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Albumin–bilirubin grade as a predictor of survival in hepatocellular carcinoma patients with thrombocytopenia

World journal of Gastrointestinal Oncology 2024年第5期16卷 1763-1772页

作者： Zhong-Ran Man xuan-Kun Gong kang-lin Qu Qing Pang bin-Quan Wu Department of hepatobiliary surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of hepatobiliary surgery Anhui No.2 Provincial People’s HospitalHefei 230041Anhui ProvinceChina

bAcKGROUND The models for assessing liver function,mainly the child–Pugh(cP),albuminbilirubin(AlbI),and platelet–AlbI(PAlbI)classifications,have been validated for use in estimating the prognosis of hepatocellular carcinoma(hcc)***,thrombocytopenia is a common finding and may influence the prognostic value of the three models in *** To investigate and compare the prognostic performance of the above three models in thrombocytopenic hcc *** A total of 135 patients with thrombocytopenic hcc who underwent radical surgery were retrospectively *** scores on the cP,AlbI and PAlbI classifications were estimated ***–Meier curves with logrank tests and cox regression models were used to explore the significant factors associated with overall survival(Os)and recurrence-free survival(RFs).REsUlTs The preoperative platelet counts were significantly different among the cP,AlbI and PAlbI *** a median follow-up of 28 mo,39.3%(53/135)of the patients experienced postoperative recurrence,and 36.3%(49/135)*** analysis suggested thatα-fetoprotein levels,tumor size,vascular invasion,and AlbI grade were significant predictors of Os and *** to the multivariate cox regression model,AlbI was identified as an independent prognostic ***,cP and PAlbI grades were not statistically significant prognostic *** The AlbI grade,rather than cP or PAlbI grade,is a significant prognostic indicator for thrombocytopenic hcc patients.

关键词： hepatocellular carcinoma Thrombocytopenia child-Pugh Albumin-bilirubin Platelet-albumin-bilirubin

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Optimization of performance of the KM2A full array using the crab Nebula

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chinese Physics c 2024年第6期48卷 169-178页

作者：曹臻 F.Aharonian 安琪阿西克古白云翔包逸炜 D.bastieri 毕效军毕玉江蔡金庭曹晴曹文羽曹喆常进常劲帆陈尚明陈恩生陈亮陈林陈龙陈明君陈玛丽陈起辉陈素弘陈天禄陈阳程宁程耀东崔明阳崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 D.della Volpe 董绪强段凯凯樊军辉范一中方军方堃冯存峰封莉冯少辉丰晓婷冯有亮 s.Gabici 高博高川东高林青高启高卫高伟康葛茂茂耿利斯 G.Giacinti 龚光华苟全补顾旻皓郭福来郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何佳银何新波何钰 M.heller 贺远强侯博文侯超侯贤胡红波胡铨胡世聪黄代绘黄天奇黄文俊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜晓巍姜泽军金敏康明铭柯通 D.Kuleshov.K.Kurinov 李兵兵李澄李骢李丹李飞李海波李会财李华阳李军李剑李捷李凯李文龙李文莲李秀荣李昕李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣闵振 W.Mitthumsiri 穆慧君南云程 A.Neronov 区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 D.Ruffolo A.sáiz D.semikoz 邵澄宇邵琅 O.shchegolev 盛祥东舒富文宋慧超 Yu.V.stenkin V.stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐庆文唐泽波田文武王超王昌贝王广威王洪光王惠惠王建成汪凯王利苹王玲玉王培汉王冉王为王祥高王祥玉王阳王玉东王岩谨王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁峰徐仁新徐伟立薛良闫大海颜景志颜田杨朝文杨帆杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮查敏张彬彬张丰张海明张恒英张建立张丽霞张力张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张毅张勇赵兵赵静赵雷赵立志赵世平郑福周斌周浩周佳能周猛周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 lhAAsO collaboration key laboratory of Particle Astrophyics&Experimental Physics Division&computing center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese Academy of sciences Beijing 100049China Tianfu cosmic Ray Research center Chengdu 610000China Dublin Institute for Advanced studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany state key laboratory of Particle Detection and Electronics China University of science and Technology of china Hefei 230026China school of Physical science and Technology&school of Information science and Technology Southwest Jiaotong UniversityChengdu 610031China school of Astronomy and space science Nanjing UniversityNanjing 210023China center for Astrophysics Guangzhou UniversityGuangzhou 510006China hebei Normal University Shijiazhuang 050024China key laboratory of Dark Matter and space Astronomy&key laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Tsung-Dao lee Institute&school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China key laboratory for Research in Galaxies and cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China key laboratory of cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China school of Physics and Astronomy(Zhuhai)&school of Physics(Guangzhou)&sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275China school of Physics and Astronomy Yunnan UniversityKunming 650091China Département de Physique Nucléaire et corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary science Shandong UniversityQingdao 266237China APc Universit'e Paris Cit'eCNRS/IN2P3CEA/IRFUObservat

The full array of the large high Altitude Air shower Observatory(lhAAsO)has been in operation since july *** its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2021 to August 2022,resulting in an improvement in significance of the detection in the crab Nebula of approximately 15%,compared with that of previous *** the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of *** aspects of the full KM2A array performance,such as the pointing error,were also calibrated using the crab *** resulting energy spectrum of the crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from lhAAsO and other experiments.

关键词： γ-ray crab Nebula significance

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Emerging strategies and developments in oxygen reduction reaction using high-performance platinum-based electrocatalysts

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Nano Research 2024年第5期17卷 3516-3532页

作者： Asad Ali Aatto laaksonen Guo huang shahid hussain shuiping luo Wen chen Pei kang shen jinliang Zhu xiaoyan ji Energy Engineering Division of Energy ScienceLuleåUniversity of Technology97187 LuleåSweden Department of Materials and Environmental chemistry Arrhenius LaboratoryStockholm UniversitySE-10691 StockholmSweden center of Advanced Research in bionanoconjugates and biopolymers “Petru Poni”Institute of Macromolecular ChemistryIasi 700469Romania state key laboratory of Materials-Oriented and chemical Engineering Nanjing Tech UniversityNanjing 211816China college of Materials science and Engineering Shenzhen UniversityShenzhen 518060China school of Resources Environment and MaterialsState Key Laboratory of Processing for Non-ferrous Metal and Featured MaterialsGuangxi UniversityNanning 530004China

The global practical implementation of proton exchange membrane fuel cells(PEMFcs)heavily relies on the advancement of highly effective platinum(Pt)-based electrocatalysts for the oxygen reduction reaction(ORR).To achieve high ORR performance,electrocatalysts with highly accessible reactive surfaces are needed to promote the uncovering of active positions for easy mass *** this critical review,we introduce different approaches for the emerging development of effective ORR electrocatalysts,which offer high activity and *** strategies,including morphological engineering,geometric configuration modification via supporting materials,alloys regulation,core-shell,and confinement engineering of single atom electrocatalysts(sAEs),are discussed in line with the goals and requirements of ORR performance *** review the ongoing development of Pt electrocatalysts based on the syntheses,nanoarchitecture,electrochemical performances,and *** eventually explore the obstacles and research directions on further developing more effective electrocatalysts.

关键词： oxygen reduction reaction(ORR) Pt-based electrocatalysts proton exchange membrane fuel cells(PEMFcs) morphology and alloys strategies single atom electrocatalysts(sAEs)

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Rescattering of stimulated Raman side scattering in nonuniform plasmas

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： s.Tan Q.Wang Y.chen W.b.Yao c.Z.xiao j.F.Myatt school of Physics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Physics and computational Mathematics Beijing 100094China school of Electrical and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Rescattering of stimulated Raman side scattering(sRss)is observed for the first time via two-dimensional(2D)particle-in-cell(PIc)*** construct a theoretical model for the rescattering process,which can predict the region of occurrence of mth-order sRss and estimate its *** rescattering process is identified by the 2D PIc simulations under typical conditions of a direct-drive inertial confinement fusion *** electrons produced by second-order sRss propagate nearly perpendicular to the density gradient and gain nearly the same energy as in first-order sRss,but there is no cascade acceleration to produce superhot *** studies for a wide range of ignition conditions show that sRss and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering

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PVDF/6h-sic composite fiber films with enhanced piezoelectric performance by interfacial engineering for diversified applications

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journal of Materials science & Technology 2024年第3期170卷 238-245页

作者： linlin Zhou Tao Yang chunyu Guo kang Wang Enhui Wang laipan Zhu hailong Wang sheng cao Kuo-chih chou xinmei hou Institute for carbon Neutrality University of Science and Technology BeijingBeijing 100083China beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China school of Materials science Engineering Zhengzhou UniversityZhengzhou 450001China state key laboratory of Featured Metal Materials and life-cycle safety for composite structures Guangxi UniversityNanning 530004China

Piezoelectric silicon carbide(sic)has been quite attractive due to its superior chemical and physical properties as well as wide potential ***,the inherent brittleness and unsatisfactory piezoelectric response of piezoelectric semiconductors remain the major obstacles to their diversified ***,flexible multifunctional PVDF/6h-sic composite fiber films are fabricated and utilized to assemble both piezoelectric nanogenerators(PENGs)and stress/temperature/light *** open cir-cuit voltage(V_(oc))and the density of short circuit current(I_(sc))of the PENG based on the PVDF/5 wt%6h-sic composite fiber films reach 28.94 V and 0.24μA cm^(-2),showing a significant improvement of 240%and 300%compared with that based on the pure PVDF *** effect of 6h-sic nanoparticles(NPs)on inducing interfacial polarization and stress concentration in composite fiber films is proved by first-principles calculation and finite element *** stress/temperature/light sensors based on the composite fiber film also show high sensitivity to the corresponding *** study shows that the PVDF/6h-sic composite fiber film is a promising candidate for assembling high-performance energy harvesters and diverse sensors.

关键词： 6h-sic PVDF Multifunctional composite fiber film Energy harvester stress/temperature/light sensor

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sulfur doped iron-nitrogen-hard carbon nanosheets as efficient and robust noble metal-free catalysts for oxygen reduction reaction in PEMFc

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journal of Energy chemistry 2024年第2期89卷 422-433,I0010页

作者： bin liu jiawang li bowen Yan Qi Wei xingyu Wen huarui xie huan he Pei kang shen Zhi Qun Tian collaborative Innovation center of sustainable Energy Materials School of Physical Science and TechnologyGuangxi UniversityGuangxi Key Laboratory of Electrochemical Energy MaterialsState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresNanning 530004GuangxiChina

Transition metal-nitrogen-carbon(M-N-c)as a promising substitute for the conventional noble metalbased catalyst still suffers from low activity and durability for oxygen reduction reaction(ORR)in proton exchange membrane fuel cells(PEMFcs).To tackle the issue,herein,a new type of sulfur-doped ironnitrogen-hard carbon(s-Fe-N-hc)nanosheets with high activity and durability in acid media were developed by using a newly synthesized precursor of amide-based polymer with Fe ions based on copolymerizing two monomers of 2,5-thiophene dicarboxylic acid(TDA)as s source and 1,8-diaminonaphthalene(DAN)as N source via an amination *** as-synthesized s-Fe-N-hc features highly dispersed atomic Fe Nxmoieties embedded into rich thiophene-s doped hard carbon nanosheets filled with highly twisted graphite-like microcrystals,which is distinguished from the majority of M-N-c with soft or graphitic carbon *** unique characteristics endow s-Fe-N-hc with high ORR activity and outstanding durability in 0.5 M h_(2)sO_(4).Its initial half-wave potential is 0.80 V and the corresponding loss is only 21 m V after 30,000 ***,its practical PEMFc performance is a maximum power output of 628.0 mW cm^(-2)and a slight power density loss is 83.0 m W cm^(-2)after 200-cycle practical ***,theoretical calculation shows that the activity of Fe Nxmoieties on ORR can be further enhanced by sulfur doping at meta-site near FeN_(4)*** results evidently demonstrate that the dual effect of hard carbon substrate and s doping derived from the precursor platform of amid-polymers can effectively enhance the activity and durability of Fe-N-c catalysts,providing a new guidance for developing advanced M-N-c catalysts for ORR.

关键词： Transition metal-nitrogen-carbon Oxygen reduction reaction hard carbon Amide based polymer reaction Proton exchange membrane cells

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Advances in magnesium-containing bioceramics for bone repair

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biomaterials Translational 2024年第1期5卷 3-20页

作者： Qi l. Zhao T. Yan j. Ge W. jiang W. Wang j. Gholipourmalekabadi M. lin K. Wang x. Zhang l. Department of Oral and cranio-Maxillofacial surgery Shanghai Ninth People’s Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology Shanghai China Department’s Education Deputy Department of Medical Biotechnology Iran University of Medical Sciences Tehran Iran Institute of Translational Medicine Shanghai University Organoid Research Center Shanghai University Shanghai China

Reconstruction of bone defects or fractures caused by ageing, trauma and tumour resection is still a great challenge in clinical treatment. Although autologous bone graft is considered as gold standard, the source of natural bone is limited. In recent years, regenerative therapy based on bioactive materials has been proposed for bone reconstruction. specially, numerous studies have indicated that bioactive ceramics including silicate and phosphate bioceramics exhibit excellent osteoinductivity and osteoconductivity, further promote bone regeneration. In addition, magnesium (Mg) element, as an indispensable mineral element, plays a vital role in promoting bone mineralisation and formation. In this review, different types of Mg-containing bioceramics including Mg-containing calcium phosphate-based bioceramics (such as Mg-hydroxyapatite, Mg-biphasic calcium phosphate), Mg-containing calcium silicate-based bioceramics (such as Mg2siO4, ca2Mgsi2O7and Mg-doped bioglass), Mg-based biocements, Mg-containing metal/polymer-bioceramic composites were systematacially summarised. Additionally, the fabrication technologies and their materiobiological effects were deeply discussed, clinical applications and perspectives of magnesium-containing bioceramics for bone repair are highlighted. Overall, Mg-containing bioceramics are regarded as regenerative therapy with their optimised performance. Furthermore, more in-depth two-way researches on their performance and structure are essential to satisfy their clinical needs. © 2024, chinese Medical Multimedia Press co ltd. All rights reserved.

关键词： bioactive ions bioceramics bone repair magnesium osteoconductivity

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low temperature-mediated repression and far-red light-mediated induction determine morning FlOWERING lOcUs T expression levels

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journal of Integrative Plant biology 2024年第1期66卷 103-120页

作者： hayeon Kim hye Won kang Dae Yeon hwang Nayoung lee Akane Kubota Takato Imaizumi Young hun song Department of Agricultural biotechnology Seoul National UniversitySeoul 08826Korea Department of biology Ajou UniversitySuwon 16499Korea Plant Genomics and breeding Institute Seoul National UniversitySeoul 08826Korea Graduate school of science and Technology Nara Institute of Science and TechnologyIkomaNara 630‐0192Japan Department of biology University of WashingtonSeattleWA 98195USA Institute of Agricultural life sciences Seoul National UniversitySeoul 08826Korea

In order to flower in the appropriate season,plants monitor light and temperature changes and alter downstream pathways that regulate florigen genes such as Arabidopsis(Arabidopsis thaliana)FlOWERING lOcUs T(FT).In Arabidopsis,FT messenger RNA levels peak in the morning and evening under natural long-day conditions(lDs).however,the regulatory mechanisms governing morning FT induction remain poorly *** morning FT peak is absent in typical laboratory lDs characterized by high red:far-red light(R:FR)ratios and constant ***,we demonstrate that ZEITlUPE(ZTl)interacts with the FT repressors TARGET OF EATs(TOEs),thereby repressing morning FT expression in natural *** lDs with simulated sunlight(R:FR=1.0)and daily temperature cycles,which are natural lD-mimicking environmental conditions,FT transcript levels in the ztl mutant were high specifically in the morning,a pattern that was mirrored in the toe1 toe2 double *** night-to-morning temperatures increased the inhibitory effect of ZTl on morning FT expression by increasing ZTl protein levels early in the ***-red light counteracted ZTl activity by decreasing its abundance(possibly via phytochrome A(phyA))while increasing GIGANTEA(GI)levels and negatively affecting the formation of the ZTl-GI complex in the ***,the phyA-mediated high-irradiance response and GI play pivotal roles in morning FT *** findings suggest that the delicate balance between low temperature-mediated ZTl activity and the far-red light-mediated functions of phyA and GI offers plants flexibility in fine-tuning their flowering time by controlling FT expression in the morning.

关键词： far-red light FlOWERING lOcUs T flowering time GIGANTEA low night-to-morning temperature natural long days phytochrome A red to far-red ratio ZEITlUPE

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Methionine sources and genotype affect embryonic intestinal development,antioxidants,tight junctions,and growth-related gene expression in chickens

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Animal Nutrition 2024年第1期16卷 218-230页

作者： james K.lugata sawadi F.Ndunguru Gebrehaweria K.Reda xénia E.Ozsváth Eszter Angyal levente czeglédi Gabriella Gulyás Renáta Knop jános Oláh Zoltán Mészár Rita Varga brigitta csernus csaba szabó Department of Animal Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Department of Animal husbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture and Food sciences and Environmental Management Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research and Educational Farm University of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Evolutionary Zoology and human biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Methionine(Met)is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and *** present study examined the effect of in ovo injection of Dl-Met and l-Met sources and genotypes on chicken embryonic-intestinal development and *** eggs of the two genotypes,TETRA-sl layer hybrid(Tsl)—commercial layer hybrid and hungarian Partridge colored hen breed(hPc)—a native genotype,were randomly distributed into four treatments for each *** treatment groups include the following:1)control non-injected eggs(NoIn);2)saline-injected(saIn);3)Dl-Met injected(DlM);and 4)l-Met injected(lM).The in ovo injection was carried out on 17.5 d of embryonic development;after hatching,eight chicks per group were sacrificed,and the jejunum was extracted for *** results showed that both DlM and lM groups had enhanced intestinal development as evidenced by increased villus width,villus height,and villus area(Pcompared to the *** DlM group had significantly reduced crypt depth,glutathione(Gsh)content,glutathione s-transferase 3 alpha(GsT3),occludin(OclN)gene expression and increased villus height to crypt depth ratio in the Tsl genotype than the lM group(Phe hPc genotype has overexpressed insulin-like growth factor 1(IGF1)gene,tricellulin(MD2),occludin(OclN),superoxide dismutase 1(sOD1),and GsT3 genes than the Tsl genotype(Pconclusion,these findings showed that in ovo injection of Met enhanced intestinal development,and function,with genotypes responding differently under normal *** also influenced the expression of intestinal antioxidants,tight junction,and growth-related genes.

关键词： Dl-Methionine l-Methionine In ovo injection Intestinal development Poultry

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Neutral color and self-healable electrochromic system based on cuI/cu and I_(3)^(-)/I^(-)conversions

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Nano Research 2024年第5期17卷 4437-4443页

作者： junsen Zhong bingkun huang Kunjie Yang Zuju Ma lingyu Du Ning luo Fengjiao Tang chuanxin hou Fuyi jiang litao kang college of Environment and Materials Engineering Yantai UniversityYantai 264005China school of Energy and Power Engineering Shandong UniversityJinan 250061China shandong laboratory of Advanced Materials and Green Manufacturing(Yantai) Yantai 264001China

The electrochromic(Ec)mechanisms of inorganic materials are usually based on reversible cation insertion/extraction or metal deposition/dissolution,which are plagued by ion trapping and dendrite growth,*** this paper,a novel conversion-type electrochromic mechanism is proposed,by making good use of the cuI/cu redox *** cuI-based electrochromic system shows a neutral color switching from transparent and dim *** simply increasing the bleaching voltage,I_(3)^(-)/I^(-)redox couple can be further *** generated I_(3)^(-)will readily react with cu,effectively improving the conversion reversibility and thereby rejuvenating the degraded electrochromic *** to the well-designed electrode and the self-healing ability,this conversion electrochromic system achieves rapid response times(tcoloring:23 s,tbleaching:6 s),decant optical modulation amplitude(26.4%),high coloration efficiency(86.15 cm^(2)·c^(-1)),admirable cyclic durability(without performance degradation after 480 cycles)and excellent optical memory ability(transmittance variationh open-circuit storage).The establishment of this conversion-type electrochromism may inspire the exploration of novel electrochromic materials and devices.

关键词： electrochromic cuI conversion reaction self-healing neutral color

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