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^18F-FDG PET心肌代谢显像对左心室室壁瘤患者长期预后的价值

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中华核医学杂志 2008年第6期28卷 361-364页

作者：张晓丽刘秀杰胡盛寿 Thomas h.schindler 田月琴高润霖吴清玉魏红星杨秀滨王浩何作祥 heinrich R.Schelbert 中国医学科学院、中国协和医科大学阜外心血管病医院核医学科北京100037 中国医学科学院、中国协和医科大学阜外心血管病医院心外科北京100037 中国医学科学院、中国协和医科大学阜外心血管病医院心内科北京100037 中国医学科学院、中国协和医科大学阜外心血管病医院超声科北京100037 Department of Molecular and Medical Pharmacology David Geffen School of Medicine at UCLA

目的评估^18F-脱氧葡萄糖（FDG）PET心肌代谢显像对左心室室壁瘤患者长期预后的价值。方法对70例左心室室壁瘤患者[超声心动图示左心室射血分数（LVEF）为（36±8）％]行“Tc”．甲氧基异丁基异腈（MIBI）SPECT心肌灌注显像和“F—FDG ... 详细信息

目的评估^18F-脱氧葡萄糖（FDG）PET心肌代谢显像对左心室室壁瘤患者长期预后的价值。方法对70例左心室室壁瘤患者[超声心动图示左心室射血分数（LVEF）为（36±8）％]行“Tc”．甲氧基异丁基异腈（MIBI）SPECT心肌灌注显像和“F—FDG PET—心肌代谢显像，对经冠状动脉造影确诊的左心室室壁瘤患者进行随访，计算室壁瘤部位、非室壁瘤部位以及左心室心肌灌注和代谢积分，以及灌注-代谢不匹配分（MMS）。MMS≥2．0为心肌存活。室壁瘤部位心肌不存活者中，药物治疗为组1，手术治疗为组2；室壁瘤部位心肌存活者中，药物治疗为组3，手术治疗为组4。心源性死亡和心脏事件为随访终点。以Kaplan—Meier方法获得生存曲线，并用Log—rank法比较率的差异。结果组1至组4患者例数分别为14，23，10和23例。随访1～105（72±32）个月，16例患者发生心源性死亡。组3的心源性年死亡率为11．6％，高于组4的1．5％（Х^2=12．87，P〈0．0001），也高于组1的4．8％（Х^2=4．13，P〈0．05）和组2的2．2％（Х^2=10．46，P=0．001）。Cox回归多因素分析显示室壁瘤部位的MMS[风险比（hR）1．40，95％可信区间（CI）为1．11～1．75，P=0．003]和血运重建术（hR 0．35，95％CI为0．18～0．69，P=0．002）是预测心源性死亡的独立危险因子。结论“F—FDG PET心肌代谢显像和^99Tc^m-MIBI SPECT心肌灌注显像对于室壁瘤患者的饴疗方案制定及长期预后估测有重要意义。

关键词：心脏室壁瘤体层摄影术发射型计算机脱氧葡萄糖

Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： point source cylindrical cavity porous medium wave-field transformation stress concentration O353.4

Incorporating the Istanbul-Ankara high-speed railway into the Belt and Road Initiative:Negotiation,institutional alignment and regional development

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Journal of Geographical Sciences 2021年第5期31卷 747-762页

作者： Seth.schindler Mustafa Kemal BAYIRBAG GAO Boyang Global Development Institute University of ManchesterM139PL ManchesterUnited Kingdom Department of Political Science and Public Administration Middle East Technical UniversityAnkara 06800Turkey School of Management Science and Engineering Central University of Finance and EconomicsBeijing 100081China

This article contributes to a small but growing body of multi-sited and multi-scalar research on the Belt and Road *** focus on relations at the national,regional and international scales,and present original research from China and Turkey,to show how the Istanbul-Ankara high-speed railway has served as a testing ground for China's Belt and Road Initiative(BRI).Its construction was initially funded by the European Investment Bank,but it is now part of the backbone of the Turkish Government's Middle Corridor plan which enhances west-east connectivity and integration with the Caucasus and Central *** show that in contrast to multinational corporations from the OECD that seek to remain footloose,Chinese state-owned enterprises(SOEs)seek to adapt to,apprehend and ultimately shape local *** the case of Turkey this proved difficult given its institutional alignment with the European ***,while the railway project was completed successfully by a consortium led by a Chinese SOE,Turkey's dynamic and complex regulatory environment discourages Chinese SOEs in the infrastructure *** conclude that the Turkish and Chinese governments are currently pursuing complementary territorial visions yet their cooperation is project-based and pragmatic.

关键词： Belt and Road Initiative infrastructure high speed rail regional development Turkey China

A Bayesian Approach with Prior Mixed Strategy Nash Equilibrium for Vehicle Intention Prediction

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Automotive Innovation 2023年第3期6卷 425-437页

作者： Giovanni Lucente Reza Dariani Julian schindler Michael Ortgiese Institute of Transporation Systems German Aerospace Center(DLR)Lilienthalplatz 738108 BraunschweigGermany Fakultat Verkehrs‑und Maschinensysteme TU BerlinStrabe des 17.Juni 13510623 BerlinGermany

The state-of-the-art technology in the field of vehicle automation will lead to a mixed traffic environment in the coming years,where connected and automated vehicles have to interact with human-driven *** this context,it is necessary to have intention prediction models with the capability of forecasting how the traffic scenario is going to evolve with respect to the physical state of vehicles,the possible maneuvers and the interactions between traffic participants within the seconds to *** article presents a Bayesian approach for vehicle intention forecasting,utilizing a game-theoretic framework in the form of a Mixed Strategy Nash Equilibrium(MSNE)as a prior estimate to model the reciprocal influence between traffic *** likelihood is then computed based on the Kullback-Leibler *** game is modeled as a static nonzero-sum polymatrix game with individual preferences,a well known strategic *** the MSNE for these games is in the PPAD∩PLS complexity class,with polynomial-time *** approach shows good results in simulations in the long term horizon(10s),with its computational complexity allowing for online applications.

关键词： Vehicle intention prediction Trajectory prediction Bayesian approach Mixed strategy Nash equilibrium

Turning of aluminum metal matrix composites： influence of the reinforcement and the cutting condition on the surface layer of the workpiece

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Advances in Manufacturing 2016年第3期4卷 225-236页

作者： Jan C. Aurich Marco Zimmermann Stefan schindler Paul Steinmann Institute for Manufacturing Technology and ProductionSystems University of Kaiserslautern KaiserslauternGermany Chair of Applied Mechanics University of Erlangen-Nuremberg Erlangen Germany

Aluminum metal matrix composites （Al-MMCs） are difficult to machine. The reinforcement of aluminum using ceramic particles accelerates tool wear. Moreover, demanded machining accuracies or properties of the surface layer are difficult to achieve. In the present study, the effect of silicon carbide reinforcement particles on the surface layer of the workpiece was investigated using multiple cutting conditions for dry turning. Three differently reinforced Al-MMCs regarding the volume percent-age （17% and 30%） and the particle size （0.6 μm and 3 μm） and their non-reinforced matrix were considered as the workpiece materials. The reinforcement and the cutting condition affect the results of turning. A greater particle volume percent improves the surface roughness and decreases the tensile stress in the surface. The smaller particle size caused a lower tensile stress in the surface. A general effect of the particle size on the workpiece roughness can not be concluded. The most important cutting parameter for the surface layer of the workpiece is the feed. Greater feeds decrease the tensile stress in the surface, but deteriorate the surface quality.

关键词： Aluminum metal matrix composite(Al-MMC) Forces . Workpiece roughness Surface Residual stress