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Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate

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Synthetic and Systems Biotechnology 2018年第2期3卷 113-120页

作者： hong Zhang Chiajung Yeh Zonglian Jin Liwei Ding Bryan Y.Liu Li Zhang h.kathleen dannelly Beijing Chao-Yang hospital affiliated to Capital Medical University 8 Gongti South RoadChaoyang DistrictBeijing10020China hangzhou Weiquan Foods Co. LTD R&D Center1688 Wu Zhong RoadMinhang DistrictShanghai201100China College of Applied Arts and Science of Beijing Union University 197 Bei Tu Cheng West RoadHaitian DistrictBeijing100108China SPRIM China 100 Zunyi RoadChangning DistrictShanghai200336China Indiana State University Department of Biology600 Chestnut StreetTerre HauteIN 47809USA

The human gut microbiota is an important environmental factor for human health with evolutionarily conserved roles in immunity,metabolism,development,and behavior of the *** organisms are claimed to offer several functional properties including stimulation of immune *** purpose of this study is to investigate the effects of a probiotic supplementation on adult volunteers who have contracted the common cold four or more times in the past *** study is a single center,doubleblind,randomized,controlled,prospective *** received a probiotic drink containing Lactobacillus paracasei(at least 3×10^7 colony forming units(CFU)ml^-1),Lactobacillus casei 431®(at least 3×10^7 CFU ml1)and Lactobacillus fermentium PCC®(at least 3×10^6 CFU ml^-1)or an identical placebo without probiotics for a 12-week study *** consumption of probiotics significantly reduced the incidence of upper respiratory infection(ph an oral temperature higher than 38℃(phe placebo *** that consumed probiotics demonstrated a significantly higher level of IFN-g in the serum(phe gut(phe placebo group and a significant higher level of serum IFN-g(pheir baseline test *** contrast,there were no significant differences in the serum IL-4,IL-10,IgA,IgG or IgM between the probiotics and the placebo *** of this study demonstrated that probiotics were safe and effective for fighting the common cold and influenza-like respiratory infections by boosting the immune system.

关键词： Probiotics Upper respiratory infections human microbiota IFN-g sIgA

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湖泊沉积植物DNA宏条形码技术在青藏高原植被调查中的应用

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中国科学:地球科学 2024年

作者：吴铠李凯贾伟瀚 kathleen R.STOOF-LEIChSENRING Ulrike hERZSChUh 倪健廖梦娜田芳浙江师范大学生命科学学院 Polar Terrestrial Environmental Systems Research Group Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research Institute of Environmental Science and Geography University of Potsdam Institute of Biochemistry and Biology University of Potsdam 首都师范大学资源环境与旅游学院

得益于环境DNA技术的快速发展,沉积DNA(sedDNA)正在成为偏远地区植被监测和调查的便捷方法,并具有较大的发展潜力.青藏高原气候环境条件恶劣,同时小型湖泊众多,利用sedDNA进行植被调查不仅有助于了解高原现代植被状况,也是进行高原古植... 详细信息

得益于环境DNA技术的快速发展,沉积DNA(sedDNA)正在成为偏远地区植被监测和调查的便捷方法,并具有较大的发展潜力.青藏高原气候环境条件恶劣,同时小型湖泊众多,利用sedDNA进行植被调查不仅有助于了解高原现代植被状况,也是进行高原古植被重建的潜在需求.本研究以中国青藏高原西南部59个泡子/湖泊表层沉积物为研究对象,使用通用植物引物g-h扩增叶绿体trn L(UAA)内含子P6环区,获取了sedDNA中的植物组成信息,并将其与野外植被调查记录和沉积物花粉数据进行对比分析,探讨了基于沉积物的植物DNA宏条形码技术在青藏高原地区现代植被监测和古植被重建中的适用性和局限性.研究结果表明,植物DNA宏条形码信号共记录了186个陆生植物类群,其中30.1%的序列可以鉴定到种水平.植物sedDNA方法可以揭示调查地点周围的主要植物类群(包括菊科、莎草科和禾本科)以及重要植被组合.植物sedDNA的类群数量和分类学分辨率均超过花粉分析(75个类群,其中5.3%的类群可以鉴定到种水平).与花粉保留大量的区域植物信号(包括松属和蒿属)不同,植物sedDNA反映了高度局地的植物信号,凸显了植物sedDNA在局地植被监测和重建中的重要性.综上所述,(小型)湖泊植物sedDNA宏条形码研究在未来的青藏高原区域植被监测和重建中值得更多的关注.

关键词：沉积DNA 宏条形码花粉植被组成青藏高原

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Application of plant DNA metabarcoding of lake sediments for monitoring vegetation compositions on the Tibetan Plateau

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Science China Earth Sciences 2024年

作者： Kai WU Kai LI Weihan JIA kathleen R.STOOF-LEIChSENRING Ulrike hERZSChUh Jian NI Mengna LIAO Fang TIAN College of Life Sciences Zhejiang Normal University Polar Terrestrial Environmental Systems Research Group Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research Institute of Environmental Science and Geography University of Potsdam Institute of Biochemistry and Biology University of Potsdam College of Resource Environment and Tourism Capital Normal University

Benefiting from the rapid development of environmental DNA (eDNA) technologies,sedimentary DNA (sedDNA)emerges as a promising tool for monitoring plant compositions in remote *** Tibetan Plateau (TP),renowned for its harsh environment and numerous ponds and lakes,presents a potentially demanding region for the application of sedDNA on vegetation ***,we used the g and h universal primers for the P6 loop region of the chloroplast trn L (UAA)intron to amplify plant DNA in surface sediments from 59 ponds and small lakes on the southwestern *** applicability and limitations of using plant DNA metabarcoding for modern vegetation monitoring and palaeo-vegetation reconstructions have been assessed by comparing sedDNA,pollen,and vegetation survey *** results showed that plant DNA metabarcoding recorded 186 terrestrial taxa,of which 30.1%can be identified at the species *** plant sedDNA approach can effectively disclose the dominant plant taxa (including Asteraceae,Cyperaceae and Poaceae) and significant vegetation assemblages in the vicinity of the investigated *** number of taxa and taxonomic resolution of plant sedDNA exceeded that of pollen analysis(75 taxa detected,5.3%can be identified at species level).Unlike pollen that retains a broad spectrum of regional plant signals(including Pinus and Artemisia),plant sedDNA mirrors very local plants,underscoring its utility in local vegetation monitoring and *** conclude,plant DNA metabarcoding of (small) lake sediments warrant increased attention in the future for local vegetation monitoring and reconstructions on the TP.

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Resilience, the 6th Vital Sign: Conceptualizing, Contextualizing, and Operationalizing All Six Vital Signs

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health 2024年第7期16卷 657-673页

作者： Rose E. Constantino Betty J. Braxter Chi Ching Vivian hui Larissa C. Allen Lillian J. Wolfe Katherine h. Endres Jezyl Cempron Cutamora Laurence L. Garcia Daisy R. Palompon kathleen Thimsen Brayden N. Kameg Margarete L. Zalon Department of health and Community Systems School of Nursing University of Pittsburgh Pittsburgh PA USA Undergraduate Affairs School of Nursing University of Pittsburgh Pittsburgh PA USA The hong Kong Polytechnic University Hong Kong China School of Nursing Adjunct Faculty at the University of Pittsburgh Pittsburgh PA USA School of Nursing University of Pittsburgh Pittsburgh PA USA Department of health Promotion and Development School of Nursing University of Pittsburgh Pittsburgh PA USA College of Nursing Cebu Normal University Cebu City Philippines School of Nursing University of Nevada Las Vegas USA Department of health and Community Systems University of Pittsburgh PA USA Department of Nursing University of Scranton Scranton PA USA

There are five vital signs that healthcare providers assess: temperature, pulse, respiration, blood pressure, and pain. Normal levels for the five vital signs are published by the American heart Association, and other specialty organizations, however, the sixth vital sign (resilience) which adopts the measure of immune resilience is suggested in this paper. Resilience is the ability of the immune system to respond to attacks and defend effectively against infections and inflammatory stressors, and psychological resilience is the capacity to resist, adapt, recover, thrive, and grow from a challenge or a stressor. Individuals with better optimal immune resilience had better health outcomes than those with minimal immune resilience. The purpose of this paper is to conceptualize, contextualize, and operationalize all six vital signs. We suggest measuring resilience subjectively and objectively. Subjectively, use a 5-item guided interview revised from the Connor-Davidson Resilience Scale (CDRC), a scale of 10 items. The revised CDRC scale is a 5-item scale. The scale is rated on a 5-point Likert scale from 0 (not true) to 4 (true all the time). The total score ranges from 0 to 20, with higher total scores indicating greater resilience. The scale demonstrated good construct validity and internal consistency (α = 0.85) during the development of the scale. The CD-RISC had a good Cronbach’s alpha level of 0.85. The Revised CD-RISC can be completed in 2 - 4 minutes. To measure resilience objectively, we suggest using Immune Resilience (IR) levels, the level of resilience to preserve and/or rapidly restore immune resilience functions that promote disease resistance and control inflammation and other inflammatory stress. IR levels are gauged with two peripheral blood metrics that quantify the balance between CD8 and CD4 T-cell levels and gene expression signatures tracking longevity-associated immunocompetence and mortality- or entropy-associated inflammation. IR deregulation i

关键词： Conceptualization Contextualization Operationalization Body Temperature Pulse Respiration Blood Pressure Pain Resilience

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Prevention of Deep Vein Thrombosis by Panax Notoginseng Saponins Combined with Low-Molecular-Weight heparin in Surgical Patients

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Chinese Journal of Integrative Medicine 2022年第9期28卷 771-778页

作者： WANG Chun-mei GUO Xiang-feng LIU Li-min hUANG Ying MENG Liang SONG Li-po WU Ying-feng NING Ya-chan kathleen h.Reilly WANG hai-bo Department of Vascular Surgery Xuanwu HospitalCapital Medical UniversityBeijing100053China Children’s hospital Capital Institute of Pediatrics Beijing100020China Department of Orthopaedics Xuanwu HospitalCapital Medical UniversityBeijing100053China Centers for Disease Control and Prevention New York CityNY12237USA Peking University Clinical Research Institute Peking University First HospitalBeijing100191China

Objective:To evaluate the efficacy of deep vein thrombosis(DVT)prevention among realworld surgical inpatients who received panax notoginseng saponins(PNS)combined with low-molecularweight heparin(LMWh).Methods:A prospective cohort study was conducted among surgical patients between January 2016 and November 2018 in Xuanwu hospital,Capital Medical University,Beijing,*** received LMWh alone or PNS combined with LMWh for preventing *** primary outcome was incidence of lower extremity DVT,which was screened once a *** in the LMWh group were given LMWh(enoxaparin)via hypodermic injection,4000-8000 AxalU once *** in the exposure group received PNS(Xuesaitong oral tablets,100 mg,3 times daily)combined with LMWh given the same as LMWh ***:Of the 325 patients screened for the study,281 participants were included in the final *** cohort was divided into PNS+LMWh group and LMWh group with 134 and 147 participants,*** was a significant difference of DVT incidence between two groups(P=0.01),with 21(15.7%)incident DVT in the PNS+LMWh group,and 41(27.9%)incident DVT in the LMWh *** with participants without DVT,the participants diagnosed with DVT were older and had higher D-dimer *** multivariate logistic regression moclel showed a significant lower risk of incident DVT among participants in the PNS+LMWh group compared with the LMWh group(odds ratio 0.46,95%confidence interval,0.25-0.86).There were no significant differences in thromboelaslography values(including R,K,Angle,and MA)and differences in severe bleeding between two *** symptomatic pulmonary embolism occurred during the ***:Combined application of PNS and LMWh can effectively reduce the incidence of DVT among surgical inpatients compared with LMWh monotherapy,without increased risk of bleeding.

关键词： panax notoginseng saponins deep vein thrombosis low-molecular-weight heparin thromboelastography risk factor

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Chinese Medical Journal 2012年第16期125卷 2819-2825页

作者： WANG Xiao-fang Jessie L. Norris LIUYingjie kathleen h. Reilly WANG Ning National Center for AIDS/STD Control and Prev'ention Chinese Center for Disease Control and Prevention Beijing 102206 China Institute for AIDS/STD Control and Prevention Beijing Chaoyang District Center for Disease Control and Prevention Beijing 100021 China

Background Previous studies have shown evidence of health-related risk behaviors among women who have sex with women （WSW）, such as sex with men, multiple bisexual partners, and drug use. Women who have sex with women have also been known to avoid routine physical examinations and conceal their same-sex history from physicians, which can affect their ability to receive an accurate diagnosis and treatment. No previous research has targeted women who have sex with women in China. We sought to describe women who have sex with women in China and explore risk factors for their reproductive tract infections （RTI）/sexually transmitted infections （STI）. Methods Participants were recruited through outreach in venues and online for a cross-sectional study. Data were collected using interviews and laboratory tests. Results We recruited 224 women who have sex with women. In the year preceding their participation in the study, 92% （206/224） of women reported sexual relations with women. The RTI rates were： gonorrhea （15.8%）, chlamydia （3.5%）, syphilis （0.5%）, bacterial vaginosis （14.4%）, hepatitis B virus （hBV）（0.9%）, hepatitis C virus （hCV）（0.5%）, and candidiasis （6.9%）. No hIV or herpes simplex virus （hSV） positive cases were detected. Factors associated with gonorrhea infection were non-Beijing local residency （odds ratio （OR）=2.1, 95% confidence interval （C/）： 1.2-3.8） and genital-genital contact （OR=3.1, 95% CI： 1.3-7.2）; factors associated with curable STI （excluding bacterial vaginosis, candidiasis, hBV and hCV） were non-Beijing local residency （OR=1.9; 95% CI： 1.2-3.0） and bleeding during or after sex （OR=18.1; 95% CI： 5.2-62.6）; and the factor associated with RTI （including all the infections tested） was bleeding during or after sex （OR=37.8, 95% CI： 11.2-127.4）. Conclusions Behaviors that may cause RTI/STI exist among Chinese women who have sex with women. Researchers should consider these behaviors when planninq correspondin.q prevention and interventions.

关键词： women who have sex with women, lesbian, gay, bisexual, transgender hIV/AIDS sexual transmission,sexually transmitted infection

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Estimation of Population-Size Changes and hIV Prevalence among Female Sex Workers from 2006 to 2009 in Kaiyuan,Yunnan,China

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Biomedical and Environmental Sciences 2012年第4期25卷 489-494页

作者： WANG Jun Jie YANG Qian FAN Pan Ying REILLY kathleen h. DING Guo Wei WANG Ning National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Kaiyuan Center for Disease Control and Prevention Kaiyuan 661600 Yunnan China Department of Public health Peking Union Medical College Tsinghua University Beij'ing 100730 China Tulane University health Sciences Center School of Public Health and Tropical Medicine New Orleans LA USA

Objective This study is to estimate the population size and prevalence of hIV and herpes simplex virus type 2 （hSV-2） infections among female sex workers （FSWs） in Kaiyuan, Yunnan Province, China. Methods Eight cross-sectional studies were conducted among FSWs in Kaiyuan from 2006 to 2009. Based on the data from two study time points each year, the total numbers of FSWs and hIV positive FSWs were estimated by using the capture-recapture technique （CR）. Results Estimated sizes of FSWs in Kaiyuan were 1 629, 1 672, 1 186, and 1 014 in the respective years from 2006 to 2009. Although the crude prevalence rates of hIV and hSV-2 varied over time, the adjusted prevalence among this population was relatively stable at 10%-12% and the adjusted hSV-2 prevalence ranged from 67% to72%. Conclusion The reason for the slight decrease of the size of the FSW population is unknown. The adjusted prevalence rates of hIV and hSV-2 among them were stable over the course of this study.

关键词： Population hIV FSWs Capture-recapture

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Peripheral Vascular and Neuromuscular Responses to Ultramarathon Running

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Journal of Science in Sport and Exercise 2022年第2期4卷 99-108页

作者： Rian Q.Landers-Ramos kathleen R.Dondero Robert W.Rowland Derrick Larkins Odessa Addison Department of Kinesiology Towson University8000 York RdTowsonMD 21252USA Department of Physical Therapy and Rehabilitation Sciences University of Maryland School of MedicineBaltimoreMDUSA Veterans Affairs Geriatric Research Education and Clinical CenterBaltimoreMDUSA

Participation in ultramarathon events has grown substantially in the past ***,poor understanding of the physiological outcomes associated with participation in this sport prevents athletes and clinicians from adequately addressing performance and recovery *** purpose of this review was to summarize developments in the literature in the last 10 years regarding acute and chronic responses to ultramarathon running with a focus on the peripheral vascular system,neuromuscular outcomes,and running *** suggests that there are acute impairments in large artery compliance especially following the longer ultramarathon ***,most literature indicates that chronic vascular impairments are not evident in ultramarathon *** central and peripheral fatigue mechanisms contribute to declines in muscle force production that may last up to several weeks in some muscles following an *** in gait kinematics and skeletal muscle oxidative capacity increase the metabolic cost of running over prolonged running distances(>4 h).Several factors such as elevation changes and nutritional practices make interpretation of findings *** studies are needed to better understand the interplay among systems and how external factors contribute to these outcomes to optimize performance and inform recovery strategies in this increasingly popular sport.

关键词： Aerobic exercise Vascular stiffness Muscle fatigue Kinematics Ultramarathon running Running mechanics

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Predicting phosphorus sorption isotherm parameters in soil using data of routine laboratory tests

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Pedosphere 2021年第5期31卷 694-704页

作者： kathleen S.DUNNE Nicholas M.hOLDEN Karen DALY Teagasc Johnstown CastleEnvironmental Research CentreCo.Wexford Y35TC97(Ireland) UCD School of Biosystems and Food Engineering University College DublinBelfieldDublin 4 D04VIW8(Ireland)

Knowledge of phosphorus(P)sorption dynamics across different soil types could direct agronomic and environmental management of *** objective of this study was to predict P isotherm parameters for a national soil population using data of routine laboratory *** and Freundlich sorption parameters were calculated from two different ranges(0-25 and 0-50 mg P L^(-1))using an archive of representative agricultural soil types from *** linear regression(MLR)identified labile forms of aluminium(Al)and iron(Fe),organic matter(OM),cation exchange capacity(CEC),and clay as significant *** and Freundlich sorption capacities,Freundlich affinity constant,and Langmuir buffer capacity were predicted reliably,with R^(2) of independent validation>*** isotherm parameters were predicted from P sorbed at a single concentration of 50 mg P L^(-1)(S_(50)).An MLR prediction of P sorption maximum in the 0-50 mg P L-1 range was achieved,to an accurate standard,using S_(50),OM,and Mehlich-3 Fe(R^(2) of independent calibration and validation being 0.91 and 0.95,respectively).Using Giles’four shapes of isotherms(C,L,h,and S),L non-strict-and C-shaped isotherm curves accounted for 64% and 27% of the soils,*** clustering identified a separation of isotherm curves influenced by two ranges of Mehlich-3 *** with a low range of Mehlich-3 Al(2.5-698 mg kg^(-1))had no incidence of rapid sorption(C shape).Single point indices,Al,or available soil data make the regression approach a feasible way of predicting Langmuir parameters that could be included with standard agronomic soil P testing.

关键词： available phosphorus binding fertilizer soil test sorption maximum

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Gambogic Acid Induces Cell Apoptosis and Inhibits MAPK Pathway in PTEN^(-/-)/p53^(-/-) Prostate Cancer Cells In Vitro and Ex Vivo

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Chinese Journal of Integrative Medicine 2018年第2期24卷 109-116页

作者： PAN hong LU Li-yuan WANG Xue-qian LI Bin-xue kathleen Kelly LIN hong-sheng Clinical Medical College Beijing University of Chinese Medicine Laboratory of Oncology Guang'anmen HospitalChina Academy of Chinese Medical Sciences Laboratory of Genitourinary Cancer Pathogenesis Center for Cancer ResearchNational Cancer InstituteNational Institutes of Health

Objective： To investigate the effect of gambogic acid（GA） on the growth and cell death of castrate resistant prostate cancer（PC） with phosphate and tension homology（PTEN） and p53 genes deleted in vitro and ex vivo, and elucidate the underlying possible molecular mechanisms. Methods： PTEN^（-/-）/p53^（-/-）PC cells and Los Angeles prostate cancer-4（LAPC-4） cells were treated with GA for 24 h and 48 h, then cell viability was determined by cell proliferation assay. PTEN^（-/-）/p53^（-/-）PC cells organoids number was calculated under GA treatment for 1 week. In addition, cell titer glo assay was performed to analyze 3 dimensional cell viability of patients derived xenografts（PDX） 170.2 organoids. Flow cytometry was used to detect apoptotic cells treated with GA. And confocal image was performed to detect the apoptotic mitochondrial morphological changes. Apoptotic cell death related protein levels were measured through Western blot（WB） in GA treated cells and organoids. The expression levels of mitogen-activated protein kinases（MAPKs） pathway related ribonucleic acid（RNAs） and proteins were analyzed by reverse transcription polymerase chain reaction（RT-PCR） and WB, respectively. Results： The treatment of GA significantly reduced cell viability of PTEN^（-/-）/p53^（-/-）PC cells and LAPC-4 in a time-and concentration-dependent manner. In organoids, GA showed strong inhibition towards organoids＇ numbers and diameters and continuously led to a complete organoids inhibition with GA 150 nmol/L. Ex vivo results validated that GA 1 μmol/L inhibited 44.6% PDX170.2 organoids growth. As for mechanism, flow cytometry detected continuously increased apoptotic portion under GA treatment from 1.98% to 11.78%（6 h） and 29.94%（8 h, P〈0.05）. In addition, mitochondrial fragmentation emerged in GA treated cells indicated the mitochondrial apoptotic pathway might be involved. Furthermore, WB detected caspases-3,-9 activation and light chain（LC）-3 conversion with GA treatment. WB revealed decreased

关键词： gambogic acid prostate cancer apoptosis mitogen-activated protein kinase PTEN-/-/p53-/-

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