)、损伤控制性外科(DCS)和CNI联合DCS治疗对模拟高原寒冷环境下猪腹部肠管火器贯通伤的救治效果。方法40只健康长白仔猪,随机数字表法分为4组,每组10只,对照组为高原致伤组(hI),实验组分别为高原致伤+CNI治疗组(hIC)、高原致伤+DCS治疗组(hID)、高原致伤+DCS+CNI治疗组(hDC)。高原寒冷环境猪腹部火器肠管贯通伤模型建立:仔猪放入模拟高原寒冷环境的西北地区特殊环境人工实验舱48 h,并使用手枪射击右侧腹部。hIC组伤后2、8、16 h分别予以CNI静脉输注,此后每天输注3次。hID组伤后4 h予以DCS治疗。hDC组伤后CNI输注同hIC组,并于伤后4 h行DCS治疗。分别对比手术相关指标,术后并发症,伤后不同时间血液炎症相关指标、肝功能指标、24 h生命体征。结果hIC组较hI组血液学炎症指标改善,生存时间延长(PhID组和hDC组的腹腔积血、肠系膜损伤、弹孔直径、小肠挫伤、小肠破裂、结肠破裂差异无统计学意义(P>0.05)。hID组和hDC组的手术时间、术中失血量、术中补液量、麻醉复苏时间、首次排便时间差异无统计学意义(P>0.05)。伤后hIC组、hID组、hDC组比hI组的白细胞、ALT、AST、肿瘤坏死因子-α、IL-6水平低,且hDC组更明显(PhID组、hDC组生存率较对照组提高,但差异无统计学意义(P>0.05)。结论CNI联合损伤控制性外科可能是高原寒冷环境腹部火器伤救治的有效方法。

关键词：损伤控制性外科姜黄素纳米晶注射液高原寒冷环境腹部火器伤

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IFN-α对禽网状内皮组织增殖病病毒体内外增殖的抑制作用

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中国兽医杂志 2024年第10期60卷 10-17页

作者：徐凤霞孙万里张亚文常爽王一新赵鹏山东农业大学动物科技学院山东泰安271018 山东和康源生物育种股份有限公司山东济南250001

为明确禽源α干扰素(IFN-α)对禽网状内皮组织增殖病病毒(REV)体内外增殖的抑制效果,本试验在细胞和动物水平上分别采用鸡胚成纤维(DF-1)细胞和海兰褐鸡作为模型,于REV接种前(预防)和接种后(治疗)分别添加不同浓度的禽IFN-α处理,分析禽... 详细信息

为明确禽源α干扰素(IFN-α)对禽网状内皮组织增殖病病毒(REV)体内外增殖的抑制效果,本试验在细胞和动物水平上分别采用鸡胚成纤维(DF-1)细胞和海兰褐鸡作为模型,于REV接种前(预防)和接种后(治疗)分别添加不同浓度的禽IFN-α处理,分析禽IFN-α在体外和体内对REV增殖的影响。体外试验结果显示,与阳性对照组相比,禽IFN-α浓度为33 IU/mL的治疗组72 h细胞和上清中REV的增殖受到了显著抑制(Ph细胞中REV的增殖受到了显著抑制(P<0.05)。通过比较各组海兰褐鸡的平均体重、血液中REV阳性率和病毒载量、泄殖腔REV阳性率和排毒量、免疫器官指数和病毒载量系统评估禽IFN-α对REV体内增殖的影响,结果显示,与阳性对照组相比,禽IFN-α浓度为1 500 IU的治疗组海兰褐鸡21和28日龄时体重显著升高(P<0.05),14日龄时肝脏发育指数以及14和28日龄时的脾脏发育指数显著降低(P<0.05),14日龄时血液和脾脏中病毒载量显著降低(P<0.05),7和21日龄时泄殖腔排毒量显著降低(P<0.05)。本试验在体外细胞和体内动物2个层面均证实了禽IFN-α对REV增殖具有显著的抑制效果,这不仅为禽网状内皮组织增殖病的防控策略提供了新的思路和辅助手段,也为未来抗病毒药物的研发和应用提供了科学依据。

关键词：禽网状内皮组织增殖病病毒(REV) 干扰素体外水平体内水平抑制作用

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Controllable and high-throughput preparation of microdroplet using an ultra-high speed rotating packed bed

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Chinese Journal of Chemical Engineering 2022年第8期35卷 116-124页

作者： Jing xie xiangbi Jia Dan Wang Yingjiao Li Bao-chang sun Yong Luo Guang-wen Chu Jian-feng Chen State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for high Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China

Microdroplets and their dispersion,with a large specific surface area and a short diffusion distance,have been applied in various unit operations and reaction ***,it is still a challenge to control the size and size distribution of microdroplets,especially for high-throughput *** this work,a novel ultra-high speed rotating packed bed(UhS-RPB)was invented,in which rotating foam packing with a speed of 4000-12000 r·min^(-1) provides microfluidic channels to disperse liquid into microdroplets with high *** generated microdroplets can be directly dispersed into a continuous falling film for obtaining a mixture of microdroplet *** this UhS-RPB,the effects of rotational speed,liquid initial velocity,liquid viscosity,liquid surface tension and packing pore size on the average size(d_(32))and size distribution of microdroplets were systematically *** showed that the UhS-RPB could produce microdroplets with a d_(32) of 25-63μm at a liquid flow rate of 1025 L·h^(-1),and the size distribution of the microdroplets accords well with Rosin-Rammler distribution *** addi-tion,a correlation was established for the prediction of d_(32),and the predicted d_(32) was in good agreement with the experimental data with a deviation within±15%.These results demonstrated that UhS-RPB could be a promising candidate for controllable preparation of uniform microdroplets.

关键词： Ultra-high speed rotating packed bed Microdroplet Controllable preparation high throughput

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