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Biomass-derived carbon doping to enhance the current carrying capacity and flux pinning of an isotopic Mg^(11)B_(2)superconductor

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Journal of Magnesium and Alloys 2022年第7期10卷 1868-1877页

作者： M.Shahbazi Y.hao D.Patel h.liang Y.Yamauchi M.S.A.hossain QUT Centre for Materials Science and School of Chemistry and Physics Queensland University of Technology(QUT)BrisbaneQLD 4001Australia School of Mechanical and Mining Engineering Faculty of EngineeringArchitecture and Information Technology(EAIT)The University of QueenslandBrisbaneQLD 4072Australia Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandBrisbaneQLD 4072Australia JST-ERATO Yamauchi Materials Space-Tectonics Project and International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)1-1 NamikiTsukubaIbaraki 305-0044Japan

Low activation isotopic boron(11B)based magnesium diboride(Mg^(11)B_(2))superconductors doped with biomass-derived activated carbon were synthesized using11B and magnesium powder via solid-state *** effect of carbon doping on the lattice structure and superconducting properties of Mg^(11)B_(2)bulks were evaluated using X-ray powder diffraction,high resolution transmission electron microscopy,scanning electron microscopy and magnetization *** refinement of structural parameters indicates successful substitution of carbon in Mg^(11)B_(2)*** critical current density(Jc)of carbon doped Mg^(11)B_(2)synthesized at 650℃was enhanced more than two times compared with the pure Mg^(11)B_(2)*** improvement was observed for the Mg^(11)B_(2)bulks heat-treated at 800℃.This enhancement is due to successful substitution of biomass-derived carbon with high surface area into Mg^(11)B_(2)*** flux pinning mechanism of pure and doped Mg^(11)B_(2)bulks were investigated using the Dew-hughes *** study provides information regarding enhancement of the Jc of low activation Mg^(11)B_(2)superconductors suitable for next-generation fusion magnets.

关键词： Magnesium diboride Critical current Flux pinning mechanism Fusion reactor applications

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Recent advances in photochemistry for positron emission tomography imaging

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Chinese Chemical Letters 2024年第8期35卷 149-162页

作者： Jing-Jing Zhang Lujun Lou Rui Lv Jiahui Chen Yinlong Li Guangwei Wu Lingchao Cai Steven h.liang Zhen Chen Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest BiomassJiangsu Key Lab of Biomass-Based Green Fuels and ChemicalsInternational Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Department of Radiology and Imaging Sciences Emory UniversityAtlantaGA 30322United States

As a powerful noninvasive imaging technology,positron emission tomography(PET)has been playing an important role in disease theranostics and drug *** successful application of PET relies on not only the biological properties of PET tracers but also the availability of facile and efficient radiochemical reactions to enable practical production and widespread use of PET *** recently,photochemistry is emerging as a novel,mild and efficient approach to generating PET *** this review,we focus on the recent advances in newly developed photocatalytic radiochemical reactions,innovation on automated photochemical radiosynthesis modules,as well as implementation in late-stage radiolabeling and radio-pharmaceutical synthesis for PET *** believe that this review will inspire the development of more promising radiolabeling protocols for the preparation of clinically useful PET agents.

关键词： Positron emission tomography(PET) Fluorine-18 Carbon-11 Photocatalysis Automation Late-stage functionalization

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A Model for the Formation of Ring Mitochondria in Retinal Pigment Epithelium

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眼科学报 1995年第1期11卷 9-15页

作者： h.liang S·G·Crewther School of Optometry University of N.S.W. Kensington Australia.

Purpose:To investigate the mechanism and sequence of formation of ring-shaped mitochondria in retinal pigment epithelial ce3lls of a chick model of gyrate ***:Electron microscopic analysis of the ultrastructure of retinal pigment epithelial(RPE)mitochondria was carried out in chicks injected intravitreally with formoguanamine regularly(every4days)over the first 2weeksor4weeks *** is a triazine drug which induces hyperor-nithinemic symptoms in the chick eye similar to those seen in human gyrate ***:A large population of irregularly shaped mitochondria was observed in the RPE of both peripheral and central *** showed extensive morpholog-ical *** 2wk,the mitochondria appeared enlarged and abnormal in shape with vacuolisation,partial loss of their double membrane and reduced mitochon-drial *** 4wk,the mitochondria had assumed a rounder,almost circular profile,many with central holes,so-called ring ***:The appearance of ring-shaped mitochondria has been previously as-cribed to the section of cupshaped three-dimensional *** present evi-dence that ring-shaped mitochondrial profiles arise through at least two different mechanisms of membrane breakdown and intraorganelle *** nature of the three dimensional structures of these abnormal mit.

关键词：视网膜色素上皮层环状线粒体扫描电镜形态学

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Discovery and evaluation of a novel ^(18)F-labeled vasopressin 1a receptor PET ligand with peripheral binding specificity

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4014-4027页

作者： Junqi hu Yinlong Li Chenchen Dong huiyi Wei Kai Liao Junjie Wei Chunyu Zhao Ahmad Chaudhary Jiahui Chen hao Xu Ke Zhong Steven h.liang Lu Wang Weijian Ye Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine&Key Laboratory of Basic and Translational Research on Radiopharmaceuticalsthe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Radiology and Imaging Sciences Emory UniversityAtlant1GA 30322USA Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

The arginine-vasopressin(AVP)hormone plays a pivotal role in regulating various physiological processes,such as hormone secretion,cardiovascular modulation,and social *** studies have highlighted the V1a receptor as a promising therapeutic ***-depth insights into V1a receptor-related pathologies,attained through in vivo imaging and quantification in both peripheral organs and the central nervous system(CNS),could significantly advance the development of effective V1a *** address this need,we develop a novel V1a-targeted positron emission tomography(PET)ligand,[^(18)F]V1A-2303([^(18)F]8),which demonstrates favorable in vitro binding affinity and selectivity for the V1a *** tracer binding in peripheral tissues was also confirmed through rigorous cell uptake studies,autoradiography,biodistribution ***,[^(18)F]8 was employed in PET imaging and arterial blood sampling studies in healthy rhesus monkeys to assess its brain permeability and specificity,whole-body distribution,and kinetic *** research indicated[^(18)F]8 as a valuable tool for noninvasively studying V1a receptors in peripheral organs,and as a foundational element for the development of next-generation,brain-penetrant ligands specifically designed for the CNS.

关键词： Vasopressin Autism V1a receptor Positron emission tomography PET imaging Radiolabeling Fluorine 18 Kinetic modeling

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[^(18)F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models

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Acta Pharmaceutica Sinica B 2022年第1期12卷 308-315页

作者： Tuo Shao Zhen Chen Jian Rong Vasily Belov Jiahui Chen Andre Jeyarajan Xiaoyun Deng hualong Fu Qingzhen Yu Steve h.Rwema Wenyu Lin Mikhail Papisov Lee Josephson Raymond T.Chung Steven h.liang Division of Nuclear Medicine and Molecular Imaging Department of RadiologyMassachusetts General Hospital and Harvard Medical SchoolBostonmA 02114USA Liver Center and Gastrointestinal Division Department of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonA 02114USA Shriners hospitals for Children-Boston Boston BostonMA 02114USA

Monoacylglycerol lipase(MAGL) is a pivotal enzyme in the endocannabinoid system, which metabolizes 2-arachidonoylglycerol(2-AG) into the proinflammatory eicosanoid precursor arachidonic acid(AA). MAGL and other endogenous cannabinoid(EC) degrading enzymes are involved in the fibrogenic signaling pathways that induce hepatic stellate cell(hSC) activation and ECM accumulation during chronic liver disease. Our group recently developed an;F-labeled MAGL inhibitor([18F]MAGL-4-11)for PET imaging and demonstrated highly specific binding in vitro and in vivo. In this study, we determined [18F]MAGL-4-11 PET enabled imaging MAGL levels in the bile duct ligation(BDL) and carbon tetrachloride(CCl_(4)) models of liver cirrhosis;we also assessed the hepatic gene expression of the enzymes involved with EC system including MAGL, NAPE-PLD, FAAh and DAGL that as a function of disease severity in these models;[18F]MAGL-4-11 autoradiography was performed to assess tracer binding in frozen liver sections both in animal and human. [18F]MAGL-4-11 demonstrated reduced PET signals in early stages of fibrosis and further significantly decreased with disease progression compared with control mice. We confirmed MAGL and FAAh expression decreases with fibrosisseverity, while its levels in normal liver tissue are high;in contrast, the EC synthetic enzymes NAPE-PLD and DAGL are enhanced in these different fibrosis models. In vitro autoradiography further supported that[18F]MAGL-4-11 bound specifically to MAGL in both animal and human fibrotic liver tissues. Our PET ligand [18F]MAGL-4-11 shows excellent sensitivity and specificity for MAGL visualization in vivo and accurately reflects the histological stages of liver fibrosis in preclinical models and human liver tissues.

关键词： [18F]MAGL-4-11 PET imaging Liver fibrosis MAGL

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Tramacol- induced Physical Dependence and Its Effects on Behavioral Sensitization to Mthamphetamine in Mice

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中国药理通讯 2004年第2期21卷 13-14页

作者： J.-h.liang K.Wang h.-LSun NationalInstituteonDrugDependence PekingUniversityBeijing100083

AIM:Tramado is a centrally acting,synthetic analgesic with opioid agonist properties and effects on monoaminergie transmission,It is the unique non-controlled analgesic for the treatment of moderately severe acute or chronic *** recent years,however,some epidmiological data indicate that tramadol possess relatively high poly-drug abuse potential.

关键词：促进感受性感光度大鼠药理实验细菌诱导纳洛酮

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基于公共领域理论的传统医药知识及相关资源保护

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科技管理研究 2017年第4期37卷 160-165页

作者：魏晋才方志耕 Matthew h.liang 南京航空航天大学经济与管理学院江苏南京211106 温州医科大学浙江温州325034 哈佛大学公共卫生学院美国波士顿ma02115

以知识产权法的公共领域理论为视角,讨论公共领域知识的特征、权益主体、利益原则,结合国际知识产权制度框架下传统医药知识的公共领域属性和法律地位,对传统医药知识及相关资源保护的策略进行了分析。思考和梳理我国传统医学知识及相... 详细信息

以知识产权法的公共领域理论为视角,讨论公共领域知识的特征、权益主体、利益原则,结合国际知识产权制度框架下传统医药知识的公共领域属性和法律地位,对传统医药知识及相关资源保护的策略进行了分析。思考和梳理我国传统医学知识及相关资源保护的制度架构与缺陷。提出在经济和文化全球化的背景下,政府需要采取相关措施,努力争取我国传统医药和相关资源在国际知识产权体系中的法律地位和知识权益,实现中医传统知识与现代科学及国际医药知识体系的对接,促进传统医药知识的保护与发展。

关键词：知识产权保护传统医学遗传资源

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Recent developments on PET radiotracers for TSPO and their applications in neuroimaging

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Acta Pharmaceutica Sinica B 2021年第2期11卷 373-393页

作者： Lingling Zhang Kuan hu Tuo Shao Lu hou Shaojuan Zhang Weijian Ye Lee Josephson Jeffrey h.Meyer Ming-Rong Zhang Neil Vasdev Jinghao Wang hao Xu Lu Wang Steven h.liang Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine and PET/CT-MRI CenterThe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Neurology the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Radiopharmaceuticals Development National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital&Department of RadiologyHarvard Medical SchoolBostonMA 02114USA Azrieli Centre for Neuro-Radiochemistry Brain Health Imaging CentreCentre for Addiction and Mental Health&Department of PsychiatryUniversity of TorontoToronto ON M5T 1R8Canada Department of Pharmacy the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

The 18 kDa translocator protein(TSPO),previously known as the peripheral benzodiazepine receptor,is predominately localized to the outer mitochondrial membrane in steroidogenic *** TSPO expression is relatively low under physiological conditions,but is upregulated in response to glial cell *** the primary index of neuroinflammation,TSPO is implicated in the pathogenesis and progression of numerous neuropsychiatric disorders and neurodegenerative diseases,including Alzheimer’s disease(AD),amyotrophic lateral sclerosis(ALS),Parkinson’s disease(PD),multiple sclerosis(MS),major depressive disorder(MDD)and obsessive compulsive disorder(OCD).In this context,numerous TSPO-targeted positron emission tomography(PET)tracers have been *** them,several radioligands have advanced to clinical research *** this review,we will overview the recent development of TSPO PET tracers,focusing on the radioligand design,radioisotope labeling,pharmacokinetics,and PET imaging ***,we will consider current limitations,as well as translational potential for future application of TSPO *** review aims to not only present the challenges in current TSPO PET imaging,but to also provide a new perspective on TSPO targeted PET tracer discovery *** these challenges will facilitate the translation of TSPO in clinical studies of neuroinflammation associated with central nervous system diseases.

关键词： TSPO Microglial activation Neuroinflammation Positron emission tomography(PET) CNS disorders

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Cancer cell-secreted microRNA-214 facilitate tumor growth by inducing CD4+CD25+ regulatory T cells

Cancer cell-secreted microRNA-214 facilitate tumor growth by...

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遗传学与表观遗传学前沿暨第三届中国青年遗传学家论坛

作者：陈熹 h.liang J.Zhang K.Zen C-Y.Zhang Nanjing University

Regulatory T cell(Treg)expansion-mediated immune tolerance is generally associated with ***,the mechanism underlying the expansion of Treg by cancer cells remains incompletely *** we report that microRNAs secreted by cancer cells induce CD4+CD25+*** cells increase plasma miR-214 level in cancer patients and tumor-implanted *** vesicles(MVs)-containing miR-214 secreted from cancer cells entered into CD4+T cells,reduced the expression of phosphatase and tensin homolog(PTEN),leading to the polarization of CD4+T cells into Tregs in vitro and in ***,Tregs,whose numbers were increased due to circulating miR-214,facilitated the growth of implanted tumors in *** contrast,MV-delivered anti-miR-214 antisense oligonucleotides blocked the Treg induction by miR-214 secreted by implanted cancer cells and decreased tumor *** results provide the first evidence that cancer cell can actively secret miRNA to promote Treg expansion and therefore to facilitate cancer cell immune escape.

关键词： microRNA secreted microRNA regulatory T cell PTEN microvesicle immune evasion tumor

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小麦花药培养单倍体的直接产生

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麦类作物学报 1988年第1期 16-18页

作者： George h.liang

小麦单倍体已可从愈伤组织中再生出来,而愈伤组织既可通过马铃薯培养基(hu 等,1984;DeBuyser 等,1980;Schaeffer 等,1979)又可通过确定的化学培养基

关键词：单倍体植株一步法幼苗光照条件基因型平均数单步法计算方法遗传型平均指标小麦花药培养小麦单倍体

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