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World Journal of Gastroenterology 2014年第45期20卷 17075-17083页

作者： hanaa M El-Karaksy Lamiaa M Mohsen Doa'a A Saleh Mona S hamdy Noha A Yassin mohamed Farouk mohamed E Salit Mortada h El-Shabrawi Department of Pediatrics Kasr Al-Ainy School of Medicine Cairo University Department of Community Medicine Kasr AlAiny School of Medicine Cairo University Department of Clinical and Chemical Pathology Kasr Al-Ainy School of Medicine Cairo University Department of Obstetrics and Gynecology Kasr Al-Ainy School of Medicine Cairo University

AIM: To identify possible maternal risk factors for hepatitis B virus (hBV) acquisition and assess the efficacy of immunoprophylaxis given to infants born to hepatitis B virus surface antigen (hBsAg) positive mothers.

关键词： Egypt hepatitis B virus hepatitis B virus surface antigen positive mothers Immunoprophylaxis Perinatal transmission

ON A SECOND ORDER DISSIPATIVE ODE IN hILBERT SPACE WITh AN INTEGRABLE SOURCE TERM

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Acta Mathematica Scientia 2012年第1期32卷 155-163页

作者： Alain haraux mohamed Ali Jendoubi UPMC Univ Paris 06 UMR 7598Laboratoire Jacques-Louis Lions CNRS UMR 7598Laboratoire Jacques-Louis Lions Facult des Sciences de Bizerte Dpartement de Mathmatiques

Asymptotic behaviour of solutions is studied for some second order equations including the model casex（t）＋γx（t）＋ ↓△φb（x（t）） = h（t） with γ 〉 0 and h ∈ L1（O, ＋∞; h）, φ being continuouly differentiable with locally Lipschitz continuous gradient and bounded from below. In particular when φ is convex, all solutions tend to minimize the potential φ as time tends to infinity and the existence of one bounded trajectory implies the weak convergence of all solutions to equilibrium points.

关键词： dissipative dynamical system asymptotic behaviour gradient system heavyball with friction

Samarium( II )-electrocatalyzed chemoselective reductive alkoxylation of phthalimides

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Organic Chemistry Frontiers 2022年第5期9卷 1308-1314页

作者： Yu-Feng Zhang mohamed Mellah Universite Paris-Saclay CNRSInstitut de Chimie Moleculaire et des Materiaux d’OrsayBatiment 42091405 OrsayFrance

The unprecedented samarium electrocatalyzed reductive alkoxylation of phthalimides in a single step is *** mild conditions,using electrogenerated Sm(II)with TMSCl(trimethyl chlorosilane),N-substituted 3-alkoxyl isoind... 详细信息

关键词： catalyzed reductive substituted

Frequency of diabetic retinopathy and associated risk factors in Khartoum,Sudan:population based study

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 948-954页

作者： Einas S Elwali Ahmed O Almobarak Mona A hassan Amir A Mahmooud heitham Awadalla mohamed h Ahmed Department of Medicine and hIV Metabolic Clinic Milton Keynes University Hospital NHS Foundation Trust Eaglestone Milton Keynes Buckinghamshire MK 6 5LD UK

AIM： To assess the frequency and associated risk fac- tors of diabetic retinopathy among Sudanese individuals with diabetes attending Makka Eye complex in Khartoum, Sudan. METhODS： The cross sectional hospital based study recruited 316 individuals with diabetes from Makkah Eye Complex Retina Clinic. Standard questionnaire was used to collect demographic data, medical history and life style characteristics. Blood samples were taken to measure hbAlc and lipid profile. Fundus and slit lamp examination were performed for screening of diabetic retinopathy. RESULTS： Among 316 participants, 187 （59.2%） were males and 129 （40.8%） were females. The mean age of participants was 58.7＋_10.5y. The overall frequency of retinopathy was 261 （82.6%）. The percentages of the total participants with proliferative diabetic retinopathy （PDR） were 126 （39.9%） and non-proliferative diabetic retinopathy （NPDR） were 135 （42.7%）. importantly, duration of diabetes mellitus （DM）（72.2% of more than 10y）, being on oral hypoglycaemic drugs （versus insulin）, and hypertension were all significant risk factors for diabetic retinopathy （P=0.00, 0.01 and 0.00 respectively）. Complications ofdiabetes like diabetic foot （17.7%）, history of amputation （6.7%） and clinically significant macular edema （CSME）（47.4%） of the eyes were all significant risk factors （P〈0.05）. Logistic regression analysis showed that duration of diabetes, hypertension and CSME were found to be absolute risk factors （P=-0.007, 0.003 and 0,000 respectively）. Duration of DM of more than 10y have more than double risk （OR--2.8）, while having hypertension triples the risk of retinopathy （OR=3.1）. CONCLUSION： high rates of diabetic retinopathy are noted among individuals with diabetes attending Makkah Eye hospital in capital Khartoum. Urgent strategies are needed to monitor and treat hypertension and optimize diabetes control in individuals with diabetes. More investment in diabetes services is urgently needed.

关键词： diabetes Sudan diabetic retinopathy insulin

Validation of degree-day models for predict!ng the emergence of two fruit flies (Diptera: lephritidae) in northeast Egypt

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Insect Science 2021年第1期28卷 153-164页

作者： mohamed hBayoumy J.P.Michaud Faten AABadr Nabil MGhanim Faculty of Agriculture Economic Entomology DepartmentMansoura UniversityMansouraEgypt Department of Entomology Kansas State UniversityAgricultural Research Center-HaysHaysKansasUSA Agricultural Research Center Plant Protection Research InstituteDokkyGizaEgypt

We estimated thermal developmental thresholds(7o)and degree-day(DD)constants for the immature stages of two tephritid pests,Bcictrocera zonata(Saunders)and Ceratitis capitata(Weidenmann).Males of both species were trapped in an Egyptian guava orchard during the fruiting seasons of 2016 and 2017 and trap catches were compared with peak flights predicted by the DD model based on local weather *** capitata had faster development than *** at 20 and 25°C,but their overall developmental rate was similar at 30 and 35°*** thermal threshold of development(7o)of *** was higher than that of ***,indicating greater sensitivity to *** 35°C yielded the fastest development of both species,survival was higher at 30°C,with *** experiencing a slight advantage,suggesting better tropical *** development of *** and *** was estimated to require 338 and 373 d,respectively,and 616 and 424 DD for a complete *** catches over both seasons showed good correspondence to peaks of fly activity predicted by the DD models;deviations from expectation ranged from 0 to 7 d for both fly *** species had four overlapping generations per season,with *** abundance peaking in the first generation in both years,but only in 2016 for *** models predict about eight and 12 generations per year in northeast Egypt for *** and ***,*** models should be useful for timing pest control measures to coincide with periods of peak fly activity in fruit orchards.

关键词： Bactrocera zonata Ceratitis capitata development forecasting thermal threshold

Mitigating diabetes-related complications:Empowering metformin with cholecalciferol and taurine supplementation in type 2 diabetic rats

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World Journal of Diabetes 2024年第8期15卷 1778-1792页

作者： Mai S Attia Fadwa Ayman mohamed S Attia Galal Yahya Mansour h Zahra Magdi mohamed Ibrahim Khalil Abdel Aziz A Diab Department of Zoology Faculty of ScienceZagazig 44519Egypt Department of Pharmaceutics Faculty of PharmacyZagazig 44519Egypt Department of Microbiology and Immunology Faculty of PharmacyZagazig UniversityZagazig 44519Egypt Department of Biochemistry Faculty of MedicineZagazig 44519Egypt

BACKGROUND Type 2 diabetes is one of the most prevalent chronic diseases worldwide,significantly impacting patients'quality of *** treatment options like metformin(MET)effectively counteract hyperglycemia but fail to alleviate diabetes-associated complications such as retinopathy,neuropathy,nephropathy,hepatopathy,and cardiovascular *** To propose the supplementation of cholecalciferol(ChO)and taurine(TAU)to enhance MET efficacy in controlling diabetes while minimizing the risk of associated *** The study involved sixty rats,including ten non-diabetic control rats and fifty experimental rats with type 2 diabetes induced by *** experimental rats were further subdivided into positive control and treatment *** four treatment groups were randomly allocated to a single MET treatment or MET combined with supplements either ChO,TAU,or *** Diabetic rats exhibited elevated levels of glucose,insulin,homeostasis Model Assessment of Insulin Resistance(hOMA-IR),glycated hemoglobin percentage,lipid markers,aspartate aminotransferase,and malondialdehyde,along with reduced levels of antioxidant enzymes(catalase and superoxide dismutase).The administration of ChO and TAU supplements alongside MET in diabetic rats led to a noticeable recovery of islet *** antioxidative,anti-inflammatory,and anti-apoptotic properties of the proposed combination therapy significantly ameliorated the aforementioned *** The supplementation of ChO and TAU with MET showed the potential to significantly improve metabolic parameters and protect against diabetic complications through its antioxidative,anti-inflammatory,and antiapoptotic effects.

关键词： Diabetes complications Metformin Cholecalciferol Taurine Glycated hemoglobin% Antioxidant

Prognostic significance of peritoneal metastasis from colorectal cancer treated with first-line triplet chemotherapy

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World Journal of Clinical Cases 2022年第8期10卷 2429-2438页

作者： Shouki Bazarbashi Abdulrahman Alghabban mohamed Aseafan Ali h Aljubran Ahmed Alzahrani Tusneem AM Elhassan Oncology Center King Faisal Specialist Hospital&Research CenterRiyadh 11211RiyadhSaudi Arabia

BACKGROUND Peritoneal metastasis from colorectal cancer(CRC)carries a poor prognosis in most *** majority of those studies used either a single-agent or doublet chemotherapy regimen in the first-line *** To investigate the prognostic significance of peritoneal metastasis in a cohort of patients treated with triplet chemotherapy in the first-line *** We retrospectively evaluated progression-free survival(PFS)and overall survival(OS)in 51 patients with metastatic CRC treated in a prospective clinical trial with capecitabine,oxaliplatin,irinotecan,and bevacizumab in the first-line setting according to the presence and absence of peritoneal ***,univariate and multivariate analyses for PFS and OS were performed to assess the prognostic significance of peritoneal metastasis at the multivariate *** Fifty-one patients were treated with the above triplet *** had peritoneal *** patient characteristics of both groups showed a significant difference in the sidedness of the primary tumor(left-sided primary tumor in 60%of the peritoneal group vs 86%in the nonperitoneal group,P=0.03)and the presence of liver metastasis(40%for the peritoneal group vs 75%for the nonperitoneal group,P=0.01).Univariate analysis for PFS showed a statistically significant difference for age less than 65 years(P=0.034),presence of liver metastasis(P=0.046),lung metastasis(P=0.011),and those who underwent metastasectomy(P=0.001).Only liver metastasis and metastasectomy were statistically significant for OS,with P values of 0.001 and 0.002,*** analysis showed that age(less than 65 years)and metastasectomy were statistically significant for PFS,with P values of 0.002 and 0.001,*** the other hand,the absence of liver metastasis and metastasectomy were statistically significant for OS,with P values of 0.003 and 0.005,*** Peritoneal metastasis in patients with metastatic CRC tre

关键词： Colorectal cancer Peritoneal carcinomatosis Triplet chemotherapy Survival Prognostic factors Metastasectomy

Comparative studies for the fractional optimal control in transmission dynamics of West Nile virus

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International Journal of Biomathematics 2017年第7期10卷 75-105页

作者： N. h. Sweilam O.M.Saad D. G. mohamed Department of Mathematics Faculty of Science Cairo University Giza Egypt Department of Mathematics Faculty of Science Helwan University Cairo Egypt

In this paper, optimal control for a novel West Nile virus （WNV） model of fractional order derivative is presented. The proposed model is governed by a system of fractional differential equations （FDEs）, where the fractional derivative is defined in the Caputo sense. An optimal control problem is formulated and studied theoretically using the Pon- tryagin maximum principle. Two numerical methods are used to study the fractional- order optimal control problem. The methods are, the iterative optimal control method （OCM） and the generalized Euler method （GEM）. Positivity, boundedness and conver- gence of the IOCM are studied. Comparative studies between the proposed methods are implemented, it is found that the IOCM is better than the GEM.

关键词： West Nile virus fractional optimal control generalized Euler method Caputo's fractional derivative Griinwald-Letnikovs definition iterative optimal controlmethod Pontryagin's maximum principle.

Synthesis of Certain 3-Aminopyrazolo[5,4-b]pyridine and 3,4-Substituted Pyrido[2′,3′：3,4]pyrazolo[5,1-c][1,2,4]triazine Derivatives

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Chinese Journal of Chemistry 2007年第12期25卷 1887-1891页

作者： EL-LOUh, Ali Khader Khalil ABUNADA, Nada mohamed EL-ShOUBAKI, mohamed Chemistry Department Faculty of Science Al-Azhar University-Gaza Gaza 76888 Palestine Chemistry Department Faculty of Applied Sciences Al-Aqsa University Gaza Palestine 4051 Israel

2-Thioxo-1,2-dihydropyridine derivatives 2a, 2b were reacted with methyl iodide to give 2-methylthiopyridines 3a, 3b, which were reacted with hydrazine hydrate to produce 3-aminopyrazolo[5,4-b]pyridines 4a, 4b. Compounds 4a, 4b were diazotized to afford the corresponding diazonium salts 5a, 5b, which were reacted with some active methylene compounds 6a-6h to give the corresponding pyrido[2′,3′ ： 3,4]pyrazole[5,1-c][1,2,4]triazines 7-14.

关键词： pyrazolo[3,4-b]pyridine pyrido[2′,3′ : 3,4]pyrazole[5 1-c] [ 1,2,4]triazine 2-arylmethylidene-2-cyanothioacetamine 2-thioxopyridine

Phytochemical studies and anti-ulcerative colitis effect of Moringa oleifera seeds and Egyptian propolis methanol extracts in a rat model

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Asian Pacific Journal of Tropical Biomedicine 2019年第3期9卷 98-108页

作者： Attia h.Atta Samar M.Mouneir Soad M.Nasr Doaa Sedky Amany M.mohamed Shimaa A.Atta hassan mohamed Desouky Department of Pharmacology Faculty of Veterinary Medicine Cairo University Department of Parasitology & Animal Diseases National Research Centre Immunology Department Theodor Bilharz Research Institute Department of Animal Reproduction and Artificial Insemination National Research Centre

Objective: To analyze the phytochemical constituents, and to explore potential protective effect of the methanol extract of Moringa oleifera(M. oleifera) seeds and Egyptian propolis, each alone or concurrently administered on acetic acid-induced ulcerative colitis in rats. Methods: Eight groups of 5 rats each were used: normal control group with distilled water, model group, two groups with M. oleifera seeds(100 and 200 mg/kg), two groups with propolis(50 and 100 mg/kg), one group with concurrent administration of both, and one group with prednisolone(reference drug). Macro-and microscopic picture, ulcer index and lesion scores, oxidative markers, inflammatory mediators, in vitro activity of the inflammatory enzymes and 1, 1-diphenyl-2-picrylhydrazyl free radicals scavenging activity were evaluated. The phytochemical constituents of both extracts were explored by GC-MS analysis. Results: Both treatments modulated the macro-and microscopic picture, decreased the ulcerative index, lesion score, oxidative markers and inflammatory mediators, and inhibited the COX-1 and COX-2 enzymes. Propolis appeared to be powerful free radicals scavenger. A powerful synergistic effect of both treatments in modulating the course of the disease was reported. GCMS analysis of methanol extract of M. oleifera seeds and propolis revealed the presence of 50 and 34 compounds, respectively. Conclusions: M. oleifera seeds and propolis methanol extracts have modulated the course of acetic acid-induced ulcerative colitis. Moreover, both treatments induce a good synergistic effect against the disease. Isolation of the active constituents is recommended.

关键词： Moringa oleifera seeds Propolis Ulcerative colitis Phytochemical