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hER2 inhibition in gastro-oesophageal cancer:A review drawing on lessons learned from breast cancer

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World Journal of Gastrointestinal Oncology 2018年第7期10卷 159-171页

作者： hazel lote Nicola Valeri Ian Chau Centre for Molecular Pathology Institute of Cancer Research Department of Medicine Royal Marsden Hospital

human epidermal growth factor receptor 2(hER2)-inhibition is an important therapeutic strategy in hER2-amplified gastro-oesophageal cancer(GOC).A significant proportion of GOC patients display hER2 amplification,yet hER2 inhibition in these patients has not displayed the success seen in hER2 amplified breast *** of the current evidence surrounding hER2 has been obtained from studies in breast cancer,and we are only recently beginning to improve our understanding of hER2-amplified *** there are numerous licensed hER2 inhibitors in breast cancer,trastuzumab remains the only licensed hER2 inhibitor for hER2-amplified *** trials investigating lapatinib,trastuzumab emtansine,pertuzumab and MM-111 in GOC have demonstrated disappointing results and have not yet changed the treatment *** deruxtecan may hold promise and is currently being investigated in phase Ⅱ ***2 amplified GOC differs from breast cancer due to inherent differences in the hER2 amino-truncation and mutation rate,loss of hER2 expression,alterations in hER2 signalling pathways and differences in insulin-like growth factor-1 receptor and MET *** alterations involving different micro RNA profiles in GOC as compared to breast cancer and intrinsic differences in the immune environment are likely to play a *** key to effective treatment of hER2 amplified GOC lies in understanding these mechanisms and tailoring hER2 inhibition for GOC patients in order to improve clinical outcomes.

关键词： human epidermal growth factor receptor 2 Gastro-oesophageal cancer Trastuzumab Resistance Biomarkers Breast cancer

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

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Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

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Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

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Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAEI h.GhANDVAR E.JUMAEV S.KhATIR T.CUONG-LE School of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for Engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Strategic options for syphilis control in Papua New Guineae impact and cost-effectiveness projections using the syphilis interventions towards elimination (SITE) model

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Infectious Disease Modelling 2021年第1期6卷 584-597页

作者： Shepherd Machekera Peniel Boas Poruan Temu Zimmbodilion Mosende Namarola lote Angela Kelly-hanku S.Guy Mahiane Robert Glaubius Jane Rowley Anup Gurung Eline Korenromp Government of Papua New Guinea National Department of HealthAOPI CenterWaigani DrivePO Box5896Port MoresbyPapua New Guinea World Vision International Ruta PlaceMorata StGordons.P.O Box 4254BorokoNational Capital DistrictPort MoresbyPapua New Guinea UNAIDS Papua New Guinea Country Office Port MoresbyPapua New Guinea WhO Papua New Guinea Country Office Communicable Disease&Health Emergency Dept.AOPI CentreWaigani DrivePort MoresbyPapua New Guinea Papua New Guinea Institute of Medical Research 441 Homate StreetPO Box 60GorokaEastern Highland ProvincePapua New Guinea Kirby Institute UNSW SydneyWallace Wurth BuildingHigh StreetUNSW Australia KensingtonNSW 2052SydneyAustralia Avenir health ModellingPlanning and Policy Analysis Dept.655 Winding Brook DriveGlastonburyCT06033USA Independent Consultant 135 Gloucester TerraceW26DXLondonUK Avenir health ModellingPlanning and Policy Analysis Dept.150 Route de FerneyPO box 2100CH-1211 Geneva 2Switzerland

Objectives:Papua New Guinea(PNG)has among the highest rates of sexually transmitted infections(STIs)globally and is committed to reducing their *** Syphilis Interventions Towards Elimination(SITE)model was used to explore the expected impact and cost of alternative syphilis intervention scale-up ***:SITE is a dynamical model of syphilis transmission among adults 15-49 *** are divided into nine groups based on sexual behaviour and into six stages of *** model was calibrated to PNG using data from routine surveillance,biobehavioural surveys,research studies and program *** included syphilis prevalence,risk behaviours,intervention coverage and service delivery unit *** compared different interventions(clinical treatment,contact tracing,syphilis screening,and condom promotion)for incidence and cost per infection averted over ***:Increasing treatment coverage of symptomatic primary/secondary-stage syphilis cases from 25-35%in 2020 to 60%from 2023 onwards reduced estimated incidence over 2021-2030 by 55%,compared to a scenario assuming constant coverage at 2019-2020 *** introduction of contact tracing in 2020,assuming 0.4 contacts per symptomatic person treated,reduced incidence over 2021-2030 by 10%.Increasing screening coverage by 20-30 percentage points from the 2019-2020 level reduced incidence over 2021-2030 by 3e16%depending on the target ***-up clinical,symptom-driven treatment and contact tracing had the lowest cost per infection averted,followed by condom promotion and periodic screening of female sex workers and men who have sex with ***:PNG could considerably reduce its syphilis burden by scaling-up clinical treatment and contact tracing alongside targeted behavioural risk reduction *** is a useful tool countries can apply to inform national STI programming and resource allocation.

关键词： Syphilis Prevention Treatment Cost-effectiveness Resource allocation National program strategy

Musculoskeletal disorders in nursing staff

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World Journal of Methodology 2025年第2期15卷 9-14页

作者： Agapi Kolovou Asterios N Gkougkoulias Nikolaos Stefanou Elena Manuela Samaila Maria Tsekoura Marianna Vlychou Charalampos Matzaroglou Zoe h Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Department of Radiology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Orthopaedic and Trauma Center University of VeronaVerona 37134Italy Department of Physiotherapy School of Health Rehabilitation SciencesUniversity of PatrasPatra 26504DytikíElládaGreece

Nursing staff provides patient care in an occupational environment that often imposes challenges that affect significantly the musculoskeletal ***-related musculoskeletal disorders are common in nursing stuff and have a negative impact in their professional and daily *** the current editorial,the duties of nursing staff,the types of musculoskeletal disorders,the predis-posing factors(including factors related to professional tasks/ergonomics and to working schedules,psychological,social and individual factors)and their impact on working ability and quality of life nursing staff are summarized and pre-ventive measures are proposed.

关键词： Musculoskeletal disorders Nursing staff Predisposing factors Ergonomics Prevention