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Two New ent-Kaurane Diterpenoids from Isodon adenantha

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Chinese Chemical letters 2000年第11期11卷 995-996页

作者： jiang, B Xu, JC Yang, h Zhao, QS Sun, hD Chinese Acad Sci Kunming Inst Bot Lab Phytochem Kunming 650204 Peoples R China

Two new ent-kaurane diterpenoids, adenanthins B (1) and C (2), were isolated from the EtOAc extract of Isodon adenantha. Their structures were elucidated by spectroscopic evidences.

关键词： Two New ent-Kaurane Diterpenoids from Isodon adenantha hMBC

Nanotechnology in retinal drug delivery

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International Journal of Ophthalmology(English edition) 2018年第6期11卷 1038-1044页

作者： Sibo jiang Yesenia l Franco Yan Zhou Jianjun Chen Department of Pharmaceutics University of Florida Department of Pharmaceutics University of Minnesota School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug Screening Southern Medical University

Retinal diseases, including age-related macular degeneration （AMD） and diabetic retinopathy （DR） are the leading causes of blindness in adults over the age of 50 years in the US. While most of those conditions do not have a cure, currently available treatment options attempt to prevent further vision loss. For many ophthalmic drugs, an efficient delivery system to provide maximum therapeutic efficacy and promote patient compliance remains an unmet medical need. An exploration of literature via PubMed spanning from 2007 to 2017 was conducted to identify studies that have evaluated nanotechnology as platforms for delivering therapeutic agents to the posterior segment of the eye where the retina is located. Until now, four routes that have been utilized for retinal drug delivery are the intravitreal, periocular, subretinal, and systemic routes. Intravitreal injections are now widely used in clinical practice due to their ability to directly target the back of the eye but are highly invasive procedures that may cause several complications, particularly with repeated uses over a short timespan. Nanotechnology shows great promise to revolutionize retinal drug delivery, offering many advantages such as a targeted delivery system towards the specific site of the retina as well as sustained delivery of therapeutic agents. In this review, specific eye anatomy and constraints on ocular drug administration are illustrated. Further, we list and highlight several examples of nanosystems, such as hydrogels, liposomes, dendrimers, and micelles, used via different drug delivery routes to treat various retinal diseases.

关键词： nanotechnology nanoparticle drug delivery retina age-related macular degeneration diabetic retinopathy

Crack patterns corresponding to the residual strength plateau of ceramics subjected to thermal shock

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Acta Mechanica Sinica 2012年第3期28卷 670-674页

作者： h.-l.hou X.-E Wu P.Yan F.Song J.li C.-P.jiang School of Aeronautic Science and Engineering B eihang University100191 BeijingChina State Key laboratory of Nonlinear Mechanics(lNM) Institute of MechanicsChinese Academy of Sciences100190 BeijingChina lSPM CNRS UPR 3407Universite Paris XIII99 Avenue Jean-Baptiste Clement93430 VilletaneuseFrance

The formation strength plateau of ceramics is addressed. A set of of 99A1203 are conducted, mechanism of the residual subjected to thermal shock thermal shock experiments where the thin specimens of 1 mm× 10 mm×50 mm exhibit parallel through edge cracks, and thus permit quantitative measurements of the crack patterns. The cracks evolve with the severity of ther- mal shock. It is found that there is a correlation between the length and density of the thermal shock cracks. The increase of crack length weakens the residual strength, whereas the increase of crack density improves it. In a considerably wide temperature range, the two contrary effects just counteract each other; consequently a plateau appears in the variation curve of the residual strength. A comparison between the numerical and experimental results of the residual strength is made, and they are found in good agreement. This work is helpful to a deep understanding of the thermal shock failure of ceramics.

关键词： Ceramics Thermal shock Crack patterns Residual strength - Stress intensity factor

Correlation of work function and stacking fault energy through Kelvin probe force microscopy and nanohardness in diluteα-magnesium

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Journal of Magnesium and Alloys 2024年第1期12卷 237-250页

作者： Yigit Türe Ali Arslan Kaya hüseyin Aydin jiang Peng Servet Turan Eskisehir Technical University Porsuk Vocational SchoolElectronics and Automation DepartmentProgram of MechatronicsEskisehirTurkey Mugla Sitki Kocman University Engineering FacultyMetallurgy and Materials Engineering DepartmentMuglaTurkey hüseying Aydın TUBITAK MRCTurkey jiang Peng Chongqing UniversityChina Eskisehir Technical University Engineering FacultyMaterials Science and Engineering DepartmentEskisehirTurkey

Electronic interactions of the Group 2A elements with magnesium have been studied through the dilute solid solutions in binary Mg-Ca,Mg-Sr and Mg-Ba *** investigation incorporated the difference in the‘Work Function'(ΔWF)measured via Kelvin Probe Force Microscopy(KPFM),as a property directly affected by interatomic bond types,*** electronic structure,nanoindentation measurements,and Stacking Fault Energy values reported in the *** was shown that the nano-hardness of the solid-solutionα-Mg phase changed in the order of Mg-Ca>Mg-Sr>***,it was shown,by also considering the nano-hardness levels,that SFE of a solid-solution is closely correlated with its‘Work Function'***-hardness measurements on the eutectics andΔWF difference between eutectic phases enabled an assessment of the relative bond strength and the pertinent electronic structures of the eutectics in the three *** withΔWF and at least qualitative verification of those computed SFE values with some experimental measurement techniques were considered important as those computational methods are based on zero Kelvin degree,relatively simple atomic models and a number of *** asserted by this investigation,if the results of measurement techniques can be qualitatively correlated with those of the computational methods,it can be possible to evaluate the electronic structures in alloys,starting from binary systems,going to ternary and then multi-elemental *** investigation has shown that such a qualitative correlation is *** all,the SFE values are not treated as absolute values but rather become essential in comparative investigations when assessing the influences of alloying elements at a fundamental level,that is,free electron density *** study indicated that the principles of‘electronic metallurgy'in developing multi-elemental alloy systems can be followed via practical experimental methods,i.e.ΔWF measurements using KPF

关键词： Mg alloys Dilute alloys Work function Stacking fault energy Kelvin probe force microscopy Short range order Miedema Nanoindentation Eutectics

Morphology Control and Optical Absorption Properties of Ag Nanoparticles by Ion Implantation

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Journal of Materials Science & Technology 2009年第5期25卷 669-672页

作者： G.X. Cai F. Ren X.h. Xiao l.X. Fan X.D. Zhou C.Z. jiang Key laboratory of Acoustic and Photonie Materials and Devices of Ministry of Education Wuhan University Wuhan 430072 China

Ion implantation is a powerful method for fabricating nanoparticles in dielectric. For the actual application of nanoparticle composites, a careful control of nanoparticles has to be achieved. In this letter, the size, distribution and morphology of Ag nanoparticles are controlled by controlling the ion current density, ion implantation sequence and ion irradiation dose. Single layer Ag nanoparticles are formed by Ag^＋ ion implantation at current density of 2.5 μ^A/cm2. By Ag and Cu ions sequential implantation, the size of single layer Ag nanoparticles increases. While, by Cu and Ag ions sequential implantation, uniform Ag nanoparticles with wide distribution are formed. The morphology of Ag nanoparticles changes to hollow and sandwiched nanoparticles by Cu^＋ ion irradiation to doses of 3×10^16 and 5×10^16 ions/cm^2. The optical absorption properties of Ag nanoparticles are also tailored by these ways.

关键词： Nanoparticles Ion implantation Transmission electron microscopy

Microstructural evolution of Mg-7Al-2Sn Mg alloy during multi-directional impact forging

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Journal of Magnesium and Alloys 2015年第3期3卷 180-187页

作者： M.G.jiang h.Yan l.Gao R.S.Chen The Group of Magnesium Alloys and Their Applications Institute of Metal ResearchChinese Academy of Sciences62 Wencui RoadShenyang 110016China University of Chinese Academy of Sciences 19 Yuquan RoadBeijing 100049China General Motors China Science lab 56 Jinwan RoadPudongShanghai 201206China

Multi-directional impact forging(MDIF)was applied to a Mg-7Al-2Sn(wt.%)Mg alloy to investigate its effect on the microstructural *** process exhibited high grain refinement *** MDIF 200 passes,the grain size drastically decreased to 20µm from the initial coarse grains of~500µm due to dynamic recrystallization(DRX).Meanwhile,original grain boundaries remained during MDIF and large numbers of fine sphericalβ-Mg_(17)Al_(12) particles dynamically precipitated along the original grain boundaries with high Al concentration,acting as effective pinning obstacles for the suppression of DRXed grain ***,micro-cracks nucleated during MDIF and propagated along the interface between the remained globular or cubic Al-Mn particles and Mg matrix.

关键词： Magnesium alloy Forging Grain refinement Dynamic precipitation

Prediction of the Atomic Electron Affinities Using a Wavelet Neural Network

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Chinese Chemical letters 1998年第2期9卷 203-206页

作者： liu, l Shao, XG Cai, WS jiang, Y Pan, ZX Univ Sci & Technol China Dept Chem Hefei 230026 Peoples R China Univ Sci & Technol China Dept Appl Chem Hefei 230026 Peoples R China Univ Sci & Technol China Dept Phys Hefei 230026 Peoples R China

Wavelet Neural Network (WNN) was employed in a rapid calculation of the atomic electron affinities, with atomic ionization potentials and atomic electron configurations chosen as input parameters. Many unmeasured valu... 详细信息

关键词： Wavelet Neural Network (WNN) atomic electron affinities

Zeolite-Catalyzed Thionation of Diphenyl-type Compounds

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Chinese Chemical letters 1997年第5期8卷 381-384页

作者： jiang, W Wang, Ql Ma, YD Zuo, BJ Wang, l ShANDONG UNIV DEPT CHEMJINAN 250100PEOPLES R CHINA ShANDONG MED UNIV DEPT PHARMJINAN 250012PEOPLES R CHINA

The synthesis of phenothiazine and phenoxthine was performed very efficiently through the thionation of diphenylamine and diphenyl ether, respectively, with elemental sulfur by using hydrothermally treated hY zeolites... 详细信息

关键词： type Wang Zeolite-Catalyzed Thionation of Diphenyl-type Compounds

Effects of cold preservation and warm reperfusion on rat fatty liver

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World Journal of Gastroenterology 2000年第2期6卷 271-274页

作者： Sun B jiang hC Piao DX Qiao hQ Zhang l harbin Med Univ Clin Hosp 1 Dept Gen Surg Harbin 150001 Peoples R China

INTRODUCTIONAlthough liver transplantation for irreversible liverdiseases is increasingly prevalent worldwide,patientdie while waiting for donors because of *** important problem commonlyencountered is that fatty livers often affect theoutcome of liver *** is reported thatthe incidence of abnormal fatty livers in autopsiesafter accidental death ranged from 15% to 24%.Since fatty livers may result in a primarynonfunction (PNF)liver graft,which contributes

关键词： fatty liver cold preservation warm reperfusion rats