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Anticancer property of sediment actinomycetes against mCF-7 and mDA-mB-231 cell lines

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Asian Pacific Journal of Tropical Biomedicine 2012年第2期2卷 92-96页

作者： Ravikumar S Fredimoses m Gnanadesigan m School of marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi-623 409Ramanathapuram District Department of Biotechnology K.S.Rangasamy College of Arts & ScienceThiruchengodu- 637209Namakkal District

ObjectiveTo investigate the anticancer property of marine sediment actinomycetes against two different breast cancer cell *** vitro anticancer activity was carried out against breast (mCF-7 and mDA-mB-231) cancer cell lines. Partial sequences of the 16s rRNA gene, phylogenetic tree construction, multiple sequence analysis and secondary structure analysis were also carried out with the actinomycetes *** the selected five actinomycete isolates, ACT01 and ACT02 showed the IC50 value with (10.13±0.92) and (22.34±5.82) μg/mL concentrations, respectively for mCF-7 cell line at 48 h, but ACT01 showed the minimum (18.54±2.49 μg/mL) level of IC50 value with.m.A-mB-231 cell line. Further, the 16s rRNA partial sequences of ACT01, ACT02, ACT03, ACT04 and ACT05 isolates were also deposited in NCBI data bank with the accession numbers of GQ478246, GQ478247, GQ478248, GQ478249 and GQ478250, respectively. The phylogenetic tree analysis showed that, the isolates of ACT02 and ACT03 were represented in group I and III, respectively, but ACT01 and ACT02 were represented in group II. The multiple sequence alignment of the actinomycete isolates showed that, the maximum identical conserved regions were identified with the nucleotide regions of 125 to 221st base pairs, 65 to 119th base pairs and 55, 48 and 31st base pairs. Secondary structure prediction of the 16s rRNA showed that, the maximum free energy was consumed with ACT03 isolate (-45.4 kkal/mol) and the minimum free energy was consumed with ACT04 isolate (?7.6 kkal/mol).ConclusionsThe actinomycete isolates of ACT01 and ACT02 (GQ478246 and GQ478247) which are isolated from sediment sample can be further used as anticancer agents against breast cancer cell lines.

关键词： Actinomycetes Breast cancer mCF–7 mDA–mB–231 Phylogenetic tree Anticancer property multiple sequence analysis Secondary structure analysis Sediment Anticaner agent Cell line

在弹性地层和多孔地层的井眼中测井——井下仪器对斯通利波的影响

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国外油气勘探 1995年第1期7卷 103-113页

作者： X. m. Tang C. h. Cheng 邱玉春测井技术编辑部

详细研究了在弹性地层和多孔地层的井眼中声波测井井下仪器(模拟成刚性的)对斯通利波传播特征的影响。在弹性地层的井眼中,井下仪器的存在使斯通利波速度降低,而使斯通利波激发增强。当存在由于地层和井内流体的非弹性而引起的固有衰减... 详细信息

详细研究了在弹性地层和多孔地层的井眼中声波测井井下仪器(模拟成刚性的)对斯通利波传播特征的影响。在弹性地层的井眼中,井下仪器的存在使斯通利波速度降低,而使斯通利波激发增强。当存在由于地层和井内流体的非弹性而引起的固有衰减时,井下仪器使因流体引起的斯通利波衰减降低,而使因地层引起的斯通利波衰减增大。针对渗透性多孔地层的井眼,对Tang等人(1991)简化的Boit-Rosenbaum模型作了改进,把井下仪器对斯通利波传播的影响纳入模型中。根据弹性地层公式,提出了一种简单而有效的在多孔地层井眼中斯通利波激发的计算方法。在多孔地层中进行声波测井期间,斯通利波幅度受地层渗透率以及与渗透率无关的其它因素的影响。后一种影响包括由于多孔地层的弹性性质而引起的声波激发和传播以及在层界面处的反射。利用本文研究的结果,可以把渗透率影响与非渗透率影响分开,结合一条多孔地层的合成斯通利波曲线对比作了说明。

关键词：声波测井斯通利波弹性介质多孔介质测井仪

hYPOGLYCEmIC ACTIVITY OF FERULIC ACID AND RELATED COmPOUNDS FROm RICE BRAN IN DIABETIC mICE

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HYPOGLYCEMIC ACTIVITY OF FERULIC ACID AND RELATED COMPOUNDS ...

比较CT和mRI在鉴别非弥漫型自身免疫性胰腺炎与胰腺导管腺癌的诊断效能

The Second International Symposium on Natural Antioxidants: molecular mechanisms and health Effects

作者： h.m.rishita m.Ohnishi T.Tsuno A.hosodai E.Nomurai h.Taniguchi Faculty of Education Wakayama University Department of Pharmaceutical Science Kansai Shinkyu medical College Tsuno Food Industrial Co. Industrial Technology Center of Wakayama Prefecture Industrial Technology Center of Wakayama Prefecture Industrial Technology Center of Wakayama Prefecture

Ferulic acid is a ubiquitous plant constituent that arises from the metabolism of phenylalanine and tyrosine. During the investigation of antioxidant activity of ferulic acid and related compounds in vivo, we found th... 详细信息

关键词： STZ hYPOGLYCEmIC ACTIVITY OF FERULIC ACID AND RELATED COmPOUNDS FROm RICE BRAN IN DIABETIC mICE

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国际医学放射学杂志 2019年第1期 127-128页

作者： S.Lee J.h.Kim S.Y.Kim J.h.Byun h.J.Kim m.h.Kim 汪俊萍 Department of Radiology and Research Institute of Radiology University of Ulsan College of MedicineAsan Medical Center

摘要目的采用阅片者自身对照的方式比较CT和mRI在鉴别非弥漫型自身免疫性胰腺炎(AIP)与胰腺导管腺癌(PDA)的诊断效能。方法本研究共纳入61例非弥漫型AIP

关键词：自身免疫性胰腺炎胰腺导管腺癌诊断效能 mRI 弥漫型 CT

Effects of heat Treatment on hardness and Dry Wear Properties of a Semi-Solid Processed Fe-27 wt pct Cr-2.9 wt pct C Cast Iron

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Journal of materials Science & Technology 2008年第3期24卷 330-334页

作者： A.Wiengmoon T.Chairuangsri N.Ch.m.ang N.Poolthong J.T.h.Pearce Department of Physics Faculty of ScienceNaresuan University Department of Industrial Ch.m.stry and Electron microscopy Research and Service Center Faculty of ScienceChiang Mai University Department of Physics Faculty of ScienceChiang Mai University Division of materials Technology School of EnergyEnvironmental and MaterialsKing Mongkut's University of Technology Thonburi National metal and materials Technology Center

EfFects of heat treatments on hardness and dry wear properties of a semi-solid processed Fe-26.96 wt pct Cr- 2.91 wt pct C cast iron were studied. heat treatments included tempering at 500℃, destabilisation at 1075℃ and destabilisation at 1075℃ plus tempering at 500℃, all followed by air cooling. Electron microscopy revealed that, in the as-cast condition, the primary proeutectic austenite was round in shape while the eutectic m7C3 carbide was found as radiating clusters mixed with directional clusters. Tempering did not change the microstructure significantly when observed by scanning or transmission electron microscopy. Destabilisation followed by air cooling led to a precipitation of secondary m23C6 carbide and a transformation of the primary austenite to martensite. Precipitation behaviour is comparable to that observed in the conventionally cast iron. Tempering after destabilisation resulted in a higher amount of secondary carbide precipitation within the tempered martensite in the eutectic structure. Vickers macrohardness and microhardness in the proeutectic zones were measured. Dry wear properties were tested by using a pin-on-disc method. The maximum hardness and the lowest dry wear rate were obtained from the destabilisation-plus-tempering heat treatment due to the precipitation of secondary carbides within the martensite matrix and a possible reduction in the retained austenite.

关键词： Semi-solid process high chromium cast iron heat treatment hardness Wear

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现代政治学

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Electrical Investigation of Some Silver Containing Ceramics Obtained from Coprecipitated Oxalates

1964年

作者： G·m·卡德 J·h·赫兹李诰译

来源：汇雅图书（南通市图书馆... 评论

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Journal of materials Science & Technology 1999年第1期15卷 87-90页

作者： m.I.El-hofy(Physics Department, Faculty of Science, menoufia University, Shebin El-Kom, Egypt)A.m.Donia(Ch.m.stry Department, Faculty of Science, menoufia University, Shebin El-Kom, Egypt)m.m.Abou-Sekkina(Ch.m.stry Department, Faculty of Science, Taota Un Physics Department Faculty of Science Menoufia University Shebin El-Kom Egypt Ch.m.stry Department Faculty of Science Menoufia University Shebin El-Kom Egypt Ch.m.stry Department Faculty of Science Tanta University Tanta Egypt

Silver-ceramics (Ag2mO2)(m=Co, Ni, or Cu) were prepared through thermal decompositionof coprecipitated oxalates. Pellets of these materials were annealed at 350℃ for different timeperiods up to 5 h. The effect of ann... 详细信息

关键词： CuO Figure Electrical Investigation of Some Silver Containing Ceramics Obtained from Coprecipitated Oxalates

成人无症状肝脂肪变性的冠状动脉CT血管成像

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国际医学放射学杂志 2022年第1期 110-111页

作者： m.m.Yu X.L.Tang h.Jin S.Yang h.Yun Q.B.Wang 李鹏飞

摘要冠状动脉CT血管成像（CCTA）对成人无症状肝脂肪变性（hS）的长期预后价值尚不清楚。目的评估CCTA对成人无症状hS的长期预后价值。材料与方法前瞻性纳入

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The microsatellite polymorphism of h.m. oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting

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Chinese medical Journal 2005年第18期118卷 1525-1532页

作者： LI Ping moh.m.d A. Elrayess Abuzeid h. Gomma Jutta Palmen Emma hawe Kim m. Fox Steve E. h.m.hries Cardiovascular Department Second Affiliated Hospital of JiangxiMedical College Nanchang 330006 China Centre for Cardiovascular Genetics British Heart FoundationLaboratories Department of Medicine Rayne Building 5 UniversityStreet London WC1E 6JF National heart ＆ Lung Institute and Royal Brompton hospital Cardiac Medicine Sydney Street London SW3 6NP

Background Vascular smooth.m.scle cells （VSmCs） can express h.m.-oxygenase （hO）, a rate-limiting enzyme in the degradation of h.m. to bilirubin, ferritin and carbon monoxide （ CO）. VSmC-derived CO can suppress VSmC proliferation and may serve as an antiproliferation factor. The promoter region of hO-1 shows a polymorphism with different （GT）n repeats that has been reported to differently induce gene expression. The objective of this study was to examine the effect of this variation on the occurrence of restenosis after in-stent treatment in patients with coronary artery disease. methods Candidates who underwent coronary stent implantation were genotyped for the hO-1 promoter polymorphism using polymerase chain reaction （PCR） and automated DNA capillary sequencer. Serum levels of IL-6 and C-reactive protein （CRP） were obtained at baseline, 24 hours and 48 hours after stenting. The primary end point for the study was angiographic evidence of in-stent restenosis at 6 months. All parameters for evaluation of restenosis were analysed by quantitatve computer-assisted angiographic analysis （QCA）. Results One hundred and eighty-seven patients who underwent coronary stent implantation were studied of wh.m.27.8% showed 〉150% restenosis after 6 months. The distribution of （GT）n repeats of all patients in the promoter region of hO-1 genotype ranged from 22 to 42, with （GT） 25 and （GT） 32 being the two most common alleles. The allelic repeats were divided into the short class （S） with 29 （ GT）., the middle class （m） with 30- 37 （GT）n and the long class （L） with 38 （GT）n. There was no significant difference in the restenosis between the genotype groups or between post operation levels of inflammation markers, but carriers of the S allele （ n = 120） had 33.3% lower baseline IL-6 compared with non-S carriers （n =67, P =0. 0008）. Conclusions Although no association was observed between the hO-1 promoter polymorphism and coronary in-stent restenosis following the stent procedure, the

关键词： h.m. oxygenase·polymorphism·interleukin-6·C- reactive protein·restenosis