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Eth2Vec:Learning contract-wide code representations for vulnerability detection on Ethereum smart contracts

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Blockchain(Research and Applications) 2022年第4期3卷 109-122页

作者： Nami Ashizawa Naoto Yanai Jason Paul Cruz Shingo okamura School of Information Science and Technology Osaka UniversityOsaka 565-0871Japan Osaka University Osaka 565-0871Japan National Institute of Technology Nara CollegeNara 639-1080Japan

Ethereum smart contracts are computer programs that are deployed and executed on the Ethereum blockchain to enforce agreements among untrusting *** the most prominent platform that supports smart contracts,Ethereum has been targeted by many attacks and plagued by security ***,many smart contract vulnerabilities have been discovered in the past *** detect and prevent such vulnerabilities,different security analysis tools,including static and dynamic analysis tools,have been created,but their performance decreases drastically when codes to be analyzed are constantly being *** this paper,we propose Eth2Vec,a machine-learning-based static analysis tool that detects smart contract ***2Vec maintains its robustness against code rewrites;i.e.,it can detect vulnerabilities even in rewritten *** machine-learning-based static analysis tools require features,which analysts create manually,as *** contrast,Eth2Vec uses a neural network for language processing to automatically learn the features of vulnerable *** doing so,Eth2Vec can detect vulnerabilities in smart contracts by comparing the similarities between the codes of a target contract and those of the learned *** performed experiments with existing open databases,such as Etherscan,and Eth2Vec was able to outperform a recent model based on support vector machine in terms of well-known metrics,i.e.,precision,recall,and F1-score.

关键词： Ethereum Smart contracts Blockchain Neural networks Static analysis Code similarity Vulnerability detection

Identification of an intronic enhancer regulating RANKL expression in osteocytic cells

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Bone Research 2023年第3期11卷 607-616页

作者： Minglu Yan Masayuki Tsukasaki Ryunosuke Muro Yutaro Ando Kazutaka Nakamura Noriko Komatsu Takeshi Nitta Tadashi okamura Kazuo Okamoto hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Microbiology Tokyo Dental CollegeTokyoJapan Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The bony skeleton is continuously renewed throughout adult life by the bone remodeling process,in which old or damaged bone is removed by osteoclasts via largely unknown *** regulate bone remodeling by producing the osteoclast differentiation factor RANKL(encoded by the TNFSF11 gene).however,the precise mechanisms underlying RANKL expression in osteocytes are still ***,we explored the epigenomic landscape of osteocytic cells and identified a hitherto-undescribed osteocytic cell-specific intronic enhancer in the TNFSF11 gene *** analyses showed that transcription factors involved in cell death and senescence act on this intronic enhancer ***-cell transcriptomic data analysis demonstrated that cell death signaling increased RANKL expression in osteocytic *** deletion of the intronic enhancer led to a high-bone-mass phenotype with decreased levels of RANKL in osteocytic cells and osteoclastogenesis in the adult stage,while RANKL expression was not affected in osteoblasts or *** data suggest that osteocytes may utilize a specialized regulatory element to facilitate osteoclast formation at the bone surface to be resorbed by linking signals from cellular senescence/death and RANKL expression.

关键词： utilize removed linking

高速发动机中曲轴振动、发动机结构振动与噪声相关性的研究

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汽车与新动力 1998年第1期 23-36页

作者： okamura h.okamura T Morita T Morita T 朱晓天

在大多数高速发动机中,曲轴系统会成为最危险的激振源之一。由于曲轴具有较大的动能和弹性势能,并直接承受脉冲激振力,因而通常会产生较大的发动机结构振动和噪声。然而,所有的激振力仅通过曲轴主轴承从旋转的曲轴系统传到发动机结构体... 详细信息

在大多数高速发动机中,曲轴系统会成为最危险的激振源之一。由于曲轴具有较大的动能和弹性势能,并直接承受脉冲激振力,因而通常会产生较大的发动机结构振动和噪声。然而,所有的激振力仅通过曲轴主轴承从旋转的曲轴系统传到发动机结构体。为了研究曲轴系统与发动机结构之间的相互激振的影响,以及曲轴振动与发动机结构噪声之间的相关性,对以下三种现象进行了测量:曲轴三维振动特性;每个曲轴主轴承的振动特性;发动机1m处结构噪声。将不同工况下同时获得的这些测量结果与计算结果作了比较。用两种柴油机(直列4缸机和直列6缸机)和一种汽油机(V形6缸机)进行了试验和分析。

关键词：高速柴油机汽油机曲轴振动噪声

Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice

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World Journal of Gastroenterology 2017年第13期23卷 2294-2307页

作者： Takuhito Sezaki Yuki hirata Teruki hagiwara Yuki I Kawamura Tadashi okamura Rieko Takanashi Kenta Nakano Miwa Tamura-Nakano Linda C Burkly Taeko Dohi Department of Gastroenterology Research Center for Hepatitis and ImmunologyResearch InstituteNational Center for Global Health and Medicine Research Center for hepatitis and Immunology Research InstituteNational Center for Global Health and Medicine 2~(nd)Department of Internal Medicine Osaka Medical College Section of Animal Models Department of Infectious DiseasesResearch InstituteNational Center for Global Health and Medicine Communal Laboratory Research InstituteNational Center for Global Health and Medicine Biogen

AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil(5-FU)-induced *** Diarrhea was induced in wild-type(WT), Fn14 knockout(KO), and IL-13 receptor(IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinomabearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also ***5-FU induced high Fn14 expression in epithelial cells. The severity of 5-FU-induced diarrhea was lower in Fn14 KO mice compared with WT mice. Administration of anti-TWEAK antibody reduced 5-FU-induced diarrhea without affecting the antitumor effects of 5-FU in vivo. 5-FU-induced expression of IL-13, IL-17 A, TNF-α, and IFN-γ in the ileum was Fn14 dependent. The severity of 5-FU-induced diarrhea was lower in IL-13Rα1 KO mice, indicating major role for IL-13 signaling via IL-13Rα1 in pathogenesis. We found that IL-13Rα2, an IL-13 neutralizing/cell protective receptor, was strongly induced by IL-33 in vitro and in vivo. IL-13Rα2 was upregulated in the ileum of 5-FU-treated Fn14 KO mice. Thus, the deletion of Fn14 upregulated IL-13Rα2 expression, which reduced IL-13 expression and activity. CONCLUSION Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways, including those associated with IL-13, IL-33, and IL-13Rα2, to attenuate 5-FUinduced intestinal side effects.

关键词： Cancer chemotherapy Interleukin-13 Interleukin-33 Interleukin-13 receptor α2

Structural Changes of Water Molecules Upon the Reduction of Quinones in The Reaction Center from Rhodobactery Sphaeroides

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复旦学报（自然科学版） 2007年第5期46卷 589-页

作者： T.Iwata M.L.Paddock M.Y.okamura h.Kandori Department of Materials Science and Engineering Nagoya Institute of Technology Department of Physics University of California at San Diego

1 Results The photosynthetic bacterial reaction center (RC) is a membrane protein *** RC is composed of three protein subunits and redox components such as bacteriochlorophylls, bacteriopheophytins,and *** RC performs the photochemical electron transfer from the bacteriochlorophyll dimer through a series of electron donor and acceptor molecules to a secondary quinone,*** accepts electrons from a primary quinone,QA,in two sequential electron transfer *** second electron trans...

关键词： photosynthetic reaction center proton uptake FTIR spectroscopy

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

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International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi okamura Akira Yamaguchi Kazuyuki Ishihara hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. however, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects:how far shall we wander?

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Acta Pharmacologica Sinica 2019年第8期40卷 1119-1126页

作者： Qin Lu Sheng-ming Wang Yi-xiao Liu hong Chen Rui Zhang Wen-hui Zhang Yuan-yuan Zou Jia-wei Zhou Xin-yi Guo Ying Zhang Teng-Li huang Yu-hang Liu Si-qi Zhang Kyosuke Yamanishi hiromichi Yamanishi hideaki higashino haruki okamura Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of Medicine hirakata Ryoikuen

Successful prevention and treatment of hypertension depend on the appropriate combination of antihypertensive drug therapy and nondrug lifestyle *** most hypertension guidelines recommend moderate-to high-intensity exercise,we decided to explore a mild yet effective type of exercise to add to hypertension management,especially in populations with complications or *** comparing the short-term cardiovascular effects of low-speed walking versus high-speed walking for 3 kilometers(km)(3 km/h versus 6 km/h)in young,healthy volunteers,we delivered low-speed walking(low-intensity walking,2.5 metabolic equivalents of task,METs)as exercise therapy in 42 prehypertensive and 43 hypertensive *** found that one session of 3 km low-intensity walking exerted a transient pressure-lowering effect as well as a mild negative chronotropic effect on heart rate in both the prehypertensive and hypertensive subjects;these short-term benefits on blood pressure and heart rate were accompanied by a brief increase in urine β-endorphin *** we prescribed regular low-intensity walking with a target exercise dose(exercise volume)of 500-1000 METs-min/week(50-60 min/day and 5-7 times/week)in hypertensive subjects in addition to their daily *** low-intensity walking also showed mild but significant blood pressure-lowering and heart rate-reducing effects in 7 hypertensive subjects within two *** is hypothesized that regular low-intensity exercise of the necessary dose could be taken as a pragmatic and supplementary medication for hypertension management.

关键词： hypertension prehypertension exercise medication low-intensity walking metabolic equivalent of task blood pressure heart rate urine β-endorphin

CA诱导成骨细胞Akt磷酸化及TNF-α的表达

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CA诱导成骨细胞Akt磷酸化及TNF-α的表达

2007年新潟县中越近海地震期间柏崎刈羽核电站垂直阵观测的土的非线性行为

中华口腔医学会第七届全国口腔病理学术会议

作者：仇丽鸿 Kaya Yoshida hirohiko okamura Tatsuji haneji The University of Tokushima Graduate School Tokushima 770-8504 Japan 中国医科大学口腔医学院

＜正＞肿瘤坏死因子（TNF-α）是多功能的细胞因子,可以引起炎症性骨丧失。Calyculin A是一种蛋白磷酸酶抑制剂,本研究采用分子生物学的方法,检测CA对成骨细胞中TNF-α的影响,探讨其分子作用机制。结果表明,1nM CA作用于成骨细胞1h时,...

＜正＞肿瘤坏死因子（TNF-α）是多功能的细胞因子,可以引起炎症性骨丧失。Calyculin A是一种蛋白磷酸酶抑制剂,本研究采用分子生物学的方法,检测CA对成骨细胞中TNF-α的影响,探讨其分子作用机制。结果表明,1nM CA作用于成骨细胞1h时,可以明显促进 TNF-αmRNA的表达,PI3K抑制剂LY,WM预处理,则抑制CA诱导的TNF-α表达。Western

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世界地震译丛 2012年第2期43卷 62-76页

作者： h. Mogi S. S. Man h. Kawakami S. okamura 胡勐乾(译) 侯春林(校) 吕春来(复校) 不详环境保护部核与辐射安全中心

2007年新潟县中越近海地震期间柏崎刈羽核电站遭受到极强的震动。该核电站周围密集的地震检波器阵观测到的加速度记录目前已对公众开放,将会提供有价值的资料。基于在主震及前震、余震中观测到的垂直阵记录,利用归一化输入输出最小化(NI... 详细信息

2007年新潟县中越近海地震期间柏崎刈羽核电站遭受到极强的震动。该核电站周围密集的地震检波器阵观测到的加速度记录目前已对公众开放,将会提供有价值的资料。基于在主震及前震、余震中观测到的垂直阵记录,利用归一化输入输出最小化(NIOM)方法研究了S波速度随时间的变化。在地表下50m与50～100m的地层中,发现在主震的主运动期间S波速度显著降低,显示了非线性行为。然而在地表100m以下的基岩层中,观测到了近似线性的行为。并且发现在100m以内的地层中,主运动后不久S波速度增大,说明这些地层没有发生较大的液化。最后,基于得到的S波速度研究了剪切模量和剪应变之间的关系。地表层及中间层的归一化剪切模量(G/G0)降低到约0.2(应变水平1×10-3～1×10-2)和0.6(在应变水平1×10-3～2×10-3)。

关键词：非线性行为核电站垂直阵地震期观测近海 S波速度柏