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大学物理 1987年第1期 37-37页

作者： h.gould 孔惠洁徐州师院

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大学物理 1987年第1期6卷 37-37页

作者： h.gould 孔惠洁不详徐州师院

来自美国综合医疗保健系统的高血压患者824650例中，血管紧张素转换酶抑制药或血管紧张素受体阻滞药的使用与新型冠状病毒疾病2019发生率的关系

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中华高血压杂志(中英文) 2021年第4期29卷 399-399页

作者：刘青练桂丽 An J wei R Zhou h Luong TQ gould MK Mefford MT harrison TN Creekmur B Lee MS Sim JJ Brettler Jw Martin JP Ong-Su AL Reynolds K

先前报告认为使用血管紧张素转换酶抑制药(angiotensin-converting enzyme inhibitor,ACEI)或血管紧张素受体阻滞药(angiotensin receptor blocker,ARB)可能上调血管紧张素转换酶2受体,显著加重严重急性呼吸综合征冠状病毒2的感染性。...

先前报告认为使用血管紧张素转换酶抑制药(angiotensin-converting enzyme inhibitor,ACEI)或血管紧张素受体阻滞药(angiotensin receptor blocker,ARB)可能上调血管紧张素转换酶2受体,显著加重严重急性呼吸综合征冠状病毒2的感染性。研究者评估了高血压患者使用ACEI或ARB和新型冠状病毒疾病2019(coronavirus disease 2019,COVID-19)感染性之间的相关性。方法和结果:研究者于2020年3月1日从南加州凯萨医疗机构中选择高血压患者。

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Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps

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世界最新医学信息文摘 2014年第7期 7-7页

作者： P.Gevaert K.T.Nouri-Aria h.wu C.E.harper P.Takhar D.J.Fear F.Acke N.De Ruyck G.Banfield h.h.Kariyawasam C.Bachert S.R.Durham h.J.gould

Background Chronic rhinosinusitis with nasal polyps (NP) and allergic rhinitis (AR) is characterized by local Th2 inflammation and upregulation of IgE; however, IgE in NP is ‘polyclonal’ and allergen specific, whereas IgE in AR is ‘oligoclonal’ and allergen specific. Germinal center (GC) reactions occur in AR, while only the formation of GC-like structures in NP is described. The aim of this study was to investigate the involvement of local IgE production, class switch recombination, and receptor revision in *** we compared the levels of local IgE, germline gene transcripts, and mature Ig mRNA expression, recombination activating gene (RAG1 and RAG2), key markers of Th2 inflammation, and GC reactions in NP tissue vs AR and control tissue. Nasal mucosa was immunostained for the co-expression of RAG1 and RAG2 in B cells, plasma cells, and T cells, using dual or triple immunofluorescence (IF).Results In NP, local IgE level and key markers of local class switching are increased compared with AR and normal controls (NC). In NP, switch circle transcripts reveal ongoing local class switch recombination to IgE. Up to 30% of B cells, plasma cells, and Tcells in nasal polyps re-express both RAG1 and RAG2, required for receptor revision. RAG1 and RAG2 mRNA concentrations are increased in NP and correlated with the magnitude of inflammation and the presence of S. aureus enterotoxin (superantigen)specific IgE in the nasal polyp *** Our results provide the first evidence of local receptor revision and class switching to IgE, and B-cell differentiation into IgEsecreting plasma cells in NP.

关键词： IgE AR Th Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps

An Earth-mass planet in a time of COVID-19:KMT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： weicheng Zang Cheongho han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew gould Shude Mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael D.Albrow Sun-Ju Chung Kyu-ha hwang Youn Kil Jung Yoon-hyun Ryu In-Gu Shin Sang-Mok Cha Dong-Jin Kim hyoun-woo Kim Seung-Lee Kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park Richard w.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan Maoz Matthew T.Penny wei Zhu Ian A.Bond Fumio Abe Richard Barry David P.Bennett Aparna Bhattacharya Martin Donachie hirosane Fujii Akihiko Fukui Yuki hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas J.Rattenbury Yuki Satoh hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

we report the discovery of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVID-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

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用间-四羟苯基-氯(Foscan~)对女阴表皮内肿瘤进行光动力治疗

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世界核心医学期刊文摘（皮肤病学分册） 2005年第4期1卷 13-13页

作者： Campbell S.M. gould D.J. Salter L. 冯义国 Cornwall Dermatol. Research Project Royal Cornwall Hospital Truro Cornwall TR1 3LJUnitedKingdom

Background: Photodynamic therapy (PDT) has unique properties which make it suitable for the local treatment of superficial epithelial disorders; it has been suggested as a useful treatment for carcinoma in situ of the vulva. Objectives: To evaluate the effect of the systemic photosensitizing agent metatetrahydroxyphenyl-chlorin(mThPC or temoporfin; Foscan., Biolitec, Edinburgh, U.K.) in vulval intraepithelial neoplasia type III (VIN III). Methods: PDT using mThPC was performed in six patients with VIN III. A dose of 0.1 mg kg-1 body weight mThPC was injected intravenously and the area of VIN irradiated 96 h later with 652-nm light from a diode laser. Patients were reviewed 1 week, 6 months and 2 years following treatment. Results: Patients experienced only minimal pain from the initial treatment but two patients subsequently developed severe pain at the treated site for up to 2 weeks following PDT. All patients developed oedema and slough formation at the treated site and one patient developed cellulitis. At 6 months two patients had developed small recurrences of VIN at the original site and one patient had an area of VIN at a new site. These were treated either with further PDT or with a small excision. At 2 years there was no recurrence of VIN at the original site in all patients reviewed. Conclusions: This small case series demonstrates that mThPC-PDT is a useful initial treatment for VIN III. It is relatively selective, shows good cosmesis and conserves form and function. This is a major advantage over surgery. Repeat treatments are also possible, which is important in a condition such as VIN, which tends to be multifocal. Systemic mThPC-PDT appears to have an advantage over topical 5-aminolaevulinic acid-PDT as the photosensitizer is distributedwidely in areas of disease and consequently identifies foci which may not be apparent clinically but become evident when illuminated.

关键词：光动力治疗 Foscan 羟苯基女阴光敏剂用间小样本研究氨基乙酰丙酸蜂窝织炎二极管激光器

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