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地方病译丛 1993年第6期14卷 22-24页

作者： h.namba 黄瑢瑢

在富碘区,虽然碘的每日摄入量变化很大,从50μg到数毫克不等,但血清甲状腺激素(Th)和促甲状腺激素(TSh)浓度却几乎恒定不变,甚至在缺碘地区。

关键词：甲状腺肿碘摄入过量

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晶圆干燥缺陷的机理与控制

电子工业专用设备 2005年第7期34卷 29-33页

作者： G.W.Gale h.Ohno h.namba T.Orii Y.Takagi M.Yamasaka Tokyo Electron Limited 3-6 Akasaka 5-chome Tokyo Electron AT Limited650 MitsuzawaHosaka-choNirasaki CityYamanashi 407-0192 JAPAN Minato-kuTokyo 107-8481 JAPAN

长期以来,人们对于硅片在经过hF湿法处理之后出现的水印早已有所认识,尤其是图形包含亲水和疏水层时最为明显。我们系统地研究了经过hF后道处理之缺陷形成的机理,并确认了与先前报道的水印截然不同的缺陷类型。根据X射线和其它分析表明... 详细信息

长期以来,人们对于硅片在经过hF湿法处理之后出现的水印早已有所认识,尤其是图形包含亲水和疏水层时最为明显。我们系统地研究了经过hF后道处理之缺陷形成的机理,并确认了与先前报道的水印截然不同的缺陷类型。根据X射线和其它分析表明,认为这些缺陷与周围环境残余的汽相hF和随后的晶圆表面反应有关。根据反应腔室hF浓度的不同可以产生不同类型的缺陷。由于水印是由硅在水中的氧化和随后产生的氧化物的分解形成的,少量的hF具有加速这个过程的效果。形成不同缺陷的条件,还有避免这些缺陷的策略均得以认定。正确的排空管理是一个关键的因素。最后发现,重参杂的硅更易产生缺陷。

关键词：表面缺陷水印机理分析缺陷控制

“EII META-MODEL” ON INTEGRATION FRAMEWORK FOR VIABLE ENTERPRISE SYSTEMS——CITY PLANNING METAPhOR BASED ON STRUCTURAL SIMILARITY

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Systems Science and Systems Engineering 2003年第1期12卷 111-126页

作者： Yukio namba Junichi IIJIMA Monex Inc.TokyoJapan Department of Industrial Management & EngineeringGraduate School of Decision Science and TechnologyTokyo Institute of TechnologyJapanMonexInc.TokyoJapan Department of Industrial Management & EngineeringGraduate School of Decision Science and TechnologyTokyo Institute of TechnologyJapan

Enterprise systems must have the structure to adapt the change of business environment. When rebuilding enterprise system to meet the extended operational boundaries, the concept of IT city planning is applicable and effective. The aim of this paper is to describe the architectural approach from the integrated information infrastructure (In3) standpoint and to propose for applying the 'City Planning' concept for rebuilding 'inter-application spaghetti' enterprise systems. This is mainly because the portion of infrastructure has increased with the change of information systems from centralized systems to distributed and open systems. As enterprise systems have involved heterogeneity or architectural black box in them, it may be required the integration framework (meta-architecture) as a discipline based on heterogeneity that can provide comprehensive view of the enterprise systems. This paper proposes 'EII Meta-model' as the integration framework that can optimize the overall enterprise systems from the IT city planning point of view. EII Meta-model consists of 'Integrated Information Infrastructure Map (In3-Map)', 'Service Framework' and 'IT Scenario'. It would be applicable and effective for the viable enterprise, because it has the mechanism to adapt the change. Finally, we illustrate a case of information system in an online securities company and demonstrate applicability and effectiveness of EII Meta-model to meet their business goals.

关键词： IT city planning enterprise system EII Meta-model integrated information infrastructure

Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

A case of nodular posterior scleritis simulating intraocular tumor

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 685-688页

作者： Yukiko Shibata Satoru Kase Kenichi namba Susumu Ishida Department of Ophthalmology Social Medical Corporation Tokeidai Memorial Hospital Department of Ophthalmology Faculty of Medicine and Graduate School of Medicine Hokkaido University

Dear Editor,I am Dr. Yukiko Shibata, from the Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, hokkaido University. I write to present the case of posterior scleritis simulating intrao... 详细信息

关键词： nodular posterior scleritis intraocular tumor

Characterization of a Microhollow Cathode Discharge Plasma in helium or Air with Water Vapor

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Plasma Science and Technology 2013年第2期15卷 129-132页

作者： D. FUKUhARA S. namba K. KOZUE T. YAMASAKI K. TAKIYAMA Graduate school of Engineering Hiroshima University1-4-1 KagamiyamaHigashi-HiroshimaHiroshima 739-8527Japan

Microhollow cathode discharge （MhCD） plasmas were generated in gas mixtures containing water vapor at pressures of up to 100 kPa of he or 20 kPa of air. The cathode diameter was 1.0 mm with a length of 2.0 ram. The electricM characteristics showed an abnormal glow mode. Spectroscopic measurements were carried out to examine the plasma and radicals. An analysis of the spectral profile of ha at 656.3 nm enabled a derivation of the electron densities, namely 2× 1014 cm-3 （at 10 kPa） and 6× 1014 cm-3 （at 4 kPa） for the helium and air atmospheres, respectively, in the negative glow region. By comparing the observed Oh radical spectra with those calculated by the simulation code L[FBASE, the gas temperature was deduced to be 900 K for 4 kPa of he at a discharge current of 50 mA.

关键词： microhollow cathode discharge atmospheric pressure plasma plasma spec-troscopy

Estimating freight production/attraction using nighttime satellite imagery

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Communications in Transportation Research 2022年第1期2卷 167-180页

作者： Tomoya Kawasaki Wataru Nakanishi Satoshi hyodo Yusaku namba hirokazu Mori hirotoshi Kishi Department of Systems Innovation The University of TokyoTokyo113-8656Japan Institute of Science and Engineering Kanazawa UniversityIshikawa920-1192Japan Department of Transportation Systems Engineering Nihon UniversityChiba274-8501Japan Nomura Research Institute Tokyo100-0004Japan

An appropriate understanding and accurate estimation of zonal freight production(FP)and attraction(FA)volume is one of the most important topics and the initial step in developing the origin and destination(OD)*** general,zonal FP and FA are difficult to be obtained as observed data,particularly in developing countries,owing to the lack of large-scale freight ***,several proxy indicators are often used for estimating FP and FA,such as the gross regional product(GRP),population,and the number of ***,these indicators do not often estimate the zonal FP and FA accurately and are even not available *** nighttime light intensity(NLI)data that is human-induced light emission data and one of the open alternative data,possibly improves the accuracy of FP and FA ***,few studies have examined the relationship between NLI and FP/***,the objectives of this study are to examine whether NLI can be a significant indicator for estimating zonal FP and FA relative to other socio-economic indicators and to examine the types of NLIs that can accurately estimate the FP and FA through a case study in *** a result of the analysis,NLI data are identified as a significant variable for the estimation of FP and FA among various socio-economic *** some of the indicators related to secondary industries provide higher accuracy,NLI exhibits better estimates than the popular indicators such as GRP and *** addition,we propose three types of total NLI that multiply the unit NLI by the zonal area and this generates higher accuracy of unit NLI,the average light intensity of all pixels in a *** have also found that the use of habitable area for the estimation of total NLI provides the highest accuracy among the four types of NLIs including unit *** the analysis,NLI data is sufficiently applicable for estimating zonal FP and FA,relative to other important socio-economic indicators,although space tr

关键词： Nighttime light intensity Freight production and attraction Land cover data Elastic net Regression analysis

A New Indole Derivative Isolated from the Root of Tuber Fleeceflower(Polygonum multiflorum)

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中草药 1998年第1期29卷 5-11页

作者： Yang Xiuwei Gu Zheming Ma Chaomei Masao hattori Tsuneo namba 北京医科大学天然药物及仿生药物国家重点实验室!北京100083

从何首乌（PolygonummultiflorumThunb.）的根中分离出11个化合物，根据光谱学分析分别鉴定为：大黄酚（chrysophanol，Ⅰ）、大黄素甲醚（physcione，Ⅱ）、大黄素（emodin，Ⅲ）、ω-羟基大黄素（citreorosein，Ⅳ）、大黄酚8－O-β-D... 详细信息

从何首乌（PolygonummultiflorumThunb.）的根中分离出11个化合物，根据光谱学分析分别鉴定为：大黄酚（chrysophanol，Ⅰ）、大黄素甲醚（physcione，Ⅱ）、大黄素（emodin，Ⅲ）、ω-羟基大黄素（citreorosein，Ⅳ）、大黄酚8－O-β-D-吡喃葡萄糖苷（chrysophanol8-O-β-D-glucopyranoside，Ⅴ）、大黄素甲醚8-O-β-D-吡喃葡萄糖苷（Physcione8-O-β-D-glucopyranoside，Ⅵ）、大黄素8-O-β-D-吡喃葡萄糖苷（emodin8-O-β-D-glucopyranoside，Ⅶ）、决明酮8-O-β-D-吡喃葡萄糖苷（torachrysone8-O-β-D-glucopyranoside,Ⅷ）、2，3，5，4′-四羟基芪2-O-β-D-吡喃葡萄糖苷（2，3，5，4′－tetrahydroxystilbene2-O-β-D-glucopyranoside，Ⅸ）、没食子酸甲基酯（methylgallate，Ⅹ）和吲哚-3－（L-α-氨基-α-羟基内酸）甲酯[Indole－3－（L－α－amino－α－hydroxypropionicacid）methylester]。其中，化合物Ⅺ为新的天然产物。上述蒽醌和萘类化合物以及芦荟大黄素（aloe－emodin，Ⅻ）、大黄酸（rhein，）、芦荟大黄素8－O-β-D-吡喃葡萄糖苷（aloe－emodin8－O-β-D－glucopyranoside，）、大黄酚8－O-β-D－（6′－O-丙酰基）吡喃葡萄糖苷（chrysophanol8-O-β-D-（6′－O－malonyl）glucopyra－

关键词：何首乌吲哚衍生物吲哚-3-(L-α-氨基-α-羟基丙酸)甲酯重组hIV-Ⅰ蛋白酶