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Consensus on glycemic management for patients with coronary heart disease and type 2 diabetes

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Journal of Geriatric Cardiology 2024年第7期21卷 689-702页

作者： Li-nong JI Yun-Dai ChEN Cardiovascular Subcommittee of Chinese International Exchange and Promotion Association for Medical and healthcare

The prevalence of patients with coronary heart disease(ChD)and diabetes mellitus is notably high,posing sig-nificant residual cardiovascular risks even after routine interventions such as antihypertensive,lipid-lowering,and antithrombot-ic *** studies have demonstrated that certain glucose-lowering medications confer cardiovascular benefits for pa-tients with type 2 ***,a survey indicates that cardiologists may not be fully acquainted with the optimal screen-ing timing,indicators,and diagnostic criteria for type 2 diabetes,and there is insufficient awareness and a low rate of prescrip-tion of novel glucose-lowering medications with proven cardiovascular efficacy,such as glucagon-like peptide-1 receptor agon-ists(GLP-1 RAs)and sodium-glucose co-transporter-2 inhibitors(SGLT-2i).In this context,based on domestic and international guidelines or consensus and the latest evidence-based evidence,this consensus aims to standardize the glycemic management for patients with acute coronary syndrome,chronic coronary syndrome,and perioperative management for percutaneous coronary *** highlights the key points of screening and diagnosis of type 2 diabetes,and the comprehensive management of cardiovascular risk in patients with *** consensus elaborates on the principles and algorithms of glycemic management for ChD patients,without involving acute complications of diabetes,clarifies the clinical practice of glucose-lowering medications with cardiovascular benefits,and promotes the standardized use of these medications in cardiovascular and other related spe-cialty ***,it addresses the glucose-lowering treatment to comprehensively reduce cardiovascular risks.

关键词： coronary patients routine

Cycloaddition Reactions of Epoxides and CO_(2)Catalyzed by Bifunctional Rare-Earth Metal Complexes Bearing Amino-Bridged Tris(phenolato)Ligands

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Chinese Journal of Chemistry 2024年第14期42卷 1571-1581页

作者： Yongjie Chen Yanwei Wang Jun nong Dan Yuan Yingming Yao Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceDushu Lake CampusSoochow UniversitySuzhouJiangsu215123 China

Eight zwitterionic rare earth metal complexes stabilized by amino-bridged tris(phenolato)ligands bearing quaternary ammonium side-arms were synthesized and *** complexes were used as single-component catalysts for the cycloaddition of CO_(2)and epoxides,and their catalytic activities are obviously higher than those of their binary *** studies revealed that the halide anions(Cl^(–),Br^(–),I^(–))and the metal complexes influenced the catalytic activity,and the lanthanum complex bearing iodide anion showed the highest catalytic activity for this addition reaction.A variety of mono-substituted epoxides were converted to cyclic carbonates in good to excellent yields(55%—99%)with high selectivity(>99%)at 30℃and 1 bar CO_(2),whereas internal epoxides required higher both reaction temperatures(60—120℃)and catalyst loading(2 mol%)for high *** catalyst was recyclable for four times without noticeable loss of catalytic *** on the results of kinetic studies and in℃situ IR reactions,a plausible reaction mechanism was proposed.

关键词： Bifunctional catalyst Carbon dioxide Cyclic carbonate Rare-earth metal Tris(phenolato)ligand Insertion Cycloaddition C1 building blocks

Aluminum exposure impairs oocyte quality via subcellular structure disruption and DNA damage-related apoptosis in mice

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Journal of Environmental Sciences 2024年第5期139卷 308-319页

作者： hongge Li Jingcai Liu Weihua nong Mengying Shen Sheng Dou Shaochen Sun Junli Wang The Affiliated hospital of Youjiang Medical University for Nationalities Guangxi 533000China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China School of Medical Laboratory Youjiang Medical University for NationalitiesGuangxi 533000China Industrial College of Biomedicine and health Industry Youjiang Medical University for NationalitiesGuangxi 533000China Reproductive Medicine Guangxi Medical and Health Key Discipline Construction ProjectThe Affiliated Hospital of Youjiang Medical University for NationalitiesGuangxi 533000China

Aluminum(Al)can lead to an exposure of creature in varieties ways for its universality,and it could disturb normal physiological metabolism,with the damage to multisystem including *** the oocyte quality is critical for female reproduction,we inspected the toxicity of Al on mouse oocyte *** constructed in vitro exposure mouse model,and we found that 5 mmol/L Al had adverse effects on oocyte maturation by impairing organelle and *** spindle and misaligned chromosomes which might be considered to be caused by elevated levels of acetylation,as well as abnormal distribution of actin dynamics could hinder normal meiosis of *** dysfunction indicated that Al affected proteins synthesis,transport and digestion,which would further damage oocyte *** order to explore the mechanism of Al toxicity,our further investigation demonstrated that Al caused mitochondrial dysfunction and imbalance calcium homeostasis,resulting in limited energy ***,high level of reactive oxygen species,DNA damage and apoptosis caused by oxidative stress were also the manifestation of Al toxicity on *** conclusion,our study provided the evidence that Al exposure affected oocyte quality through its effects on spindle organization,actin dynamics,organelle function and the induction of DNA damage-related apoptosis with mouse model.

关键词： Aluminum Oocyte Cytoskeleton Organelle DNA damage

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Semantic segmentation via pixel-to-center similarity calculation

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 87-100页

作者： Dongyue Wu Zilin Guo Aoyan Li Changqian Yu nong Sang Changxin Gao National Key Laboratory of Science and Technology on Multispectral Information Processing School of Artificial Intelligence and AutomationHuazhong University of Science and TechnologyWuhanChina Meituan Inc. BeijingChina

Since the fully convolutional network has achieved great success in semantic segmentation,lots of works have been proposed to extract discriminative pixel ***,the authors observe that existing methods still suffer from two typical challenges:(i)The intra-class feature variation between different scenes may be large,leading to the difficulty in maintaining the consistency between same-class pixels from different scenes;(ii)The inter-class feature distinction in the same scene could be small,resulting in the limited performance to distinguish different classes in each *** authors first rethink se-mantic segmentation from a perspective of similarity between pixels and class *** weight vector of the segmentation head represents its corresponding semantic class in the whole dataset,which can be regarded as the embedding of the class ***,the pixel-wise classification amounts to computing similarity in the final feature space between pixels and the class *** this novel view,the authors propose a Class Center Similarity(CCS)layer to address the above-mentioned challenges by generating adaptive class centers conditioned on each scenes and supervising the similarities between class *** CCS layer utilises the Adaptive Class Center Module to generate class centers conditioned on each scene,which adapt the large intra-class variation between different *** designed Class Distance Loss(CD Loss)is introduced to control both inter-class and intra-class distances based on the predicted center-to-center and pixel-to-center ***,the CCS layer outputs the processed pixel-to-center similarity as the segmentation *** experiments demonstrate that our model performs favourably against the state-of-the-art methods.

关键词： computer vision deep neural networks image segmentation scene understanding

Mechanical responses of anchoring structure under triaxial cyclic loading

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 545-560页

作者： Peng Wang nong Zhang Qun Wei Xingliang Xu Guangzhen Cui Aoran Li Sen Yang Jiaguang Kan State Key Laboratory of Coal Resources and Safe Mining School of MinesChina University of Mining and TechnologyXuzhou221116China School of Civil Engineering Xuzhou University of TechnologyXuzhou221116China School of Mechanical Engineering Jiangsu University of TechnologyChangzhou213001China

Dynamic load on anchoring structures(AS)within deep roadways can result in cumulative damage and *** study develops an experimental device designed to test AS under triaxial *** device enables the investigation of the mechanical response,failure mode,instability assessment criteria,and anchorage effect of AS subjected to combined cyclic dynamic-static triaxial stress *** results show that the peak bearing strength is positively correlated with the anchoring matrix strength,anchorage length,and edgewise compressive *** bearing capacity decreases significantly when the anchorage direction is severely *** free face failure modes are typically transverse cracking,concave fracturing,V-shaped slipping and detachment,and spallation ***,when the anchoring matrix strength and the anchorage length decrease while the edgewise compressive strength,loading rate,and anchorage inclination angle increase,the failure intensity *** is determined by a negative tangent modulus of the displacement-strength curve or the continued deformation increase against the general downward *** cyclic loads,the driving force that breaks the rock mass along the normal vector and the rigidity of the AS are the two factors that determine roadway ***,a control measure for surrounding rock stability is proposed to reduce the internal driving force via a pressure relief method and improve the rigidity of the AS by full-length anchorage and grouting modification.

关键词： Triaxial stress Dynamic-static combination load Cyclic loading Anchoring structure(AS) Cumulative damage

Spatio-temporal variation of water salinity in mangroves revealed by continuous monitoring and its relationship to floristic diversity

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Plant Diversity 2024年第1期46卷 134-143页

作者： Wei Wang Kun Xin Yujun Chen Yuechao Chen Zhongmao Jiang nong Sheng Baowen Liao Yanmei Xiong Research Institute of Tropical Forestry Chinese Academy of ForestryGuangzhou 510520PR China Guangdong Zhanjiang Mangrove National Nature Reserve Administration Zhanjiang 524088PR China

Salinity is among the most critical factors limiting the growth and species distribution of coastal *** salinity in estuarine ecosystems varies temporally and spatially,but the variation patterns across different time scales and salinity fluctuation have rarely been *** effects of salinity on floristic diversity in mangroves are not fully understood due to the temporal and spatial heterogeneity of *** this study,we monitored water salinity at an interval of 10-min over one year in three mangrove catchment areas representing the outer part,middle part,and inner part respectively of Dongzhai Bay,hainan,*** number of mangrove community types and dominant mangrove species of the three catchment areas were also *** found that the diurnal variation and dry-season intra-month variation in water salinity were driven by tidal *** seasonal variation in water salinity was mainly driven by rainfall with higher salinity occurring in the dry season and lower salinity occurring in the wet ***,water salinity was highest at the outer part,intermediate at the middle part,and lowest at the inner part of the *** intra-month and annual fluctuations of water salinity were highest at the middle part and lowest at the outer part of the *** number of mangrove community types and dominant species were lowest at the outer part,intermediate at the middle part,and highest at the inner part of the *** results suggest that the temporal variation of water salinity in mangroves is driven by different factors at different time scales and therefore it is necessary to measure water salinity at different time scales to get a complete picture of the saline environment that mangroves ***,lower salinity levels benefit mangrove species richness within a bay landscape,however,further research is needed to distinguish the effects of salinity fluctuation and salinity level in affecting mangrove species richness.

关键词： Coastal wetlands Mangroves Salinity fluctuation Species diversity Species richness

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Mazabraud’s syndrome in female patients:Two case reports

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World Journal of Orthopedics 2024年第6期15卷 593-601页

作者： Xiu-Mao Li Ze-hao Chen Ke-Yi Wang Jun-Nan Chen Zhao-nong Yao Yu-hong Yao Xiao-Wei Zhou nong Lin Department of Orthopedics The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Orthopedics Research Institute Zhejiang UniversityHangzhou 310009Zhejiang ProvinceChina State Key Laboratory of Transvascular Implantation Devices Hangzhou 310009Zhejiang ProvinceChina Songyang Branch of the Second Affiliated hospital School of MedicineZhejiang UniversityLishui 331124Zhejiang ProvinceChina

BACKGROUND Mazabraud’s syndrome(MS)is a rare and slowly progressive benign disease characterized by the concurrent presence of fibrous dysplasia of bone and intramuscular myxoma,and is thought to be associated with mutations of the GNAS *** date,only about 100 cases of MS have been reported in the literature,but its standard treatment strategy remains *** SUMMARY We report two cases of MS in young women who underwent different treatments based on their symptoms and disease *** first patient,aged 37,received internal fixation and intravenous bisphosphonate for a pathological fracture of the right femoral neck,excision of a right vastus medialis myxoma was subsequently performed for pain control,and asymptomatic psoas myxomas were monitored without *** testing confirmed a GNAS gene mutation in this *** second patient,aged 24,underwent right vastus intermedius muscle myxoma resection,and conservative treatment for fibrous dysplasia of the *** patients were followed-up for 17 months and 3 years,respectively,and are now in a stable *** Various treatments have been selected for MS patients who suffer different *** main treatment for myxomas is surgical resection,while fibrous dysplasia is selectively treated if the patient experiences pathological fracture or severe ***,given the documented instances of malignant transformation of fibrous dysplasia in individuals with MS,close follow-up is necessary.

关键词： Mazabraud's syndrome Fibrous dysplasia Intramuscular myxoma Bisphosphonate Case report

Effects of Potassium-Solubilizing Bacteria on Growth, Antioxidant Activity and Expression of Related Genes in Fritillaria taipaiensis P. Y. Li

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 789-806页

作者： Jiaqi Lang Mingyan Ye Ya Luo Yueheng Wang Zhifen Shi Xiaotian Kong Xuan Li nong Zhou Chongqing Engineering Laboratory of Green Planting and Deep Processing of Famous-Region Drug in the Three Gorges Reservoir Region College of Biology and Food EngineeringChongqing Three Gorges UniversityChongqing404120China College of Modern Chinese Medicine Industry Chengdu University of Traditional Chinese MedicineChengdu611130China College of Pharmacy Dali UniversityDali671000China

This study aimed to examine the effects of inoculating Fritillaria taipaiensis *** leaves with different strains ofpotassium-solubilizing bacteria (KSB), or combinations thereof, focusing on aspects of photosynthesis and physiologicaland biochemical characteristics. At present, some studies have only studied the rhizosphere microbialcommunity characteristics of F. taipaiensis and have not discussed the effects of different microbial species on thegrowth promotion of F. taipaiensis. This paper will start from the perspective of potassium-solubilizing bacteria toconduct an in-depth study. Seed cultivation commenced at the base with three different KSBs in early October2022. The growth of F. taipaiensis leaves was observed after different treatments. Both single-plant and compoundinoculations were executed. A total of eight treatment groups were established, with aseptic fertilizer and sterilizedsoil functioning as the control group. The results reveal that intercellular CO_(2) concentration (Ci), stomatal conductance(Gs), and transpiration rate (Tr) were at their apex in the S7 group. Most treatment groups exhibited anincrease in leaf area, photosynthetic pigment content, soluble sugar, soluble protein, Superoxide Dismutase(SOD), Peroxidase (POD), Catalase (CAT) activities, and proline content. The expression levels of POD, SOD,and CAT genes were evaluated, following inoculation with different KSB. The highest was the S7 group. Theinoculation with various KSB, or combinations thereof, appears to bolster the growth and development of F. *** composite inoculation group S7, comprising Bacillus cereus, Burkholderia cepacia, and Bacillus subtilis,manifested the most favorable impact on the diverse indices of F. taipaiensis, thereby furnishing valuableinsights for the selection of bacterial fertilizer in the artificial cultivation of F. taipaiensis.

关键词： Fritillaria taipaiensis bacteria antioxidant enzyme genes leaf physiology and biochemistry photosynthetic characteristics

Research on Bast Fiber Extracted from the White Bark of Three Species in the Genus Broussonetia

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Chinese Journal of Polymer Science 2024年第6期42卷 729-738页

作者： Shan-Shan Jin Si-nong Wang Yan-Yan huang Jing-Yu Zhang Peng Liu hui Yu hong-Dong Zhang Yu-Liang Yang Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai200433China State key laboratory of Molecular Engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting *** plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and *** chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular *** yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOh treatment were *** microscope was used to characterize the fiber length-width ratio and ***,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber *** study demonstrates the high potentiality of these three species for papermaking applications.

关键词： Broussonetia genus Cellulose Alkaline pulping Kratky-Porod chain model Fiber rigidity

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