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AAV mediated carboxyl terminus of hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/Ps1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei hu Jing Yang shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo tang Changhe shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NhC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(hsp70)interacting protein(ChIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed ChIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate ChIP overexpression in APP/Ps1 mouse *** overexpression significantly ameliorated the performance of APP/Ps1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/Ps1 mice of a younger age,ChIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of hsP70 and hsP40,which have functional relevance to ChIP,were also *** nuclei transcriptome sequencing in the hippocampus of ChIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that ChIP effectively reduces the behavior and pathological manifestations of APP/Ps1 ***,overexpression of ChIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/Ps1 mice carboxyl terminus of hsp70 interacting protein gene therapy

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAEI h.GhANDVAR E.JUMAEV s.KhATIR T.CUONG-LE school of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and science Center for Engineering Application and Technology solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANsYs, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词： Kinetic energy

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

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Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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science China Life sciences 2025年第1期68卷 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong tang Zhetuo Qi haiyang Xie shusen Zheng Qiang Wei Xiao Xu Department of hepatobiliary and Pancreatic surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NhFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of hepatobiliary and Pancreatic surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of hepatobiliary and Pancreatic surgery Department of Liver TransplantationShulan (Hangzhou) Hospital hangzhou Medical College Zhejiang University school of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(he et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PThT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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Construction Concept and Innovative Practices of Virtual Power Plants in Megacities Under Electricity Market Environment

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Dianwang Jishu/Power system Technology 2025年第1期49卷 103-112页

作者： tang, Jun Gao, hongchao Yu, Tao Kang, Chongqing state Grid shanghai Municipal Electric Power Company Pudong New Area Shanghai 200122 China National Key Laboratory of New Power system Operation and Control [Tsinghua University Haidian District Beijing 100084 China

With the accelerated construction of new power systems, the Virtual Power Plant (VPP), a key component of the new energy framework, provides critical support for safe supply, energy conservation, and emission reduction for power systems. however, the increasingly diverse technological forms and application scenarios of VPPs present challenges for standardization in large-scale development. A timely summary and generalization of VPP development principles, construction pathways, and technical practices can promote technical synergy and drive industry growth. This paper takes the VPP in a megacity as a typical use case. It thoroughly discusses the top-level design of the VPP by reviewing and analyzing four perspectives of form, policy, market, and standards. secondly, this paper examines a multi-spatiotemporal regulation technology system for VPPs from three dimensions precise response, regional coordination, and fast regulation, which supports the normalized operation of shanghai’s VPP. Then, this paper introduces the large-scale demonstration outcomes of shanghai’s VPP, offering a valuable reference for development constructions and innovative practices of VPPs at the megacity scale. Finally, by analyzing the construction and operational outlook of shanghai's VPP, this paper distills a clear pathway for its future development. © 2025 Power system Technology Press. All rights reserved.

关键词： Virtual Power Plants

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Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： sura h.AL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. surface plasmon resonance（sPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based sPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

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staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding shujun Liu Zhijie Qi Tian tang Yunfan Zhang Zhiyuan Ma Jingwen sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu shi haoxue Wang Lijie huang su Zhang Ruixin Zhang song Wang Guangxu Lu Peifu tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical school of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

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Pyrite Geochemistry and s-hg Isotopes Reveal the Ore Genesis of the hydrothermal Vein-type Cuiluan Ag-Pb-Zn Deposit in NE China

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Journal of Earth science 2025年

作者： Lidong Zhang Changzhou Deng Yao tang Xinran Ni Bizheng Yang shanshan Liang Weipeng Liu Jishuang Ding Xiaohui Zeng heilongjiang Institute of Natural Resources survey state Key Laboratory of Ore Deposit Geochemistry， Institute of Geochemistry， Chinese Academy of sciences College of Earth and Planetary sciences， Chengdu University of Technology

The Xing'an-Mongolian orogenic belt is an important Ag-Pb-Zn metallogenic province in China. The study on the genesis of the newly discovered Cuiluan hydrothermal vein-type Ag-Pb-Zn deposit located in the Lesser Xing'an Range， within the eastern of Xing'an-Mongolian orogenic belt， is pivotal in understanding the metallogenic mechanism and regularity of Ag-Pb-Zn deposits in this region. This study utilizes pyrite trace elements and sulfur isotopic geochemistry， and mercury isotope of rocks and ores to constrain the genesis of the Cuiluan deposit. Pyrite geochemical data show that Ag exists in the form of galena inclusions (Ag++(Bi3+， sb3+) ? Pb2+) in the polymetallic sulfide stage， and independent Ag-bearing minerals （matildite and gustavite） precipitate during the main mineralization stage. The small varied δ34s values （3.24‰ - 4.94‰） of pyrites from four hydrothermal stages are within the range of magmatic s isotopes， indicating that the ore-forming fluid of the Cuiluan deposit mainly originated from the magma. The Δ199hg values of the ores are close to 0‰， which are consistent with the Δ199hg values of mantle， further indicating that the ore-forming materials came from the lithospheric mantle. Combined with the regional tectonic evolution， we conclude that the plate subduction of Paleo-oceans in NE China triggered the partial melting of metasomatized mantle. The mantle-derived magma rose along the deep fractures and evolved ore-forming fluids， and finally caused the formation of Cuiluan quartz vein-type Ag-Pb-Zn deposit in the shallow crust. Accompany with previous documents， we infer that the fractures in the large-scale “Granite sea” in the Lesser Xing'an Range may have significant potential for vein-type Ag-Pb-Zn exploration.

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