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微纳电子技术 1974年第6期 10-12页

作者： h.okamoto S.Sakata 周章文

在比较低的砷压条件下生长的汽相外延GaAs高阻层中,发现了几种有兴趣的性质,比如:(ⅰ)大的正电阻率温度系数(PTCR),(ⅱ)大的光电导,和(ⅲ)电流控制的负阻,提出了可能的解释。

关键词：高阻层 GaAs 衬底基片外延层电阻系数电阻率电阻负阻电流控制温度系数地层薄层

Abnormal uterine bleeding successfully treated via ultrasoundguided microwave ablation of uterine myoma lesions: Three case reports

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World Journal of Clinical Cases 2024年第5期12卷 980-987页

作者： Toshiyuki Kakinuma Kaoru Kakinuma Rora okamoto Kaoru Yanagida Michitaka Ohwada NobuhiroTakeshima Takeshima Department of Obstetrics and GynecologyInternational University of Health and Welfare HospitalTochigi 329-2763Japan

BACKGROUND Microwave endometrial ablation(MEA)is a minimally invasive treatment method for heavy menstrual ***,additional treatment is often required after recurrence of uterine myomas treated with ***,because this treatment ablates the endometrium,it is not indicated for patients planning to become *** overcome these issues,we devised a method for ultrasound-guided microwave ablation of uterine myoma feeder *** report three patients successfully treated for heavy menstrual bleeding,secondary to uterine myoma,using our novel *** SUMMARY All patients had a favorable postoperative course,were discharged within 4 h,and experienced no ***,no postoperative recurrence of heavy menstrual bleeding was *** method also reduced the myoma’s maximum *** This method does not ablate the endometrium,suggesting its potential appli-cation in patients planning to become pregnant.

关键词： Uterine myoma Microwave heavy menstrual bleeding Dysmenorrhea Fertility preservation Case report

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聚氨酯弹性体的电致伸缩效应

聚氨酯工业 2005年第1期20卷 5-9页

作者：丛羽奇吴建锋黄伟生林保平李建清冈本弘东南大学化学化工系南京210096 东南大学仪器科学系南京210096 爱知工业大学应用化学系

电致伸缩是指在外电场作用下电介质所产生的与场强二次方成正比的应变。近年来对聚氨酯电致伸缩性能的研究发现,聚氨酯弹性体综合了压电聚合物与传统的锆钛酸铅(PZT)压电陶瓷片的优点,具有很好的应用前景,本文简单介绍了聚氨酯的电致伸... 详细信息

电致伸缩是指在外电场作用下电介质所产生的与场强二次方成正比的应变。近年来对聚氨酯电致伸缩性能的研究发现,聚氨酯弹性体综合了压电聚合物与传统的锆钛酸铅(PZT)压电陶瓷片的优点,具有很好的应用前景,本文简单介绍了聚氨酯的电致伸缩效应。

关键词：聚氨酯弹性体电致伸缩效应应用前景锆钛酸铅性能 PZT 研究压电陶瓷片电介质场强

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

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International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo okamoto Kenta Nakano Tadashi Okamura Akira Yamaguchi Kazuyuki Ishihara hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. however, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis

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World Journal of Gastroenterology 2006年第28期12卷 4511-4516页

作者： Martin h Bluth Sameer A Patel Brian K Dieckgraefe hiroshi okamoto Michael E Zenilman Department of Surgery State University of New York-Downstate Medical CenterBrooklynNew YorkUnited States Department of Surgery Montefiore Medical Center and Albert Einstein College of MedicineBronxNew YorkUnited States Department of Medicine Division of GastroenterologyWashington University School of MedicineSt. LouisMissouriUnited States Department of Biochemistry Tohoku University Graduate School of MedicineSendaiJapan

AIM： Pancreatic regenerating protein （reg Ⅰ ） stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal and 13-cells. This suggests that reg Ⅰand its receptor may play a role in recovery after pancreatic injury. We hypothesized that reg Ⅰ and its receptor are induced in acute pancreatitis. METhODS： Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls （4 rats/group）. Reg Ⅰ receptor mRNA, serum reg Ⅰ protein, and tissue reg Ⅰ protein levels were determined by Northern analysis, enzymelinked immunosorbent assay （ELISA）, and Western analysis, respectively. Immunohistochemistry was used to localize changes in reg Ⅰ and its receptor. RESULTS： Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum reg Ⅰ concentrations from controls. however, Western blot demonstrated increased tissue levels of reg Ⅰ at 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in reg Ⅰ receptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION： Acute pancreatitis results in increased tissue reg Ⅰ protein levels localized to the acinar and ductal cells, and a parallel threefold induction of reg Ⅰ receptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg Ⅰand its receptor may be important for recovery from acute pancreatitis.

关键词： Acute pancreatitis Reg, reg receptor Taurocholate Regeneration

Fast Optical Switching Using Oriented Cyanine Dye-Doped Nematic Liquid Crystal

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Chinese Physics Letters 2006年第10期23卷 2786-2789页

作者：金朝辉李忠玉 KASATANI Kazuo okamoto hiroaki Department of Advanced Materials Science and Engineering Faculty of Engineering Yamaguchi University Tokiwadai Ube 755-8611 Japan

A cyanine dye, 2-[7-（1,3-dihydro-1,3,3-trimethyl-2h-indol-2-ylidene）-1,3,5-heptatrienyl]-1,3,3-trimethyl-3h-indolium iodide （NK-125）, is doped in 4-cyano-4＇-pentylbiphenyl （5 CB）, and the mixture is sandwiched between two pieces of rubbed glass plates. The third-order nonlinear optical properties of the oriented NK-125-SCB layers are measured by the resonant femtosecond degenerate four-wave mixing （DFWM） technique at 760 nm. The third-order nonlinear optical susceptibility of one of the present samples is 5.5×10^-8 esu. The slow DFWM response of the NK-125-SCB layers due to a population grating is accelerated by the increasing laser power because of amplified spontaneous emission （ASE）. On the other hand, we do not observe a similar phenomenon for NK-125- polyethylene glycol （PEG-400）. Oriented NK-125 molecules in nematic liquid crystals must have very high ASE efficiency. hence the population grating in a DFWM signal disappears within about 4 ps. It is expected that NK-125-SCB can be used as a material for very fast all-optical switching.

关键词： RELAXATION DYNAMICS ENERGY-TRANSFER SQUARYLIUM DYE COATING FILMS POLYMER-FILMS FAST-RESPONSE NONLINEARITIES STATE SUSCEPTIBILITY SPECTROSCOPY

Temperature and Nitric Oxide Generation in a Pulsed Arc Discharge Plasma

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Plasma Science and Technology 2007年第6期9卷 747-751页

作者： T.NAMIhIRA S.SAKAI M.MATSUDA D.WANG T.KIYAN h.AKIYAMA K.okamoto K.TODA Graduate School of Science and Technology Kumamoto University2-39-1 KurokamiKumamoto cityKumamoto 860-8555Japan Department of Intensive and Critical Care Medicine Shinshu University School of Medicine3-1-1 AsahiMatsumoto cityNagano 390-8621Japan Department of Environmental Science Kumamoto University2-39-1 KurokamiKumamoto cityKumamoto 860-8555Japan

Nitric oxide （NO） is increasingly being used in medical treatments of high blood pressure, acute respiratory distress syndrome and other illnesses related to the lungs. Currently a NO inhalation system consists of a gas cylinder of N2 mixed with a high concentration of NO. This arrangement is potentially risky due to the possibility of an accidental leak of NO from the cylinder. The presence of NO in the air leads to the formation of nitric dioxide （NO2）, which is toxic to the lungs. Therefore, an on-site generator of NO would be highly desirable for medical doctors to use with patients with lung disease. To develop the NO inhalation system without a gas cylinder, which would include a high concentration of NO, NAMIhIRA et al have recently reported on the production of NO from room air using a pulsed arc discharge. In the present work, the temperature of the pulsed arc discharge plasma used to generate NO was measured to optimize the discharge condition. The results of the temperature measurements showed the temperature of the pulsed arc discharge plasma reached about 10,000 K immediately after discharge initiation and gradually decreased over tens of microseconds. In addition, it was found that NO was formed in a discharge plasma having temperatures higher than 9,000 K and a smaller input energy into the discharge plasma generates NO more efficiently than a larger one.

关键词： pulsed arc discharge plasma temperature nitric oxide medical application

Pharmacokinetic study of paclitaxel in malignant ascites from advanced gastric cancer patients

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World Journal of Gastroenterology 2006年第9期12卷 1412-1415页

作者： Michiya Kobayashi Junichi Sakamoto Tsutomu Namikawa Ken okamoto Takehiro Okabayashi Kengo Ichikawa Keijiro Araki Department of Tumor Surgery Kochi Medical School KohasuOko-choNankoku 783-8505Japan Department of Epidemiological & Clinical Research Information Management Kyoto University Graduate School of Medicine Yoshida Hon-machiSakyo-ku 606-8317Japan Department of Tumor Surgery Kochi Medical School Kohasu Oko-cho Nankoku 783-8505 Japan

AIM： To examine the paclitaxel concentrations in plasma and ascites after its intravenous administration in patients with ascites due to peritonitis carcinomatosa resulting from advanced gastric cancer. METhODS： Two patients with ascites due to peritonitis carcinomatosa resulting from gastric cancer were included in this study. The paclitaxel concentrations in plasma and ascites were investigated for 72 h in case 1 and 168 h in case 2 after intravenous administration. RESULTS： The paclitaxel concentration in plasma peaked immediately after administration, followed by rapid decrease below the threshold value of 0.1 μmol （85 ng/mL） within 24 h. In contrast, the paclitaxel concentration in ascites increased gradually for 24 h after administration to a level consistent with the level found in plasma. After 24 h the level of paclitaxel in ascites and plasma became similar, with the optimal level being maintained up to 72 h following administration. CONCLUSION： The concentration of paclitaxel in ascites is maintained within the optimal level for the treatment of cancer cells for up to 72 h after intravenous administration. Paclitaxel is a promising drug for the treatment of malignant ascites of gastric cancer.

关键词： Paclitaxel Chemotherapy Gastric cancer Peritoneal carcinomatosis Pharmacokinetic study Ascites

Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis

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Bone Research 2019年第1期7卷 66-75页

作者： Yuta Nakai Kazuo okamoto Asuka Terashima Shogo Ehata Jun Nishida Takeshi Imamura Takashi Ono hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Orthodontic Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityYushima 1-5-45Bunkyo-kuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Molecular Pathology Graduate School of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Molecular Medicine for Pathogenesis Ehime University Graduate School of MedicineShitsukawaToonEhimeJapan

Bone is one of the preferred sites for the metastasis of malignant tumours,such as breast cancer,lung cancer and malignant *** cells colonizing bone have the capacity to induce the expression of receptor activator of nuclear factor-κB ligand(RANKL),which promotes osteoclast differentiation and ***-induced osteoclastic bone resorption leads to a vicious cycle between tumours and bone cells that fuels osteolytic tumour growth,causing bone pain and ***,RANKL contributes to bone metastasis by acting as a chemoattractant to bone for tumour cells that express its receptor,*** inhibition of the RANKL–RANK pathway is a promising treatment for bone metastasis,and a human monoclonal anti-RANKL antibody,denosumab,has been used in the ***,orally available drugs targeting RANKL must be developed to increase the therapeutic benefits to *** we report the efficacy of the small-molecule RANKL inhibitor AS2676293 in treating bone metastasis using mouse *** administration of AS2676293 markedly inhibited bone metastasis of human breast cancer cells MDA-MB-231-5a-D-Luc2 as well as tumour-induced ***2676293 suppressed RANKLmediated tumour migration in the transwell assay and inhibited bone metastasis of the murine cell line B16F10,which is known not to trigger osteoclast *** on the results from this study,RANKL inhibition with a small-molecule compound constitutes a promising therapeutic strategy for treating bone metastasis by inhibiting both osteoclastic bone resorption and tumour migration to bone.

关键词： Bone tumours metastasis