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Genetic Variation of Multiple Serotypes of Enteroviruses Associated with hand, Foot and Mouth Disease in Southern China

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Virologica Sinica 2021年第1期36卷 61-74页

作者： Yonghong Zhou Le van Tan Kaiwei Luo Qiaohong Liao Lili Wang Qi Qiu Gang Zou Ping Liu Nguyen To Anh Nguyen Thi Thu hong Min he Xiaoman Wei Shuanbao Yu Tommy Tsan-Yuk Lam Jie Cui h.rogier van doorn hongjie Yu School of Public health Fudan UniversityKey Laboratory of Public Health SafetyMinistry of EducationShanghai 200032China Oxford University Clinical Research Unit Ho Chi Minh City 700000Vietnam hunan Provincial Center for Disease Control and Prevention Changsha 410005China Division of Infectious Disease Key Laboratory of Surveillance and Early-warning on Infectious DiseaseChinese Centre for Disease Control and PreventionBeijing 102206China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai 200032China Anhua County Center for Disease Control and Prevention Anhua 413000China CAS Key Laboratory of Special Pathogens and Biosafety Center for Emerging Infectious DiseasesWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Centre of Influenza Research&State Key Laboratory of Emerging Infectious Diseases School of Public HealthThe University of Hong KongHong Kong SAR 999077China CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200032China Centre for Tropical Medicine Nuffield Department of MedicineUniversity of OxfordOxford OX37DQUK

Enteroviruses(EVs)species A are a major public health issue in the Asia–Pacific region and cause frequent epidemics of hand,foot and mouth disease(hFMD)in *** infections are common in children;however,hFMD can also cause severe illness that affects the central nervous *** molecularly characterize EVs,a prospective hFMD virological surveillance program was performed in China between 2013 and *** swabs,rectal swabs and stool samples were collected from suspected hFMD patients at participating *** were detected using generic real-time and nested reverse transcription-polymerase chain reactions(RT-PCRs).Then,the complete VP1 regions of enterovirus A71(EV-A71),coxsackievirus A16(CVA16)and CVA6 were sequenced to analyze amino acid changes and construct a viral molecular *** the 2836 enrolled hFMD patients,2,517(89%)were EV *** most frequently detected EVs were CVA16(32.5%,819),CVA6(31.2%,785),and EV-A71(20.4%,514).The subgenogroups CVA16B1 b,CVA6D3 a and EV-A71C4 a were predominant in China and recombination was not observed in the VP1 *** analysis revealed amino acid variations at the 30,29 and 44 positions in the VP1 region of EV-A71,CVA16 and CVA6(compared to the respective prototype strains Br Cr,G10 and Gdula),***,in 21 of 24(87.5%)identified EV-A71 samples,a known amino acid substitution(D31 N)that may enhance neurovirulence was *** study provides insights about the genetic characteristics of common hFMD-associated ***,the emergence and virulence of the described mutations require further investigation.

关键词： Enteroviruses(EVs) hand foot and mouth disease(hFMD) Enterovirus A71(EV-A71) Coxsackievirus A16(CVA16) Coxsackievirus A6(CVA6)

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Can liver stiffness measurement accurately predict disease progression and clinical outcome in patients with metabolic dysfunction-associated steatotic liver disease and bridging fibrosis or cirrhosis?

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hepatobiliary Surgery and Nutrition 2023年第6期12卷 912-915页

作者： Diederick J.van doorn Adriaan G.holleboom R.Bart Takkenberg Joanne Verheij Marten A.Lantinga Department of Gastroenterology and hepatology Amsterdam UMCUniversity of AmsterdamAmsterdam Gastroenterology Endocrinology MetabolismAmsterdamThe Netherlands Department of Vascular Medicine Internal MedicineAmsterdam UMCUniversity of AmsterdamAmsterdam Gastroenterology Endocrinology MetabolismAmsterdamThe Netherlands Department of hepatopancreatobiliary Pathology Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands

Diederick *** doorn1,Adriaan ***2,*** Takkenberg1,Joanne Verheij3,Marten ***11Department of Gastroenterology and hepatology,Amsterdam UMC,University of Amsterdam,Amsterdam Gastroenterology Endocrinology Metabolism,Amsterdam,The Netherlands;2Department of Vascular Medicine,Internal Medicine,Amsterdam UMC,University of Amsterdam,Amsterdam Gastroenterology Endocrinology Metabolism,Amsterdam,The Netherlands;3Department of hepatopanc Metabolic dysfunction-associated steatotic liver disease(MASLD)-until recently termed non-alcoholic fatty liver disease(NAFLD)-is a rising cause of chronic liver disease with an estimated global prevalence of 30%(1).

关键词： Cirrhosis liver stiffness steatotic liver disease

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Diagnostic and Laparoscopic Management of Unicornuate Uterus with Rudimentary horn

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Case Reports in Clinical Medicine 2014年第6期3卷 378-381页

作者： Els van doorn Rainer Kimmig Bahriye Aktas Department of Obstetrics and Gynecology University of Essen Essen Germany

We describe here a case report of a female patient with a unicornuate uterus with noncommunicating left rudimentary horn. The patient presented herself to us due to persistent lower abdominal pains, primarily dysmenorrhea and suspected internal genital endometriosis. Further to additional diagnosis and imaging by vaginal and abdominal ultrasound and abdominal MRI, a suspected rare congenital malformation of the genital tract was established. A normal vagina with cervical system without pathological findings was presented during the operation. The diagnostic hysteroscopy and laparoscopy indicated an intact right unicornuate uterus with a regular tube and ovary. A left rudimentary horn, noncommunicating with cervix and vagina was also presented, also together with a regular tube and ovary. The chromopertubation carried out proved the patency of the right tube. The decision was taken intraoperatively to remove the left rudimentary horn with ipsilateral tube. The surgery could be carried out without complications. We are reporting a patient with persistent lower abdominal pain, who desires to have children, to conceive with a unicornuate uterus and left rudimentary horn with retrograde menstruation and proliferative endometrium. Surgical minimal invasive treatment by laparoscopically removing of the left rudimentary horn and tube took place.

关键词： Unicornuate Uterus Rudimentary horn Diagnostic and Laparoscopic Management Endometriosis Retrograde Menstruation

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An Agent-Based Assessment of Land Use and Ecosystem Changes in Traditional Agricultural Landscape of Portugal

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Intelligent Information Management 2014年第2期6卷 55-80页

作者： Lilibeth A.Acosta Mark D.A.Rounsevell Martha Bakker Ann van doorn Montserrat Gomez-Delgado Marc Delgado Potsdam Institute for Climate Impact Research PotsdamGermany School of Environmental Science and Management University of the Philippines Los BanosLos BanosPhilippines School of GeoSciences University of EdinburghEdinburghUK Land Use Planning Group Wageningen University and Research CentreWageningenThe Netherlands Alterra Environmental Sciences GroupWageningenThe Netherlands Departamento de Geología Geografía y Medio AmbienteUnidad docente de GeografíaUniversidad de AlcaláAlcaláde HenaresEspana Department of Geography Faculty of SciencesVrije Universiteit BrusselBrusselBelgium

This paper presents an assessment of land use changes and their impacts on the ecosystem in the Montado, a traditional agricultural landscape of Portugal in response to global environmental change. The assessment uses an agent-based model (ABM) of the adaptive decisions of farmers to simulate the influence on future land use patterns of socio-economic attributes such as social relationships and farmer reliance on subsidies and biophysical constraints. The application and development of the ABM are supported empirically using three categories of input data: 1) farmer types based on a cluster analysis of socio-economic attributes;2) agricultural suitability based on regression analysis of historical land use maps and biophysical attributes;and 3) future trends in the economic and climatic environments based on the A1fi scenario of the Intergovernmental Panel on Climate Change. Model sensitivity and uncertainty analyses are carried out prior to the scenario analysis in order to verify the absence of systematic errors in the model structure. The results of the scenario analysis show that the area of Montado declines significantly by 2050, but it remains the dominant land use in the case study area, indicating some resilience to change. An important policy challenge arising from this assessment is how to encourage next generation of innovative farmers to conserve this traditional landscape for social and ecological values.

关键词： Abandonment Agent-Based Model Cluster Analysis Ecosystem and Biodiversity Land Use Change Logistic Regression Portugal Scenario Analysis Traditional Agricultural Landscape

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Bench-top aqueous two-phase extraction of isolated individual single-walled carbon nanotubes

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Nano Research 2015年第5期8卷 1755-1769页

作者： Navaneetha K. Subbaiyan A. Nicholas G. Parra-Vasquezt Sofie Cambre Miguel A. Santiago Cordoba Sibel Ebru Yalcin Christopher E. hamilton Nathan h. Mack Jeffrey L. Blackburn Stephen K. doorn Juan G. Duque Chemistry Division Physical Chemistry and Applied Spectroscopy Group (C-PCS) Center for Integrated Nanotechnologies (CINT) and Materials Science & Technology Division (MST-7) Los Alamos National Laboratory Los Alamos New Mexico 87544 USA Experimental Condensed Matter Physics Laboratory University of Antwerp Antwerp B-2610 Belgium National Renewable Energy Laboratory Golden Colorado 80401 USA

Isolation and purification of single-walled carbon nanotubes （SWCNTs） are prerequisites for their implementation in various applications. In this work, we present a fast （-5 min）, low-cost, and easily scalable bench-top approach to the extraction of high-quality isolated SWCNTs from bundles and impurities in an aqueous dispersion. The extraction procedure, based on aqueous two-phase （ATP） separation, is widely applicable to any SWCNT source （tested on samples up to 1.7 nm in diameter） and independent of defect density, purity, diameter, and length. The extracted dispersions demonstrate that the removal of large aggregates, small bundles, and impurities is comparable to that by density gradient ultracentrifugation, but without the need for high-end instrumentation. Raman and fluorescence-excitation spectroscopy, single-nanotube fluorescence imaging, atomic force and transmission electron microscopy, and thermogravimetric analysis all confirm the high purity of the isolated SWCNTs. By predispersing the SWCNTs without sonication （only gentle stirring）, full-length, pristine SWCNTs can be isolated （tested up to 20 μm）. hence, this simple ATP method will find immediate application in the generation of SWCNT materials for all levels of nanotube research and applications, from fundamental studies to high-performance devices.

关键词： carbon nanotubes aqueous two-phase (ATP)separation aggregate removal isolation sorting

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球虫病的天然防治措施

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国外畜牧学（猪与禽） 2017年第5期37卷 20-22页

作者：肖昌韩浩月 DIck van doorn

研究显示,用无抗球虫药的饲料来生产肉鸡,存在部分可能性,或在某些情况下完全可能。用球虫病天然的防制方案进行的一项田间试验显示了一个有应用前景的结果。

关键词：抗球虫药田间试验艾美尔球虫养禽业家禽生产养禽场球虫卵囊肠道健康家禽养殖癸氧喹酯

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荷兰合作银行专家讨论家禽业市场前景

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国外畜牧学（猪与禽） 2024年第5期44卷 56-58页

作者： Dick van doorn 郑素威(译) 王晓亮(校) 王晶晶(审) 不详

目前家禽业市场的总体发展趋势是缓慢增长,但不同市场的发展速度略有不同。荷兰合作银行专家Jeroen van den hurk和Nan Dirk Mulder与Poultry World杂志分享了家禽业发展趋势和面临的风险。

关键词：家禽市场前景发展趋势

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临床检查和MR成像在宫颈癌治疗前分期的比较:系统回顾和meta分析

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国际医学放射学杂志 2013年第5期 497-498页

作者： M,G.Thomeer C,Gerestein S,Spronk h,C.van doorn E.van der ham M.G.hunink 刘珏 Department of Radiology Erasmus University Medical Centre

摘要目的对临床检查和MR成像在宫颈癌病人子宫旁浸润和疾病进展分期(FIGO分期>ⅡB)中的诊断作用进行文献回顾。方法使用MEDLINE、EMBASE和Cochrane数据库进行文献检索。2位观察者记录用于分析的相关数据和应用QUADAS评分系统进行方法学... 详细信息

摘要目的对临床检查和MR成像在宫颈癌病人子宫旁浸润和疾病进展分期(FIGO分期>ⅡB)中的诊断作用进行文献回顾。方法使用MEDLINE、EMBASE和Cochrane数据库进行文献检索。2位观察者记录用于分析的相关数据和应用QUADAS评分系统进行方法学质量评价。应用Deeks漏斗图进行发表偏倚分析。在回归模型中加入了协变量,用于研究临床检查和MRI技术及方法学对汇总结果的影响。结

关键词：宫颈癌 MRI 病人 meta 宫旁浸润临床检查 MR

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54例荷兰籍迟发性Pompe病患者的临床表现和自然病程

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 17-18页

作者： hagemans M.L.C. Winkel L.P.F. van doorn P.A. A.T. van Der Ploeg 郭俊 Erasmus MC-Sophia Dr Molewaterplein 60 3015 GJ Rotterdam Netherlands Dr.

Late-onset Pompe’s disease (acid maltase deficiency, glycogen storage diseas e type II) is a slowly progressive myopathy caused by deficiency of acid α-glu cosidase. Current developments in enzyme replacement therapy require detailed kn owledge of the kind and severity of symptoms and the natural course of the disea se in the patient population.A detailed questionnaire covering the patients’med ical history and current situation was developed and information was gathered fr om 54 Dutch patients. The mean age of the participants was 48.6 ±15.6 *** first complaints started at a mean age of 28.1±14.3 years and were mostly rela ted to mobility problems and limb-girdle weakness. Fifty-eight percent of the adult patients indicated the presence of mild muscular symptoms during childhood . Twenty-eight percent of the patients waited > 5 years for the final diagnosis after the first visit to a physician for disease related complaints. At the tim e of questionnaire completion,48%of the study population used a wheelchair and 37%used artificial *** such as rising from an armchair,taking stairs or getting upright after bending over were difficult or impossible for m ore than two-thirds of the *** age at onset, the rate of disease pr ogression and the sequence of respiratory and skeletal muscle involvement varied substantially between patients. Seventy-six percent of the participants indica ted being troubled by fatigue and 46%by pain. This survey has mapped the age at onset, presenting symptoms, heterogeneity in progression and range of disease s everity in a large group of Dutch patients. We conclude that early manifestation s in childhood require proper attention to prevent unnecessary delay of the diag nosis. The follow-up of patients with late-onset Pompe’s disease should focus on respiratory and limb-girdle muscle function, the capacity to perform daily activities, and the presentation of fatigue and pain.

关键词： Pompe 酸性麦芽糖酶糖原贮积病问卷反馈 α-葡萄糖苷酶发病年龄肌病首次就诊缺乏症疼痛情况

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WONCA研究论文摘要汇编——患者家庭医疗的经历:荷兰2006年医疗改革后的纵向研究

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中国全科医学 2016年第31期19卷 3780-3780页

作者： van DEN hOMBERGh P van doorn-KLOMBERG A CAMPBELL S 本刊编辑部

背景2006年,荷兰医疗体制向以市场为导向的体制转变。本文的研究问题是2006年后患者对于家庭医疗的体验是否已经发生改变。本文探讨了家庭医生的表现和实践特征对患者经历的影响。方法在一系列年度横断面患者调查中测定家庭医生的表现... 详细信息

背景2006年,荷兰医疗体制向以市场为导向的体制转变。本文的研究问题是2006年后患者对于家庭医疗的体验是否已经发生改变。本文探讨了家庭医生的表现和实践特征对患者经历的影响。方法在一系列年度横断面患者调查中测定家庭医生的表现和实践特征。作为荷兰认证计划的一部分进行患者抽样,该计划涉及1 657个实践中的2 966名家庭医生。记录患者的经历、性别、年龄、健康状况、年度咨询以及实践的类型和地点。采用线性回归分析来描述患者经历的时间变化趋势以及家庭医生的表现和实践特征的影响。结果 78 985例患者评估了2 966名家庭医生的表现,45 773例患者评估了1 657个实践特征。2007—2012年对家庭医生的表现和实践特征有积极经历的患者数量分别增加了4.8%(β=0.20,P<0.001)和6.6%(β=0.10,P<0.004)。高龄、无慢性病、更频繁的咨询、单独参加实践预示着更好的患者经历。结论在2007—2012年有积极家庭医疗经历的患者数量增加。虽然没有得出直接原因,但是从2006年以来荷兰家庭医学的多种改革中应该会发现可能的解释。

关键词：全科医生患者数量家庭医生实践特征家庭医疗线性回归分析医疗改革医疗体制

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