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Long-term esophageal and respiratory outcomes in children with esophageal atresia and tracheoesophageal fistula

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Gastroenterology Report 2016年第4期4卷 310-314,I0002页

作者： Richard h.Cartabuke Rocio Lopez prashanthi N.Thota Department of Internal Medicine Cleveland ClinicClevelandOHUSA Department of Biostatistics Cleveland ClinicClevelandOHUSA Department of Gastroenterology and hepatology Cleveland ClinicClevelandOHUSA

Objectives:Few studies have evaluated the long-term complications and outcomes of esophageal atresia with or without tracheoesophageal fistula(EA/TEF)beyond *** aim of our study was to characterize the esophageal and respiratory morbidity of EA/TEF through evaluation of clinical symptoms,diagnostic testing and therapeutic intervention at a tertiary care ***:patients with congenital EA/TEF evaluated from 2011 to 2014 were *** characteristics,type and mode of repair of EA/TEF,clinical symptoms,radiographic,endoscopic,bronchoscopic and medication use data were ***:A total of 43 patients were *** median age of this predominantly Caucasian population was 8 years(interquartile range:3,20).Twenty(62.5%)had type C(EA with distal TEF)***-one(48.8%)patients had heartburn,19(44.1%)had acid regurgitation,and 31(72.1%)had dysphagia to *** swallow in 26 patients revealed strictures in 17(65.4%),dysmotility in 20(76.9%)and recurrent fistulas in four patients(15.4%).Thirty patients underwent upper endoscopy,of which 21(70.0%)had a stricture,and six(20.0%)had recurrent fistula requiring surgical ***(18.6%)patients underwent *** evaluation showed cough and choking in 31(72.1%)patients and dyspnea and wheezing in 32(53.4%)*** respiratory infections were reported in 19(44.2%).*** findings included tracheomalacia in 86.7% and restrictive lung disease in 54.5%of ***:There is a high burden of residual esophageal and pulmonary pathology in patients with EA/*** follow-up is required to monitor both the clinical symptoms and treatment responses.

关键词： esophageal atresia tracheoesophageal fistula gastroesophageal reflux disease(GERD) esophageal dysmotility aspiration pneumonia

Effect of Crystallization Conditions on polymorphic Diversity of Malic Acid RS-Racemate

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Transactions of Tianjin University 2013年第2期19卷 86-91页

作者： Isakov A I Kotelnikova E N Kryuchkova L Yu Lorenz h St.petersburg State University St.Petersburg 199034Russia Max planck Institute for Dynamics of Complex Technical Systems Magdeburg 39106Germany

Enantiomers （R （＋） and S（-））, RS-racemate mixture of enantiomers） of malic acid C4h605 have been （double compound） and （R ＋ S） -conglomerate （mechanical investigated by means of X-ray diffractometry and high tern- perature X-ray diffraction method. The RS-racemate was found to be able to form three polymorphic modifications, which we denominated as M1 （monoclinic, space group p21/c）, M2 （monoclinic, space group Cc）, and Tc （triclinic, space group p-l ）, the latter modification having been unknown before. Modification Tc was also described, and its X- ray diffraction characteristics, including interplanar spacings d, hkl indices, unit cell parameters, were defined. In addi- tion, X-ray diffraction characteristics for both reported earlier M1 and M2 monoclinic polymorphic modifications were measured with higher accuracy. The ability of RS-racemate to form one of the above three modifications （MI, M2, and Tc） or their mixtures containing various proportions and combinations of the components （M1 ＋ M2, M1 ＋ Tc, or M2 ＋ Tc） was found to depend on the type of crystallization medium （a melt, aqueous medium, ethanol or acetone solu- tion）, crystallization rate （from 2--3 minutes to 4 months）, and crystallization temperature. heating S-enantiomer and M1 RS-racemate up to their respective melting points （100 ℃ and 124 ℃, correspondingly） only made them undergo thermal deformations, while heating （R ＋ S） -conglomerate in the temperature range of 96--110 ℃ resulted in its homogenization to form M2 RS-racemate, which, near the melting point （118 ℃）, namely, in the range of 112-116 ℃, was transformed into MI RS-racemate. Keywords： polvmorDhism; racemic, chiral

关键词： polymorphism racemic chiral

A Chaotic pulse Train Generator Based on henon Map

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Intelligent Automation & Soft Computing 2023年第7期37卷 1197-1207页

作者： Babu h.Soumya N.Vijayakumar K.Gopakumar College of Engineering Trivandrum695016India Government Engineering College Barton HillTrivandrum695035India ApJ Abdul Kalam Technological University Trivandrum695016India

The henon map forms one of the most-studied two-dimensional discrete-time dynamical systems that exhibits chaotic *** henon map takes a point(Xn,Yn)in the plane and maps it to a new point(Xn+1,Yn+1).In this paper,a chaotic pulse generator based on the chaotic henon map is *** consists of a henon map function subcircuit to realize the henon map and another subcircuit to perform the iterative *** henon map subcircuit comprises operational amplifiers,multipliers,delay elements and resistors,whereas,the iterative subcircuit is implemented with a simple design that comprises of an edge forming circuit followed by a monostable multivibrator and a voltage controlled switch without the use of any clock *** proposed design can be used to realize the henon map and also to generate a chaotic pulse train,with a controllable time interval and pulse *** proposed circuit is implemented and simulated using Multisim 13.0 and MATLAB *** chaotic nature of the generated pulse train and also the time interval between the consecutive pulses is verified by the calculation of its Lyapunov exponents.

关键词： Chaos iterated maps henon map chaotic pulse train lyapunov exponents

Structural biology of the macroautophagy machinery

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Frontiers in Biology 2014年第1期9卷 18-34页

作者： Leon h. ChEW Calvin K. YIp Department of Biochemistry and Molecular Biology The University of British Columbia 2350 Health Sciences Mall Vancouver BC V6T1Z3 Canada

Macroautophagy is a conserved degradative process mediated through formation of a unique double- membrane structure, the autophagosome. The discovery of autophagy-related （Atg） genes required for autophagosome formation has led to the characterization of approximately 20 genes mediating this process. Recent structural studies of the Atg proteins have provided the molecular basis for their function. here we summarize the recent progress in elucidating the structural basis for autophagosome formation.

关键词： macroautophagy autophagy Atg proteins structural biology X-ray crystallography single-particle electronmicroscopy

Glycerol mediated synthesis of 5-substituted lh-tetrazole under catalyst free conditions

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Chinese Chemical Letters 2012年第2期23卷 161-164页

作者： Kamalakar p.Nandre Jagdish K.Salunke Jitendra p.Nandre Vijay S.patil Amul U.Borse Sidhanath V.Bhosale Department of Organic Chemistry North Maharashtra UniversityJalgaon 425001India School of Chemical Sciences North Maharashtra UniversityJalgaon 425001India

We have developed simple,cost effective and environmentally benign protocol for the synthesis of 5-substituted 1h-tetrazoles via[2,3]cycloaddition reaction from organic nitriles and sodium azide in glycerol under cata... 详细信息

关键词： 5-Substituted 1h-tetrazole [3+2]Cycloaddition Nitriles Glycerol Catalyst free

protective effect of basic fibroblast growth factor on laser induced retinopathy

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 744-751页

作者： Unal Kartal Emel Koptagel h.Eray Bulut haydar Erdogan Department of histology and Embryology Faculty of MedicineCumhuriyet University Department of Ophtalmology Faculty of MedicineCumhuriyet University

AIM:To investigate the side effects of the commonly used laser treatment along with testing the neuroprotective effect of bFGF on a potential retinal ***:To do this,30 chinchilla pigmented adult male rabbits were divided into the control and experimental *** control and experimental groups underwent both laser application and bFGF *** retinal tissue impairment and its renewal rate were tested under the light and electron microscopical ***:The focal laser application on rabbit eyes caused morphological alterations both in the application region and in the neighbouring *** the damaged areas,the outer nuclear layer of the neural retina was almost disappeared,retina pigment epithelium was interrupted,the retina pigment epithelium migrated intraretinally,and the damaged region along with neighbouring areas seemed to be not *** application just after the laser photocoagulation,revealed better results in application ***:It could be suggested that the bFGF application following laser photocoagulation might have protective,repairing and wound healing effects on the retina.

关键词： retina bFGF laser photocoagulation rabbit light microscopy electron microscopy

Beta Gyres in Global Analysis Fields

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Advances in Atmospheric Sciences 2009年第5期26卷 984-994页

作者： Sun-hee KIM h. Joe KWON R. L. ELSBERRY Department of Atmospheric Sciences/Typhoon Research Center Kongju National University Department of Meteorology Naval Postgraduate School

A three-component decomposition is applied to global analysis data to show the existence of a beta gyre, which causes Tropical Cyclone （TC） to drift from a large-scale environmental steering current. Analyses from the Global Data Assimilation and prediction System （GDApS） of the Korea Meteorological Adminis- tration （KMA）, the Global Forecast System （GFS） of NCEp, and the Navy Operational Global Atmospheric prediction System （NOGApS） are used in this study. The structure of the beta gyre obtained in our analyses is in good agreement with the theoretical structure, with a cyclonic circulation to the southwest of the TC center, an anticyclonic circulation to the northeast, and a ventilation flow directed northwestward near the center. The circulation of the beta gyre is strongest at the 850-hpa level where the cyclonically swirling primary circulation is strongest, and decreases with height, in a pyramid shape similar to the primary circulation. The individual structure of the beta gyre is case- and model-dependent. At a certain analysis time, one model may clearly reveal a well-defined beta gyre, but the other models may not. Within one model, the beta gyre may be well defined at some analysis times, but not at other times. The structure of the beta gyre in the analysis field is determined by the nature of the vortex initialization scheme and the model behavior during the 6-h forecast in the operational data assimilation cycle.

关键词： tropical cyclone beta gyre GDApS GFS NOGApS TCM-90 final analyses

Cytochrome p450 levels are altered in patients with esophageal squamous-cell carcinoma

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World Journal of Gastroenterology 2007年第7期13卷 997-1002页

作者： I Bergheim E Wolfgarten E Bollschweiler Ah hlscher C Bode A parlesak Department of physiology of Nutrition Hohenheim University (140e) Stuttgart 70599 Germany Department of Visceral and Vascular Surgery University of Cologne Cologne Germany

AIM： To investigate the role of cytochrome p450 （CYp） in the carcinogenesis of squamous-cell carcinoma （SCC） in human esophagus by determining expression patterns and protein levels of representative CYps in esophageal tissue of patients with SCC and controls. METhODS： mRNA expression of CYp2E1, CYp2C, CYp3A4, and CYp3A5 was determined using RT-pCR in both normal and malignant esophageal tissues of patients with untreated esophageal SCC （/7 = 21） and in controls （n = 10）. protein levels of CYp2E1, CYp2CS, CYp3A4, and CYp3A5 were measured by Western blot. RESULTS： Within the group of SCC patients, mRNA expression of CYp 3A4 and CYp2C was significantly lower in malignant tissue （-39% and -74%, respectively, p 〈 0.05） than in normal tissue. Similar results were found in CYp3A4 protein levels. Between groups, CYp3A4, CYp3A5, and CYp2C8 protein concentration was significantly higher in non-malignant tissue of SCC patients （4.8-, 2.9-, and 1.9-fold elevation, p 〈 0.05） than in controls. In contrast, CYp2E1 protein levels were significantly higher in controls than in SCC patients （＋46%, p 〈 0.05）. CONCLUSION： Significant differences exist in protein levels of certain CYps in non-malignant esophageal tissue （e.g. CYp2CB, CYp3A4, CYp3A5, and CYp2E1） between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus.

关键词： Squamous-cell carcinoma Cytochrome p450 Western blot RT-pCR human