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基于多参数MR成像的高危肿瘤内亚区域体积预测胶质母细胞瘤总体生存期和补充分子分析

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国际医学放射学杂志 2017年第6期 730-731页

作者： Y.Cui S.J.Ren K.K.Tha J.Wu h.shirato R.J.Li 张毓婧 Department of Radiation Oncology Stanford University

摘要目的通过整合多参数MR影像,建立并验证一个可预测胶质母细胞瘤预后的基于容积的定量影像学标志物,同时研究其与分子特征的关系及协同作用。方法回顾性分

关键词：胶质母细胞瘤生存期 MR 多参数

运用不同商业软件得到CT灌注图像的差异:使用急性卒中病人的同源数据的定量分析

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国际医学放射学杂志 2010年第2期 173-173页

作者： K.S.M.Kudo M.Sasaki K.Yamada S.Momoshima h.Utsunomiya h.shirato 谢丽璇 Advanced Medical Research Center Iwate Medical University 19-1 Uchimaru Morioka 020-8505Japan

目的使用不同CT制造商提供的商业化软件对卒中病人同源数据的CT灌注成像结果进行定性及定量分析,以检测其差异性。材料与方法本研究由机构审查委员会批准并经病人知

关键词：卒中病人同源数据平均脑血流量定量分析脑血容量差异商业软件图像 CT

CT灌注分析在反卷积算法中示踪剂延时诱导效应的差异:数字模型的定量评价

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国际医学放射学杂志 2009年第3期 293-293页

作者： K.Kudo M.Sasaki K.Ogasawara S.Terae S.Ehara h.shirato 宋建军 Advanced Medical Research Center Iwate Medical University19-1 UchimaruMorioka 020-8505Japan

研究获机构审查委员会批准,并得到病人知情同意。其目的是使用实际来源的数据创建的数字模型来评价CT灌注影像上在不同的反卷积算法下示踪剂延时诱导效应的差异。对3种方法的奇异值分解(singular value decompo-sition,SVD)进行了评价... 详细信息

研究获机构审查委员会批准,并得到病人知情同意。其目的是使用实际来源的数据创建的数字模型来评价CT灌注影像上在不同的反卷积算法下示踪剂延时诱导效应的差异。对3种方法的奇异值分解(singular value decompo-sition,SVD)进行了评价。对于标准的奇异值分解(sSVD),在脑血流量和平均通过时间上延迟诱导有显著误差。

关键词：诱导效应电子效应卷积算法示踪剂示踪物奇异值分解数字模型差异 CT

hypofractionated stereotactic rad iotherapy alone without whole-brain irradiation for patien ts with solitary and oligo brain metastasis using noninvasive fixation of the skull

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癌症 2003年第7期22卷 744-744页

作者： Aoyama h.shirato h Onimaru R Kagei K Ikeda J Ishii N Sawamura Y Miyasaka K Department of Radiology Department of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of Radiology Hokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapan

To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy(hSRT)using noninvasive fixation of the sk ull on solitary or oligo brain metastatic p atients as an alternative to stereotactic radiosurgery(SRS)using invasive fixation.The subjects were 87patients who had 4or fewer brain meta stases(50solitary,37oligometastases).Treatment was conducted on 159meta stases by using a linac-based stereotactic system.T he median isocentric dose was 35Gy in4fractions.Whole-brain irradiati on was not applied as an initial treatment.For the salvage treatmen t of metachronous brain metastases,repeat hSRT or whole-brain irradiation was applied.The actuarial1-year local tumor control rate was 81%.Treatment-related complicatio ns were observed in 4patients in the e arly period(hs)and in 2patients in the late period.T he median survival period was 8.7mon ths.Metachronous brain metastases occurred in 30patients,and none of the 18patients who were eligible for salvage hSRT refused to re ceive it again.hypofractionated stereotactic radiotherapy achieved tumor control and survival equivalent to those of SRS reported i n the literature.The results suggested that hSRT could be an alternative for solitary or oligo br ain metastatic patients with less to xicity and less invasiveness compared to

关键词：脑肿瘤头颅无创固定法定向放射治疗病例报告

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立体定向放射外科加全脑放射治疗与单独立体定向放射外科治疗脑转移瘤的比较:一项随机对照试验

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世界核心医学期刊文摘(神经病学分册) 2006年第10期 4-4页

作者： Aoyama h. shirato h. Tago M. 郭俊 Department of Radiology hokkaido University Graduate School of Medicine North 15 West 7 Kitaku Sapporo 060- 8638 Japan Dr.

Context: In patients with brain metastases, it is unclear whether adding up- front whole- brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. Objective: To determine if WBRT combined with SRS results in improvements in survival, brain tumor control, functional preservation rate, and frequency of neurologic death. Design, Setting, and Patients: Randomized controlled trial of 132 patients with 1 to 4 brain metastases, each less than 3 cm in diameter, enrolled at 11 hospitals in Japan between October 1999 and December 2003. Interventions: Patients were randomly assigned to receive WBRT plus SRS (65 patients) or SRS alone (67 patients). Main Outcome Measures: The primary end point was overall survival; secondary end points were brain tumor recurrence, salvage brain treatment, functional preservation, toxic effects of radiation, and cause of death. Results: The median survival time and the 1- year actuarial survival rate were 7.5 months and 38.5% (95% confidence interval, 26.7% - 50.3% ) in the WBRT + SRS group and 8.0 months and 28.4% (95% confidence interval, 17.6% - 39.2% ) for SRS alone (P=.42). The 12- month brain tumor recurrence rate was 46.8% in the WBRT + SRS group and 76.4% for SRS alone group (P he WBRT + SRS group (n = 10) than with SRS alone (n = 29) (P h was attributed to neurologic causes in 22.8% of patients in the WBRT + SRS group and in 19.3% of those treated with SRS alone (P=.64). There were no significant differences in systemic and neurologic functional preservation and toxic effects of radiation. Conclusions: Compared with SRS alone, the use of WBRT plus SRS did not improve survival for patients with 1 to 4 brain metastases, but intracranial relapse occurred considerably more frequently in those who did not receive WBRT. Consequently, salvage treatment is frequently required when up- front WBRT is not used.

关键词：放射外科全脑放射治疗脑转移瘤立体定向随机对照试验

^(123)I-MIBG心肌显像预测依那普利对扩张型心肌病患者治疗效果的临床价值

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国际心血管病杂志 2006年第4期33卷 271-274页

作者：李寿霖何振山于富军池田淳白土邦男解放军白求恩国际和平医院心内科河北050082 日本仙台市东北大学医学部第1内科

目的探讨123I-MIBG心肌显像在治疗前预测依那普利对扩张型心肌病(DCM)患者治疗效果的临床价值。方法对24例DCM患者于依那普利治疗前行早期(20min)及延迟(3h)123I-MIBG心肌显像,采用心/上纵隔(h/M)比和心脏放射性洗脱率(WR)作为相对半定... 详细信息

目的探讨123I-MIBG心肌显像在治疗前预测依那普利对扩张型心肌病(DCM)患者治疗效果的临床价值。方法对24例DCM患者于依那普利治疗前行早期(20min)及延迟(3h)123I-MIBG心肌显像,采用心/上纵隔(h/M)比和心脏放射性洗脱率(WR)作为相对半定量计数分析,与超声心功能参数进行对比。根据123I-MI-BG心肌显像延迟相的h/M分为3组延迟h/M≥1.7为组Ⅰ,1.5h/Mh/M≤1.5为组Ⅲ。组Ⅰ和组Ⅱ在平均治疗4.5个月后重复以上检查。结果治疗前3组间超声心功能参数比较均无统计学差异。治疗后组Ⅰ的左室射血分数(LVEF)和左室收缩末径(LVDs)明显改善,早期h/M和延迟h/M均明显改善(Ph/M明显改善(Ph/M和WR均无明显变化,心功能参数也无改善。组Ⅰ和组Ⅱ患者均能耐受依那普利治疗,而组Ⅲ患者均不能耐受依那普利治疗。结论123I-MIBG心肌显像在治疗前预测依那普利对DCM患者的治疗效果方面有一定价值。

关键词： ^123 Ⅰ-MIBG心肌显像扩张型心肌病血管紧张素转化酶抑制剂

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