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流体弹塑性介质中波动与断裂计算的二阶GODUNOV方法

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计算数学 1999年第2期21卷 225-236页

作者：汤寒松北京航空航天大学

A finite difference method is proposed for modeling wave motion and fracture phenomenon in hydro-elasto-plastic bodies. The method is a Godunov type approach,and it has second-order accuracy and captures shocks and fracture zones with high resolution. In the class of given wav systems the Riemann problems involved in the method have unique solutions, and the solutions can be obtained with efficient procedures. Numerical results are satisfactory in computations of Riemann problems and spallation in a steel plate.

关键词：流体弹塑性介质波动断裂黎曼问题 Godunov法

soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

Prediction and optimization of flue pressure in sintering process based on shAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue tang Mansheng Chu Quan shi Zhen Zhang school of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon steelmaking(Ministry of Education) Shenyang 110819China

sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(shAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using shAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.shAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han tang Jianian hu siying Kang song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina state Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. however, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

On the existence of solutions for prescribing fractional Q-curvature problem on s~n

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Acta Mathematica sinica,English series 2025年

作者： Yan LI Zhongwei tang College of science China University of Petroleum(Beijing) school of Mathematical sciences Laboratory of Mathematics and Complex Systems MOEBeijing Normal University

The aim of this paper is to investigate the existence of solutions to the prescribing fractional Q-curvature problem on s~n under some reasonable assumption of the Laplacian sign at the critical point of prescribing curvature function K. Due to the lack of compactness, we choose to return to the basic elements of variational theory and study the deformation along the flow lines. The novelty of the paper is that we obtain the existence without assuming any symmetry and periodicity on K. In addition,to overcome the loss of compactness for high-order operator problem, we need more delicate estimates with the second order cases.

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Boosting high-performance in Zr-rich side protonic solid oxide electrolysis cells by optimizing functional interlayer

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Green Energy & Environment 2025年第1期10卷 150-160页

作者： Chunmei tang Ning Wang sho Kitano hiroki habazaki Yoshitaka Aoki siyu Ye huangpu hydrogen Energy Innovation Center School of Chemistry and Chemical EngineeringGuangzhou UniversityNo.230 Wai Huan Xi RoadGuangzhou510006China Graduate school of Chemical sciences and Engineering Hokkaido UniversityN13W8Kita-kuSapporo060-8628Japan Faculty of Engineering Hokkaido UniversityN13W8Kita-kuSapporo060-8628Japan

Protonic solid oxide electrolysis cells(P-sOECs)are a promising technology for water electrolysis to produce green ***,there are still challenges related key materials and anode/electrolyte interface.P-sOECs with Zr-rich electrolyte,called Zr-rich side P-sOECs,possess high thermodynamically stability under high steam concentrations but the large reaction resistances and the current leakage,thus the inferior *** this study,an efficient functional interlayer Ba_(0.95)La_(0.05)Fe_(0.8)Zn_(0.2)O_(3-δ)(BLFZ)in-between the anode and the electrolyte is *** electrochemical performances of P-sOECs are greatly enhanced because the BLFZ can greatly increase the interface contact,boost anode reaction kinetics,and increase proton injection into *** a result,the P-sOEC yields high current density of 0.83 A cm^(-2) at 600℃ in 1.3 Vamong all the reported Zr-rich side *** work not only offers an efficient functional interlayer for P-sOECs but also holds the potential to achieve P-sOECs with high performances and long-term stability.

关键词： Functional interlayer Zr-rich side electrolyte Protonic solid oxide electrolysis cells Current density Faradaic efficiency

Ubiquitin-specific protease 1 facilitates tumor immune escape from natural killer cells and predicts the prognosis in small cell lung cancer

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Oncology Research 2025年第1期33卷 213-224页

作者： shIQIN JIANG YIChUN tang FENG MA YUChUN NIU LEI sUN Department of Clinical Pharmacy Shenzhen Hospital of Integrated Traditional Chinese and Western MedicineShenzhen518104China Department of Pathology Zhujiang HospitalSouthern Medical UniversityGuangzhou510280China Department of Radiation Oncology The First People’s Hospital of FoshanFoshan528000China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China Department of Oncology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguan523721China

Objective:small cell lung cancer(sCLC)is commonly recognized as the most fatal lung cancer *** substantial advances in immune checkpoint blockade therapies for treating solid cancers,their benefits are limited to a minority of patients with *** the present study,novel indicators for predicting the outcomes and molecular targets for sCLC treatment were ***:We conducted bioinformatics analysis to identify the key genes associated with tumor-infiltrating lymphocytes in *** functional role of the key gene identified in sCLC was determined both in vitro and in ***:A significant correlation was observed between patient survival and CD56dim natural killer(NK)cell ***,we noted that the hub gene ubiquitin-specific protease 1(UsP1)is closely correlated with both CD56dim NK cells and overall survival in *** analysis revealed that UsP1 is upregulated in *** addition,gene set enrichment analysis revealed that UsP1 overexpression hinders NK cell-mediated immune *** co-cultivating NK-92 cells with sCLC cells,we demonstrated that NK cell cytotoxicity against sCLC could be improved either via UsP1 knock-down or pharmacological ***,using a nude-mice xenograft tumor model,we noted that UsP1 inhibition effectively suppressed tumor proliferation and increased the expression of NK cell-associated ***:Our study findings highlight the importance of NK cells in regulating ***1 overexpression can inhibit NK cell-mediated immunity;therefore,UsP1 may serve not only as a prognostic biomarker but also as a potential molecular target of sCLC therapy.

关键词： Ubiquitin-specific protease 1(UsP1) Natural killer(NK)cell small cell lung cancer(sCLC) Prognosis Immune escape

Wafer‑scale Vertical 1D GaN Nanorods/2D Mos_(2)/PEDOT:Pss for Piezophototronic Effect‑Enhanced self‑Powered Flexible Photodetectors

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Nano-Micro Letters 2025年第3期17卷 102-116页

作者： Xin tang hongsheng Jiang Zhengliang Lin Xuan Wang Wenliang Wang Guoqiang Li state Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Department of Electronic Materials School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640People’s Republic of China

van der Waals(vdW)heterostructures constructed by lowdimensional(0D,1D,and 2D)materials are emerging as one of the most appealing systems in next-generation flexible ***,hand-stacked vdW-type photodetectors are not compatible with large-areaarray fabrication and show unimpressive performance in self-powered ***,vertical 1D GaN nanorods arrays(NRAs)/2D Mos_(2)/PEDOT:Pss in wafer scale have been proposed for self-powered flexible photodetectors arrays *** as-integrated device without external bias under weak UV illumination exhibits a competitive responsivity of 1.47 A W^(−1)and a high detectivity of 1.2×10^(11)Jones,as well as a fast response speed of 54/71μs,thanks to the strong light absorption of GaN NRAs and the efficient photogenerated carrier separation in type-II ***,the strain-tunable photodetection performances of device have been ***,the device at−0.78%strain and zero bias reveals a significantly enhanced photoresponse with a responsivity of 2.47 A W^(−1),a detectivity of 2.6×10^(11)Jones,and response times of 40/45μs,which are superior to the state-of-the-art self-powered flexible *** work presents a valuable avenue to prepare tunable vdWs heterostructures for self-powered flexible photodetection,which performs well in flexible sensors.

关键词： Vertical nanorod arrays van der Waals heterostructure Piezophototronic effect self-powered photodetection Flexible sensors

Vector meson's spin alignments in high energy reactions

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science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-hui Chen Zuo-tang Liang Yu-Gang Ma Xin-Li sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China school of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the sTAR collaboration at the Relativistic heavy Ion Collider （RhIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation