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Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya Bay

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Chinese Physics C 2021年第5期45卷 190-201页

作者： F.P.An A.B.Balantekin h.R.Band M.Bishai S.Blyth G.F.Cao J.Cao J.F.Chang Y.Chang h.S.Chen S.M.Chen Y.Chen Y.x.Chen J.Cheng Z.K.Cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.h.Gong h.Gong W.Q.Gu J.Y.Guo L.Guo x.h.Guo Y.h.Guo Z.Guo R.W.hackenburg S.hans M.he K.M.heeger Y.K.heng A.higuera Y.K.hor Y.B.hsiung B.Z.hu J.R.hu T.hu Z.J.hu h.x.huang x.T.huang Y.B.huang P.huber D.E.Jaffe K.L.Jen x.L.Ji x.P.Ji R.A.Johnson D.Jones L.Kang S.h.Kettell S.Kohn M.Kramer T.J.Langford J.Lee J.h.C.Lee R.T.Lei R.Leitner J.K.C.Leung F.Li J.J.Li Q.J.Li S.Li S.C.Li W.D.Li x.N.Li x.Q.Li Y.F.Li Z.B.Li h.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link L.Littenberg B.R.Littlejohn J.C.Liu J.L.Liu C.Lu h.Q.Lu J.S.Lu K.B.Luk x.B.Ma x.Y.Ma Y.Q.Ma C.Marshall D.A.Martinez Caicedo K.T.MeDonald R.D.McKeown Y.Meng J.Napolitano D.Naumov E.Naumova J.P.Ochoa-Ricoux A.OIshevskiy h.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi x.Qian N.Raper J.Ren C.Morales Reveco R.Rosero B.Roskovec x.C.Ruan h.Steiner J.L.Sun T.Tmej K.Treskov W.-h.Tse C.E.Tull B.Viren V.Vorobel C.h.Wang J.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang x.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang h.Y.Wei L.h.Wei L.J.Wen K.Whisnant C.G.White h.L.h.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.M.xia Z.Q.xie Z.Z.xing J.L.xu T.xu T.xue C.G.Yang L.Yang Y.Z.Yang h.F.Yao M.Ye M.Yeh B.L.Young h.Z.Yu Z.Y.Yu B.B.Yue S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang h.h.Zhang J.W.Zhang Q.M.Zhang x.T.Zhang Y.M.Zhang Y.x.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao L.Zhou h.L.Zhuang J.h.Zou Instiute of Modern Physics East China University of Science and TechnologyShanghai 200237 University of Wisconsin MadisonWisconsin 53706 Wright Laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 Brookhaven National Laboratory UptonNew York 11973 Department of Physics National Taiwan UniversityTaipei Institute of high Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBejing 100084 Shenzhen University Shenzhen 518060 Sun Yat-Sen(Zhongshan)University Guangzhou North China Electric Power University Bejjing 102206 Chinese University of hong Kong Hong Kong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCaliformia 92697 University of Science and Technology of China Hefei 230026 Charles University Faculty of Mathematics and PhysicsPrague Department of Physics University of llinois at Urbana-ChampaignUrbanaIlinois 61801 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 Joint Institute for Nuclear Research DubnaMoscow Region Beijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Department of Physics University of HoustonHoustonTexas 77204 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250100 Guangxi University Nanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics National Chiao-Tung UniversityHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physies Collge of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHong Kong 999077 School

The establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars *** the Daya Bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW *** used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino *** detected electron-antineutrino candidates were consistent with the expected background rates for all the three time *** monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13-2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w *** the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows.

关键词： grav itational waves electron-antineutrinos fluence upper limit

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Antineutrino energy spectrum unfolding based on the Daya Bay measurement and its applications

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Chinese Physics C 2021年第7期45卷 1-19页

作者： F.P.An A.B.Balantekin M.Bishai S.Blyth G.F.Cao J.Cao J.F.Chang Y.Chang h.S.Chen S.M.Chen Y.Chen Y.x.Chen J.Cheng Z.K.Cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal D.Dolzhikov J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.h.Gong h.Gong M.Grassi W.Q.Gu J.Y.Guo L.Guo x.h.Guo Y.h.Guo Z.Guo R.W.hackenburg S.hans a M.he K.M.heeger Y.K.heng Y.K.hor Y.B.hsiung B.Z.hu J.R.hu T.hu Z.J.hu h.x.huang J.h.huang x.T.huang Y.B.huang P.huber D.E.Jaffe K.L.Jen x.L.Ji x.P.Ji R.A.Johnson D.Jones L.Kang S.h.Kettel S.Kohn M.Kramer T.J.Langford J.Lee J.h.C.Lee R.T.Lei R.Leitner J.K.C.Leung F.Li h.L.Li J.J.Li Q.J.Li R.h.Li S.Li S.C.Li W.D.Li x.N.Li x.Q.Li Y.F.Li Z.B.Li h.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link26 L.Littenberg B.R.Littlejohn J.C.Liu J.L.Liu J.x.Liu C.Lu h.Q.Lu K.B.Luk B.Z.Ma x.B.Ma x.Y.Ma Y.Q.Ma R.C.Mandujano C.Marshall K.T.McDonald R.D.McKeown Y.Meng J.Napolitano D.Naumov E.Naumova T.M.T.Nguyen J.P.Ochoa-Ricoux A.Olshevskiy h.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi x.Qian N.Raper J.Ren C.Morales Reveco R.Rosero B.Roskovec x.C.Ruan h.Steiner J.L.Sun T.Tmej1 K.Treskov W.-h.Tse C.E.Tull B.Viren V.Vorobel C.h.Wang J.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang x.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang h.Y.Wei L.h.Wei L.J.Wen K.Whisnant C.G.White h.L.h.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.M.xia Z.Q.xie Z.Z.xing h.K.xu J.L.xu T.xu T.xue C.G.Yang L.Yang Y.Z.Yang h.F.Yao M.Ye M.Yeh B.L.Young h.Z.Yu Z.Y.Yu B.B.Yue V.Zavadskyi S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang h.h.Zhang J.W.Zhang Q.M.Zhang S.Q.Zhang x.T.Zhang Y.M.Zhang Y.x.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao R.Z.Zhao L.Zhou h.L.Zhuang J.h.Zou Institute of Modern Physics East China University of Science and TechnologyShanghai 200337 University of Wisconsin MadisonWisconsin 53706 Brookhaven National Laboratory UptonNew York 11973 Department of Physics Nnational Taiwan UniversityTaipei Institute of high Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBeijing 100048 Shenzhen University Shenzhen 518061 Sun Yat-Sen(Zhongshan)University Guangzhou 510275 North China Electric Power University Beijing 102206 Chinese University of hong Kong Hongkong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCalifornia 92697 University of Science and Technology of China Hefei 230022 Charles University Faculty of Mathematics and PhysicsPrague Joint Institute for Nuclear Research DubnaMoscow Region Department of Physics University of Illinois at Urbana-ChampaignUrbanaIllinois 61801 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 Beijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Wright Laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250002 Guangxi University No.100 Daxue East RoadNanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics NCTUHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physics College of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHongkong 999077 School of Physics Nankai UniversityTianjin 300071 Department o

The prediction of reactor antineutrino spectra will play a crucial role as reactor experiments enter the precision *** positron energy spectrum of 3.5 million antineutrino inverse beta decay reactions observed by the Daya Bay experiment,in combination with the fission rates of fissile isotopes in the reactor,is used to extract the positron energy spectra resulting from the fission of specific *** information can be used to produce a precise,data-based prediction of the antineutrino energy spectrum in other reactor antineutrino experiments with different fission fractions than Daya *** positron energy spectra are unfolded to obtain the antineutrino energy spectra by removing the contribution from detector response with the Wiener-SVD unfolding *** results are obtained with other unfolding methods.A technique to construct a data-based prediction of the reactor antineutrino energy spectrum is proposed and *** the reactor fission fractions,the technique can predict the energy spectrum to a 2%*** addition,we illustrate how to perform a rigorous comparison between the unfolded antineutrino spectrum and a theoretical model prediction that avoids the input model bias of the unfolding method.

关键词： reactor antineutrino energy spectrum Daya Bay application

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Investigating the p-Ω interactions and correlation functions

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Ye Yan Qi huang Youchang Yang hongxia huang Jialun Ping Department of Physics Nanjing Normal University School of Science Guizhou University of Engineering Science

Motivated by experimental measurements, we investigate the p-Ω correlation functions and interactions on the basis of a quark model. By solving the inverse scattering problem with channel coupling, we renormalize the coupling to other channels into an effective single-channel p-Ω potentials. The effects of Coulomb interaction and spin-averaging are also discussed. According to our results, the depletion of the p-Ω correlation functions, which is attributed to the JP= 2+bound state not observed in the ALICE Collaboration's measurements(Nature 588, 232（2020）), can be explained by the contribution of the attractive JP= 1+component in spin-averaging. So far, we have provided a consistent description of the p-Ω system from the perspective of the quark model, including the energy spectrum, scattering phase shifts, and correlation functions. The existence of the p-Ω bound state has been supported by all three aspects. Additionally, a sign of the p-Ω correlation function's subtle sub-unity part can be seen in experimental measurements, which warrants more precise verification in the future.

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Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang xiao Ding huang Yunyi Yiyu Liu Jia Li Guangdong-hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou hKUST Fok Ying Tung Research Institute The hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/h2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/h2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期68卷 204-218页

作者： Chen xiong hong Ling Yingdan huang hanzhi Dong Bangxiang xie Qian hao xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of h3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the h3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

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Application of kernel ridge regression in predicting neutron-capture reaction cross-sections

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Communications in Theoretical Physics 2022年第9期74卷 98-104页

作者： T x huang x h Wu P W Zhao State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

This article provides the first application of the machine-learning approach in the study of the cross-sections for neutron-capture reactions with the kernel ridge regression(KRR)*** is found that the KRR approach can reduce the root-mean-square(rms)deviation of the relative errors between the experimental data of the Maxwellian-averaged(n,γ)cross-sections and the corresponding theoretical predictions from 69.8%to 35.4%.By including the data with different temperatures in the training set,the rms deviation can be further significantly reduced to 2.0%.Moreover,the extrapolation performance of the KRR approach along different temperatures is found to be effective and reliable.

关键词： kernel ridge regression machine learning neutron-capture reaction

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high Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang huang Lijie Mao Zhimin Zhang han Lin Qixin Yan xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSh)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) high metal loading Oxidase catalysis

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Sulfolane‑Based Flame‑Retardant Electrolyte for high‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： xuanlong he Jie Peng Qingyun Lin Meng Li Weibin Chen Pei Liu Tao huang Zhencheng huang Yuying Liu Jiaojiao Deng Shenghua Ye xuming Yang xiangzhong Ren xiaoping Ouyang Jianhong Liu Biwei xiao Jiangtao hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1h,1h,5h-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte high voltage Layered oxide cathode Flame retardant

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Vertical gradients of neutral winds observed by ICON and estimated by the horizontal Wind Model during the geomagnetic storm on August 26−28,2021

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Earth and Planetary Physics 2025年第1期9卷 69-80页

作者： JiaWei Wu Chao xiong YuYang huang YunLiang Zhou Department of Space Physics School of Electronic InformationHubei Luojia LaboratoryWuhan UniversityWuhan 430072China

The Michelson Interferometer for Global high-resolution Thermospheric Imaging(MIGhTI)onboard the Ionospheric Connection Explorer(ICON)satellite offers the opportunity to investigate the altitude profile of thermospheric *** this study,we used the red-line measurements of MIGhTI to compare with the results estimated by horizontal Wind Model 14(hWM14).The data selected included both the geomagnetic quiet period(December 2019 to August 2022)and the geomagnetic storm on August 26-28,*** the geomagnetic quiet period,the estimations of neutral winds from hWM14 showed relatively good agreement with the observations from *** to the ICON observations,near the equator,zonal winds reverse from westward to eastward at around 06:00 local time(LT)at higher altitudes,and the stronger westward winds appear at later LTs at lower *** around 16:00 LT,eastward winds at 300 km reverse to westward,and vertical gradients of zonal winds similar to those at sunrise hours can be *** the middle latitudes,zonal winds reverse about 2-4 h *** winds vary more significantly than zonal winds with seasonal and latitudinal *** to the ICON observations,in the northern low latitudes,vertical reversals of meridional winds are found at 08:00-13:00 LT from 300 to 160 km and at around 18:00 LT from 300 to 200 km during the June *** reversals of meridional winds are found at 04:00-07:00 LT from 300 to 160 km and at 22:00-02:00 LT from 270 to 200 km during the December *** the southern low latitudes,meridional wind reversals occur at 08:00-11:00 LT from 200 to 160 km and at 21:00-02:00 LT from 300 to 200 km during the June *** the December solstice,reversals of the meridional wind appear at 20:00-01:00 LT below 200 km and at 06:00-11:00 LT from 300 to 160 *** the northern middle latitudes,the northward winds are dominant at 08:00-14:00 LT at 230 km during the June *** winds persist until

关键词： horizontal neutral winds vertical gradients Ionospheric Connection Explorer satellite horizontal Wind Model 14 geomagnetic storm

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Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai huang Shuaige Bai Ting Luo Bin Feng Min Liu Fan Zheng Shuang huang Yanpeng Fang Dan Ding Wenbin Zeng xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

hepatocellular carcinoma （hCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of hCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of hCC. however, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in hCC.

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