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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang henrik Biverstål Nicolas GBazan Shuai Tan Nailin li Makiko Ohshima Marianne Schultzberg Xiaofei li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

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Effect of two-step cooling process on mechanical properties of TRIP steel with high performance

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Journal of Iron and Steel Research International 2018年第4期25卷 426-432页

作者： M.l. li h. Jiang Y.l. he l.B. Chen G.T. Zhang h. Wang X.G. lu l. li School of Materials Science and Engineering Shanghai University Shanghai 200072 China State Key laboratory of Advanced Special Steel Shanghai University Shanghai 200072 China Pangang Group Research Institute Panzhihua 617000 Sichuan China

A novel two-step cooling experiment was established to simulate the slow cooling process of continuous annealing production line for transformation-induced plasticity （TRIP） steel. The microstructures and mechanical properties of TRIP steel soaked at 700℃ for different time were investigated by tensile test, scanning electron microscopy, X-ray diffraction, and thermodynamic and kinetic calculation. It is shown that the steel soaked for 15 s exhibits the optimal product of strength and elongation （PSE 〉 30,000 MPa%） due to the transformation of austenite to proeutectoid ferrite, which delays the bainite transformation and improves the stability of retained austenite. In addition, the mechanical properties of TRIP steel soaked over 30 s are much lower, resulting from the precipitation of cementite, which decreases the stability of retained austenite and weakens the TRIP effect.

关键词： Transformation induced plasticity steel Two-step cooling Microstructure Mechanical property

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Electromagnetoelastic behaviors of functionally graded piezoelectric solid cylinder and sphere

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Acta Mechanica Sinica 2007年第1期23卷 55-63页

作者： h. l. Dai Y.M. Fu J.h. Yang Department of Engineering Mechanics Hunan University Changsha 410082 China

Analytical studies on electromagnetoelastic behaviors are presented for the functionally graded piezoelectric material （FGPM） solid cylinder and sphere placed in a uniform magnetic field and subjected to the external pressure and electric loading. When the mechanical, electric and magnetic properties of the material obey an identical power law in the radial direction, the exact displacements, stresses, electric potentials and perturbations of magnetic field vector in the FGPM solid cylinder and sphere are obtained by using the infinitesimal theory of electromagnetoelasticity. Numerical examples also show the significant influence of material inhomogeneity. It is interesting to note that selecting a specific value of inhomogeneity parameter β can optimize the electromagnetoelastic responses, which will be of particular importance in modern engineering designs.

关键词： Functionally graded piezoelectric material (FGPM) Electromagnetoelastic Solid cylinder Solid sphere Perturbation of magnetic field vector

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Asymptotic structure of Einstein-Gauss-Bonnet theory in lower dimensions

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Chinese Physics C 2021年第1期45卷 119-126页

作者： h.lü Pujian Mao Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin University135 Yaguan RoadTianjin 300350China

Recently,an action principle for the D→4 limit of Einstein-Gauss-Bonnet gravity has been *** is a special scalar-tensor theory that belongs to the family of horndeski *** also has well defined D→3 and D→2 *** this work,we examine this theory in three and four dimensions in the Bondi-Sachs *** both three and four dimensions,we find that there is no news function associated with the scalar field,which means that there is no scalar propagating degree of freedom in the *** four dimensions,the mass-loss formula is not affected by the Gauss-Bonnet *** is consistent with the fact that there is no scalar ***,the effects of the Gauss-Bonnet term are quite significant in the sense that they arise just one order after the integration constants and also arise in the quadrupole of the gravitational source.

关键词： asymptotic structure Einstein-Gauss-B onnet theory horn deski gravity

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Pocket formula for mass attenuation coefficient, effective atomic number, and electron density of human tissues

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Nuclear Science and Techniques 2019年第3期30卷 1-8页

作者： h.C.Manjunatha l.Seenappa Department of Physics Government College for Women

We have proposed a pocket formula for mass attenuation coefficient(μ/ρ), mass energy absorption coefficient(μ_(en)/ρ), and effective atomic number(Z_(eff)) in different tissues of human organs. We have also assigned a new chemical formula for all studied tissues based on their composition. We have introduced a new parameter called effective composition index(C_(eff)). Based on this, we have introduced a new method to compute the effective atomic number. The evaluated photon interaction parameters are graphically represented. The evaluated average, maximum,minimum, and standard deviations of effective atomic number are tabulated. The proposed formula produces a mass attenuation coefficient, mass energy absorption coefficient, and effective atomic number from their

关键词： Effective atomic number Mass attenuation coefficient Tissues

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Properties of Co_2FeAl heusler Alloy Nano-particles Synthesized by Coprecipitation and Thermal Deoxidization Method

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Journal of Materials Science & Technology 2013年第3期29卷 245-248页

作者： J.h.Du Y.l.Zuo Z.Wang J.h.Ma l.Xi Key laboratory for Magnetism and Magnetic Materials of Ministry of Education Lanzhou University

Co2FeAl nanoparticles were synthesized by reducing the coprecipitated precursor of COCl2·6h2O, Fe（NO3）3·9h2O and AI2（SO4）3·18h2O under h2 atmosphere with various annealing temperatures and durations. X-ray diffraction and transmission electron microscopy were used to characterize the crystal structure and microstructure of Co2FeAl particles, respectively. The investigation indicates that the crystal structure of CO2FeAI particles tends to be B2 structure, in which atoms are partially ordered. The saturation magnetization and hyperfine field of CO2FeAI particles, which were measured under a vibrating sample magnetometer and a 57Fe Mossbauer spectroscope, are consistent with those of the bulk sample and thin films. Furthermore, the higher annealing temperature and the longer annealing time, the better crystallinity of CO2FeAI and more ordered arrangement of atoms will be. It turned out that the coprecipitation thermal deoxidization method could be an easy and high efficient way to obtain the half-metallic CO2FeAI nanoparticles.

关键词： heusler alloy Coprecipitation Magnetic property

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Exact solution and dynamic buckling analysis of a beam-column system having the elliptic type loading

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Applied Mathematics and Mechanics(English Edition) 2010年第10期31卷 1317-1324页

作者： h.S.ARTEM l.AYDIN Department of Mechanical Engineering Izmir Institute of Technology

This paper presents a closed form solution to the dynamic stability problem of a beam-column system with hinged ends loaded by an axial periodically time-varying compressive force of an elliptic type,i.e.,a1cn 2（τ,k 2）＋a2sn 2（τ,k 2）＋a3dn 2（τ,k 2）.The solution to the governing equation is obtained in the form of Fourier sine *** resulting ordinary differential equation is solved *** the exact analytical solutions to the dynamic buckling problems is ***,the availability of exact solutions can provide adequate understanding for the physical characteristics of the *** this study,the frequency-response characteristics of the system,the effects of the static load,the driving forces,and the frequency ratio on the critical buckling load are also investigated.

关键词： dynamic buckling exact solution stability-instability Jacobi elliptic functions

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Static spheroidization and its effect on superplasticity of fine lamellae in nugget of a friction stir welded Ti-6Al-4V joint

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Journal of Materials Science & Technology 2022年第24期119卷 1-10页

作者： C.l.Jia l.h.Wu P.Xue h.Zhang D.R.Ni B.l.Xiao Z.Y.Ma Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Key laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

The spheroidization of the lamellar structure can greatly contribute to the superplasticity of the nugget zone(NZ)of Ti alloy welds,which is the key to achieve the integral superplastic forming of welds for the fabrication of large-scale complex ***,the spheroidization process is complex and costly since it cannot be obtained generally,unless the lamellae suffers from a large *** this study,the static spheroidization was achieved for the fine lamellae structure in the nugget of a friction stir welded(FSW)Ti-6Al-4V joint,particularly by the annealing without any *** specialα/βinterface obeying a Burgers orientation relationship(BOR)after FSW was first time directly observed,whose effect on the spheroidization was discussed.A new static spheroidization mechanism with the gradual coalescence of the adjacent lamellae was discovered,which we named as“termination coalescence”.There was a slower coarsening rate in the lamellar structure than in the classical equiaxed one,due to the BOR in the lamellae,although both of them exhibited a volume diffusion character during ***,the similar superplasticity can be achieved for the base material and NZ after *** study can provide a new way to the spheroidization and a theoretical basis for the integral superplastic forming of welds during production.

关键词： Friction stir welding Titanium alloys Spheroidization mechanism Coalescence Superplasticity Static annealing

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Colloidal(Gd0.98Nd0.02)2O3 nanothermometers operating in a cell culture medium within the first and second biological windows

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Journal of Rare Earths 2020年第5期38卷 483-491页

作者： M.l.Debasu h.Oliveira J.Rocha l.D.Carlos Department of Physics CICECO-Aveiro Institute of MaterilsUniversidade de Aveiro3810-193AveiroPortugal Department of Chemistry CICECO-Aveiro Institute of MaterialsUniversidade de Aveiro3810-193AveiroPortugal Department of Biology CESAMLaboratory of Biotechnology and CytomicsUniversidade de Aveiro3810-193AveiroPortugal

Non-contact,self-referenced and near-infrared luminescent nanothermometers have been recognized as emerging tools in the fields of nanomedicine and nanotechnology due to their great capability of precise temperature readout at the nanoscale and real-time deep-tissue ***,the development of multifunctional and biocompatible luminescent nanothermometers operating within the optically transparent biological windows with high thermal sensitivity(>2.0%/K)remains ***,we present(Gd0.98Nd0.02)2O3 nanothermometers operated effectively within the first and second biological windows upon continuous-wave laser diode excitation at 808 *** thermometric parameters are defined by the relative changes in the emission intensities originating from the two Stark components of the 4 F3/2 level(R2 and R1)to the 4 I9/2(900-1000 nm),4 I11/2(1035-1155 nm)and 4 I13/2(1300-1450 nm)*** thermo metric parameters are evaluated for colloidal samples in a cell culture medium and powder samples,and the highest thermal sensitivity(2.18%/K at 298 K)is attained for the former in the first biological window(both the excitation and emission in the 800-965 nm range).The repeatability and temperature uncertainty are 99%and 1.2 K,*** nanothermometers are biocompatible with human MNT-1 melanoma and haCaT cells for 24 h of exposure and nanoparticle concentration up to 0.400 mg/ml,showing their potential for applications in nanomedicine,e.g.,intracellular imaging and temperature mapping.

关键词： Gd2O3 Nd3^+-doped nanoparticles luminescent nanothermometry Thermal sensitivity Cytotoxicity of nanoparticles Rare earths

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ANTIPERIODIC WAVElETS

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Journal of Computational Mathematics 1996年第1期14卷 32-39页

作者： h.l. Chen(Institute of Mathematics, Academia Sinica, Beijing) ACAD SINICA INST MATHBEIJING 100080PEOPLES R CHINA

In this paper, we construct the orthogonal wavelet basis in the space of antiperiodic functions by appealing the spline methods. Differing from other results in papers([1,2,3,6,8]), here we derive the 3-scale equation, by using this equation we construct some basic functions, those functions can be used to construct different orthonormal basis in some spline function spaces.

关键词： Math ANTIPERIODIC WAVElETS Pro

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