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B7-h7 (hhLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling

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Cellular & Molecular Immunology 2021年第6期18卷 1503-1511页

作者： Sadiye Amcaoglu rieder Jingya Wang Natalie White Ariful Qadri Catherine Menard Geoffrey Stephens Jodi LKarnell Christopher ERudd Roland Kolbeck Present address:Viela Bio GaithersburgMDUSA Universite de Montreal MontrealQCCanada MedImmune/AstraZeneca GaithersburgMDUSA Biopharmaceuticals Early RIAAstraZenecaGaithersburgMDUSA Biopharmaceuticals Early RIAAstraZenecaGaithersburgMDUSA View author publications

Modulation of T-cell responses has played a key role in treating cancers and autoimmune ***,understanding how different receptors on T cells impact functional outcomes is *** influence of B7-h7(hhLA2)and CD28h(TMIGD2)on T-cell activation remains *** we examined global transcriptomic changes in human T cells induced by *** through TCR with OKT3 and B7-h7 resulted in modest fold changes in the expression of select genes;however,these fold changes were significantly lower than those induced by OKT3 and B7-1 *** transcriptional changes induced by OKT3 and B7-h7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine ***,B7-h7 was coinhibitory when simultaneously combined with TCR and CD28 *** inhibitory activity was comparable to that observed with ***,in physiological assays using T cells and APCs,blockade of B7-h7 enhanced T-cell activation and proliferation,demonstrating that this ligand acts as a break *** work defines that the transcriptomic changes induced by B7-h7 are insufficient to support full costimulation with TCR signaling and,instead,B7-h7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling.

关键词： T cell inhibition Checkpoint pathway T cell transcriptomics

h pylori infection causes chronic pancreatitis in Mongolian gerbils

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World Journal of Gastroenterology 2007年第29期13卷 3939-3947页

作者： Gabriele rieder Arno Karnholz Mechthild Stoeckelhuber Juanita L Merchant Rainer haas Max von Pettenkofer-Institute for hygiene and Medical Microbiology Ludwig-Maximilians-University 80336 Munich Germany Institute of Anatomy Ludwig- Maximilians-University 80336 Munich Germany University of Michigan Departments of Internal Medicine and Molecular and Integrative Physiology Ann Arbor Michigan United States

AIM： To investigate whether chronic h pylori infection has the potential to induce pancreatitis in the Mongolian gerbil model, and whether it is dependent on an intact type Ⅳ secretion system. METhODS： Mongolian gerbils were infected with wild type （WT） h pylori type Ⅰ strain B128 or its isogenic mutant B128 △cag γ （defective type Ⅳ secretion）. After seven months of infection, h pylori was reisolated from antrum and corpus and hpylori DNA was analyzed by seminested polymerase chain reaction （PCR）. Inflammation and histological changes were documented in the gastric antrum, corpus, and pancreas by immunohistochemistry. Cytokine mRNA, gastric ph, plasma gastrin, amylase, lipase, and glucose levels were determined. RESULTS： The h pylori infection rate was 95%. Eight infected animals, but none of the uninfected group, developed transmural inflammation and chronic pancreatitis. Extensive interstitial fibrosis and inflammation of the pancreatic lobe adjacent to the antrum was confirmed by trichrome stain, and immuno-histochemically. Pro-inflammatory cytokine mRNA was significantly increased in the antral mucosa of all infected gerbils. In the corpus, only cytokine levels of WT-infected animals andthose developing transmural inflammation and pancreatitis were significantly increased. Levels of lipase, but not glucose or amylase levels, were significantly reduced in the pancreatitis group. h pylori DNA was detected in infected antral and corpus tissue,but not in the pancreas CONCLUSION： h pylori infection is able to induce chronic pancreatitis in Mongolian gerbils independently of the type Ⅳ secretion system, probably by an indirect mechanism associated with a penetrating ulcer.

关键词： h pylori Mongolian gerbil Pancreatitis Gastritis Penetrating ulcer

Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice

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World Journal of Gastroenterology 2017年第16期23卷 2995-3002页

作者： Shomron Ben-horin Jane M Andrews Konstantinos h Katsanos Florian rieder Flavio Steinwurz Konstantinos Karmiris Jae hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-hu Chen Ofir har-Noy Charles N Bernstein Department of Gastroenterology Sheba Medical CenterSackler School of MedicineTel-Aviv UniversityRamat-Gan 52621Israel the First Affiliated hospital of Sun Yat-Sen University Guangzhou 510700Guangdong provinceChina Department of Gastroenterology and hepatology Inflammatory Bowel Disease ServiceRoyal Adelaide HospitalSchool of MedicineUniversity of AdelaideAdelaideSA 5005Australia Division of Gastroenterology School of Health SciencesUniversity of IoanninaIoannina 45500Greece Department of Gastroenterology Hepatology and NutritionDigestive Disease Diseases and Surgery InstituteCleveland Clinic FoundationClevelandOH 44109United States Unit of Inflammatory Bowel Disease Hospital Israelita Albert EinsteinSao PauloSP 05652-900Brazil Department of Gastroenterology Venizeleio General HospitalHeraklion71409 CreteGreece Department of Internal Medicine Yonsei University College of MedicineSeoul 03722South Korea NIhR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of NottinghamNottingham NG7 2UHUnited Kingdom Dipartimento di Medicina Interna e SpecialitàMediche “Sapienza”University of Rome00185 RomaItaly Comprehensive Digestive Institute of Nevada Las VegasNV 89113United States Department of Gastroenterology and hepatology Soroka University Medical CenterBeer-Sheva 6400111Israel Department of Gastroenterology University Hospital ZvezdaraBelgrade 11000Serbia Department of Gastroenterology University-Hospital of Saint-Etienne42100 Saint EtienneFrance Gastroenterology Unit S.Orsola-Malpighi40138 BolognaItaly IBD Clinical and Research Centre University of ManitobaWinnipegMB R3T2N2Canada

AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METhODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P however, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients.

关键词： Inflammatory bowel disease Corticosteroids 5-aminosalicylates Ulcerative colitis

由结核菌素调查结果对结核病问题作出估计时的方法学问题

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国际结核病与肺部疾病杂志 1996年第2期 60-67页

作者： h.L.rieder 李荣德 Tuberculosis Section of the International Union Against Tuberculosis and Lung Disease ParisFrance

背景:国家结核菌素皮肤试验调查。目的:检查结核菌素皮肤试验的工作特征,确定在不同情况下由结核菌素调查对感染率和感染的危险率所作估计的有效性,并检查由这种调查来估计社区中结核病问题的大小时受到的限制。方法:本报告利用假设的... 详细信息

背景:国家结核菌素皮肤试验调查。目的:检查结核菌素皮肤试验的工作特征,确定在不同情况下由结核菌素调查对感染率和感染的危险率所作估计的有效性,并检查由这种调查来估计社区中结核病问题的大小时受到的限制。方法:本报告利用假设的和选定在不同时点上地区和全国调查的真实资料,来说明方法学问题。结果:从理论上讲,结核菌素皮肤试验调查的主旨所在,为获知感染的危险率,用以对不同人口中结核杆菌的传染程度作出比较。但结核菌素皮肤试验调查的实施及其结果的分析与解释中,并非不存在重要的技术性问题。对于感染率的准确估计尤其易受在不同情况下千变万化的试验特异性的影响。另外,感染的年危险率有平均的特性,因而排除了对传染模式的变化进行快速评估的可能。最后一点,由于管理质量的不同,和由潜伏感染进展为明显结核病的危险性不定,因而感染危险率的估计值未必能提供可据以算出传染病例发生率的标准化参数。结论:虽然结核菌素皮肤试验调查提供了当前用以评估一社区在较长时期内结核病传染模式的最常用方法,但如果想得到对结核病问题的准确估计,必须在解释这类调查的结果时谨慎从事。

关键词：结核菌素皮肤试验感染率结核病年感染危险率方法学结核杆菌感染截止点分支杆菌调查结果传染性

耐药性结核病:流行病学的论题和公共卫生的挑战

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国际结核病与肺部疾病杂志 1995年第2期 43-45页

作者： h.L.rieder 阚冠卿 Tuberculosis Section of the International Unton Against Tuberculosis and Lung Disease Paris France

30年以前,Canetti含蓄地警告‘…鉴于野生菌株引起的结核病的最优的化学治疗可显著地降低耐药性发生率,普遍的感觉倾向于耐药性已退入历史…’随后医务界从美国和其它地方的教训苦涩地明白了Canetti真正的意思是最优的化学治疗而不是最... 详细信息

30年以前,Canetti含蓄地警告‘…鉴于野生菌株引起的结核病的最优的化学治疗可显著地降低耐药性发生率,普遍的感觉倾向于耐药性已退入历史…’随后医务界从美国和其它地方的教训苦涩地明白了Canetti真正的意思是最优的化学治疗而不是最优的药物。英国医学研究委员会(British Medical ResearchCouncil)早在链霉素试验中发现、现在已广泛了解:每一野生结核菌菌株内每1—10百万个细菌中约有1个细菌至少对已知药物的一种自然耐药。

关键词：耐药性菌株流行病学公共卫生肺结核病人 tuberculosis 化学治疗初始耐药性利福平英国医学研究委员会治疗史

国家结核病规程的两项极好的管理手段:既往治疗史和两个月痰的情况

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国际结核病与肺部疾病杂志 1998年第2期 41-43页

作者： A.Trébucq h.L.rieder 屠德华 International Union Against Tuberculosis and lung Disease parsFrance

ilkinson等~1在最近的论文中论证了给予异烟肼(h),利福平(R),吡嗪酰胺(Z)和链霉素(S)四种药周二次在直接观察下治疗6个月,可不必了解既往治疗史,也不需获得强化期治疗结束时的痰涂片检查结果,他们的论据是在他们的研究中发现该资料对预... 详细信息

ilkinson等~1在最近的论文中论证了给予异烟肼(h),利福平(R),吡嗪酰胺(Z)和链霉素(S)四种药周二次在直接观察下治疗6个月,可不必了解既往治疗史,也不需获得强化期治疗结束时的痰涂片检查结果,他们的论据是在他们的研究中发现该资料对预测以后的失败或复发几乎不起作用。由于掌握既往史和强化期结束时痰检查情况是国际防痨和肺病联合会(IUATLD)和世界卫生组织(WhO)对结核病控制规程所推荐的重要策略的组成部分~2。在放弃它之前对它们的合理性进行讨论是恰当的。

关键词：国家结核病规程管理手段治疗史直接观察下治疗强化期利福平 tuberculosis 结核病控制保健中心再治疗

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弹性针织物干收缩的原因

技术创新 2005年第4期 29-31页

作者： O.Wiedmier O.rieder h.Planck 邓肯道夫纺织工艺研究所，德国

不论圆机还是经编机生产的弹性针织物，如胸衣、运动服和休闲服、细针距长袜和短袜，常会出现尺寸利裁剪形状的偏差。由于这些针织物的市场销售份额增加，存在的不均匀性使难题增多。

关键词：弹性针织物原因收缩市场销售不均匀性经编机休闲服运动服细针距圆机胸衣短袜裁剪

荧光显微术与萋-尼氏染色技术在检查痰抗酸杆菌方面的比较

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国际结核病与肺部疾病杂志 2000年第Z1期 60-64页

作者： F.Ba h.L.rieder 吴雪琼 Laboratoire National de Reference pour la Tuberculose Programme National de lutte contre la Tuberculose Dakar Senegal 。Tubercolosis

背景:塞内加尔达喀尔国家结核病参比实验室。目的:比较荧光显微镜和明视野显微镜检查抗酸杆菌的结果。方法:1996年1月至1998年6月期间2630份痰标本被同时制备2种涂片,在1000倍物镜下分别进行萋-尼氏染色和荧光显微术检查,并应用这两种... 详细信息

背景:塞内加尔达喀尔国家结核病参比实验室。目的:比较荧光显微镜和明视野显微镜检查抗酸杆菌的结果。方法:1996年1月至1998年6月期间2630份痰标本被同时制备2种涂片,在1000倍物镜下分别进行萋-尼氏染色和荧光显微术检查,并应用这两种方法同时检查一例标本的68张涂片来确定判断一张涂片为阴性所需的检查时间。结果:诊断和随访检查时两者的符合率分别为96.9％和92.3％。当标本中每100个视野至少10条菌时,两者的检出率相似,但当标本中每100个视野少于10条菌时,荧光显微术的检出率较高。在同倍物镜下,荧光显微术判断一张涂片为阴性所需的检查时间平均为3分34秒,而萋-尼氏染色技术需7分44秒。结论:两者的检查结果非常相似。对于含菌量少的病例,荧光显微镜似比明视野显微镜的检出率更高,而且所需检查时间少一半多。

关键词：抗酸染色金胺O 荧光显微镜结核病萋-尼氏染色

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针织物弹性纱线织疵的起因

国际纺织导报 2005年第10期33卷 25-27页

作者： A.Seidel A.Kltzer O.rieder h.Planck 吕青邓肯道夫纺织技术与工艺研究所

以紧身内衣为例定义了针织物的弹性纱线织疵。研究和评定了形成弹性织疵的影响因素。总结了生产工艺链中各个阶段的影响因素。

关键词：针织物弹性纱线织疵