检索结果-南通市图书馆

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg marina manoraj jenny Cheung jennifer Zhang Kaveh mirmoeini jPaul Santerre Tessa Gordon Gregory hBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Thermoelastic Analysis of Non-uniform Pressurized Functionally Graded Cylinder with Variable Thickness Using First Order Shear Deformation Theory(FSDT) and Perturbation method

在线全文

学校读者我要写书评

暂无评论

Chinese journal of mechanical Engineering 2015年第6期28卷 1149-1156页

作者： KhOShGOFTAR m j mIRZAALI m j RAhImI G h Faculty of mechanical Engineering Tarbiat Modares University Department of mechanical Engineering Faculty of Engineering Arak University Department of mechanical Engineering Politecnico di Milano

Recently application of functionally graded materials（FGms） have attracted a great deal of interest. These materials are composed of various materials with different micro-structures which can vary spatially in FGms. Such composites with varying thickness and non-uniform pressure can be used in the aerospace engineering. Therefore, analysis of such composite is of high importance in engineering problems. Thermoelastic analysis of functionally graded cylinder with variable thickness under non-uniform pressure is considered. First order shear deformation theory and total potential energy approach is applied to obtain the governing equations of non-homogeneous cylinder. Considering the inner and outer solutions, perturbation series are applied to solve the governing equations. Outer solution for out of boundaries and more sensitive variable in inner solution at the boundaries are considered. Combining of inner and outer solution for near and far points from boundaries leads to high accurate displacement field distribution. The main aim of this paper is to show the capability of matched asymptotic solution for different non-homogeneous cylinders with different shapes and different non-uniform pressures. The results can be used to design the optimum thickness of the cylinder and also some properties such as high temperature residence by applying non-homogeneous material.

关键词： non-homogenous cylinder First order Shear Deformation Theory matched asymptotic method perturbation method functionally graded material

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis h.Pagan Rivera jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Classification and technical target of water electrolysis for hydrogen production

在线全文

学校读者我要写书评

暂无评论

journal of Energy Chemistry 2024年第8期95卷 554-576,I0012页

作者： Kahyun ham Sooan Bae jaeyoung Lee Ertl Center for Electrochemistry and Catalysis Gwangju Institute of Science and Technology(GIST)123 Cheomdangwagi-RoBuk-guGwangju 61005South Korea Department of heterogeneous Reactions Max Planck Institute for Chemical Energy ConversionStiftstr.34-36Mülheim an der RuhrGermany School of Earth Sciences and Environmental Engineering GIST123 CheomdangwagiroBuk-guGwangju 61005South Korea International Future Research Center of Chemical Energy Storage and Conversion Processes GIST123 CheomdangwagiroBuk-guGwangju 61005South Korea eSuS Co. Ltd.#408S6 BuildingSchool of Environment and Energy EngineeringGIST123 CheomdangwagiroBuk-guGwangju 61005South Korea

Continuous efforts are underway to reduce carbon emissions worldwide in response to global climate *** electrolysis technology,in conjunction with renewable energy,is considered the most feasible hydrogen production technology based on the viable possibility of large-scale hydrogen production and the zero-carbon-emission nature of the ***,for hydrogen produced via water electrolysis systems to be utilized in various fields in practice,the unit cost of hydrogen production must be reduced to$1/kg h_(2).To achieve this unit cost,technical targets for water electrolysis have been suggested regarding components in the *** this paper,the types of water electrolysis systems and the limitations of water electrolysis system components are *** suggest guideline with recent trend for achieving this technical target and insights for the potential utilization of water electrolysis technology.

关键词： Water electrolysis hydrogen production Technical target Electrochemistry

Parameters for Cold Collisions of Lithium and Caesium Atoms

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2011年第6期28卷 56-58页

作者： jamieson m.j Ouerdane h School of Computing Science University of GlasgowGlasgow G128QQUK mediterranean Institute of Fundamental Physics Via Appia Nuova 3100040 MarinoRomeItaly CNRT matériaux UmS CNRS 3318 6 Boulevard Maréchal Juin14050 Caen CedexFrance

We calculate the s-wave scattering length and effective range and the p-wave scattering volume for 7Li atoms interacting with 133Cs atoms via the X1Σ+molecular *** length and volume are found by fitting the log-derivative of the zero energy wave function evaluated at short range to a long range expression that accounts for the leading van der Waals dispersion potential and then incorporating the remaining long range dispersion contributions to first *** effective range is evaluated from a quadrature *** calculated parameters are checked from the zero energy limits of the scattering phase *** comment on ill-conditioning in the calculated s-wave scattering length.

关键词： potential dispersion checked

health risk of whole body vibration in mining trucks during various operational conditions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Central South University 2017年第8期24卷 1808-1816页

作者： Rahimdel m.j mirzaei m Sattarvand j hoseinie S.h Department of mining Engineering Sahand University of TechnologyTabriz ***Iran Department of mechanical Engineering Sahand University of TechnologyTabriz ***Iran Department of mining Engineering Isfahan University of TechnologyIsfahan ***Iran

mining machineries are generally exposed to intensive vibrations in harsh mining environment. If vibrations are beyond the tolerable limit, the machine and its operator health will be under the risk. In this work, the vibration of a mining truck at different operational conditions are simulated and discussed. To achieve this aim, three haul roads with low, medium and poor qualities are considered based on the ISO standard. Accordingly, the vibration of a mining truck in different speeds, payload and distribution qualities of materials in the dump body are evaluated in each haul road quality using Trucksim software. The simulation results with statistical discussions indicate that the truck speed and the materials distribution quality have significant effects on the root mean square(RmS) of vertical vibrations. however, the effect of the payload is not considerable on the RmS. moreover, the accumulation of materials on the rear side of the truck dump body is efficient on the vibrational health risk.

关键词： mining trucks operational conditions health risk whole body vibration

microstructures in a carburized steel after isothermal pearlitic treatment

在线全文

学校读者我要写书评

暂无评论

journal of materials Science & Technology 2023年第29期160卷 66-75页

作者： j.Abraham mathews h.Farahani j.Sietsma R.h.Petrov m.G.mecozzi m.j.Santofimia Department of materials Science and Engineering Delft University of TechnologyMekelweg 22628 CDDelftThe Netherlands Tata Steel Research&Development IJmuidenThe Netherlands Department of Electromechanical Systems and Metal EngineeringGhent UniversityTech Lane Ghent Science park-Campus A ZwijnaardeTechnologiepark 46Belgium

The influence of carbon concentration variations on pearlite formation(20 h at 600℃)in a case-carburized steel is *** resultant microstructure shows three distinct regions:carburized case,a transition region,and the original *** microstructural transition from the case to the core regions is observed to be relatively *** investigated region of the carburized case(0.9 wt.%C)con-tains two types of pearlite:ferrite+cementite and ferrite+m_(23)C_(6),where the pearlitic aggregate with m_(23)C_(6)shows faster formation *** kinetics of pearlite formation in the transition region(0.3 wt.%C)is very slow and is observed with only m_(23)C_(6)*** around 40%austenite decomposes into pearlite in the transition region,which,in comparison to the carburized case region of 0.9 wt.%C is a fraction that is lower by a factor of *** is absent in the investigated core region(0.16 wt.%C).The microstructure in this region is predominantly martensite and pro-eutectoid ferrite,with a fraction of ferrite well below the equilibrium *** formation in this region is limited by the redistribution of mainly Ni,mn,and Cr,and their resulting solute drag effect on the austenite/ferrite interface.A ther-modynamic and kinetic argumentation of these observations is provided with the help of thermodynamic data,precipitation simulations,and a general mixed-mode Gibbs energy balance model.

关键词： Pearlite formation Carburized steel m 2_(3)C_(6)carbide Kinetics Solute drag