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Particuology 2024年第7期90卷 51-60页

作者： Johannes Lunewski Eberhard schmidt Institute of Particle technology University of WuppertalGermany

Dynamic image analysis provides an automated evaluation method to determine the size and shape of multiple particles. this method represents a common application for ordinary bulk material. the latest draft of ISO 13322–2:2021 describes the state of the art, but lacks instructions for handling fibrous bulk material. Interlocking fibres complicate the measurement conditions and require a disentanglement of fibrous samples during a pre-dispersion step. A further error source includes the fibre orientation inside the measurement zone of the device. If the thresholding algorithm fails to differentiate between the fibre projection area and the background, a subsequent image optimisation solves the problem. this article addresses the mentioned problems by analysing cotton cellulose and polyacrylonitrile fibres. Besides the execution of a pre-dispersion step, the experiments compare the discrepancies between dry and wet dispersion. here, the software packages PAQXOS and ImageJ perform the image evaluation. In this case, the wet dispersion setup with a subsequent image evaluation by ImageJ provides comprehensible results.

关键词： Bootstrap method Dynamic image analysis Fibre diameter Fibre length distribution Natural fibres Synthetic fibres

RARRES2's impact on lipid metabolism in triplenegative breast cancer:a pathway to brain metastasis

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Military Medical Research 2024年第2期11卷 311-312页

作者： Quazi t.h.Shubhra Institute of Chemistry University of Silesia in Katowice41‑500 ChorzowPoland Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Breast cancer brain metastasis(BCBrM)is a crucial and hard area of research which guarantees an urgent need to understand the underlying molecular mechanisms.A recent study by Li et al.[1]published in Military Medical Research investigated the role of retinoic acid receptor responder 2(RARRES2)in regulating lipid metabolism in BCBrM,highlighting the clinical relevance of alterations in lipid metabolites,such as phosphatidylcholine(PC)and triacylglycerols(tAGs),by RARRES2 through the modulation of phosphatase and tensin homologue(PtEN)-mammalian target of rapamycin(mtOR)-sterol regulatory element-binding protein 1(SREBP1)signaling *** commentary aims to elaborate on the key findings and their relevance to the field.

关键词： Retinoic acid receptor responder 2(RARRES2) Lipid metabolism Cancer PtEN-mtOR-SREBP1 signaling Metabolic reprogramming Brain metastasis

Mechanistic modeling of copper corrosions in data center environments

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Building Simulation 2024年第3期17卷 483-492页

作者： Rui Zhang Jianshun Zhang Roger schmidt Jeremy L.Gilbert Department of Mechanical and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings and transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excellence in Environmental and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingly used to take advantage of“free-cooling”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pollutants to indoor environment of data centers and cause corrosion damage to the information technology *** evaluate the reliability of information technology equipment under various thermal and air-pollution conditions,a mechanistic model based on multi-ion transport and chemical reactions was *** model was used to predict Cu corrosion caused by Cl_(2)-containing pollutant *** also accounted for the effects of temperature(25℃and 28℃),relative humidity(50%,75%,and 95%),and *** also identified higher air temperature as a corrosion barrier and higher relative humidity as a corrosion accelerator,which agreed well with the experimental *** average root mean square error of the prediction was 13.7Å.the model can be used to evaluate the thermal guideline for data centers design and operation when Cl_(2)is present based on pre-established acceptable risk of corrosion in data centers’environment.

关键词： chloride pollutant mixture copper corrosion model data center temperature relative humidity synergistic effect

Pre-activated macrophage membrane-encased aggregationinduced emission featuring nanoparticles:a novel possibility for tuberculosis treatment

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Signal transduction and targeted therapy 2024年第7期9卷 2848-2850页

作者： Qiang Cai Yihao tian Quazi t.h.Shubhra Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanChina Department of human Anatomy and histology and Embryology School of Basic Medical SciencesWuhan UniversityWuhanChina Institute of Chemistry University of Silesia in KatowiceSzkolna 9KatowicePoland

In a recent study published in Nature Nanotechnology,Li et *** the synthesis of a novel photosensitizer with unique aggregation-induced emission(AIE)characteristics.1 they microencapsulated this photosensitizer inside engineered nanoparticles(NPs)coated with pre-activated macrophage cell membranes(CMs),an innovative approach marking a significant leap in nanomedicine by offering a pathway to potent tuberculosis(tB)treatments that bypass antibiotic resistance with unparalleled precision.

关键词： tuberculosis macrophage aggregation

Viral and nonviral nanocarriers for in vivo CRISPR-based gene editing

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Nano Research 2024年第10期17卷 8904-8925页

作者： Zhongyuan Guo Audrey t.Zhu Ronnie h.Fang Liangfang Zhang Aiiso Yufeng Li Family Department of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Division of host-Microbe Systems and therapeutics Department of PediatricsUniversity of California San DiegoLa JollaCA 92093USA

the continued development of clustered regularly interspaced short palindromic repeats(CRISPR)technology has the potential to greatly impact clinical medicine,particularly for disease diagnosis and *** high demand for the in vivo delivery of CRISPR-based therapies,significant challenges *** include rapid degradation by enzymes,inefficient disease site targeting,and the risk of undesired off-target *** platforms,with their tailorable properties,have been engineered to efficiently package CRISPR payloads in various formats,including as plasmid DNA,mRNA,and ribonucleoprotein complexes,for in vivo *** them,recombinant adeno-associated viruses,virus-like particles,and lipid nanoparticles have displayed exceptional *** review will discuss the development of these and other nanocarriers for in vivo CRISPR-based genome editing.

关键词： clustered regularly interspaced short palindromic repeats(CRISPR) in vivo gene editing nanocarriers recombinant adeno-associated viruses(rAAVs) virus-like particle(VLP) lipid nanoparticle(LNP)

Superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mechanisms

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Journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： h.t.Jeong S.W.Lee W.J.Kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

the superplastic behavior and associated deformation mechanisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with a grain size of 3.2μm,primarily composed of the BCCβphase and a small amount of the hCPαphase,were examined in a temperature range of 473 K to 623 *** microstructural refinement of this alloy was achieved by employing high-ratio differential speed *** best superplasticity was achieved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),where tensile elongations of 550±600%were *** the heating and holding stage of the tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider this effect when analyzing and understanding the superplastic deformation behavior and *** the investigated strain rate range,the superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,while at high strain rates,lattice diffusion-controlled dislocation climb creep was the rate-controlling deformation *** was concluded that solute drag creep is unlikely to *** the late stages of deformation at 523 K,it was observed that grain boundary sliding led to the agglomeration of theαphase,resulting in significant strain *** mechanism maps were constructed forβ-Mg-Li alloys in the form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using the constitutive equations for various deformation mechanisms derived based on the data of the current tests.

关键词： Magnesium-lithium alloy Superplasticity Severe plastic deformation Grain size Grain growth

Correlation of work function and stacking fault energy through Kelvin probe force microscopy and nanohardness in diluteα-magnesium

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Journal of Magnesium and Alloys 2024年第1期12卷 237-250页

作者： Yigit türe Ali Arslan Kaya hüseyin Aydin Jiang Peng Servet turan Eskisehir technical University Porsuk Vocational SchoolElectronics and Automation DepartmentProgram of MechatronicsEskisehirTurkey Mugla Sitki Kocman University Engineering FacultyMetallurgy and Materials Engineering DepartmentMuglaTurkey hüseying Aydın TUBITAK MRCTurkey Jiang Peng Chongqing UniversityChina Eskisehir technical University Engineering FacultyMaterials Science and Engineering DepartmentEskisehirTurkey

Electronic interactions of the Group 2A elements with magnesium have been studied through the dilute solid solutions in binary Mg-Ca,Mg-Sr and Mg-Ba *** investigation incorporated the difference in the‘Work Function'(ΔWF)measured via Kelvin Probe Force Microscopy(KPFM),as a property directly affected by interatomic bond types,*** electronic structure,nanoindentation measurements,and Stacking Fault Energy values reported in the *** was shown that the nano-hardness of the solid-solutionα-Mg phase changed in the order of Mg-Ca>Mg-Sr>***,it was shown,by also considering the nano-hardness levels,that SFE of a solid-solution is closely correlated with its‘Work Function'***-hardness measurements on the eutectics andΔWF difference between eutectic phases enabled an assessment of the relative bond strength and the pertinent electronic structures of the eutectics in the three *** withΔWF and at least qualitative verification of those computed SFE values with some experimental measurement techniques were considered important as those computational methods are based on zero Kelvin degree,relatively simple atomic models and a number of *** asserted by this investigation,if the results of measurement techniques can be qualitatively correlated with those of the computational methods,it can be possible to evaluate the electronic structures in alloys,starting from binary systems,going to ternary and then multi-elemental *** investigation has shown that such a qualitative correlation is *** all,the SFE values are not treated as absolute values but rather become essential in comparative investigations when assessing the influences of alloying elements at a fundamental level,that is,free electron density *** study indicated that the principles of‘electronic metallurgy'in developing multi-elemental alloy systems can be followed via practical experimental methods,i.e.ΔWF measurements using KPF

关键词： Mg alloys Dilute alloys Work function Stacking fault energy Kelvin probe force microscopy Short range order Miedema Nanoindentation Eutectics

Efficient guiding and focusing of intense laser pulse using periodic thin slits

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Matter and Radiation at Extremes 2024年第4期9卷 29-39页

作者： L.Xu t.W.huang K.Jiang C.N.Wu h.Peng P.C.hen R.Li h.B.Zhuo C.t.Zhou Shenzhen Key Laboratory of Ultraintense Laser and Advanced Material technology Center for Intense Laser ApplicationTechnologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118People’s Republic of China

Slits have been widely used in laser-plasma interactions as plasma optical components for generating high-harmonic light and controlling laser-driven particle ***,we propose and demonstrate that periodic thin slits can be regarded as a new breed of optical elements for efficient focusing and guiding of intense laser *** fundamental physics of intense laser interaction with thin slits is studied,and it is revealed that relativistic effects can lead to enhanced laser focusing far beyond the pure diffractive focusing *** addition,the interaction of an intense laser pulse with periodic thin slits makes it feasible to achieve multifold enhancement in both laser intensity and energy transfer efficiency compared with conventional *** results provide a novel method for manipulating ultra-intense laser pulses and should be of interest for many laser-based applications.

关键词： laser pulse intense

Photoluminescence and ratiometric thermo-response of Eu^(2+)and Eu^(3+)in BaAl_(2)B_(2)O_(7):Eu^(2+),Eu^(3+)phosphor materials

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Journal of Rare Earths 2024年第7期42卷 1240-1249,I0002页

作者： Ziyao Wang haitao Fu Xiufeng Zhan Bo tong Guofeng Ma h.t.(Bert)hintzen Institute of Innovative Science and technology Shenyang UniversityShenyang110044China College of Mechanical Engineering Shenyang UniversityShenyang110044China Faculty of Applied Sciences Delft University of Technology2629 JBDelftthe Netherlands

A novel Eu^(2+)-Eu^(3+)co-activated ratiometric thermo-sensitive phosphor was developed and synthesized by solid-state *** valence state of Eu,photoluminescence and thermo-sensitive performance of the phosphor prepared either in ambient air or carbothermally were investigated and *** phosphor shows high sensitivity(Sa=0.0173 K^(-1),S_(r)=0.461%/K)and superior signal discriminability(Δν∼10380 cm^(−1)).the thermo-sensitive performance is subject to the dual effects of different thermo-responses by Eu^(2+)versus Eu^(3+)combined with energy transfer from Eu^(2+)to Eu^(3+),so that the sensitivity of the phosphor in the temperature range presents a non-monotonic *** development of the BaAl_(2)B_(2)O_(7):Eu^(2+),Eu^(3+)phosphor is not only expected to be relevant for application in the field of temperature sensing,but also of reference significance for improving the sensitivity by means of energy transfer between co-activator ions over a wider temperature range of Eu^(2+)-Eu^(3+)co-activated ratiometric thermo-sensitive phosphors.

关键词： Photoluminescence Ratiometric thermo-response Phosphor Eu^(2+)/Eu^(3+) Rare earths