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Biochanin A attenuates spinal cord injury in rats during early stages by inhibiting oxidative stress and inflammasome activation

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Neural Regeneration Research 2024年第9期19卷 2050-2056页

作者： Xigong Li jing Fu Ming Guan haifei shi Wenming Pan Xianfeng Lou Department of Orthopedics The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang ProvinceChina Department of Stomatology Xixi HospitalHangzhouZhejiang ProvinceChina Department of Orthopedics and Spine Surgerythe Affiliated Hospital of Xuzhou Medical Schoolthe Second People’s Hospital of ChangshuChangshuJiangsu ProvinceChina

Previous studies have shown that Biochanin A,a flavonoid compound with estrogenic effects,can serve as a neuroprotective agent in the context of cerebral ischemia/reperfusion injury;howeve r,its effect on spinal cord injury is still unclea r. In this study,a rat model of spinal cord injury was established using the heavy o bject impact method,and the rats were then treated with Biochanin A(40 mg/kg) via intrape ritoneal injection for 14 consecutive *** res ults showed that Biochanin A effectively alleviated spinal cord neuronal injury and spinal co rd tissue injury,reduced inflammation and oxidative stress in spinal cord neuro ns,and reduced apoptosis and *** addition,Biochanin A inhibited the expression of inflammasome-related proteins(ASC,NLRP3,and GSDMD)and the Toll-like receptor 4/nuclear factor-κB pathway,activated the Nrf2/heme oxygenase 1 signaling pathway,and increased the expression of the autophagy markers LC3 Ⅱ,Beclin-1,and *** r,the therapeutic effects of Biochanin A on early post-s pinal cord injury were similar to those of *** findings suggest that Biochanin A protected neurons in the injured spinal cord through the Toll-like receptor 4/nuclear factor κB and Nrf2/heme oxygenase 1 signaling *** findings suggest that Biochanin A can alleviate post-spinal cord injury at an early stage.

关键词： apoptosis autophagy Biochanin A heme oxygenase 1 inflammation Nrf2 protein nuclear factor kappa-B oxidative stress spinal cord injury Toll-like receptor 4

Studying large biomolecules as sedimented solutes with solid-state NMR

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Biophysics Reports 2024年第4期10卷 201-212页

作者： Fan shi Tong Zhang juan Li Chaowei shi Shengqi Xiang MOE Key Lab for Cellular Dynamics School of Life Sciences Division of Life Sciences and Medicine University of Science and Technology of China hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of China

Sedimentation solid-state NMR is a novel method for sample preparation in solid-state NMR（ssNMR）studies. It involves the sedimentation of soluble macromolecules such as large protein complexes. By utilizing ultra-high centrifugal forces, the molecules in solution are driven into a high-concentrated hydrogel, resulting in a sample suitable for solid-state NMR. This technique has the advantage of avoiding the need for chemical treatment, thus minimizing the loss of sample biological activity. Sediment ssNMR has been successfully applied to a variety of non-crystalline protein solids, significantly expanding the scope of solid-state NMR research. In theory, using this method, any biological macromolecule in solution can be transferred into a sedimented solute appropriate for solid-state NMR analysis. however, specialized equipment and careful handling are essential for effectively collecting and loading the sedimented solids to solid-state NMR rotors. To improve efficiency, we have designed a series of loading tools to achieve the loading process from the solution to the rotor in one step. In this paper, we illustrate the sample preparation process of sediment NMR using the h1.4-NCP167complex, which consists of linker histone h1.4 and nucleosome core particle, as an example.

关键词： Sedimentation NMR Solid-state NMR Ultracentrifugation Magic angle spinning Nucleosome

A novel thermally-stable single-phase phosphor Ca2InTaO6:Dy3+ for NUV-excited white LEDs

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journal of Rare Earths 2024年第10期42卷 1855-1864页

作者： jian hu Ruirui Cui jun Zhang Peng Linghu Youzhen shi Xiang Guo Key Laboratory of Micro-Nano-Electronics and Software Technology of Guizhou Province College of Big Data and Information EngineeringGuizhou University College of Computer and Information Engineering Guizhou University of Commerce

The work focuses on the utilization of the conventional solid-state sintering procedure to synthesize white phosphors Ca2InTaO6:xDy3+（0.02≤x≤0.12）.Utilizing X-ray diffraction,the phase structure of samples was examined,and the crystal structure was refined using the Rietveld method.A scanning electron microscope was used to analyze the microstructure of ***-principles calculations confirm that the indirect bandgap of Ca2InTaO6is 3.786 eV,The luminous properties and energy transfer mechanism of Ca2InTaO6:xDy3+were studied using photoluminescence ***4F9/2→6h13/2transition of Dy3+ions is responsible for the greatest emission peak,which was measured at 575 *** to research,the lifespan falls as the concentration of Dy3+doping amount rises because of frequent interaction and ene rgy transfer between Dy3+*** correlated color temperature of the WLEDs packaged with Ca2InTaO6:0.08Dy3+is 4677 K and CIE 1931 chromaticity coordinates are（0.3578,0.3831）.Meantime,the phosphor also shows outstanding te mperature stability property,which maintains 83.8% of its initial emission intensity at 450 K（activation energy of 0.1467 eV）.The W-LEDs retain their performance for 100 min when powered at 3.4 V voltage and 600 mA current,demonstrating the packed W-LEDs' sustaine d operation at high temperatures.

关键词： Ca2InTaO6:Dy3+ phosphors Photoluminescence Rare earths Thermal imaging Thermal stability W-LEDs

Oxidation Evolution and Activity Origin of N-Doped Carbon in the Oxygen Reduction Reaction

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Transactions of Tianjin University 2024年第4期30卷 369-379页

作者： jiaqi Wu Chuanqi Cheng Shanshan Lu Bin Zhang Yanmei shi Department of Chemistry School of ScienceInstitute of Molecular PlusTianjin UniversityTianjin 300072China School of Materials Science and Engineering Institute of New Energy MaterialsTianjin UniversityTianjin 300072China Tianjin Key Laboratory of Molecular Optoelectronic Science Collaborative Innovation Center of Chemical Science and EngineeringTianjin 300072China

N-doped carbon materials,with their applications as electrocatalysts for the oxygen reduction reaction(ORR),have been extensively ***,a negletcted fact is that the operating potential of the ORR is higher than the theoretical oxida-tion potential of carbon,possibly leading to the oxidation of carbon ***,the infl uence of the structural oxidation evolution on ORR performance and the real active sites are not *** this study,we discover a two-step oxida-tion process of N-doped carbon during the *** fi rst oxidation process is caused by the applied potential and bubbling oxygen during the ORR,leading to the oxidative dissolution of N and the formation of abundant oxygen-containing functional *** oxidation process also converts the reaction path from the four-electron(4e)ORR to the two-electron(2e)***,the enhanced 2e ORR generates oxidative h_(2)O_(2),which initiates the second stage of oxidation to some newly formed oxygen-containing functional groups,such as quinones to dicarboxyls,further diversifying the oxygen-containing functional groups and making carboxyl groups as the dominant *** also reveal the synergistic eff ect of multiple oxygen-containing functional groups by providing additional opportunities to access active sites with optimized adsorption of OOh*,thus leading to high effi ciency and durability in electrocatalytic h_(2)O_(2) production.

关键词： Oxygen reduction reaction N-doped carbon Reaction path Structural evolution Oxidation in reduction

Mechanisms of isomerization and hydration reactions of typicalβ-diketone at the air-droplet interface

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journal of Environmental Sciences 2024年第7期141卷 225-234页

作者： Yuemeng ji Weiyong Luo Qiuju shi Xiaohui Ma Ziqi Wu Weina Zhang Yanpeng Gao Taicheng An Guangdong-hong Kong-Macao joint Laboratory for Contaminants Exposure and health Guangdong Key Laboratory of Environmental Catalysis and Health Risk ControlInstitute Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of EducationSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China

Acetylacetone(AcAc)is a typical class ofβ-diketones with broad industrial applications due to the property of the keto-enol isomers,but its isomerization and chemical reactions at the air-droplet interface are still ***,using combined molecular dynamics and quantum chemistry methods,the heterogeneous chemistry of AcAc at the air-droplet interface was investigated,including the attraction of AcAc isomers by the droplets,the distribution of isomers at the air-droplet interface,and the hydration reactions of isomers at the air-droplet *** results reveal that the preferential orientation of two AcAc isomers(keto-and enol-AcAc)to accumulate and accommodate at the acidic air-droplet *** isomerization of two AcAc isomers at the acidic air-droplet interface is more favorable than that at the neutral air-droplet interface because the“water bridge”structure is destroyed by h_(3)O^(+),especially for the isomerization from keto-Ac Ac to *** the acidic air-droplet interface,the carbonyl or hydroxyl O-atoms of two AcAc isomers display an energetical preference to ***-diol is the dominant products to accumulate at the air-droplet interface,and excessive keto-diol can enter the droplet interior to engage in the *** photooxidation reaction of AcAc will increase the acidity of the air-droplet interface,which indirectly facilitate the uptake and formation of more *** results provide an insight into the heterogeneous chemistry ofβ-diketones and their influence on the environment.

关键词： Acetylacetone Air-droplet interface Theoretical simulation Isomerization hydration reaction mechanism

hydrogen storage thermodynamics and kinetics of as-cast Ce-Mg-Ni-based alloy

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journal of Iron and Steel Research International 2024年第3期31卷 752-766页

作者： Yan Qi Xin Zhang jun Li Dong-liang Zhao shi-hai Guo Yang-huan Zhang Department of Functional Material Research Central Iron and Steel Research InstituteBeijing 100081China China Rare Earth New Material(Weishan)Co..Ltd. Jining 277600ShandongChina Collaborative Innovation Center of Integrated Exploitation of Bayan Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina

The reaction kinetics of alloys based on magnesium are known to be greatly improved by the partial substitution of Mg with rare earths and transition metals,particularly *** enhanced superficial hydrogen dissociation rate,the weakened Mg-h bond and the lower activation energy following element replacement are thought to be related to the better *** experimental alloys Ce5Mg_(95-x)Ni_(x)(x=5,10,15)were smelted by the vacuum induction *** phase transformation and structural evolution of experimental alloys before and after reaction with hydrogen were char-acterized by X-ray diffraction,scanning electron microscopy and transmission electron *** cast specimens contain CeMg_(12),Mg and Mg_(2)Ni phases,and the increase in Ni content results in an obvious growth of Mg_(2)Ni *** isothermal and non-isothermal hydrogenation and dehydrogenation kinetics of the experimental specimens were investi-gated using the Sievert apparatus,differential scanning calorimetry and thermal gravimetric *** activation energy may be calculated using the Arrhenius and Kissinger *** experimental alloys have been shown to have good activation properties,with a reversible hydriding and dehydriding capacities of around 5.0 wt.%in the first *** initial dehydrogenation temperature of Mgh_(2) decreases from 557.5 to 537.7 K with changing Ni content from 5 to 15 at.%.The dehydrogenation activation energy also reduces from 77.09 to 62.96 kj/mol,which explains the improved hydrogen storage performance caused by Ni *** can be shown that the impact of Ni on the decomposition enthalpy of Mgh_(2) is quite modest,with the absolute enthalpy(Δhr)only decreasing from 78.48 to 76.15 kj/mol.

关键词： Mg-based alloy Ni content hydrogen storage kinetics Thermodynamic property Activation energy

Ligand effect in surface atomic sites of group VI B transition metals on ultrathin Pt nanowires for enhanced oxygen reduction

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Nano Research 2024年第6期17卷 5298-5304页

作者： Yuwei he Yueguang Chen Renjie Wu Zhihe Xiao Mengxian Li Chunfeng shi Leyu Wang State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Petroleum Molecular and Process Engineering SINOPEC Research Institute of Petroleum Processing Co.Beijing 100083China

Increasing the utilization efficiency of platinum is critical for advancing proton exchange-membrane fuel cells(PEMFCs).Despite extensive research on catalysts for the cathodic oxygen reduction reaction(ORR),developing highly active and durable Pt-based catalysts that can suppress surface dealloying in corrosive acid conditions remains ***,we report a facile synthesis of bimetallic ultrathin PtM(M=Mo,W,and Cr)nanowires(NWs)composed of group VI B transition metal atomic sites anchored on the *** NWs possess uniform sizes and well-controlled atomic *** to PtW and PtCr catalysts,the PtMo0.05 NWs exhibit the highest half-wave potential of 0.935 V and a mass activity of 1.43 A·mgPt^(−1).Remarkably,they demonstrate a remarkable 23.8-fold enhancement in mass activity compared to commercial Pt/C for ORR,surpassing previously reported Pt-based ***,the PtMo NWs cathode in membrane electrode assembly tests achieves a remarkable peak power density of 1.443 W·cm^(−2)(h_(2)-O_(2)conditions at 80℃),which is 1.09 times that of commercial Pt/*** ligand effect in the bimetallic surface not only facilitates strong coupling between Mo(4d)and Pt(5d)atomic orbitals to hinder atom leaching but also modulates the d-states of active site,significantly optimizing the adsorption of key oxygen(*O and*Oh)species and accelerating the rate-determining step in ORR pathways.

关键词： ligand effect oxygen reduction reaction group VI B transition metal ultrathin nanowires multiple oxygen species

Meiotic nuclear divisions 1 suppresses the proliferation and invasion of pancreatic cancer cells via regulating h2A.X variant histone

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BIOCELL 2024年第1期48卷 111-122页

作者： DONGQIN WANG YAN shi ZhIQIANG WANG jING ZhANG LUYAO WANG hONGYU MA ShUhUA shi XIAOFU LIAN hUA hUANG XIAOjING WANG ChAOQUN LIAN Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease Molecular Diagnosis CenterThe Department of Pulmonary Critical Care MedicineFirst Affiliated Hospital of Bengbu Medical CollegeBengbu233030China Department of Genetics School of Life SciencesBengbu Medical CollegeBengbu233000China Department of Clinical Medicine Bengbu Medical CollegeBengbu233030China Research Center of Clinical Laboratory Science Bengbu Medical CollegeBengbu233030China

Introduction:Among all malignant tumors of the digestive system,pancreatic carcinoma exhibits the highest mortality ***,prevention and effective treatment are urgent issues that need to be ***:The study focused on meiotic nuclear divisions 1(MND1),integrating data from the Gene Expression Profiling Interactive Analysis(GEPIA)database with prognostic survival ***,experiments at cellular level were employed to demonstrate the effect of MND1 on the proliferation and migration of *** small-molecule inhibitor of MND1 was used to suppress the migration of PC cells by knocking down MND1 using small interfering RNA(siRNA)in Patu-8988 and Panc1 cell ***:The results of Cell Counting Kit-8 indicated that the suppression of MND1 resulted in a decrease in cell *** healing and Transwell assays revealed that MND1 knockdown reduced cell migration and *** cytometry revealed that inhibiting MND1 hindered the cell ***,MND1 could stimulate the proliferation,migration,and invasion of Patu-8988 and Panc1 cells by increasing the expression of ***,MND1 had a positive effect on h2AFX expression in PC *** MND1 expression suggests the low overall survival rate of individuals diagnosed with ***:These findings suggest that MND1 has the potential to be a gene with the ability to accurately diagnose and treat PC.

关键词： Pancreatic carcinoma MND1 h2AFX Cell cycle

Alloy strategy to synthesize Pt-early transition metal oxide interfacial catalysts

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Nano Research 2024年第4期17卷 3390-3397页

作者： shi-Long Xu hang Nan Wanqun Zhang Yue Lin Sheng-Qi Chu hai-Wei Liang hefei National Research Center for Physical Sciences at the Microscale Department of ChemistryUniversity of Science and Technology of ChinaHefei 230026China School of Materials and Chemical Engineering Anhui Jianzhu UniversityHefei 230601China Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China

Metal oxide supported metal catalysts show promising catalytic performance in many industry-relevant ***,the enhancement of performance is often limited by the insufficient metal/metal oxide *** this work,we demonstrate a general synthesis of Pt-early transition metal oxide(Pt-MO_(x),M=Ti,Zr,V,and Y)catalysts with rich interfacial sites,which is based on the air-induced surface segregation and oxidation of M in the supported Pt-M alloy *** characterizations verify the dynamic structural response of Pt-M alloy catalysts to air and the formation of Pt-MO_(x) catalysts with abundant interfacial *** prepared Pt-TiO_(x) interfacial catalysts exhibit improved performance in hydrogenation reactions of benzaldehyde,nitrobenzene,styrene,and furfural,as a result of the heterolytic dissociation of h_(2) at Pt-metal oxide interfacial sites.

关键词： Pt-early transition metal oxide interfacial catalyst alloy oxidation strategy interfacial sites hydrogenation reactions heterolytic dissociation